Self-recognition drives the preferential accumulation of promiscuous CD4+ T-cells in aged mice

T Cell Receptor Cross-Reactivity between Similar Foreign and Self Peptides Influences Naive Cell Population Size and Autoimmunity

(2015) Ryan W. Nelson et al.   IMMUNITY

Revisiting Thymic Positive Selection and the Mature T Cell Repertoire for Antigen

(2014) Nienke Vrisekoop et al.   IMMUNITY

West Nile Virus-Specific CD4 T Cells Exhibit Direct Antiviral Cytokine Secretion and Cytotoxicity and Are Sufficient for Antiviral Protection

(2014) J. D. Brien et al.   JOURNAL OF IMMUNOLOGY

Clonal Expansions and Loss of Receptor Diversity in the Naive CD8 T Cell Repertoire of Aged Mice

(2014) M. Ahmed et al.   JOURNAL OF IMMUNOLOGY

The Ability To Rearrange Dual TCRs Enhances Positive Selection, Leading to Increased Allo- and Autoreactive T Cell Repertoires

(2014) Peggy P. Ni et al.   JOURNAL OF IMMUNOLOGY

Age-Related Decrease in TCR Repertoire Diversity Measured with Deep and Normalized Sequence Profiling

(2014) O. V. Britanova et al.   JOURNAL OF IMMUNOLOGY

The TCR's sensitivity to self peptide–MHC dictates the ability of naive CD8+ T cells to respond to foreign antigens

(2014) Ross B Fulton et al.   NATURE IMMUNOLOGY

Intrinsic CD4+ T cell sensitivity and response to a pathogen are set and sustained by avidity for thymic and peripheral complexes of self peptide and MHC

(2014) Stephen P Persaud et al.   NATURE IMMUNOLOGY

T Cell-Positive Selection Uses Self-Ligand Binding Strength to Optimize Repertoire Recognition of Foreign Antigens

(2013) Judith N. Mandl et al.   IMMUNITY

West Nile virus infection and immunity

(2013) Mehul S. Suthar et al.   NATURE REVIEWS MICROBIOLOGY

Maintenance of Peripheral Naive T Cells Is Sustained by Thymus Output in Mice but Not Humans

(2012) Ineke den Braber et al.   IMMUNITY

T cells and their eons-old obsession with MHC

(2012) Lei Yin et al.   IMMUNOLOGICAL REVIEWS

Diversity-oriented approaches for interrogating T-cell receptor repertoire, ligand recognition, and function

(2012) Michael E. Birnbaum et al.   IMMUNOLOGICAL REVIEWS

Defective CD8 T Cell Responses in Aged Mice Are Due to Quantitative and Qualitative Changes in Virus-Specific Precursors

(2012) V. Decman et al.   JOURNAL OF IMMUNOLOGY

Lifelong Persistent Viral Infection Alters the Naive T Cell Pool, Impairing CD8 T Cell Immunity in Late Life

(2012) M. J. Smithey et al.   JOURNAL OF IMMUNOLOGY

Quantification of lymph node transit times reveals differences in antigen surveillance strategies of naive CD4+ and CD8+ T cells

(2012) J. N. Mandl et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Changes in primary lymphoid organs with aging

(2012) Ivan K. Chinn et al.   SEMINARS IN IMMUNOLOGY

Persistent degenerative changes in thymic organ function revealed by an inducible model of organ regrowth

(2011) Ann V. Griffith et al.   AGING CELL

High prevalence of low affinity peptide–MHC II tetramer–negative effectors during polyclonal CD4+T cell responses

(2011) Joseph J. Sabatino et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Repeated In Vivo Stimulation of T and B Cell Responses in Old Mice Generates Protective Immunity against Lethal West Nile Virus Encephalitis

(2011) Jennifer L. Uhrlaub et al.   JOURNAL OF IMMUNOLOGY

Nonrandom attrition of the naive CD8+ T-cell pool with aging governed by T-cell receptor:pMHC interactions

(2011) B. D. Rudd et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Giant cell arteritis: immune and vascular aging as disease risk factors

(2011) Shalini V Mohan et al.   ARTHRITIS RESEARCH & THERAPY

Negative Selection and Peptide Chemistry Determine the Size of Naive Foreign Peptide-MHC Class II-Specific CD4+ T Cell Populations

(2010) H. H. Chu et al.   JOURNAL OF IMMUNOLOGY

Key role of T cell defects in age-related vulnerability to West Nile virus

(2009) James D. Brien et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Simultaneous detection of many T-cell specificities using combinatorial tetramer staining

(2009) Evan W Newell et al.   NATURE METHODS

Positive selection optimizes the number and function of MHCII-restricted CD4+ T cell clones in the naive polyclonal repertoire

(2009) H. H. Chu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Single Peptide-MHC Complex Positively Selects a Diverse and Specific CD8 T Cell Repertoire

(2009) B. Wang et al.   SCIENCE

Homeostasis of Naive and Memory T Cells

(2008) Charles D. Surh et al.   IMMUNITY

Endogenous Naive CD8+ T Cell Precursor Frequency Regulates Primary and Memory Responses to Infection

(2008) Joshua J. Obar et al.   IMMUNITY

Age-associated decline in T cell repertoire diversity leads to holes in the repertoire and impaired immunity to influenza virus

(2008) Eric J. Yager et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Efficacy and effectiveness of influenza vaccination

(2008) Kristin L. Nichol   VACCINE