Article
Immunology
Ann-Mari Svennerholm, Anna Lundgren, Susannah Leach, Marjahan Akhtar, Firdausi Qadri
Summary: The ETVAX oral vaccine demonstrated the potential to induce strong mucosal immune responses in a majority of vaccinated Swedish adults and individuals of different age groups, including infants, in Bangladesh, showing promise in combating enterotoxigenic Escherichia coli infections.
JOURNAL OF INFECTIOUS DISEASES
(2021)
Article
Immunology
Richard I. Walker, A. Louis Bourgeois
Summary: Oral immunization is an effective strategy against mucosal enteric pathogens. Inactivated whole bacterial cells can also induce protective immunity. Developing a safe and simple delivery format with controlled immunogenic amounts of complex antigens is essential. Enhancing the efficacy of whole cell vaccines can be achieved through genetic engineering and the use of mucosal adjuvants. The development of ETVAX, a vaccine candidate against enterotoxigenic Escherichia coli (ETEC), has shown promising results.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Microbiology
Marlena M. Westcott, Maria Blevins, Thomas F. Wierzba, Alexis E. Morse, Kinnede R. White, Leigh Ann Sanders, John W. Sanders
Summary: Photochemical inactivation with psoralen and UVA light (PUVA) can improve the immunogenicity of an ETEC vaccine and preserve the functional integrity of protein antigens.
Article
Immunology
Addison E. Stone, Saraswatie Rambaran, Ivy V. Trinh, Marcus Estrada, Curtis W. Jarand, Blake S. Williams, Amelie E. Murrell, Chelsea M. Huerter, William Bai, Surya Palani, Yukihiro Nakanishi, Renee M. Laird, Frederic M. Poly, Wayne F. Reed, Jessica A. White, Elizabeth B. Norton
Summary: The stability of vaccine formulation is crucial to its efficacy. Biochemical evaluations provide information on composition and thermal stability, but animal models are needed to validate efficacy. This study assessed formulations of the mucosal adjuvant dmLT and found that immunization route and co-administered antigen had a greater impact on vaccine immunogenicity than dmLT formulation stability.
Article
Immunology
Renee W. Y. Chan, Shaojun Liu, Jonathan Y. Cheung, Joseph G. S. Tsun, Kate C. Chan, Kathy Y. Y. Chan, Genevieve P. G. Fung, Albert M. Li, Hugh Simon Lam
Summary: Comirnaty vaccine induces mucosal IgA and IgG responses with neutralizing activity, while CoronaVac vaccine primarily induces IgG responses in plasma, demonstrating differences in immune response between the two vaccine platforms.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Immunology
Victor Araujo Correa, Amanda Izeli Portilho, Elizabeth De Gaspari
Summary: Vaccines are crucial in controlling infectious diseases, but most vaccines are not effective in providing mucosal protection. More research is needed to develop vaccines that can elicit mucosal immunity and provide protection at the first site of contact with pathogens.
Review
Cell Biology
Megan V. C. Barnes, Peter J. M. Openshaw, Ryan S. Thwaites
Summary: Despite decades of research, respiratory syncytial virus (RSV)-induced bronchiolitis remains a major cause of infant hospitalization with no vaccines or specific therapies currently available. Recent studies have shown the role of Type-2 immune responses in RSV disease and suggest that it dampens Type-1 antiviral immunity. Other immunoregulatory pathways implicated in RSV disease highlight the importance of localized mucosal responses in the respiratory mucosa.
Article
Immunology
Shaswath S. Chandrasekar, Yashdeep Phanse, Rachel E. Hildebrand, Mostafa Hanafy, Chia-Wei Wu, Chungyi H. Hansen, Jorge E. Osorio, M. Suresh, Adel M. Talaat
Summary: The study demonstrated that using a heterologous immunization strategy can induce neutralizing antibodies against SARS-CoV-2 in mice, showing potential for a protective vaccine. This approach also induced polyfunctional T-cell responses, while the homologous plasmid vaccine strategy mainly led to local T-cell responses.
Article
Immunology
Peter F. Wright, Alejandra C. Prevost-Reilly, Harini Natarajan, Elizabeth B. Brickley, Ruth Connor, Wendy F. Wieland-Alter, Anna S. Miele, Joshua A. Weiner, Robert D. Nerenz, Margaret E. Ackerman
Summary: Respiratory/mucosal and serum/systemic antibody responses to SARS-CoV-2 infection are distinct host defense mechanisms influenced by age, severity of illness, and immunoglobulin class. Stimulation of respiratory immunity is crucial for SARS-CoV-2 vaccines aiming to limit transmission.
JOURNAL OF INFECTIOUS DISEASES
(2022)
Article
Immunology
Mariam Maltseva, Yannick Galipeau, Tyler M. Renner, Lise Deschatelets, Yves Durocher, Bassel Akache, Marc-Andre Langlois
Summary: Continuous viral evolution of SARS-CoV-2 has led to variants capable of immune evasion, vaccine breakthrough infections, and increased transmissibility. Intranasal administration of adjuvanted protein subunit vaccines can induce robust immune responses in mice, producing antibodies against the virus.
Article
Microbiology
Ian E. Hollifield, Natalya I. Motyka, Kaylynn A. Fernando, Jacob P. Bitoun
Summary: Enterotoxigenic E. coli (ETEC) is a common cause of secretory diarrhea in children and adults. The ability of ETEC to survive within macrophages and their interaction with the host immune system is not well understood.
Article
Immunology
Nsofwa Sukwa, Cynthia Mubanga, Luiza M. Hatyoka, Obvious N. Chilyabanyama, Mwelwa Chibuye, Samson Mundia, Masiliso Munyinda, Ethel Kamuti, Muyunda Siyambango, Sharif Badiozzaman, Samuel Bosomprah, Nils Carlin, Joanna Kaim, Bjorn Sjostrand, Michelo Simuyandi, Roma Chilengi, Ann-Mari Svennerholm
Summary: The study evaluated the safety, tolerability, and immunogenicity of an inactivated ETEC vaccine, ETVAX (R). The vaccine demonstrated good safety and tolerability in adults and children, and the 1/4 dose induced a stronger immune response in children.
Article
Respiratory System
Ruben Cornelis Anthonie de Groot, Silvia Cristina Estevao, Patrick Michael Meyer Sauteur, Aditya Perkasa, Theo Hoogenboezem, Emiel Benny Margriet Spuesens, Lilly Maria Verhagen, Anna Maria Christiane van Rossum, Wendy Wilhelmina Josephina Unger
Summary: Mycoplasma pneumoniae-specific mucosal antibodies protect against bacterial adhesion to respiratory epithelial cells, and are induced only during M. pneumoniae infection and not during asymptomatic carriage.
EUROPEAN RESPIRATORY JOURNAL
(2022)
Article
Immunology
Diprasom Das, Harm HogenEsch, Shankar Thangamani
Summary: This study reveals that treatment with broad-spectrum antibiotics increases the colonization and dissemination of Candida auris from the intestine. Furthermore, the intestinal colonization of C. auris alters the microbiome composition of antibiotic-treated mice. In C. auris infected mice, the number of CD11b+ CX3CR1+ macrophages in the intestine is significantly decreased, while the increase of Th17 and Th22 cells is comparable to Candida albicans infection. Candida-specific IgA is significantly increased in the serum of C. auris infected mice.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Multidisciplinary Sciences
Rui Tada, Miki Ogasawara, Daisuke Yamanaka, Yasuhiro Sakurai, Yoichi Negishi, Hiroshi Kiyono, Naohito Ohno, Jun Kunisawa, Yukihiko Aramaki
Summary: Research shows that polyphenols can enhance antigen-specific mucosal and systemic antibody responses in mice when used as mucosal adjuvants, with effects not limited to polymerised caffeic acid and showing similar activities across different types of polyphenols.
Article
Pharmacology & Pharmacy
Stephanie Longet, Vincenzo Aversa, Daire O'Donnell, Joshua Tobias, Monica Rosa, Jan Holmgren, Ivan S. Coulter, Ed C. Lavelle
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2017)
Review
Medicine, General & Internal
John D. Clemens, G. Balakrish Nair, Tahmeed Ahmed, Firdausi Qadri, Jan Holmgren
Article
Immunology
J. -B. Sun, J. Holmgren, M. S. Cragg, Z. Xiang
SCANDINAVIAN JOURNAL OF IMMUNOLOGY
(2017)
Article
Immunology
Jan Holmgren, Umesh D. Parashar, Stanley Plotkin, Jacques Louis, Su-Peing Ng, Eric Desauziers, Valentina Picot, Mitra Saadatian-Elahi
Article
Immunology
Jan Holmgren, Stefan Nordqvist, Margareta Blomquist, Frida Jeverstam, Michael Lebens, Sukanya Raghavan
Article
Pharmacology & Pharmacy
Sara Rattik, Polyxeni T. Mantani, Ingrid Yao Mattisson, Irena Ljungcrantz, Lena Sundius, Harry Bjorkbacka, Manuela Terrinoni, Michael Lebens, Jan Holmgren, Jan Nilsson, Maria Wigren, Gunilla Nordin Fredrikson
VASCULAR PHARMACOLOGY
(2018)
Article
Multidisciplinary Sciences
Manuela Terrinoni, Jan Holmgren, Michael Lebens, Maximilian Larena
SCIENTIFIC REPORTS
(2019)
Article
Immunology
Christopher J. H. Davitt, Stephanie Longet, Aciel Albutti, Vincenzo Aversa, Stefan Nordqvist, Becky Hackett, Craig P. McEntee, Monica Rosa, Ivan S. Coulter, Michael Lebens, Joshua Tobias, Jan Holmgren, Ed C. Lavelle
MUCOSAL IMMUNOLOGY
(2019)
Editorial Material
Immunology
Jan Holmgren
Article
Immunology
Audur Anna Aradottir Pind, Magdalena Dubik, Sigrun Thorsdottir, Andreas Meinke, Ali M. Harandi, Jan Holmgren, Giuseppe Del Giudice, Ingileif Jonsdottir, Stefania P. Bjarnarson
FRONTIERS IN IMMUNOLOGY
(2019)
Article
Immunology
Stephanie Longet, Aine Abautret-Daly, Christopher J. H. Davitt, Craig P. McEntee, Vincenzo Aversa, Monica Rosa, Ivan S. Coulter, Jan Holmgren, Sukanya Raghavan, Ed C. Lavelle
Article
Dermatology
Matthew Malone, Erik Nygren, Tina Hamberg, Michael Radzieta, Slade O. Jensen
Summary: This study investigated the bacterial binding capabilities of non-medicated wound dressings through a series of in vitro experiments and in vivo observations. The results showed that under clinically relevant conditions and in human wounds, the ability of bacterial binding did not effectively reduce the number of bacteria.
INTERNATIONAL WOUND JOURNAL
(2023)
Article
Biotechnology & Applied Microbiology
Diego Chambi, Jenny Lundqvist, Erik Nygren, Luis Romero-Soto, Katherine Marin, Andras Gorzsas, Mattias Hedenstrom, Markus Carlborg, Markus Brostrom, Ola Sundman, Cristhian Carrasco, Leif J. Jonsson, Carlos Martin
Summary: A halotolerant, exopolysaccharide-producing bacterium isolated from the Salar de Uyuni salt flat in Bolivia was identified as Bacillus atrophaeus. The strain showed good growth and exopolysaccharide (EPS) production in synthetic media with glucose as the carbon source. Enzymatically produced cellulosic hydrolysates promoted the growth, while hemicellulosic hydrolysates produced using hydrothermal pretreatment inhibited the growth.
FERMENTATION-BASEL
(2022)
Article
Immunology
Manuela Terrinoni, Jan Holmgren, Michael Lebens, Maximilian Larena
FRONTIERS IN IMMUNOLOGY
(2019)
Article
Biotechnology & Applied Microbiology
Manuela Terrinoni, Stefan L. Nordqvist, Susanne Kallgard, Jan Holmgren, Michael Lebens
APPLIED AND ENVIRONMENTAL MICROBIOLOGY
(2018)