Article
Microbiology
Masayuki Kuraoka, Nicholas C. Curtis, Akiko Watanabe, Hidetaka Tanno, Seungmin Shin, Kevin Ye, Elizabeth Macdonald, Olivia Lavidor, Susan Kong, Tarra Von Holle, Ian Windsor, Gregory C. Ippolito, George Georgiou, Emmanuel B. Walter, Garnett Kelsoe, Stephen C. Harrison, M. Anthony Moody, Goran Bajic, Jiwon Lee
Summary: Influenza virus is constantly evolving, and the immune system responds by changing antibody responses; early exposure to the virus influences later immune responses; influenza vaccination may provide a more diverse immune imprint for infants compared to a single virus infection.
Article
Multidisciplinary Sciences
Kevin R. McCarthy, Tarra A. Von Holle, Laura L. Sutherland, Thomas H. Oguin, Gregory D. Sempowski, Stephen C. Harrison, M. Anthony Moody
Summary: Immune memory established by initial infection with influenza virus has a lasting imprint on later responses, which differ from those induced by early childhood immunization. A study comparing immune imprints from vaccination and infection in non-human primates found that initial exposure by infection led to strong but limited antibody responses, while initial vaccination elicited weaker but broader binding responses to different HA strains. This suggests that the mode of initial exposure affects the strength and breadth of the immune response.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Microbiology
David R. McIlwain, Han Chen, Zainab Rahil, Neda Hajiakhoond Bidoki, Sizun Jiang, Zach Bjornson, Nikita S. Kolhatkar, C. Josefina Martinez, Brice Gaudilliere, Julien Hedou, Nilanjan Mukherjee, Christian M. Schuerch, Angelica Trejo, Melton Affrime, Bonnie Bock, Kenneth Kim, David Liebowitz, Nima Aghaeepour, Sean N. Tucker, Garry P. Nolan
Summary: The study demonstrates that the oral influenza vaccine VXA-A1.1 can protect humans from H1N1 virus challenge, and identifies specific cellular immune responses associated with protection, providing important insights for enhancing influenza vaccine efficacy.
CELL HOST & MICROBE
(2021)
Article
Immunology
Zhaoyi Long, Jiang He, Qinglu Shuai, Ke Zhang, Jim Xiang, Huan Wang, Shuang Xie, Shengyu Wang, Wensheng Du, Xinsheng Yao, Junqiong Huang
Summary: This study found that H3 stalk-specific memory B cells can expand and secrete antibodies that bind to the stalk in vitro, although no increase in serum H3 stalk-reactive antibodies was found after vaccination, indicating potential for developing a universal vaccine strategy.
Article
Multidisciplinary Sciences
David Forgacs, Rodrigo B. Abreu, Giuseppe A. Sautto, Greg A. Kirchenbaum, Elliott Drabek, Kevin S. Williamson, Dongkyoon Kim, Daniel E. Emerling, Ted M. Ross
Summary: This study utilized high-throughput single cell sequencing to analyze B cell receptor repertoires in 17 participants vaccinated with influenza virus vaccine, revealing the presence of significantly expanded clonotypes in some participants and convergent evolution in 60% of participants. The binding profiles confirmed the subtype-specificity of public plasmablasts to the HA head.
Review
Microbiology
Katharina Roltgen, Scott D. Boyd
Summary: Human immune responses to SARS-CoV-2 have made significant progress in understanding the nature of antibody responses and their role in protecting against infection or modulating the severity of COVID-19, aiding in the development of effective vaccines. However, important questions remain unanswered regarding the duration and effectiveness of antibody responses, immunity differences between infection and vaccination, cellular basis for serological findings, and the potential impact of viral variants on current immunity.
CELL HOST & MICROBE
(2021)
Article
Biochemistry & Molecular Biology
Philip A. Mudd, Anastasia A. Minervina, Mikhail Pogorelyy, Jackson S. Turner, Wooseob Kim, Elizaveta Kalaidina, Jan Petersen, Aaron J. Schmitz, Tingting Lei, Alem Haile, Allison M. Kirk, Robert C. Mettelman, Jeremy Chase Crawford, Thi H. O. Nguyen, Louise C. Rowntree, Elisa Rosati, Katherine A. Richards, Andrea J. Sant, Michael K. Klebert, Teresa Suessen, William D. Middleton, Joshua Wolf, Sharlene A. Teefey, Jane A. O'Halloran, Rachel M. Presti, Katherine Kedzierska, Jamie Rossjohn, Paul G. Thomas, Ali H. Ellebedy
Summary: SARS-CoV-2 mRNA vaccines induce potent immune responses, including antibodies and CD4(+) T cell responses. Research has found that vaccine-induced follicular helper CD4(+) T cell responses play a key role in establishing long-term immunity.
Article
Multidisciplinary Sciences
Wooseob Kim, Julian Q. Zhou, Stephen C. Horvath, Aaron J. Schmitz, Alexandria J. Sturtz, Tingting Lei, Zhuoming Liu, Elizaveta Kalaidina, Mahima Thapa, Wafaa B. Alsoussi, Alem Haile, Michael K. Klebert, Teresa Suessen, Luis Parra-Rodriguez, Philip A. Mudd, Sean P. J. Whelan, William D. Middleton, Sharlene A. Teefey, Iskra Pusic, Jane A. O'Halloran, Rachel M. Presti, Jackson S. Turner, Ali H. Ellebedy
Summary: SARS-CoV-2 mRNA vaccination induces a persistent germinal center reaction in humans, resulting in affinity-matured long-term antibody responses that potently neutralize the virus.
Article
Biology
Kenneth B. Hoehn, Jackson S. Turner, Frederick Miller, Ruoyi Jiang, Oliver G. Pybus, Ali H. Ellebedy, Steven H. Kleinstein
Summary: The study found that after seasonal influenza vaccination, GC B cell lineages often exhibit measurable evolution, suggesting that the poor efficacy of seasonal influenza vaccines is not solely due to the inhibition of vaccine-specific B cell evolution.
Article
Multidisciplinary Sciences
Alice Cho, Frauke Muecksch, Dennis Schaefer-Babajew, Zijun Wang, Shlomo Finkin, Christian Gaebler, Victor Ramos, Melissa Cipolla, Pilar Mendoza, Marianna Agudelo, Eva Bednarski, Justin DaSilva, Irina Shimeliovich, Juan Dizon, Mridushi Daga, Katrina G. Millard, Martina Turroja, Fabian Schmidt, Fengwen Zhang, Tarek Ben Tanfous, Mila Jankovic, Thiago Y. Oliveria, Anna Gazumyan, Marina Caskey, Paul D. Bieniasz, Theodora Hatziioannou, Michel C. Nussenzweig
Summary: Infection with SARS-CoV-2 leads to evolving B cell responses over at least a year, while vaccination with mRNA vaccines results in high plasma neutralizing activity against various variants. Memory B cells from vaccinated individuals show increased neutralizing activity between prime and boost, but do not exhibit further expansion in potency or breadth.
Article
Cell Biology
Alice R. Burton, Stephane M. Guillaume, William S. Foster, Adam K. Wheatley, Danika L. Hill, Edward J. Carr, Michelle A. Linterman
Summary: This study reveals defects in the human germinal center reaction and memory B cell response following influenza vaccination in elderly individuals.
Review
Immunology
Stefania P. Bjarnarson, Siggeir F. Brynjolfsson
Summary: The importance of antibodies, especially neutralizing antibodies, has been recognized for many years. Measuring the levels of antigen-specific antibodies is easier than measuring the T-cell response when examining immune responses to a pathogen after vaccination or infection, but it does not provide a complete picture. Determining the levels of neutralizing antibodies is more challenging, but it gives a better indication of the quality of the antibody response. Inducing long-lived antibody-secreting plasma cells is crucial for a persistent humoral immune response.
CLINICAL AND EXPERIMENTAL IMMUNOLOGY
(2022)
Article
Immunology
Vincent Pernin, Maria Meneghini, Alba Torija, Thomas Jouve, Arnaud Del Bello, Ivan Sanz-Munoz, Jose Maria Eiros, Laura Donadeu, Carol Polo, Francisco Morandeira, Sergio Navarro, Cristina Masuet, Alexandre Fava, Moglie LeQuintrec, Nassim Kamar, Elena Crespo, Oriol Bestard
Summary: The study indicates the effectiveness of belatacept in inhibiting T-dependent antigen-specific humoral immune responses, highlighting the importance of active immunization before starting belatacept therapy.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Virology
Annette Fox, Louise Carolan, Vivian Leung, Hoang Vu Mai Phuong, Arseniy Khvorov, Maria Auladell, Yeu-Yang Tseng, Pham Quang Thai, Ian Barr, Kanta Subbarao, Le Thi Quynh Mai, H. Rogier van Doorn, Sheena G. Sullivan
Summary: Prior vaccination and infection have different effects on the immunogenicity and effectiveness of influenza vaccines. In this study, prior infection enhanced vaccine immunogenicity, while prior vaccination attenuated it. Comparing antibody responses to A(H3N2) viruses, it was found that prior infection increased antibody titers, while prior vaccination decreased them. This study highlights the importance of considering the immunological history when developing new vaccine strains.
Review
Allergy
Gemma E. Hartley, Emily S. J. Edwards, Robyn E. O'Hehir, Menno C. van Zelm
Summary: Since early 2020, the world has been facing a viral pandemic caused by SARS-CoV-2 and its variants, leading to a global mass morbidity and an estimated 6 million deaths. Immunology plays a critical role in combating this pandemic and is essential for successful vaccination and disease treatment. Recent research shows that the formation and durability of immune memory cells following vaccination are associated with protection against severe disease from SARS-CoV-2 infection.
Review
Immunology
David J. Topham, Phuong Nguyen, Mark Y. Sangster
CURRENT OPINION IN IMMUNOLOGY
(2018)
Article
Immunology
Yanjun Feng, Devon Livingston-Rosanoff, Linda Roback, Aarthi Sundararajan, Samuel H. Speck, Edward S. Mocarski, Lisa P. Daley-Bauer
JOURNAL OF IMMUNOLOGY
(2018)
Article
Virology
Brenda L. Tesini, Preshetha Kanagaiah, Jiong Wang, Megan Hahn, Jessica L. Halliley, Francisco A. Chaves, Phuong Q. T. Nguyen, Aitor Nogales, Marta L. DeDiego, Christopher S. Anderson, Ali H. Ellebedy, Shirin Strohmeier, Florian Krammer, Hongmei Yang, Sanjukta Bandyopadhyay, Rafi Ahmed, John J. Treanor, Luis Martinez-Sobrido, Hana Golding, Surender Khurana, Martin S. Zand, David J. Topham, Mark Y. Sangster
JOURNAL OF VIROLOGY
(2019)
Review
Microbiology
Mark Y. Sangster, Phuong Q. T. Nguyen, David J. Topham
Article
Biochemical Research Methods
Christopher S. Anderson, Mark Y. Sangster, Hongmei Yang, Thomas J. Mariani, Sidhartha Chaudhury, David J. Topham
BMC BIOINFORMATICS
(2020)
Article
Microbiology
Phuong Nguyen-Contant, A. Karim Embong, Preshetha Kanagaiah, Francisco A. Chaves, Hongmei Yang, Angela R. Branche, David J. Topham, Mark Y. Sangster
Article
Biophysics
Daniel J. Steiner, John S. Cognetti, Ethan P. Luta, Alanna M. Klose, Joseph Bucukovski, Michael R. Bryan, Jon J. Schmuke, Phuong Nguyen-Contant, Mark Y. Sangster, David J. Topham, Benjamin L. Miller
BIOSENSORS & BIOELECTRONICS
(2020)
Article
Microbiology
Ryan M. Pace, Janet E. Williams, Kirsi M. Jarvinen, Mandy B. Belfort, Christina D. W. Pace, Kimberly A. Lackey, Alexandra C. Gogel, Phuong Nguyen-Contant, Preshetha Kanagaiah, Theresa Fitzgerald, Rita Ferri, Bridget Young, Casey Rosen-Carole, Nichole Diaz, Courtney L. Meehan, Beatrice Caffe, Mark Y. Sangster, David Topham, Mark A. McGuire, Antti Seppo, Michelle K. McGuire
Summary: This study did not detect SARS-CoV-2 RNA in breast milk samples, indicating no transmission of the virus through milk. Breast milk from infected mothers contains anti-SARS-CoV-2 IgA and IgG, which neutralizes the virus and supports the recommendation to continue breastfeeding during maternal COVID-19 illness.
Review
Microbiology
Phuong Nguyen-Contant, Mark Y. Sangster, David J. Topham
Summary: Squalene-based emulsion adjuvants enhance immune responses and antibody production of influenza vaccines, as well as increasing the diversity and affinity of antibodies against influenza hemagglutinin. These adjuvants are widely used and can provide broad protection against influenza virus clades.
Article
Endocrinology & Metabolism
Aarthi Sundararajan, Kranti Vora, Shahin Saiyed, Senthilkumar Natesan
Summary: The study found that the levels of circulatory-DHEA-S in pregnant women were higher in those with adverse birth outcomes, especially in cases of stillbirth. Pregnant women with lower cortisol/DHEA-S ratio were also more likely to experience adverse birth outcomes.
CLINICAL ENDOCRINOLOGY
(2021)
Article
Endocrinology & Metabolism
Aarthi Sundararajan, Kranti Vora, Shahin Saiyed, Senthilkumar Natesan
Summary: The study found significant increases in salivary cortisol and DHEA-S levels during pregnancy, with high levels of salivary cortisol and DHEA-S showing a significant association with pregnancy. Therefore, the indicated time range for saliva sampling may best mirror the established profile of circulatory cortisol in pregnant women. Unlike cortisol, the study indicates that the profile of salivary DHEA-S is distinct from that of circulatory DHEA-S during pregnancy.
HORMONE AND METABOLIC RESEARCH
(2021)
Article
Microbiology
A. Karim Embong, Phuong Nguyen-Contant, Jiong Wang, Preshetha Kanagaiah, Francisco A. Chaves, Theresa F. Fitzgerald, Qian Zhou, Gabrielle Kosoy, Angela R. Branche, Benjamin L. Miller, Martin S. Zand, Mark Y. Sangster, David J. Topham
Summary: Infection with SARS-CoV-2 leads to strong antibody production. The study shows that pre-existing memory B cells generated by other coronaviruses play a role in recognizing the proteins of SARS-CoV-2. Additionally, the avidity of IgG antibodies and memory B cells increases after infection.
Letter
Hematology
Michael T. Brady, Nathan Laniewski, Myla Strawderman, Charles C. Chu, Preshetha Kanagaiah, Mark Y. Sangster, David J. Topham, Jonathan W. Friedberg, Clive S. Zent
AMERICAN JOURNAL OF HEMATOLOGY
(2023)
Article
Oncology
Clive S. Zent, Michael T. Brady, Carolyne Delage, Myla Strawderman, Nathan Laniewski, Phuong N. Contant, Preshetha Kanagaiah, Mark Y. Sangster, Paul M. Barr, Charles C. Chu, David J. Topham, Jonathan W. Friedberg
Review
Biotechnology & Applied Microbiology
Kranti Suresh Vora, Aarthi Sundararajan, Shahin Saiyed, Kuldeep Dhama, Senthilkumar Natesan
HUMAN VACCINES & IMMUNOTHERAPEUTICS
(2020)
