Editorial Material
Urology & Nephrology
Justine Bacchetta, Kyle D. Wood
Summary: This article reviews the significant progress in understanding and treating genetic primary hyperoxaluria, including the impact of gene mutations, medical therapy, and novel treatments. It also discusses the different perspectives of adult and pediatric nephrologists, as well as the challenges faced by physicians and patients in developing countries.
CLINICAL KIDNEY JOURNAL
(2022)
Article
Biochemistry & Molecular Biology
Silvia Berto, Martino Marangella, Concetta De Stefano, Demetrio Milea, Pier Giuseppe Daniele
Summary: New complexes such as [Cacit](4-) and [Ca2H2(PO4)(2)] significantly lower beta values in patients with nephrolithiasis. Investigation of the Ca-phosphate-citrate aqueous system through potentiometric titrations revealed that the [Ca(PO4)cit](4-) species is only noticeable at pH > 8.5.
Article
Urology & Nephrology
Megan Prochaska, John Asplin, Arlene Chapman, Elaine Worcester
Summary: The study found that men had higher calcium oxalate supersaturation in urine before RYGB, while women had higher urine calcium oxalate supersaturation and calcium phosphate supersaturation, as well as lower urine volumes after RYGB.
AMERICAN JOURNAL OF NEPHROLOGY
(2021)
Article
Endocrinology & Metabolism
Nina Lenherr-Taube, Michelle Furman, Esther Assor, Yesmino Elia, Carol Collins, Kenneth Thummel, Michael A. Levine, Etienne Sochett
Summary: Idiopathic infantile hypercalcemia is a rare disorder with variable clinical features and the response to dietary calcium and vitamin D restriction in mild cases is not able to consistently normalize elevated 1,25(OH)2D concentrations or prevent worsening of renal calcification. Therapeutic options should focus on the defect in vitamin D metabolism.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Review
Nutrition & Dietetics
Joseph J. Crivelli, Tanecia Mitchell, John Knight, Kyle D. Wood, Dean G. Assimos, Ross P. Holmes, Sonia Fargue
Summary: The prevalence of kidney stone disease is on the rise, with calcium oxalate being the most common stone composition. Dietary oxalate intake and endogenous production of oxalate play important roles in the pathophysiology of calcium oxalate stone disease, while oxalate-degrading bacteria in the gut microbiome may mitigate stone risk.
Article
Pharmacology & Pharmacy
Bingbing Hou, Mingming Liu, Yang Chen, Weijian Ni, Xiaoguo Suo, Yuexian Xu, Qiushi He, Xiaoming Meng, Zongyao Hao
Summary: The novel RIPK3 inhibitor Cpd-42 shows promising therapeutic potential for CaOx nephrocalcinosis by attenuating necroptosis and inflammation more effectively than the classic inhibitor dabrafenib. Cpd-42 reduces tissue injury, improves kidney function, and decreases intrarenal crystal deposition in a mouse model of CaOx nephrocalcinosis.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Genetics & Heredity
Amar J. Majmundar, Eugen Widmeier, John F. Heneghan, Ankana Daga, Chen-Han Wilfred Majmundar, Florian Buerger, Hannah Heneghan, Ihsan Ullah, Ali Amar, Isabel Ottlewski, Daniela A. Braun, Tilman Jobst-Schwan, Jennifer A. Lawson, Muhammad Yasir Zahoor, Nancy M. Rodig, Velibor Tasic, Caleb P. Nelson, Shagufta Khaliq, Ria Schoenauer, Jan Halbritter, John A. Sayer, Hanan M. Fathy, Michelle A. Baum, Shirlee Shril, Shrikant Mane, Seth L. Alper, Friedhelm Hildebrandt
Summary: Rare, dominant loss-of-function OXGR1 variants are associated with recurrent calcium oxalate nephrolithiasis and nephrocalcinosis. OXGR1 encodes alpha-ketoglutarate (AKG) receptor 1 in the distal nephron and plays a crucial role in calcium transport. The study provides evidence for the involvement of OXGR1 in the pathogenesis of NL/NC.
GENETICS IN MEDICINE
(2023)
Article
Urology & Nephrology
Nancy S. Krieger, John Asplin, Ignacio Granja, Luojing Chen, Daiana Spataru, Tong Tong Wu, Marc Grynpas, David A. Bushinsky
Summary: In this study, the effects of potassium citrate and chlorthalidone on calcium oxalate stone formation and bone quality were investigated using a genetic hypercalciuric stone-forming rat model. The results showed that potassium citrate plus chlorthalidone combination was more effective in reducing stone formation, while chlorthalidone alone improved bone quality.
KIDNEY INTERNATIONAL
(2021)
Article
Urology & Nephrology
Stanislav Yuzhakov, Shavano D. Steadman, Brandon J. Otto, Vincent G. Bird, Benjamin K. Canales
Summary: The study demonstrates a correlation between 24-hour urine calcium oxalate supersaturation (CaOx SS) and in vivo stone growth in individuals with pure CaOx stones. Higher CaOx SS levels were associated with increased stone growth rates, indicating potential for noninvasive study of stone growth modulators and improved stone risk prediction through CT volumetric analysis.
JOURNAL OF UROLOGY
(2021)
Article
Environmental Sciences
Anthony J. Branco, Anoushka S. Vattamparambil, Greg M. Landry
Summary: Nephrolithiasis, particularly calcium oxalate stones, causes severe pain and is highly recurrent. Environmental pollutants, such as lead, may increase the risk of calcium oxalate nephrolithiasis. Fruit fly models suggest that lead-induced increases in CaOx crystallization could be involved in kidney stone formation.
ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY
(2021)
Article
Urology & Nephrology
Raymond Khargi, Ryan M. Blake, Alan J. Yaghoubian, Caroline Canning, Alexander Fang, Christopher Connors, Blair Gallante, Anna Ricapito, Johnathan A. Khusid, William M. Atallah, Mantu Gupta
Summary: This study aims to identify unique urinary metabolic abnormality profiles in octogenarians with calcium oxalate kidney stones, in order to guide empiric stone prevention therapy more precisely in this population.
WORLD JOURNAL OF UROLOGY
(2023)
Article
Immunology
Qiuyue Ma, Melissa Grigorescu, Adrian Schreiber, Ralph Kettritz, Maja Lindenmeyer, Hans-Joachim Anders, Stefanie Steiger
Summary: Genetic background plays a significant role in determining the formation of kidney stones in mice, while the intestinal microbiome has minimal impact on this phenomenon.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Plant Sciences
Fahimeh Haghighatdoost, Reyhaneh Sadeghian, Behnood Abbasi
Summary: Higher consumption of tea is associated with an increased risk of calcium oxalate kidney stone, while coffee drinking is not relevant. However, caution should be taken when interpreting the results due to the low consumption of coffee in the population studied.
PLANT FOODS FOR HUMAN NUTRITION
(2021)
Review
Health Care Sciences & Services
Kyriaki Stamatelou, David S. Goldfarb
Summary: In the past two decades, there have been no major breakthroughs in the understanding and therapy of kidney stones, which remains a challenging disease for patients, physicians, and healthcare systems. Epidemiological studies play a crucial role in identifying global changes in the prevalence and burden of kidney stones and modifiable risk factors. The expanding knowledge of kidney stone epidemiology significantly enhances the modern management of the disease.
Article
Medicine, General & Internal
Piero Ruggenenti, Maria Rosa Caruso, Monica Cortinovis, Annalisa Perna, Tobia Peracchi, Giovanni Antonio Giuliano, Stefano Rota, Paolo Brambilla, Giuliana Invernici, Davide Villa, Olimpia Diadei, Matias Trillini, Grazia Natali, Giuseppe Remuzzi
Summary: The study found that adding fresh lemon juice supplementation to a standard diet may reduce stone recurrence in patients with calcium oxalate nephrolithiasis, but the treatment effect was likely compromised by declining patient adherence to lemon juice supplementation.