A truncated and dimeric format of an Affibody library on bacteria enables FACS-mediated isolation of amyloid-beta aggregation inhibitors with subnanomolar affinity

Engineering of a bispecific affibody molecule towards HER2 and HER3 by addition of an albumin-binding domain allows for affinity purification and in vivo half-life extension

(2014) Magdalena Malm et al.   Biotechnology Journal

First-in-Human Molecular Imaging of HER2 Expression in Breast Cancer Metastases Using the 111In-ABY-025 Affibody Molecule

(2014) J. Sorensen et al.   JOURNAL OF NUCLEAR MEDICINE

Therapeutic bispecific antibodies cross the blood-brain barrier in nonhuman primates

(2014) Y. J. Yu et al.   Science Translational Medicine

Site-Specific Radiometal Labeling and Improved Biodistribution Using ABY-027, A Novel HER2-Targeting Affibody Molecule-Albumin-Binding Domain Fusion Protein

(2013) A. Orlova et al.   JOURNAL OF NUCLEAR MEDICINE

Inhibiting HER3-Mediated Tumor Cell Growth with Affibody Molecules Engineered to Low Picomolar Affinity by Position-Directed Error-Prone PCR-Like Diversification

(2013) Magdalena Malm et al.   PLoS One

Central amyloid- -specific single chain variable fragment ameliorates A  aggregation and neurotoxicity

(2013) R. M. Nisbet et al.   PROTEIN ENGINEERING DESIGN & SELECTION

Is abeta a sufficient biomarker for monitoring anti-abeta clinical studies? A critical review

(2013) Jens Moreth et al.   Frontiers in Aging Neuroscience

Engineered antibody approaches for Alzheimer’s disease immunotherapy

(2012) Remy Robert et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Staphylococcal display for combinatorial protein engineering of a head-to-tail affibody dimer binding the Alzheimer amyloid-β peptide

(2012) Hanna Lindberg et al.   Biotechnology Journal

Surface display of a single-domain antibody library on Gram-positive bacteria

(2012) Filippa Fleetwood et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Inhibition of Amyloid Formation

(2012) Torleif Härd et al.   JOURNAL OF MOLECULAR BIOLOGY

A Plaque-Specific Antibody Clears Existing β-amyloid Plaques in Alzheimer's Disease Mice

(2012) Ronald B. DeMattos et al.   NEURON

Withania somnifera reverses Alzheimer's disease pathology by enhancing low-density lipoprotein receptor-related protein in liver

(2012) N. Sehgal et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Bacterial display in combinatorial protein engineering

(2011) John Löfblom   Biotechnology Journal

Mouse models of Alzheimer's disease

(2011) Alicia M. Hall et al.   BRAIN RESEARCH BULLETIN

Non-immunoglobulin based protein scaffolds

(2011) John Löfblom et al.   CURRENT OPINION IN BIOTECHNOLOGY

Monoclonal antibodies against β-amyloid (Aβ) for the treatment of Alzheimer's disease: the Aβ target at a crossroads

(2011) Francesco Panza et al.   EXPERT OPINION ON BIOLOGICAL THERAPY

A Therapeutic Antibody Targeting BACE1 Inhibits Amyloid-  Production in Vivo

(2011) J. K. Atwal et al.   Science Translational Medicine

Boosting Brain Uptake of a Therapeutic Antibody by Reducing Its Affinity for a Transcytosis Target

(2011) Y. J. Yu et al.   Science Translational Medicine

Affibody molecules: Engineered proteins for therapeutic, diagnostic and biotechnological applications

(2010) J. Löfblom et al.   FEBS LETTERS

Extending Half-life by Indirect Targeting of the Neonatal Fc Receptor (FcRn) Using a Minimal Albumin Binding Domain

(2010) Jan Terje Andersen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Alzheimer's disease: strategies for disease modification

(2010) Martin Citron   NATURE REVIEWS DRUG DISCOVERY

N-terminal engineering of amyloid-β-binding Affibody molecules yields improved chemical synthesis and higher binding affinity

(2010) Joel Lindgren et al.   PROTEIN SCIENCE

Sequestration of the Aβ Peptide Prevents Toxicity and Promotes Degradation In Vivo

(2010) Leila M. Luheshi et al.   PLOS BIOLOGY

A phase 2 multiple ascending dose trial of bapineuzumab in mild to moderate Alzheimer disease

(2009) S. Salloway et al.   NEUROLOGY

Interaction of Alzheimer’s Aβ Peptide with an Engineered Binding Protein—Thermodynamics and Kinetics of Coupled Folding–Binding

(2008) Wolfgang Hoyer et al.   JOURNAL OF MOLECULAR BIOLOGY

The Blood-Brain Barrier in Health and Chronic Neurodegenerative Disorders

(2008) Berislav V. Zlokovic   NEURON

Stabilization of a β-hairpin in monomeric Alzheimer's amyloid-β peptide inhibits amyloid formation

(2008) Wolfgang Hoyer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A novel affinity protein selection system based on staphylococcal cell surface display and flow cytometry

(2008) N. Kronqvist et al.   PROTEIN ENGINEERING DESIGN & SELECTION

Engineering of a femtomolar affinity binding protein to human serum albumin

(2008) A. Jonsson et al.   PROTEIN ENGINEERING DESIGN & SELECTION

Antibody-based approaches in Alzheimer’s research: safety, pharmacokinetics, metabolism, and analytical tools

(2007) Peter Lichtlen et al.   JOURNAL OF NEUROCHEMISTRY