Article
Physiology
Xiaoyao Liu, Mingjing Yin, Ying Li, Jianqun Wang, Junlong Da, Zhongshuang Liu, Kai Zhang, Lixue Liu, Wenxuan Zhang, Peijun Wang, Han Jin, Bin Zhang
Summary: This study successfully improved the performance of L-PRF scaffold by using genipin as a crosslinker. The results showed that genipin-modified L-PRF had better biomechanical performance, slower biodegradation, good bioavailability, and sustained release of growth factors. In vitro and in vivo experiments demonstrated that 0.01% w/v and 0.1% w/v genipin-crosslinked L-PRF had good porous structure, significantly promoted cell proliferation, and enhanced bone regeneration.
FRONTIERS IN PHYSIOLOGY
(2022)
Review
Chemistry, Multidisciplinary
Xu Xue, Yan Hu, Yonghui Deng, Jiacan Su
Summary: Hydrogels are promising candidates for bone tissue engineering due to their unique 3D network structure. Injectable hydrogels based on biocompatible materials offer advantages in minimally invasive surgery and drug delivery. Advanced approaches and innovative ideas of bioactive hydrogels are expected to enhance the quality of life for patients with bone injuries.
ADVANCED FUNCTIONAL MATERIALS
(2021)
Article
Materials Science, Multidisciplinary
Wendong Gao, Yin Xiao
Summary: Cell membrane coating technology plays an important role in tissue regeneration by enhancing the bioactivity and functionality of biomaterials. This review provides an overview of recent advances in cell membrane-coated materials, including the methodologies used to construct them, and discusses their applications, limitations, and challenges in tissue regeneration.
APPLIED MATERIALS TODAY
(2022)
Article
Engineering, Biomedical
Yunfan Zhang, Xueyu Dou, Lingyun Zhang, Hufei Wang, Ting Zhang, Rushui Bai, Qiannan Sun, Xing Wang, Tingting Yu, Decheng Wu, Bing Han, Xuliang Deng
Summary: In this study, a semi-interpenetrating network composite gel was prepared to fulfill the mechanical and cell compatibility requirements of hydrogels. The gel successfully encapsulated ASA via electrostatic interactions and achieved sustained release, promoting stem cell proliferation and differentiation. In vivo studies confirmed the potential of this gel in bone tissue engineering.
BIOACTIVE MATERIALS
(2022)
Review
Chemistry, Multidisciplinary
Mafalda S. Santos, Marta S. Carvalho, Joao C. Silva
Summary: Periodontitis is an inflammatory infection caused by bacterial plaque accumulation. Current treatments lack bioactive signals for tissue repair and regeneration. Electrospun nanofibers have shown promising results for periodontal regeneration due to their ability to mimic the natural extracellular matrix. This review provides an overview of the current state of electrospun nanofibrous scaffolds in periodontal regeneration strategies.
Article
Biotechnology & Applied Microbiology
Beibei Liu, Jiannan Wu, Xiaodi Sun, Qingxun Meng, Jian Zhang
Summary: A GelMA/HAMA dual network hydrogel loaded with osteogenic growth peptide (OGP) was developed to provide long-term sustained release of OGP for effective bone regeneration and rebuilding. The hydrogel polymers showed suitable physical characteristics, porosity structure, and biocompatibility. In vitro experiments demonstrated that the GelMA/HAMA-OGP hydrogel promoted cell proliferation, adhesion, and increased osteogenic-related gene and protein expression. This study offers a fresh perspective on bone regeneration therapy.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Article
Engineering, Biomedical
Lian Ruan, Mengrong Su, Xinyun Qin, Qingting Ruan, Wen Lang, Minhui Wu, Yujie Chen, Qizhuang Lv
Summary: This paper provides a systematic review of the application of sustained-release drug microspheres in tissue engineering, including the introduction of drug delivery systems, types and characteristics of microspheres, preparation methods and materials, applications, and future prospects.
MATERIALS TODAY BIO
(2022)
Review
Biochemistry & Molecular Biology
Muhammad Umar Aslam Khan, Saiful Izwan Abd Razak, Wafa Shamsan Al Arjan, Samina Nazir, T. Joseph Sahaya Anand, Hassan Mehboob, Rashid Amin
Summary: The study discusses the selection of suitable biopolymers and additives for the preparation of polymer composites with desired properties, focusing on the interfacial interactions between biopolymers and nanofillers in controlling the mechanical characteristics of the composites, as well as the applications of biopolymeric composites in drug release, tissue engineering, and wound healing.
Article
Biotechnology & Applied Microbiology
V. H. Giang Phan, Hai-Sang Duong, Quynh-Giao Thi Le, Gopinathan Janarthanan, Sanjairaj Vijayavenkataraman, Hoang-Nam Huynh Nguyen, Bich-Phuong Thi Nguyen, Panchanathan Manivasagan, Eue-Soon Jang, Yi Li, Thavasyappan Thambi
Summary: This work proposes a novel approach for controlling protein therapeutic release using lamellar inorganic solids incorporated into injectable hydrogels. The nanoengineered injectable system shows improved mechanical properties and high binding affinity to proteins. It demonstrates potential applications in 3D printing and tissue regeneration.
JOURNAL OF NANOBIOTECHNOLOGY
(2023)
Review
Biotechnology & Applied Microbiology
Julie F. Jameson, Marisa O. Pacheco, Henry H. Nguyen, Edward A. Phelps, Whitney L. Stoppel
Summary: Researchers are developing engineered cellular and acellular therapeutic approaches as alternatives to corneal transplants from human cadavers due to the limited availability of healthy donors. The main goals are to optimize corneal graft properties, reduce complications, and improve outcomes in engineered tissue structures in the eye.
BIOENGINEERING-BASEL
(2021)
Review
Polymer Science
Negar Bakhtiary, Behafarid Ghalandari, Farnaz Ghorbani, Swastina Nath Varma, Chaozong Liu
Summary: The development of peptide-based materials, particularly hydrogels, has become a challenging but crucial aspect in biomaterials, especially in tissue engineering. These hydrogels are gaining significant attention due to their ability to mimic tissue formation conditions and their wide range of applications. Peptide-based hydrogels stand out due to their ability to mimic proteins, high water content, and tunable mechanical stability.
Review
Biotechnology & Applied Microbiology
Duraipandy Natarajan, Zhitong Ye, Liping Wang, Linhu Ge, Janak Lal Pathak
Summary: The challenges in bone graft and prosthetic implant designing for clinical application are being addressed with the revolutionary advances of nanotechnology, particularly in the use of rare earth (RE) materials with unique properties for tissue engineering. Researchers have developed smart nano-biomaterials using RE materials for bone tissue engineering and implantology applications, exploring their molecular mechanisms and potential for novel strategies. The biomedical applications of micro or nano-scale RE materials have shown promise in providing cost-effective solutions in bone tissue engineering.
BIOENGINEERING & TRANSLATIONAL MEDICINE
(2022)
Review
Biotechnology & Applied Microbiology
Shengao Qin, Jiaman Zhu, Guangyong Zhang, Qijia Sui, Yimeng Niu, Weilong Ye, Guowu Ma, Huiying Liu
Summary: Osteoarthritis, a chronic degenerative joint disease, has a significant impact on personal quality of life. Cartilage tissue engineering is a practical treatment in clinical practice for osteoarthritis. Functional motifs (mimetic peptides) derived from natural growth factors have been introduced in recent studies to overcome the limitations of natural growth factors. This review provides an overview of the selection mechanisms, biological functions, carrier scaffolds, modification methods, and repair performance of growth factor-related functional motifs in cartilage tissue engineering, as well as discusses their prospects in research and clinical application.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Review
Chemistry, Multidisciplinary
Bai-Hui Shan, Fu-Gen Wu
Summary: Growth factors play a crucial role in tissue engineering and regenerative medicine, but their application is limited due to short half-lives and potential side effects. Hydrogels have the potential to prolong growth factor half-lives and mitigate adverse effects. This review discusses recent progress in the development of growth factor-containing hydrogels for various biomedical applications and introduces strategies for optimizing growth factor release.
ADVANCED MATERIALS
(2023)
Review
Chemistry, Medicinal
Qing He, Tianjian Tong, Chenxu Yu, Qun Wang
Summary: This review provides a summary of recent research advancements and applications of algin and alginate-hybrid materials (AHMs) in medical fields. AHMs have shown great potential in wound dressing, cell culture, tissue engineering, and drug delivery due to their biocompatibility and superior properties. Different medical applications require AHMs with specific properties, such as optimal drug loading for drug delivery and improved mechanical properties for tissue engineering. Various methods and formulations have been developed to meet these needs. This review serves as a road map for the development of AHMs in medical applications.
Article
Biochemistry & Molecular Biology
Hong Zhu, Hangqi Luo, Minjie Lin, Yuan Li, Anqi Chen, Huacheng He, Feixia Sheng, Jiang Wu
Summary: This study reported the use of a shape-memorable methacrylated gelatin cryogel for the direct subcutaneous administration of endothelial progenitor cells (EPCs) and acid fibroblast growth factor (aFGF) for the treatment of pressure ulcers in diabetic rats. The cryogel system had a microporous structure, elastic mechanical strength, enhanced cell migration property, and controlled release of aFGF. In vivo results showed that the cryogel system accelerated wound closure rate, enhanced granulation formation, collagen deposition, and re-epithelization. The excellent performance of the cryogel system was attributed to its up-regulation of HIF-a, which modulated the impaired local angiogenesis. This hybrid gelatin cryogels hold great promise for biomedical applications, particularly in tissue engineering and regenerative medicine.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Chemistry, Multidisciplinary
Jing Huang, Zecong Xiao, Gengjia Chen, Tan Li, Yuan Peng, Xintao Shuai
Summary: A multifunctional nanomedicine was developed to induce robust antitumor immunity through photodynamic therapy and hypoxia alleviation. The nanomedicine could co-deliver a photosensitizer and a catalase gene into tumor cells, inducing immunogenic cell death, promoting immune cell maturation, and enhancing tumor infiltration of antigen-specific T cells. Moreover, the nanomedicine could relieve tumor hypoxia, augmenting the efficacy of photodynamic therapy and inducing strong antitumor immunity.
Article
Chemistry, Multidisciplinary
Lihua Du, Haozhe He, Zecong Xiao, Hong Xiao, Yongcheng An, Huihai Zhong, Minzhao Lin, Xiaochun Meng, Shisong Han, Xintao Shuai
Summary: Immunotherapy has great potential for tumor therapy, but the immunosuppressive tumor microenvironment limits its effectiveness. A multifunctional nanoplatform combining drug delivery and medical imaging can overcome the immunosuppressive microenvironment and improve tumor treatment efficiency.
Article
Nanoscience & Nanotechnology
Lijun Hu, Sicong Huang, Gengjia Chen, Bo Li, Tan Li, Minzhao Lin, Yongquan Huang, Zecong Xiao, Xintao Shuai, Zhongzhen Su
Summary: A polymer nanocomplex was prepared to deliver siRNA to silence the LDHA gene and inhibit lactic acid secretion and M2-like polarization of TAMs, while enhancing OXA-induced autophagy and inducing autophagic death. The combination treatment of OXA and nanocomplex showed a significantly increased chemotherapeutic effect on CC.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Biochemistry & Molecular Biology
Hongxue Shi, Russell A. Prough, Craig J. McClain, Ming Song
Summary: This study aimed to investigate the combined effects of different types of dietary fat and fructose on the development of NAFLD in a murine model. Results showed that mice fed with high-saturated fat diet exhibited severe hepatic steatosis and liver injury, while fructose supplementation exacerbated liver fibrosis. Mice fed with omega-6 polyunsaturated fat diet combined with fructose showed impaired glucose tolerance. In summary, excessive intake of fat and fructose has negative effects on liver health.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2023)
Article
Chemistry, Multidisciplinary
Shaohui Deng, Shiyin Wang, Zecong Xiao, Du Cheng
Summary: A spatially controlled siRNA activation strategy and co-delivery of Ce6 can achieve tumor-specific siRNA therapy with synergistic drug effects.
Article
Engineering, Biomedical
Minzhao Lin, Yujun Cai, Gengjia Chen, Huihai Zhong, Bo Li, Tan Li, Zecong Xiao, Xintao Shuai
Summary: This study develops a hierarchical targeting strategy to prepare a core-shell-structural nanodrug that can block programmed death ligand 1 (PD-L1) and deliver a stimulator of interferon gene (STING) agonist to tumor-infiltrating antigen-presenting cells (APCs). The nanodrug efficiently accumulates in tumor sites and stimulates APCs maturation to prime anti-tumor immunity, sensitizing triple negative breast cancer (TNBC) to immune checkpoint blockade therapy.
Review
Immunology
Maaike Schilperoort, David Ngai, Santosh R. Sukka, Kleopatra Avrampou, Hongxue Shi, Ira Tabas
Summary: The process of macrophages engulfing dying cells, known as efferocytosis, is tightly regulated and involves sensing, binding, engulfment, and digestion of apoptotic cells. Efferocytosis not only prevents tissue necrosis and inflammation caused by secondary necrosis of dying cells, but also promotes pro-resolving signaling in macrophages, which is essential for tissue resolution and repair following injury or inflammation. The cargo released from apoptotic cells after their engulfment and digestion by macrophages, containing amino acids, nucleotides, fatty acids, and cholesterol, plays a crucial role in this pro-resolving reprogramming.
IMMUNOLOGICAL REVIEWS
(2023)
Article
Chemistry, Multidisciplinary
Zecong Xiao, Yitong Tan, Yujun Cai, Jinsheng Huang, Xiaobin Wang, Bo Li, Liteng Lin, Yong Wang, Xintao Shuai, Kangshun Zhu
Summary: A pH and MMP-2 dual-sensitive polymer/calcium phosphate (CaP) hybrid nanocarrier was used to co-deliver hyaluronidase (HAase), IL-12, and anti-PD-L1 antibody (alpha PD-L1) to overcome the dense extracellular matrix (ECM) barrier in hepatocellular carcinoma (HCC). The nanocarrier released IL-12 and HAase in response to tumor acidity, promoting CTL infiltration and proliferation. In addition, the released alpha PD-L1 prevented tumor cells from escaping CTL killing effects. This combination strategy effectively suppressed HCC growth in mice and reduced immune-related adverse events.
JOURNAL OF CONTROLLED RELEASE
(2023)
Article
Chemistry, Multidisciplinary
Huihai Zhong, Gengjia Chen, Tan Li, Jinsheng Huang, Minzhao Lin, Bo Li, Zecong Xiao, Xintao Shuai
Summary: In this study, a nanoliposome (GM@LR) was constructed for delivering the GSDME-expressing plasmid and manganese carbonyl (MnCO) into TNBC cells. MnCO generated Mn2+ and carbon monoxide (CO) in the presence of H2O2. CO-activated caspase-3 cleaved the expressed GSDME, converting apoptosis to pyroptosis in 4T1 cells. Additionally, Mn2+ promoted the maturation of dendritic cells (DCs) through the activation of the STING signaling pathway. The increased proportion of intratumoral mature DCs caused massive infiltration of cytotoxic lymphocytes, leading to a robust immune response.
Article
Oncology
Xiaobin Wang, Qiaoyun Zhang, Jingwen Zhou, Zecong Xiao, Jianxin Liu, Shaohui Deng, Xiaoyang Hong, Wensou Huang, Mingyue Cai, Yongjian Guo, Jingjun Huang, Yong Wang, Liteng Lin, Kangshun Zhu
Summary: This study identified the new role of the clinically used drug tadalafil (TA) in conquering immunosuppressive tumor microenvironment (TME) in hepatocellular carcinoma (HCC). A dual pH-sensitive nanodrug carrying both TA and programmed cell death receptor 1 antibody (aPD-1) was successfully synthesized for tumor-targeted drug delivery and TME-responsive drug release. By combining TA and aPD-1, this nanodrug effectively inhibited M2 polarization and polyamine metabolism in TAMs and MDSCs, leading to remarkable immunotherapy efficacy with minimal side effects in HCC.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2023)
Article
Engineering, Biomedical
Zecong Xiao, Tan Li, Xinyao Zheng, Liteng Lin, Xiaobin Wang, Bo Li, Jingjun Huang, Yong Wang, Xintao Shuai, Kangshun Zhu
Summary: Thermal ablation is an effective method for treating hepatocellular carcinoma, but it faces challenges of high recurrence and metastasis. The combination of immune-checkpoint blockade and thermal ablation has shown little progress in treating HCC. However, a study found that using a modified nanoplatform to deliver tumor-associated antigens and a demethylases inhibitor can improve the immune response to tumor growth and metastasis, synergizing with immune-checkpoint blockade treatment.
BIOACTIVE MATERIALS
(2023)
Article
Engineering, Biomedical
Ziqi Gan, Zecong Xiao, Zhen Zhang, Yang Li, Chao Liu, Xin Chen, Yuanbo Liu, Dongle Wu, Chufeng Liu, Xintao Shuai, Yang Cao
Summary: This study developed an injectable ROS-sensitive hydrogel to release active bone marrow-derived macrophages and a C5a receptor antagonist for enhanced bacterial killing and reduced inflammation in periodontitis.
BIOACTIVE MATERIALS
(2023)
Article
Materials Science, Biomaterials
Haiyang Wang, Minzhao Lin, Gengjia Chen, Zecong Xiao, Xintao Shuai
Summary: This study developed a novel combination therapy for drug-resistant tumors using liposome nanoparticles co-encapsulating atorvastatin and chloroquine. The atorvastatin promoted the sustained generation of ROS by upregulating CPT1 concentration and promoting fatty acid oxidation in tumor cells, while chloroquine disrupted lysosomes and reduced autophagy levels. In both in vivo and in vitro experiments, the combination therapy showed significant enhancement in tumor cell apoptosis.
BIOMATERIALS SCIENCE
(2023)
Review
Materials Science, Biomaterials
Anqi Chen, Yuting Luo, Jie Xu, Xueran Guan, Huacheng He, Xuan Xuan, Jiang Wu
Summary: Psoriasis, an autoimmune inflammatory disease, requires more precise and effective topical treatments. The development of biomaterial-based therapies, such as microneedles and nanoparticles, shows promising potential for localized psoriasis treatment.
JOURNAL OF MATERIALS CHEMISTRY B
(2022)
