Article
Medicine, Research & Experimental
Weiwei Ke, Xiangxuan Zhao, Zaiming Lu
Summary: Ethanol extract of Foeniculum vulgare seeds (EEFS) significantly reduces lung cancer cell growth by targeting Bcl-2 protein expression and inducing apoptosis in vitro and in vivo. This study provides evidence for the potential of EEFS as a therapeutic drug for lung cancer.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Review
Pharmacology & Pharmacy
Alakananda Basu
Summary: The interplay between apoptosis and senescence is crucial in cancer development, and targeting the Bcl-2 family proteins could be a promising strategy for cancer therapy. Therapy-induced senescence (TIS), induced by chemotherapeutic agents, has been controversial in its effect on therapeutic outcome. Clearance of senescent cells and overcoming their pro-survival mechanisms are important challenges in cancer treatment. This review article discusses recent literature on the role of the Bcl-2 family proteins in apoptosis and senescence, and the progress and limitations in targeting them for cancer therapy.
PHARMACOLOGY & THERAPEUTICS
(2022)
Review
Biochemistry & Molecular Biology
Linlin Zhang, Zaiming Lu, Xiangxuan Zhao
Summary: Apoptosis deficiency is a crucial feature in neoplastic diseases, with the Bcl-2 family of proteins playing a decisive role in regulating apoptosis. Studies have shown that hyperactivation of Bcl-2 anti-apoptotic effects is associated with cancer occurrence and resistance to therapy, making targeting Bcl-2 inactivation a promising route for cancer treatment.
BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER
(2021)
Review
Oncology
Shanna Qian, Zhong Wei, Wanting Yang, Jinling Huang, Yinfeng Yang, Jinghui Wang
Summary: Apoptosis, a crucial biological process, plays a central role in cancer development and traditional cytotoxic therapies. The study of BCL-2 family proteins in regulating apoptosis and the development of anticancer drugs targeting BCL-2 anti-apoptotic proteins has gained increasing attention, showing great potential in cancer therapy.
FRONTIERS IN ONCOLOGY
(2022)
Article
Cell Biology
Yuefan Guo, Guangxue Wang, Zhongrui Wang, Xin Ding, Lu Qian, Ya Li, Zhen Ren, Pengfei Liu, Wenjing Ma, Danni Li, Yuan Li, Qian Zhao, Jinhui Lu, Qinchuan Li, Qinhong Wang, Zuoren Yu
Summary: The miR-221/222 cluster plays a crucial role in regulating CSCs in NSCLC, affecting tumor initiation, metastasis, and drug resistance. Reck, identified as a key direct target gene of miR-221/222, plays a critical role in the activation of the Notch1 signaling pathway in NSCLC.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Chemistry, Medicinal
Clement Veys, Manon Jammes, Francoise Redini, Laurent Poulain, Christophe Denoyelle, Florence Legendre, Philippe Galera
Summary: This study identifies the tumor-suppressive activity of miR-342-5p and miR-491-5p in osteosarcoma cells. Both miRNAs induce apoptosis and target different proteins, offering potential for therapeutic intervention in osteosarcomas.
Article
Oncology
Liyao Dong, Lin Zhang, Xinyun Zhao, Hongling Zou, Sisi Lin, Xinping Zhu, Jili Cao, Chun Zhou, Zhihong Yu, Yongqiang Zhu, Kequn Chai, Mingqian Li, Qun Li
Summary: This study elucidates the molecular mechanism whereby CYP4A22-AS1 overexpression promotes LUAD progression through the miR-205-5p/EREG and miR-34c-5p/BCL-2 axes.
CANCER CELL INTERNATIONAL
(2023)
Article
Plant Sciences
Jiazhe Liu, Yongzhi Liu, Hongchang Li, Chuangchao Wei, Anwei Mao, Weiyan Liu, Gaofeng Pan
Summary: The study found that Polyphyllin D (PD) can induce autophagy in breast cancer cells through activation of the JNK1/Bcl-2 pathway, and increase PD-induced cell apoptosis by inhibiting autophagy, thus achieving anti-tumor effects.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Luxi Qian, Karin A. Vallega, Weilong Yao, Dongsheng Wang, Yifan Zhai, Xia He, Shi-Yong Sun
Summary: This study evaluated the therapeutic efficacy of the novel Bcl-2/Bcl-X-L dual inhibitor APG1252-M1 against non-small cell lung cancer (NSCLC) cells. The results showed that APG1252-M1 effectively decreased the survival of NSCLC cells with low levels of Mcl-1 and induced apoptosis. Furthermore, the combination of APG1252-M1 with osimertinib synergistically decreased the survival of EGFR-mutant NSCLC cells, including those resistant to osimertinib, and inhibited the growth of osimertinib-resistant tumors in vivo.
MOLECULAR CARCINOGENESIS
(2022)
Article
Oncology
Li-Le Wang, Rui-Cheng Hu, Ai-Guo Dai, Shuang-Xiang Tan, Ming Xu, Chun-Chu Kong, Yun-Rong Chen, Dai-Yan Fu
Summary: CHOP regulates cisplatin resistance in NSCLC cells by promoting the expression of apoptotic proteins and inhibiting the Bcl-2/JNK signaling pathway, indicating its anti-tumor effects.
AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Cuimei Chen, Yong Zhou, Ping Ding, Liping He
Summary: Bcl-2 is upregulated in lung cancer cells, negatively correlated with patient prognosis, while miR-1 affects the chemosensitivity of lung cancer cells by targeting Bcl-2.
GENETIC TESTING AND MOLECULAR BIOMARKERS
(2021)
Review
Biochemistry & Molecular Biology
Deeksha Kaloni, Sarah T. Diepstraten, Andreas Strasser, Gemma L. Kelly
Summary: Acquired resistance to cell death is a key characteristic of cancer. The BCL-2 protein family members have important roles in regulating apoptotic cell death. Abnormal expression of pro-survival BCL-2 family proteins or reduction in pro-apoptotic BCL-2 family proteins, both leading to inhibition of apoptosis, are commonly observed in various types of cancer. The critical role of pro-survival and pro-apoptotic BCL-2 family proteins in apoptosis regulation makes them attractive targets for cancer treatment. This review discusses the roles of different pro-survival and pro-apoptotic members of the BCL-2 protein family in normal development and organismal function, as well as how defects in apoptosis control contribute to cancer development and therapy resistance. Lastly, the development of inhibitors targeting pro-survival BCL-2 proteins, known as BH3-mimetic drugs, as novel agents for cancer therapy is discussed.
Article
Cell Biology
Ali Mohammadi, Behzad Mansoori, Pascal H. G. Duijf, Elham Safarzadeh, Leila Tebbi, Souzan Najafi, Behrooz Shokouhi, Grith L. Sorensen, Uffe Holmskov, Behzad Baradaran
Summary: Low miR-330 expression in lung cancer predicts poor prognosis, but stable restoration of miR-330 expression can reduce cell viability, increase apoptotic cells, induce G2/M cell cycle arrest, and inhibit cell migration.
JOURNAL OF CELLULAR PHYSIOLOGY
(2021)
Article
Food Science & Technology
Yanfang Qian, Chenying Shi, Chen Cheng, Dengwei Liao, Junping Liu, Guitang Chen
Summary: This study demonstrates that ginger polysaccharide UGP1 can suppress the growth of colon cancer by inducing apoptosis and regulating immune system activity.
FOOD SCIENCE AND HUMAN WELLNESS
(2023)
Article
Obstetrics & Gynecology
Lily Cai, Juan-Juan Chen, Fu-Mou Deng, Lei Wang, Yu Chen
Summary: MiR-326 acts as a tumor suppressor in endometrial cancer by inhibiting proliferation and promoting apoptosis through targeting the Bcl-2 axis.
JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH
(2021)