Article
Biochemistry & Molecular Biology
Ana R. Rama, Francisco Quinonero, Cristina Mesas, Consolacion Melguizo, Jose Prados
Summary: This study presents a circular RNA-based miRNA capture system for studying the role of miR-21 in lung cancer. The miR-21 circular sponge was found to inhibit the growth, colony formation, and migration of lung cancer cells, indicating the potential of this method as a tool for capturing other miRNAs.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Chemistry, Multidisciplinary
Tianci Han, Liang Zhang, Wei Tong, Jian Zhao, Wei Wang
Summary: This study explores the interaction between cyclin D1 and calycosin and provides insights into their binding properties and potential structural changes. The results indicate that hydrogen bonding and van der Waals forces are involved in the binding of calycosin with cyclin D1, leading to structural alterations in cyclin D1. Additionally, calycosin inhibits lung cancer cell proliferation by arresting the cell cycle at the G1 phase.
ARABIAN JOURNAL OF CHEMISTRY
(2022)
Article
Chemistry, Analytical
Ali Khodadoust, Navid Nasirizadeh, Seyed Morteza Seyfati, Ramezan Ali Taheri, Mostafa Ghanei, Hasan Bagheri
Summary: In this study, a novel nano-biosensor has been developed using dual signal-labeled hairpin-structured DNA-based probes. The biosensor can sensitively and simultaneously detect miRNA-141 and miRNA-21, and it is resistant to interference from environmental factors.
Article
Biotechnology & Applied Microbiology
Li-Li Quan, Jin-Yang Liu, Li-Xia Qu, Hui La, Hai-Li Wang, Xiao-Xia Chen, Na Wang, Zhen-Zhi Wei
Summary: This study analyzed the expression of Cyclin D1 (CCND1) gene in ovarian cancer using the Oncomine database, finding that its high expression is associated with poor prognosis. Cell experiments showed that silencing CCND1 gene expression can reduce ovarian cancer cell proliferation and promote apoptosis.
Review
Cell Biology
Xinping Zhu, Masahisa Kudo, Xiangjie Huang, Hehuan Sui, Haishan Tian, Carlo M. Croce, Ri Cui
Summary: Lung cancer, particularly NSCLC, is a major cause of cancer-related deaths globally. Recent advancements in treatment have improved therapeutic efficacy, but the survival rate remains low due to inadequate screening methods and late onset of symptoms. Dysregulation of miRNAs in NSCLC plays a critical role in development, progression, and metastasis, presenting potential for diagnostic and therapeutic applications.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Oncology
Dongli Guo, Jing Jin, Jianghui Liu, Xiaoping Dong, Daojuan Li, Yutong He
Summary: Silencing miR-29b in ESCC cells can increase BTG2 expression and decrease intracellular cyclin D1 levels, leading to cell cycle arrest and accumulation in the G0/G1 phase, which reduces sensitivity to radiotherapy.
STRAHLENTHERAPIE UND ONKOLOGIE
(2021)
Article
Surgery
Li Fang, Xiuping Xu, Wenyan Zheng, Lingyun Wu, Haijun Wan
Summary: The expression levels of miR-340 and CCND1 in lung cancer tissues are closely related to the prognosis and clinicopathological characteristics of patients, with miR-340 being downregulated and CCND1 being upregulated in lung cancer tissues.
ASIAN JOURNAL OF SURGERY
(2021)
Review
Biochemistry & Molecular Biology
Valerio Nardone, Marcella Barbarino, Antonio Angrisani, Pierpaolo Correale, Pierpaolo Pastina, Salvatore Cappabianca, Alfonso Reginelli, Luciano Mutti, Clelia Miracco, Rocco Giannicola, Antonio Giordano, Luigi Pirtoli
Summary: The expanding clinical application of CDK4- and CDK6-inhibiting drugs in breast cancer has sparked interest in testing them in other tumors. Potential combinations with other therapeutic approaches are being explored, with some hypotheses about integrating CDK4 and CDK6 inhibitors with radiotherapy. However, more research is needed to further investigate the potential benefits of these combinations.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Multidisciplinary Sciences
Saroor A. Patel, Shoko Hirosue, Paulo Rodrigues, Erika Vojtasova, Emma K. Richardson, Jianfeng Ge, Saiful E. Syafruddin, Alyson Speed, Evangelia K. Papachristou, David Baker, David Clarke, Stephenie Purvis, Ludovic Wesolowski, Anna Dyas, Leticia Castillon, Veronica Caraffini, Dora Bihary, Cissy Yong, David J. Harrison, Grant D. Stewart, Mitchell J. Machiela, Mark P. Purdue, Stephen J. Chanock, Anne Y. Warren, Shamith A. Samarajiwa, Jason S. Carroll, Sakari Vanharanta
Summary: Using experimental models and analysis of patient samples, researchers have demonstrated that the transcription factor PAX8 is essential for oncogenic signaling and plays a key role in two common genetic alterations associated with ccRCC.
Article
Endocrinology & Metabolism
Yuyan Bao, Bing Hong, Guoli Qi, Zhenjian Lin, Kaiping Liu, Jie Zhou, Yanjie Yu, Xiaomin Zhang
Summary: This study aimed to determine the mechanism of the beneficial effect of crocin in lung cancer cells. The results showed that crocin inhibited the biological functions of lung cancer cells by inhibiting 0-catenin gene and downstream genes. Moreover, crocin offset the enhancing effects of overexpressed 0-catenin upon the abilities of lung cancer cells to migrate and invade.
JOURNAL OF BIOLOGICAL REGULATORS AND HOMEOSTATIC AGENTS
(2023)
Article
Oncology
Rosario Distefano, Giovanni Nigita, Patricia Le, Giulia Romano, Mario Acunzo, Patrick Nana-Sinkam
Summary: Post-transcriptional modifications in miRNA molecules have provided new insights into cancer biology and potential cancer biomarkers. In this study, we analyzed the profiles of canonical and non-canonical miRNAs in lung cancer patients of different races. We identified distinct post-transcriptional modifications in lung cancer tissues, indicating the relevance of miRNA isoforms as potential biomarkers. Concurrent profiling of canonical and non-canonical miRNAs may help identify additional biological pathways and biomarkers in lung cancer.
Article
Medicine, Research & Experimental
Yuefeng Ma, Xin Xing, Ranran Kong, Chuantao Cheng, Suoni Li, Xiaoping Yang, Shaomin Li, Feng Zhao, Liangzhang Sun, Gang Cao
Summary: The study found that overexpression of SphK1 in NSCLC can promote cell proliferation and migration through activation of STAT3, suggesting that inhibition of this pathway may be a potential strategy for NSCLC treatment.
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
(2021)
Article
Medicine, Research & Experimental
Amruta Naik, Kaitlyn M. Forrest, Oindrila Paul, Yasmine Issah, Utham K. Valekunja, Soon Y. Tang, Akhilesh B. Reddy, Elizabeth J. Hennessy, Thomas G. Brooks, Fatima Chaudhry, Apoorva Babu, Michael Morley, Jarod A. Zepp, Gregory R. Grant, Garret A. Fitzgerald, Amita Sehgal, G. Scott Worthen, David B. Frank, Edward E. Morrisey, Shaon Sengupta
Summary: This study demonstrates an association between circadian rhythms and morbidity from lower respiratory tract infections, including hospitalization and mortality even after adjusting for confounding factors. The disruption of the circadian clock impairs lung organoid’s regenerative capacity, and the circadian clock mediates lung regeneration through distinct pathways. The findings suggest that incorporating circadian rhythms into lung repair and regeneration could lead to novel therapies.
Article
Oncology
Xin Li, Wenkai Jiang, Wancheng Li, Shi Dong, Yan Du, Hui Zhang, Wence Zhou
Summary: The study confirms the inhibitory effect of betulinic acid (BA) on pancreatic cancer and reveals its mechanism of action: by regulating the expression of miR-365/BTG2/IL-6, BA inhibits the protein level and phosphorylation level of AKT/STAT3. BA can significantly inhibit the proliferation and invasion of pancreatic cancer cells and promote apoptosis. This effect is also observed in an animal model.
Article
Biotechnology & Applied Microbiology
Abdul K. Siraj, Sandeep Kumar Parvathareddy, Padmanaban Annaiyappanaidu, Saeeda O. Ahmed, Nabil Siraji, Asma Tulbah, Fouad Al-Dayel, Dahish Ajarim, Khawla S. Al-Kuraya
Summary: The study demonstrated that cyclin D1 over-expression in Middle Eastern breast cancers is associated with favorable prognostic features, serving as an independent predictor of overall survival and recurrence-free survival. Cyclin D1 expression was also found to be associated with phospho-Rb in luminal subtype of breast cancer, predicting luminal A breast cancer independently.
ONCOTARGETS AND THERAPY
(2021)