News Item
Multidisciplinary Sciences
Liam Drew
Summary: Researchers state that devices capable of recording and altering brain activity will present privacy concerns that question current human rights laws.
Article
Psychology, Applied
Francesco Bella, Chiara Ferrante
Summary: The study found that drivers exhibited more critical yielding behavior and braking performance when approaching the bicycle crossroad on the two-lane configuration. The logistic regression model indicated that the cross-section variable had the strongest effect on drivers’ likelihood of yielding.
TRANSPORTATION RESEARCH PART F-TRAFFIC PSYCHOLOGY AND BEHAVIOUR
(2021)
Article
Multidisciplinary Sciences
Christopher E. Doughty, Jenna M. Keany, Benjamin C. Wiebe, Camilo Rey-Sanchez, Kelsey R. Carter, Kali B. Middleby, Alexander W. Cheesman, Michael L. Goulden, Humberto R. da Rocha, Scott D. Miller, Yadvinder Malhi, Sophie Fauset, Emanuel Gloor, Martijn Slot, Imma Oliveras Menor, Kristine Y. Crous, Gregory R. Goldsmith, Joshua B. Fisher
Summary: The critical temperature for the failure of photosynthetic machinery in tropical trees is around 46.7°C. However, it is uncertain whether leaf temperatures experienced by tropical vegetation approach or exceed this threshold. Through analysis of data and experiments, it was found that even within pixels of moderate temperatures, the upper canopy leaves of tropical forests exceed the critical temperature 0.01% of the time. Using an empirical model, it was predicted that tropical forests can withstand an increase in air temperatures of up to 3.9±0.5°C before a potential tipping point in metabolic function.
Review
Andrology
Vera Constancio, Nuno Tiago Tavares, Rui Henrique, Carmen Jeronimo, Joao Lobo
Summary: The potential and challenges of using microRNAs (miRNAs) as biomarkers in male reproductive tract cancers.
Review
Biochemistry & Molecular Biology
Zuming Zhang, Zihui Xu, Fa Yuan, Kangxin Jin, Mengqing Xiang
Summary: This article discusses the historical background of retinal organoid technology, current methods of organoid induction, obstacles and potential solutions for next-generation retinal organoids, research progress in cell/tissue transplantation to treat retinal diseases, and the pros and cons of transplanting single-cell suspension versus retinal organoid sheet for cell therapies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Public, Environmental & Occupational Health
Will Schupmann
Summary: Clinical ethicists in the U.S. healthcare system aim to serve as a supportive resource to hospital staff and ensure adherence to ethical standards in medical decision-making. This study evaluates the extent to which clinical ethicists have achieved their aspirations of being ethics watchdogs through in-depth interviews and identifies barriers they face in leveraging professional expertise, administrative authority, and trusting relationships. The findings highlight the challenges new professions must overcome to establish their jurisdiction, the tensions between legal risk management and clinical ethics, and the strategies marginalized actors use to advance their interests in healthcare delivery.
SOCIAL SCIENCE & MEDICINE
(2023)
Review
Business
Clark H. H. Warner, Marion Fortin, Tessa Melkonian
Summary: This integrative review aims to make sense of apparently contradictory findings in ethical decision-making research by identifying moderating influences. By integrating moderators from different disciplines and eras, the authors develop a taxonomy to help researchers identify similar constructs studied under different names. The findings concerning these influences are organized into four emergent moderator categories (psychological, situational, social, and physiological), providing insights into both intuitive and deliberative ethical decision-making.
JOURNAL OF BUSINESS ETHICS
(2022)
Article
Economics
William D. Nordhaus
Summary: The prospects for long-run economic growth are uncertain, with concerns over factors such as resource depletion, overpopulation, climate change potentially hindering and even reversing economic growth.
AMERICAN ECONOMIC JOURNAL-MACROECONOMICS
(2021)
Review
Cell Biology
Sonia More, Laura Corvatta, Valentina Maria Manieri, Francesco Saraceni, Ilaria Scortechini, Giorgia Mancini, Alessandro Fiorentini, Attilio Olivieri, Massimo Offidani
Summary: The introduction of high-dose therapy and the development of new drugs have significantly improved the outcome of ASCT in MM patients. Incorporating second-generation proteasome inhibitors and monoclonal antibodies into treatment has greatly enhanced the efficacy of ASCT. The use of MRD assessment techniques has opened up the possibility of MRD-based response-adjusted trials.
Review
Biochemistry & Molecular Biology
Xin Hu, Ronggao Chen, Qiang Wei, Xiao Xu
Summary: AFP has been widely used as a biomarker for the diagnosis and prognosis of HCC, and potential novel therapies like AFP vaccines and ACT show promise in treating HCC.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2022)
Article
Environmental Sciences
Igor Araujo, Beatriz S. Marimon, Marina C. Scalon, Sophie Fauset, Ben Hur Marimon Junior, Rakesh Tiwari, David R. Galbraith, Manuel U. Gloor
Summary: The study examines the thermal safety margin of tree species in a rapidly warming region of Brazil, indicating that tropical forests may become increasingly deciduous and savanna-like in the future.
ENVIRONMENTAL RESEARCH LETTERS
(2021)
Article
Dermatology
Nathalie Y. Ly, Sophia Fruechte, Maria K. Hordinsky, Neil Sadick, Suleima Arruda, Ronda S. Farah
Summary: Novel androgenetic alopecia treatments include low-dose oral minoxidil, spironolactone, finasteride, and nutritional supplements. Technological advancements in minimally invasive procedures include photobiomodulation and platelet-rich plasma. Hair transplantation techniques such as follicular unit extraction and robotics are now available to clinicians.
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY
(2023)
Article
Surgery
Nathalie Sela, Blaire L. Anderson, Alexandra M. Moulton, Arika L. Hoffman
Summary: Despite an increase in research activity among female physicians in the transplantation field over time, gender disparities persist in publication amount and authorship positions, with male medical physicians being more productive.
JOURNAL OF SURGICAL RESEARCH
(2021)
Review
Medicine, General & Internal
Simone La Padula, Rosita Pensato, Chiara Pizza, Edoardo Coiante, Giovanni Roccaro, Benedetto Longo, Francesco D'Andrea, Francesco Saverio Wirz, Barbara Hersant, Jean Paul Meningaud
Summary: This study provides an extensive analysis of the current practice of composite tissue allotransplantation, specifically face transplantation, including pre-procedural, intra-operative, and post-procedural settings, indications, contraindications, outcomes, ethical considerations, and future perspectives. The study highlights the importance of combining the latest achievements in FT with cutting-edge regenerative medicine procedures and innovative immunological processing. Strong international networks between FT experts are crucial for achieving higher-level outcomes and reducing complication rates, while caution is required in patient selection, clinical assessment, strict follow-up, and rejection management.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Biochemistry & Molecular Biology
Martin Klein, Maria Csobonyeiova, Stanislav Ziaran, Lubos Danisovic, Ivan Varga
Summary: The regeneration of a diseased heart is a major challenge in modern cardiovascular medicine, with ongoing research on stem cell-based therapies. Telocytes (TCs) play a significant role in cardiovascular regeneration by signaling, nursing stem cells, and providing mechanical support. Dysfunction or loss of TCs is implicated in conditions like myocardial infarction and heart failure, suggesting a potential avenue for future management through TC-based cell therapy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Oncology
Malgorzata Bajor, Agnieszka Graczyk-Jarzynka, Katsiaryna Marhelava, Anna Burdzinska, Angelika Muchowicz, Agnieszka Goral, Andriy Zhylko, Karolina Soroczynska, Kuba Retecki, Marta Krawczyk, Marta Klopotowska, Zofia Pilch, Leszek Paczek, Karl-Johan Malmberg, Sebastien Walchli, Magdalena Winiarska, Radoslaw Zagozdzon
Summary: This study provides new information on the efficacy of PD-L1-targeted CAR against PD-L1(low) targets. The results show that PD-L1-CAR cells have strong reactivity and cytotoxicity against both PD-L1(high) and PD-L1(low) target cells. Additionally, PD-L1-CAR cells also exhibit potent cytotoxic effects against non-malignant cells.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2022)
Article
Biochemistry & Molecular Biology
Agnieszka Kulesza, Katarzyna Zielniok, Jakub Hawryluk, Leszek Paczek, Anna Burdzinska
Summary: This study investigated the effects of nonselective COX inhibitor ibuprofen on human bone marrow MSCs (hBM-MSCs). The results showed that ibuprofen reduced PGE(2) secretion, but did not significantly affect proliferation and migration of MSCs. However, it significantly decreased the secretion of certain pro-regenerative factors.
Article
Biochemistry & Molecular Biology
Andrzej Gawor, Zdzislaw Gajewski, Leszek Paczek, Bozena Czarkowska-Paczek, Anna Konopka, Grzegorz Wryk, Ewa Bulska
Summary: Administration of the fluorinated drug cinacalcet in rats resulted in tissue-specific fluorination of proteins, with three fluorinated proteins identified in the liver and four in the brain tissue after 21 days of treatment. The fate of fluorine released from fluorine-containing drugs and its impact on protein fluorination warrant further investigation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Immunology
Anna L. Labus, Krzysztof Mucha, Andrzej Kulesza, Magda Fliszkiewicz, Leszek Paczek, Mariusz Niemczyk
Summary: This study assessed the costs of treating acute AMR in the Polish settings, finding that the treatment costs are considerably high and nearly double that of hemodialysis. Intravenous immunoglobulin was the main contributing factor to these costs.
TRANSPLANTATION PROCEEDINGS
(2022)
Article
Pharmacology & Pharmacy
Kaja Kasarello, Iwona Koehling, Anna Kosowska, Katarzyna Pucia, Anna Lukasik, Agnieszka Cudnoch-Jedrzejewska, Leszek Paczek, Urszula Zielenkiewicz, Piotr Zielenkiewicz
Summary: Cross-kingdom gene expression regulation by xenomiRs, particularly from plants, has been found to have potential scientific significance. In this study, miR172a derived from Brassica oleracea was shown to decrease the levels of FAN protein in human and mouse cells. Furthermore, treatment with miR172a was found to mitigate inflammation in a mouse model of rheumatoid arthritis.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Oncology
Krzysztof Mucha, Rafal Staros, Bartosz Foroncewicz, Bogna Ziarkiewicz-Wroblewska, Maciej Kosieradzki, Slawomir Nazarewski, Beata Naumnik, Joanna Raszeja-Wyszomirska, Krzysztof Zieniewicz, Leszek Paczek
Summary: The study compares the risk and prognostic factors of PTLD between adult kidney and liver transplant recipients. The results showed that PTLD develops earlier in liver transplant recipients, especially in patients over 45 years old, those receiving tacrolimus or not receiving cyclosporin. In kidney transplant recipients, PTLD onset is significantly affected by tacrolimus use, male sex, and age over 45 years old. Survival is longer in liver transplant recipients under 45 years old and they are more likely to achieve complete remission. The factors affecting PTLD development and outcome differ between kidney and liver transplant recipients.
Article
Biochemistry & Molecular Biology
Barbara Moszczuk, Natalia Krata, Witold Rudnicki, Bartosz Foroncewicz, Dominik Cysewski, Leszek Paczek, Beata Kaleta, Krzysztof Mucha
Summary: This study investigates osteopontin (OPN) as a potential biomarker in nephrology. Using machine learning, urinary OPN levels were found to accurately differentiate between immunoglobulin A nephropathy (IgAN) and other glomerulopathies (GNs). However, the discrimination of membranous nephropathy (MN) and lupus nephritis (LN) was less effective. OPN appears to be a valuable biomarker for identifying IgAN patients and should be further validated in future studies.
Review
Biochemistry & Molecular Biology
Agnieszka Kulesza, Leszek Paczek, Anna Burdzinska
Summary: The molecular mechanisms underlying the immunomodulatory properties of MSCs and the role of PGE2 and COX-2 in these properties are not fully understood. This article summarizes previous observations regarding the role of PGE2 and COX-2 in the immunomodulatory properties and other vital functions of MSCs. The most consistent results suggest that MSC-derived PGE2 inhibits the early maturation of dendritic cells, suppresses the proliferation of activated lymphocytes, and stimulates the differentiation of macrophages into M2 phenotype. COX-2/PGE2 also plays an important role in maintaining the basic life functions of MSCs and affects the formation of niches conducive to hematopoiesis and carcinogenesis.
Review
Immunology
Krzysztof Mucha, Michal Pac, Leszek Paczek
Summary: Thanks to omics technologies, we have gained a better understanding of the pathogenesis of many diseases in the last decade. However, the risk factors for most autoimmune diseases are still unknown.
ARCHIVUM IMMUNOLOGIAE ET THERAPIAE EXPERIMENTALIS
(2023)
Article
Genetics & Heredity
Krzysztof Kiryluk, Elena Sanchez-Rodriguez, Xu-Jie Zhou, Francesca Zanoni, Lili Liu, Nikol Mladkova, Atlas Khan, Maddalena Marasa, Jun Y. Zhang, Olivia Balderes, Simone Sanna-Cherchi, Andrew S. Bomback, Pietro A. Canetta, Gerald B. Appel, Jai Radhakrishnan, Hernan Trimarchi, Ben Sprangers, Daniel C. Cattran, Heather Reich, York Pei, Pietro Ravani, Kresimir Galesic, Dita Maixnerova, Vladimir Tesar, Benedicte Stengel, Marie Metzger, Guillaume Canaud, Nicolas Maillard, Francois Berthoux, Laureline Berthelot, Evangeline Pillebout, Renato Monteiro, Raoul Nelson, Robert J. Wyatt, William Smoyer, John Mahan, Al-Akash Samhar, Guillermo Hidalgo, Alejandro Quiroga, Patricia Weng, Raji Sreedharan, David Selewski, Keefe Davis, Mahmoud Kallash, Tetyana L. Vasylyeva, Michelle Rheault, Aftab Chishti, Daniel Ranch, Scott E. Wenderfer, Dmitry Samsonov, Donna J. Claes, Oleh Akchurin, Dimitrios Goumenos, Maria Stangou, Judit Nagy, Tibor Kovacs, Enrico Fiaccadori, Antonio Amoroso, Cristina Barlassina, Daniele Cusi, Lucia Del Vecchio, Giovanni Giorgio Battaglia, Monica Bodria, Emanuela Boer, Luisa Bono, Giuliano Boscutti, Gianluca Caridi, Francesca Lugani, GianMarco Ghiggeri, Rosanna Coppo, Licia Peruzzi, Vittoria Esposito, Ciro Esposito, Sandro Feriozzi, Rosaria Polci, Giovanni Frasca, Marco Galliani, Maurizio Garozzo, Adele Mitrotti, Loreto Gesualdo, Simona Granata, Gianluigi Zaza, Francesco Londrino, Riccardo Magistroni, Isabella Pisani, Andrea Magnano, Carmelita Marcantoni, Piergiorgio Messa, Renzo Mignani, Antonello Pani, Claudio Ponticelli, Dario Roccatello, Maurizio Salvadori, Erica Salvi, Domenico Santoro, Guido Gembillo, Silvana Savoldi, Donatella Spotti, Pasquale Zamboli, Claudia Izzi, Federico Alberici, Elisa Delbarba, Michal Florczak, Natalia Krata, Krzysztof Mucha, Leszek Paczek, Stanislaw Niemczyk, Barbara Moszczuk, Malgorzata Panczyk-Tomaszewska, Malgorzata Mizerska-Wasiak, Agnieszka Perkowska-Ptasinska, Teresa Baczkowska, Magdalena Durlik, Krzysztof Pawlaczyk, Przemyslaw Sikora, Marcin Zaniew, Dorota Kaminska, Magdalena Krajewska, Izabella Kuzmiuk-Glembin, Zbigniew Heleniak, Barbara Bullo-Piontecka, Tomasz Liberek, Alicja Debska-Slizien, Tomasz Hryszko, Anna Materna-Kiryluk, Monika Miklaszewska, Maria Szczepanska, Katarzyna Dyga, Edyta Machura, Katarzyna Siniewicz-Luzenczyk, Monika Pawlak-Bratkowska, Marcin Tkaczyk, Dariusz Runowski, Norbert Kwella, Dorota Drozdz, Ireneusz Habura, Florian Kronenberg, Larisa Prikhodina, David van Heel, Bertrand Fontaine, Chris Cotsapas, Cisca Wijmenga, Andre Franke, Vito Annese, Peter K. Gregersen, Sreeja Parameswaran, Matthew Weirauch, Leah Kottyan, John B. Harley, Hitoshi Suzuki, Ichiei Narita, Shin Goto, Hajeong Lee, Dong Ki Kim, Yon Su Kim, Jin-Ho Park, BeLong Cho, Murim Choi, Ans Van Wijk, Ana Huerta, Elisabet Ars, Jose Ballarin, Sigrid Lundberg, Bruno Vogt, Laila-Yasmin Mani, Yasar Caliskan, Jonathan Barratt, Thilini Abeygunaratne, Philip A. Kalra, Daniel P. Gale, Ulf Panzer, Thomas Rauen, Juergen Floege, Pascal Schlosser, Arif B. Ekici, Kai-Uwe Eckardt, Nan Chen, Jingyuan Xie, Richard P. Lifton, Ruth J. F. Loos, Eimear E. Kenny, Iuliana Ionita-Laza, Anna Koettgen, Bruce A. Julian, Jan Novak, Francesco Scolari, Hong Zhang, Ali G. Gharavi
Summary: Genome-wide association analyses have identified 30 risk loci for IgA nephropathy, a progressive form of kidney disease. Functional annotations of potential causal genes suggest inflammatory signaling pathways and cytokine ligand-receptor pairs as potential new drug targets. These findings provide valuable insights into the genetic basis of IgA nephropathy and offer potential avenues for developing therapeutic interventions.
Article
Chemistry, Analytical
Natalia Korytowska-Przybylska, Sylwia Michorowska, Aleksandra Wyczalkowska-Tomasik, Leszek Paczek, Joanna Giebultowicz
Summary: Chronic kidney disease (CKD) is diagnosed using serum creatinine or cystatin C levels, but more sensitive biomarkers are needed. This study aims to verify the correlation between saliva and serum levels of trimethylamine N-oxide (TMAO) in CKD patients. The results show a good correlation between TMAO levels in saliva and serum, suggesting that saliva can be used for non-invasive monitoring of renal failure in CKD.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2023)
Article
Immunology
Paulina Nazaruk, Ignacy Tkaczyk, Marta Monticolo, Anna Maria Jedrzejczak, Natalia Krata, Leszek Paczek, Bartosz Foroncewicz, Krzysztof Mucha
Summary: The study evaluated the role of SARS-CoV-2 infection history in the vaccination schedules of kidney and liver transplant recipients and patients with chronic kidney disease (CKD). The results showed that patients with a COVID-19 history had higher antibody levels after two doses compared to three doses. Two doses also resulted in a longer median time to infection. The study suggests that vaccination schedules should take into account vaccine response rate and COVID-19 history.
Article
Cardiac & Cardiovascular Systems
Milena Michalska, Tadeusz Grochowiecki, Aleksandra Wyczalkowska-Tomasik, Leszek Paczek, Tomasz Jakimowicz, Andrzej Cacko, Katarzyna Jama, Albert Stec, Ewa Sikorska, Slawomir Nazarewski, Zbigniew Galazka
Summary: This study investigated the changes in NETosis markers in patients with thoracoabdominal aortic aneurysms undergoing t-Branch stent-graft implantation. The results showed that NETs play a significant role in the complex processes after the surgery, and a new marker for NETosis, ssDNA, was discovered.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Article
Surgery
Piotr Wilkowski, Ewa Hryniewiecka, Kornelia Jasinska, Leszek Paczek, Michal Ciszek
Summary: This observational study suggests that treating patients with recurrent UTIs in an outpatient setting with high doses of oral amoxicillin with clavulanic acid can effectively reduce treatment failure and recurrence.
ANNALS OF TRANSPLANTATION
(2023)
Article
Surgery
Tomasz Pilecki, Bozena Czarkowska-Paczek, Wojciech Lisik, Slawomir Nazarewski, Leszek Paczek
Summary: Hypertension is a risk factor for graft failure and mortality among kidney transplant recipients. Monitoring blood pressure and adequate treatment contribute to longer survival of the graft and recipient.
ANNALS OF TRANSPLANTATION
(2023)