Evolution of Chemical Diversity in a Group of Non-Reduced Polyketide Gene Clusters: Using Phylogenetics to Inform the Search for Novel Fungal Natural Products

SnPKS19Encodes the Polyketide Synthase for Alternariol Mycotoxin Biosynthesis in the Wheat Pathogen Parastagonospora nodorum

(2015) Yit-Heng Chooi et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Redundant synthesis of a conidial polyketide by two distinct secondary metabolite clusters inAspergillus fumigatus

(2015) Kurt Throckmorton et al.   ENVIRONMENTAL MICROBIOLOGY

Phylogeny of type I polyketide synthases (PKSs) in fungal entomopathogens and expression analysis of PKS genes in Beauveria bassiana BCC 2660

(2015) Juntira Punya et al.   Fungal Biology

An Aspergillus flavus secondary metabolic gene cluster containing a hybrid PKS–NRPS is necessary for synthesis of the 2-pyridones, leporins

(2015) Jeffrey W. Cary et al.   FUNGAL GENETICS AND BIOLOGY

An update to polyketide synthase and non-ribosomal synthetase genes and nomenclature in Fusarium

(2015) Frederik T. Hansen et al.   FUNGAL GENETICS AND BIOLOGY

Clustering of Two Genes Putatively Involved in Cyanate Detoxification Evolved Recently and Independently in Multiple Fungal Lineages

(2015) M. Holly Elmore et al.   Genome Biology and Evolution

HMMER web server: 2015 update

(2015) Robert D. Finn et al.   NUCLEIC ACIDS RESEARCH

Bioinformatical Analysis of the Sequences, Structures and Functions of Fungal Polyketide Synthase Product Template Domains

(2015) Lu Liu et al.   Scientific Reports

A Genomics Based Discovery of Secondary Metabolite Biosynthetic Gene Clusters in Aspergillus ustus

(2015) Borui Pi et al.   PLoS One

OmGOGAT-disruption in the ericoid mycorrhizal fungus Oidiodendron maius induces reorganization of the N pathway and reduces tolerance to heavy-metals

(2014) H.R. Khouja et al.   FUNGAL GENETICS AND BIOLOGY

The polyketide synthase gene pks4 is essential for sexual development and regulates fruiting body morphology in Sordaria macrospora

(2014) Daniel Schindler et al.   FUNGAL GENETICS AND BIOLOGY

Fungal model systems and the elucidation of pathogenicity determinants

(2014) Elena Perez-Nadales et al.   FUNGAL GENETICS AND BIOLOGY

Characterization of the biosynthetic gene cluster for the ribosomally synthesized cyclic peptide ustiloxin B in Aspergillus flavus

(2014) Myco Umemura et al.   FUNGAL GENETICS AND BIOLOGY

Functional characterization of a veA-dependent polyketide synthase gene in Aspergillus flavus necessary for the synthesis of asparasone, a sclerotium-specific pigment

(2014) Jeffrey W. Cary et al.   FUNGAL GENETICS AND BIOLOGY

Discovering the secondary metabolite potential encoded within entomopathogenic fungi

(2014) Donna M. Gibson et al.   NATURAL PRODUCT REPORTS

Oxidative rearrangements during fungal biosynthesis

(2014) Russell Cox   NATURAL PRODUCT REPORTS

Fungal type III polyketide synthases

(2014) Makoto Hashimoto et al.   NATURAL PRODUCT REPORTS

CDD: NCBI's conserved domain database

(2014) Aron Marchler-Bauer et al.   NUCLEIC ACIDS RESEARCH

Rational Domain Swaps Reveal Insights about Chain Length Control by Ketosynthase Domains in Fungal Nonreducing Polyketide Synthases

(2014) Ting Liu et al.   ORGANIC LETTERS

Polyphasic taxonomy of the genus Talaromyces

(2014) N. Yilmaz et al.   STUDIES IN MYCOLOGY

Complexity Generation in Fungal Polyketide Biosynthesis: A Spirocycle-Forming P450 in the Concise Pathway to the Antifungal Drug Griseofulvin

(2013) Ralph A. Cacho et al.   ACS Chemical Biology

Molecular Bacteria-Fungi Interactions: Effects on Environment, Food, and Medicine

(2013) Kirstin Scherlach et al.   Annual Review of Microbiology

Identification of the First Diphenyl Ether Gene Cluster for Pestheic Acid Biosynthesis in Plant EndophytePestalotiopsis fici

(2013) Xinxin Xu et al.   CHEMBIOCHEM

Bacterium Induces Cryptic Meroterpenoid Pathway in the Pathogenic FungusAspergillus fumigatus

(2013) Claudia C. König et al.   CHEMBIOCHEM

Insight into the transcriptional regulation of Msn2 required for conidiation, multi-stress responses and virulence of two entomopathogenic fungi

(2013) Qian Liu et al.   FUNGAL GENETICS AND BIOLOGY

Preparation and In Vivo Evaluation of Solid Lipid Nanoparticles of Griseofulvin for Dermal Use

(2013) Nidhi Aggarwal et al.   Journal of Biomedical Nanotechnology

The Fungal Phytotoxin Alternariol 9-Methyl Ether and Some of Its Synthetic Analogues Inhibit the Photosynthetic Electron Transport Chain

(2013) Antonio Jacinto Demuner et al.   JOURNAL OF NATURAL PRODUCTS

Detecting Sequence Homology at the Gene Cluster Level with MultiGeneBlast

(2013) Marnix H. Medema et al.   MOLECULAR BIOLOGY AND EVOLUTION

MAFFT Multiple Sequence Alignment Software Version 7: Improvements in Performance and Usability

(2013) K. Katoh et al.   MOLECULAR BIOLOGY AND EVOLUTION

The wheat powdery mildew genome shows the unique evolution of an obligate biotroph

(2013) Thomas Wicker et al.   NATURE GENETICS

Pfam: the protein families database

(2013) Robert D. Finn et al.   NUCLEIC ACIDS RESEARCH

Genome Mining of a Prenylated and Immunosuppressive Polyketide from Pathogenic Fungi

(2013) Yit-Heng Chooi et al.   ORGANIC LETTERS

Heterologous Reconstitution of the Intact Geodin Gene Cluster in Aspergillus nidulans through a Simple and Versatile PCR Based Approach

(2013) Morten Thrane Nielsen et al.   PLoS One

Prototype of an intertwined secondary-metabolite supercluster

(2013) P. Wiemann et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Plant-Symbiotic Fungi as Chemical Engineers: Multi-Genome Analysis of the Clavicipitaceae Reveals Dynamics of Alkaloid Loci

(2013) Christopher L. Schardl et al.   PLoS Genetics

Low-Volume Toolbox for the Discovery of Immunosuppressive Fungal Secondary Metabolites

(2013) Erwin Berthier et al.   PLoS Pathogens

Phylogenetic Study of Polyketide Synthases and Nonribosomal Peptide Synthetases Involved in the Biosynthesis of Mycotoxins

(2013) Antonia Gallo et al.   Toxins

Genome-Based Cluster Deletion Reveals an Endocrocin Biosynthetic Pathway in Aspergillus fumigatus

(2012) Fang Yun Lim et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Identification and Regulation offusA, the Polyketide Synthase Gene Responsible for Fusarin Production in Fusarium fujikuroi

(2012) Violeta Díaz-Sánchez et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Biosynthesis of Fusarubins Accounts for Pigmentation of Fusarium fujikuroi Perithecia

(2012) Lena Studt et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Geneious Basic: An integrated and extendable desktop software platform for the organization and analysis of sequence data

(2012) M. Kearse et al.   BIOINFORMATICS

A heptaketide naphthaldehyde produced by a polyketide synthase from Nectria haematococca

(2012) Takayoshi Awakawa et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Genetic and Biosynthetic Studies of the Fungal Prenylated Xanthone Shamixanthone and Related Metabolites in Aspergillus spp. Revisited

(2012) Thomas J. Simpson   CHEMBIOCHEM

Genome mining reveals the evolutionary origin and biosynthetic potential of basidiomycete polyketide synthases

(2012) Gerald Lackner et al.   FUNGAL GENETICS AND BIOLOGY

Navigating the Fungal Polyketide Chemical Space: From Genes to Molecules

(2012) Yit-Heng Chooi et al.   JOURNAL OF ORGANIC CHEMISTRY

Discovery and Characterization of a Group of Fungal Polycyclic Polyketide Prenyltransferases

(2012) Yit-Heng Chooi et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Illuminating the Diversity of Aromatic Polyketide Synthases in Aspergillus nidulans

(2012) Manmeet Ahuja et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Role of Pigmentation in ProtectingAspergillus nigerConidiospores Against Pulsed Light Radiation

(2012) Julia Esbelin et al.   PHOTOCHEMISTRY AND PHOTOBIOLOGY

Modeling the Effect of Temperature and Wetness on Guignardia Pseudothecium Maturation and Ascospore Release in Citrus Orchards

(2012) Paul Fourie et al.   PHYTOPATHOLOGY

Trypacidin, a Spore-Borne Toxin from Aspergillus fumigatus, Is Cytotoxic to Lung Cells

(2012) Thierry Gauthier et al.   PLoS One

Identification of a Polyketide Synthase Required for Alternariol (AOH) and Alternariol-9-Methyl Ether (AME) Formation in Alternaria alternata

(2012) Debjani Saha et al.   PLoS One

Accurate prediction of secondary metabolite gene clusters in filamentous fungi

(2012) M. R. Andersen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Association with AflR in Endosomes Reveals New Functions for AflJ in Aflatoxin Biosynthesis

(2012) Kenneth Ehrlich et al.   Toxins

Phylogenomic and functional domain analysis of polyketide synthases in Fusarium

(2011) Daren W. Brown et al.   Fungal Biology

Genome-Based Deletion Analysis Reveals the Prenyl Xanthone Biosynthesis Pathway inAspergillus nidulans

(2011) James F. Sanchez et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Comparative Characterization of Fungal Anthracenone and Naphthacenedione Biosynthetic Pathways Reveals an α-Hydroxylation-Dependent Claisen-like Cyclization Catalyzed by a Dimanganese Thioesterase

(2011) Yanran Li et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Obligate biotrophy features unraveled by the genomic analysis of rust fungi

(2011) S. Duplessis et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

HypC, the Anthrone Oxidase Involved in Aflatoxin Biosynthesis

(2010) K. C. Ehrlich et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Characterization of the Aspergillus nidulans Monodictyphenone Gene Cluster

(2010) Y.-M. Chiang et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Unraveling polyketide synthesis in members of the genus Aspergillus

(2010) Yi-Ming Chiang et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Phylogenomics reveals subfamilies of fungal nonribosomal peptide synthetases and their evolutionary relationships

(2010) Kathryn E Bushley et al.   BMC EVOLUTIONARY BIOLOGY

Identification of the Viridicatumtoxin and Griseofulvin Gene Clusters from Penicillium aethiopicum

(2010) Yit-Heng Chooi et al.   CHEMISTRY & BIOLOGY

Fungal secondary metabolites as modulators of interactions with insects and other arthropods

(2010) Marko Rohlfs et al.   FUNGAL GENETICS AND BIOLOGY

Classification, Prediction, and Verification of the Regioselectivity of Fungal Polyketide Synthase Product Template Domains

(2010) Yanran Li et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Enzymatic Synthesis of Resorcylic Acid Lactones by Cooperation of Fungal Iterative Polyketide Synthases Involved in Hypothemycin Biosynthesis

(2010) Hui Zhou et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

FastTree 2 – Approximately Maximum-Likelihood Trees for Large Alignments

(2010) Morgan N. Price et al.   PLoS One

Structure and function of an iterative polyketide synthase thioesterase domain catalyzing Claisen cyclization in aflatoxin biosynthesis

(2010) T. P. Korman et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

trimAl: a tool for automated alignment trimming in large-scale phylogenetic analyses

(2009) S. Capella-Gutierrez et al.   BIOINFORMATICS

Physically Discrete β-Lactamase-Type Thioesterase Catalyzes Product Release in Atrochrysone Synthesis by Iterative Type I Polyketide Synthase

(2009) Takayoshi Awakawa et al.   CHEMISTRY & BIOLOGY

A PLP-Dependent Polyketide Chain Releasing Mechanism in the Biosynthesis of Mycotoxin Fumonisins inFusarium verticillioides

(2009) Ryan Gerber et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

A Gene Cluster Containing Two Fungal Polyketide Synthases Encodes the Biosynthetic Pathway for a Polyketide, Asperfuranone, inAspergillus nidulans

(2009) Yi-Ming Chiang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Molecular genetic analysis of the orsellinic acid/F9775 genecluster of Aspergillus nidulans

(2009) James F. Sanchez et al.   Molecular BioSystems

Biosynthesis of the red pigment bikaverin inFusarium fujikuroi: genes, their function and regulation

(2009) Philipp Wiemann et al.   MOLECULAR MICROBIOLOGY

Chromatin-level regulation of biosynthetic gene clusters

(2009) Jin Woo Bok et al.   Nature Chemical Biology

Intimate bacterial-fungal interaction triggers biosynthesis of archetypal polyketides in Aspergillus nidulans

(2009) V. Schroeckh et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Towards Prediction of Metabolic Products of Polyketide Synthases: An In Silico Analysis

(2009) Gitanjali Yadav et al.   PLoS Computational Biology

Identification and Characterization of the Asperthecin Gene Cluster of Aspergillus nidulans

(2008) E. Szewczyk et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Deconstruction of Iterative Multidomain Polyketide Synthase Function

(2008) J. M. Crawford et al.   SCIENCE