Review
Medicine, General & Internal
Carlotta Agostini, Simone Buccianti, Matteo Risaliti, Laura Fortuna, Luca Tirloni, Rosaria Tucci, Ilenia Bartolini, Gian Luca Grazi
Summary: Liver transplantation is the preferred treatment for liver failure and selected cases of malignancies. However, there is a shortage of organs, necessitating the use of prioritizing systems and expanding the donor pool. The use of marginal donors has shown improvement in transplantation outcomes, and the introduction of machine perfusion and better understanding and treatment of complications may also contribute to better results. However, the heterogeneity of behaviors among different centers makes result comparison difficult, highlighting the need for more expert consensus.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Cell Biology
Xiaodong Du, Mingqian Li, Chen Huan, Guoyue Lv
Summary: This review discusses the origin, maturation, migration, and pathological effects of dendritic cell subsets in liver transplantation, as well as their roles in transplant rejection and tolerance. The latest progress in dendritic cell-based treatment regimens is also outlined.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Review
Clinical Neurology
Duo-Zi Wang, Bing-Hu Li, Bin-Lu Deng, Fu-Qiang Guo, Shan-Shan Hu, Neng-Wei Yu, Jie Liu
Summary: A woman who underwent solid organ transplantation and received strict immunosuppressive treatment developed anti-CASPR2 encephalitis, which was diagnosed based on positive antibodies in her serum and cerebrospinal fluid. This is the first reported case of anti-CASPR2 encephalitis in post-organ transplantation patients, highlighting the risk of immune-oriented encephalitis in patients undergoing immunosuppression, especially when combined with other immunomodulatory treatments.
NEUROLOGICAL SCIENCES
(2023)
Article
Immunology
Yi Shan, Debin Qi, Lei Zhang, Lixue Wu, Wenfang Li, Hao Liu, Tao Li, Zhiren Fu, Haili Bao, Shaohua Song
Summary: In this study, the expression and distribution of immune cells in donor organs before and after liver transplantation were explored using single-cell RNA sequencing and T cell receptor (TCR) / B cell receptor (BCR) repertoire sequencing. Functional properties of monocytes/Kupffer cells, T cells, and B cells in grafts were investigated, and shifts in TCR/BCR repertoire after transplantation were observed. This study provides novel strategies for monitoring recipient immune function and treating rejection after liver transplantation.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Medicine, General & Internal
Filippo Ghidini, Elisa Benetti, Pietro Zucchetta, Angela Amigoni, Piergiorgio Gamba, Marco Castagnetti
Summary: Transcutaneous near-infrared spectroscopy (NIRS) has been proposed for monitoring kidney and liver allograft perfusion in recent years, with studies showing significant correlations to vascular complications. Research calls for further investigation to establish normal NIRS values and influencing factors.
INTERNATIONAL JOURNAL OF CLINICAL PRACTICE
(2021)
Review
Oncology
Wenhui Zhang, Zhikun Liu, Xiao Xu
Summary: Liver transplantation is the most effective treatment for end-stage liver diseases, with significant changes in the immunometabolism microenvironment after transplantation. Immune cells play a crucial role in this environment and studying their complex pathobiology is critical to prevent post-transplant complications. The interplay between cellular metabolism and immune function is evident, with potential for shaping immune responses through targeting different metabolic pathways.
CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY
(2021)
Review
Radiology, Nuclear Medicine & Medical Imaging
Gi Young Ko, Kyu Bo Sung, Dong-Il Gwon
Summary: Living-donor liver transplantation has become a well-established treatment option for patients with end-stage liver disease due to advancements in surgical techniques and medical care. However, various vascular or non-vascular complications can arise during or after transplantation. Interventional radiologic techniques can be utilized to manage these complications effectively.
KOREAN JOURNAL OF RADIOLOGY
(2021)
Article
Immunology
Soon Kyu Lee, Min-Jung Park, Jeong Won Choi, Jin-Ah Baek, Se-Young Kim, Ho Joong Choi, Young Kyoung You, Jeong Won Jang, Pil Soo Sung, Si Hyun Bae, Seung Kew Yoon, Jong Young Choi, Mi-La Cho
Summary: In this study, a patient-derived avatar model was developed to predict immune homeostasis in liver transplantation patients. The model showed promise in evaluating treatment responses and reducing risks to patients.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Surgery
Zhihao Li, Ashwin Rammohan, Vasanthakumar Gunasekaran, Suyoung Hong, Itsuko Chih-Yi Chen, Jongman Kim, Kris Ann Hervera Marquez, Shih Chao Hsu, Elvan Onur Kirimker, Nobuhisa Akamatsu, Oren Shaked, Michele Finotti, Marcus Yeow, Lara Genedy, Philipp Dutkowski, Silvio Nadalin, Markus U. Boehnert, Wojciech G. Polak, Glenn K. Bonney, Abhishek Mathur, Benjamin Samstein, Jean C. Emond, Giuliano Testa, Kim M. Olthoff, Charles B. Rosen, Julie K. Heimbach, Timucin Taner, Tiffany CL. Wong, Chung-Mau Lo, Kiyoshi Hasegawa, Deniz Balci, Mark Cattral, Gonzalo Sapisochin, Nazia Selzner, Long Bin Jeng, Dieter Broering, Jae-Won Joh, Chao-Long Chen, Kyung-Suh Suk, Mohamed Rela, Pierre-Alain Clavien
Summary: This study aims to establish benchmark values for adult-to-adult living-donor liver transplantation (LDLT). By analyzing data from 15 high-volume centers, it was found that benchmark LDLT can reduce waitlist mortality, with Asian centers outperforming others and non-benchmark low-volume centers displaying inferior outcomes.
Article
Neurosciences
Shandiz Morega, Bogdan Catalin, Cristiana Eugenia Simionescu, Konstantinos Sapalidis, Ion Rogoveanu
Summary: The experimental results showed that Cerebrolysin treatment in a non-viral liver damage model in mice was able to maintain normal levels of cortical cells and induce an increase in cell occupation area. However, the treatment did not improve anxiety and short-term memory, and no significant difference was observed in Iba1(+) cells.
Review
Biochemistry & Molecular Biology
Ludovico Abenavoli, Giuseppe Guido Maria Scarlata, Maria Rosaria Paravati, Luigi Boccuto, Francesco Luzza, Emidio Scarpellini
Summary: Liver transplantation is the preferred treatment for patients with certain liver conditions, but rejection after transplantation is a significant issue. The gut microbiota is involved in the gut-liver axis and can affect the immune response, potentially leading to graft rejection. Evaluating changes in the gut microbiota composition is essential for monitoring the success of liver transplantation and implementing appropriate preventive measures.
Review
Immunology
Mingjie Ding, Yuting He, Shuijun Zhang, Wenzhi Guo
Summary: Liver transplantation is an effective therapy for end-stage liver disease, but most postoperative patients require immunosuppressive drugs. Some transplant recipients achieve immune tolerance with normal liver function and no organ rejection after immunosuppressive drug withdrawal. Costimulatory molecules are crucial in T cell-mediated immune responses and tolerance maintenance, with potential for inducing immune tolerance in transplantation through costimulatory blockade.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Cell Biology
Weixiong Zheng, Lingxiang Yang, Shiming Jiang, Mingxiang Chen, Jinzheng Li, Zuojing Liu, Zhongjun Wu, Jianping Gong, Yong Chen
Summary: Liver transplantation is a effective treatment for end-stage liver disease and significantly prolongs the survival time of patients, but acute and chronic rejection still remain major obstacles. Investigating induced immune tolerance is of crucial theoretical significance and socio-economic value. This paper comprehensively summarizes the important roles of Kupffer cells in establishing immune tolerance after transplantation, including phagocytosis, cell polarization, antigen presentation, and cell membrane proteins, providing a theoretical basis for further study and clinical application of Kupffer cells in liver transplantation.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Article
Oncology
Audrey E. Brown, Amy M. Shui, Dieter Adelmann, Neil Mehta, Garrett R. Roll, Ryutaro Hirose, Shareef M. Syed
Summary: This retrospective analysis of 298 HCC patients who underwent liver transplant aimed to understand the impact of the number and type of local regional therapies (LRTs) on peri-operative outcomes. Patients who received more than 3 LRTs before liver transplant had a higher risk of biliary leak but similar outcomes to those with fewer LRTs. The study highlights the need for further evaluation on the effects of multiple rounds of LRTs on transplant outcomes.
Article
Gastroenterology & Hepatology
Haihong Wang, Biying Zhang, Ruiqi Li, Jiayuan Chen, Guojie Xu, Ying Zhu, Jiao Li, Qing Liang, Qingling Hua, Lanqing Wang, Lu Wen, Min Jin, Jun Fan, Dejun Zhang, Lei Zhao, Dandan Yu, Zhenyu Lin, Jinghua Ren, Tao Zhang
Summary: The study found that KIAA1199 promotes CRC liver metastasis by activating the TGF beta signaling pathway and stimulating the production of CXCL1 and CXCL3, leading to increased infiltration of neutrophils. Genetic blockade or pharmacologic inhibition of KIAA1199 restored tumor immune infiltration, impeded tumor progression, and enhanced response to immune checkpoint blockade.
Article
Oncology
Aloysious Aravinthan, Benjamin Challis, Nicholas Shannon, Matthew Hoare, Judith Heaney, Graeme J. M. Alexander
EXPERIMENTAL CELL RESEARCH
(2015)
Article
Multidisciplinary Sciences
Annie Y. Chen, Matthew Hoare, Arun N. Shankar, Michael Allison, Graeme J. M. Alexander, Tomasz I. Michalak
Editorial Material
Cell Biology
Matthew Hoare, Masashi Narita
Article
Cell Biology
Matthew Hoare, Yoko Ito, Tae-Won Kang, Michael P. Weekes, Nicholas J. Matheson, Daniel A. Patten, Shishir Shetty, Aled J. Parry, Suraj Menon, Rafik Salama, Robin Antrobus, Kosuke Tomimatsu, William Howat, Paul J. Lehner, Lars Zender, Masashi Narita
NATURE CELL BIOLOGY
(2016)
Review
Cell Biology
Yoko Ito, Matthew Hoare, Masashi Narita
TRENDS IN CELL BIOLOGY
(2017)
Article
Multidisciplinary Sciences
Aled J. Parry, Matthew Hoare, Dora Bihary, Robert Hansel-Hertsch, Stephen Smith, Kosuke Tomimatsu, Elizabeth Mannion, Amy Smith, Paula D'Santos, Alasdair Russell, Shankar Balasubramanian, Hiroshi Kimura, Shamith A. Samarajiwa, Masashi Narita
NATURE COMMUNICATIONS
(2018)
Article
Gastroenterology & Hepatology
M. Shah, A. Shankar, I. Gee, K. Nash, M. Hoare, P. Gibbs, S. Davies, G. J. M. Alexander
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2015)
Article
Multidisciplinary Sciences
Simon F. Brunner, Nicola D. Roberts, Luke A. Wylie, Luiza Moore, Sarah J. Aitken, Susan E. Davies, Mathijs A. Sanders, Pete Ellis, Chris Alder, Yvette Hooks, Federico Abascal, Michael R. Stratton, Inigo Martincorena, Matthew Hoare, Peter J. Campbell
Article
Gastroenterology & Hepatology
Giuseppe Ferrandino, Isabel Orf, Rob Smith, Marzia Calcagno, Anita Kaur Thind, Irene Debiram-Beecham, Megan Williams, Olga Gandelman, Alexandra de Saedeleer, Graham Kibble, Anne Marie Lydon, Chris A. Mayhew, Max Allsworth, Billy Boyle, Marc P. van der Schee, Michael Allison, Matthew Hoare, Victoria K. Snowdon
CLINICAL AND TRANSLATIONAL GASTROENTEROLOGY
(2020)
Article
Multidisciplinary Sciences
Lorena Escudero Sanchez, Leonardo Rundo, Andrew B. Gill, Matthew Hoare, Eva Mendes Serrao, Evis Sala
Summary: This study evaluated the robustness of radiomic features extracted from CT images, comparing feature values in images of different thicknesses and using novel approaches to address dependencies, resulting in the discovery of highly robust features across different thicknesses.
SCIENTIFIC REPORTS
(2021)
Article
Cell Biology
Susana Goncalves, Kelvin Yin, Yoko Ito, Adelyne Chan, Ioana Olan, Sarah Gough, Liam Cassidy, Eva Serrao, Stephen Smith, Andrew Young, Masashi Narita, Matthew Hoare
Summary: COX2 plays a critical role in regulating SASP composition and senescence surveillance during RAS-induced senescence. Its downstream product, prostaglandin E-2 (PGE(2)), is also implicated in tumor suppression and shaping the immune microenvironment during senescence. Loss of COX2 dysregulates immune cells and impairs senescence surveillance in early tumorigenesis.
Article
Gastroenterology & Hepatology
Ruwanthi Kolamunnage-Dona, Sarah Berhane, Harry Potts, Edward H. Williams, James Tanner, Tobias Janowitz, Matthew Hoare, Philip Johnson
Summary: The study found that sorafenib treatment is associated with improved survival in patients with advanced hepatocellular carcinoma mainly by decreasing the rate of tumor growth and liver function deterioration, especially among HCV seropositive patients. The rate of tumor growth and serum alpha-fetoprotein rise were significantly lower in HCV seropositive patients compared to others.
JOURNAL OF HEPATOLOGY
(2021)
Article
Multidisciplinary Sciences
Stanley W. K. Ng, Foad J. Rouhani, Simon F. Brunner, Natalia Brzozowska, Sarah J. Aitken, Ming Yang, Federico Abascal, Luiza Moore, Efterpi Nikitopoulou, Lia Chappell, Daniel Leongamornlert, Aleksandra Ivovic, Philip Robinson, Timothy Butler, Mathijs A. Sanders, Nicholas Williams, Tim H. H. Coorens, Jon Teague, Keiran Raine, Adam P. Butler, Yvette Hooks, Beverley Wilson, Natalie Birtchnell, Huw Naylor, Susan E. Davies, Michael R. Stratton, Inigo Martincorena, Raheleh Rahbari, Christian Frezza, Matthew Hoare, Peter J. Campbell
Summary: In patients with liver disease, mutations in FOXO1, CIDEB, and GPAM genes were found at a higher frequency, showing convergent evolution. Master regulators of metabolic pathways are a frequent target of convergent somatic mutation in alcohol-related and non-alcoholic fatty liver disease.
Article
Gastroenterology & Hepatology
Jake P. Mann, Matthew Hoare
Summary: This study aimed to explore the relationship between genetic factors and the risk and severity of fatty liver disease. The study found that only the variants of the GPAM and NEAT1 genes were associated with liver fat, ALT, and serum lipid concentrations, while the variants of the other five genes were not associated with liver disease. The study suggests the need for larger studies to confirm these associations.
LIVER INTERNATIONAL
(2022)
Editorial Material
Gastroenterology & Hepatology
Matthew Hoare
JOURNAL OF HEPATOLOGY
(2023)