TRIM26 Negatively Regulates Interferon-β Production and Antiviral Response through Polyubiquitination and Degradation of Nuclear IRF3

Recruitment of Phosphatase PP2A by RACK1 Adaptor Protein Deactivates Transcription Factor IRF3 and Limits Type I Interferon Signaling

(2014) Lingyun Long et al.   IMMUNITY

The E3 Ubiquitin Ligase Ro52 Negatively Regulates IFN-  Production Post-Pathogen Recognition by Polyubiquitin-Mediated Degradation of IRF3

(2014) R. Higgs et al.   JOURNAL OF IMMUNOLOGY

Jmjd3 Inhibits Reprogramming by Upregulating Expression of INK4a/Arf and Targeting PHF20 for Ubiquitination

(2013) Wei Zhao et al.   CELL

Nucleic Acid Sensors and Type I Interferon Production in Systemic Lupus Erythematosus

(2013) Meena Shrivastav et al.   Frontiers in Immunology

TRAF-interacting protein (TRIP) negatively regulates IFN-β production and antiviral response by promoting proteasomal degradation of TANK-binding kinase 1

(2012) Meng Zhang et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Cyclic GMP-AMP Synthase Is a Cytosolic DNA Sensor That Activates the Type I Interferon Pathway

(2012) L. Sun et al.   SCIENCE

Activation of STAT6 by STING Is Critical for Antiviral Innate Immunity

(2011) Huihui Chen et al.   CELL

Regulation of innate immune signalling pathways by the tripartite motif (TRIM) family proteins

(2011) Taro Kawai et al.   EMBO Molecular Medicine

The helicase DDX41 senses intracellular DNA mediated by the adaptor STING in dendritic cells

(2011) Zhiqiang Zhang et al.   NATURE IMMUNOLOGY

SENP2 negatively regulates cellular antiviral response by deSUMOylating IRF3 and conditioning it for ubiquitination and degradation

(2011) Yong Ran et al.   Journal of Molecular Cell Biology

Pattern Recognition Receptors and Inflammation

(2010) Osamu Takeuchi et al.   CELL

Tripartite-motif proteins and innate immune regulation

(2010) Finlay W McNab et al.   CURRENT OPINION IN IMMUNOLOGY

The Ubiquitin E3 Ligase RAUL Negatively Regulates Type I Interferon through Ubiquitination of the Transcription Factors IRF7 and IRF3

(2010) Yanxing Yu et al.   IMMUNITY

Differential Expression of Intracellular and Secreted Osteopontin Isoforms by Murine Macrophages in Response to Toll-like Receptor Agonists

(2010) Wei Zhao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The cytosolic nucleic acid sensor LRRFIP1 mediates the production of type I interferon via a β-catenin-dependent pathway

(2010) Pengyuan Yang et al.   NATURE IMMUNOLOGY

IFI16 is an innate immune sensor for intracellular DNA

(2010) Leonie Unterholzner et al.   NATURE IMMUNOLOGY

STING regulates intracellular DNA-mediated, type I interferon-dependent innate immunity

(2009) Hiroki Ishikawa et al.   NATURE

ERIS, an endoplasmic reticulum IFN stimulator, activates innate immune signaling through dimerization

(2009) W. Sun et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Genomic analysis of the TRIM family reveals two groups of genes with distinct evolutionary properties

(2008) Marco Sardiello et al.   BMC EVOLUTIONARY BIOLOGY

Negative feedback regulation of cellular antiviral signaling by RBCK1-mediated degradation of IRF3

(2008) Min Zhang et al.   CELL RESEARCH

The Adaptor Protein MITA Links Virus-Sensing Receptors to IRF3 Transcription Factor Activation

(2008) Bo Zhong et al.   IMMUNITY