Article
Microbiology
Zi Li, Yawen Yang, Huijun Lu, Jing Zhang, Rongyi Xu, Junchao Shi, Yungang Lan, Jiyu Guan, Kui Zhao, Hongbin He, Feng Gao, Wenqi He
Summary: The study found that porcine haemagglutinating encephalomyelitis virus (PHEV) infection strongly suppresses IFN-beta production in the early stage by deactivating IRF3. However, PHEV does not disrupt the protective response pathway regulated by RIG-I/MDA5/MAVS/TBK1. Furthermore, PHEV and poly(I:C) regulate IFN-beta induction via two different pathways.
VETERINARY MICROBIOLOGY
(2021)
Article
Immunology
Cheng Qin, Chunxiao Niu, Zhuo Shen, Yaolin Zhang, Genyu Liu, Chunmei Hou, Jie Dong, Min Zhao, Qianqian Cheng, Xiqin Yang, Jiyan Zhang
Summary: Myeloid RACK1 promotes in vivo viral infection by suppressing IRF3/7 phosphorylation and limiting type 1 IFN production. RACK1 deficiency in macrophages leads to increased IFN-alpha and IFN-beta production in response to virus infection.
JOURNAL OF IMMUNOLOGY
(2021)
Article
Cell Biology
Junfang Xu, Pin Wang, Zemeng Li, Zhiqing Li, Dan Han, Mingyue Wen, Qihang Zhao, Lianfeng Zhang, Yuanwu Ma, Wei Liu, Minghong Jiang, Xuan Zhang, Xuetao Cao
Summary: The lncRNA-ISIR directly binds to IRF3, promoting its activation and enhancing immune responses. In patients, the expression level of AK131315 is correlated with the severity of lupus. IFN-I-induced lncRNA-ISIR strengthens IRF3 activation by removing suppressive protein Fli-1.
Article
Biology
Zhongxia Yu, Lijuan Wang, Jing Zhao, Hui Song, Chunyuan Zhao, Wei Zhao, Mutian Jia
Summary: This study identifies TOB1 as a negative feedback inhibitor of IRF3-directed IFN-beta expression. TOB1 inhibits Ifnb1 transcription by disrupting IRF3 binding and recruiting HDAC8 to the promoter region. Tob1 deficiency enhances antiviral response and suppresses viral replication.
COMMUNICATIONS BIOLOGY
(2022)
Article
Multidisciplinary Sciences
Hera Kim, Yashwanth Subbannayya, Fiachra Humphries, Astrid Skejsol, Sneha M. Pinto, Miriam Giambelluca, Terje Espevik, Katherine A. Fitzgerald, Richard K. Kandasamy
Summary: This study investigated the gene expression changes in THP1-derived macrophages upon TLR4 activation and identified several interferon-stimulated genes, including CMPK2. The in-depth characterization of CMPK2 expression revealed its significant induction upon TLR4 and TLR3 ligand stimulation, suggesting its potential role in anti-bacterial and antiviral responses mediated by IRF3-type I interferon signaling.
Article
Biochemistry & Molecular Biology
Angelo de Vivo, Hongseon Song, Yujin Lee, Neysha Tirado-Class, Anthony Sanchez, Sandy Westerheide, Huzefa Dungrawala, Younghoon Kee
Summary: This study identified a new interaction network among OTUD5-FACT-HDAC1/2 that limits transcription-induced replication stress.
NUCLEIC ACIDS RESEARCH
(2023)
Article
Medicine, General & Internal
Jun Wu, Xuefeng Leng, Zhengbo Pan, Linfei Xu, Haitao Zhang
Summary: Through comprehensive analysis using bioinformatics methods, this study identified that elevated expression of IRF3 is significantly associated with worse clinical outcomes and adverse overall survival in clear cell renal cell carcinoma (ccRCC). IRF3 may promote the progression of ccRCC by participating in various cancer-related biological processes and signaling pathways, making it a promising prognostic marker and therapeutic target in ccRCC.
INTERNATIONAL JOURNAL OF GENERAL MEDICINE
(2021)
Article
Biology
Georgios I. Laliotis, Adam D. Kenney, Evangelia Chavdoula, Arturo Orlacchio, Abdul Kaba, Alessandro La Ferlita, Vollter Anastas, Christos Tsatsanis, Joal D. Beane, Lalit Sehgal, Vincenzo Coppola, Jacob S. Yount, Philip N. Tsichlis
Summary: AKT-phosphorylated IWS1 promotes the alternative splicing of U2AF2, leading to regulation of mRNA nuclear export, including those encoding Type I interferons. This pathway affects sensitivity to multiple cytolytic virus infections, and may serve as a potential therapeutic target in cancer treatment.
COMMUNICATIONS BIOLOGY
(2021)
Article
Medicine, Research & Experimental
Xiang Chen, Jia Hu, Yunfei Wang, Younghee Lee, Xiaohong Zhao, Huiping Lu, Gengzhen Zhu, Hui Wang, Yu Jiang, Fan Liu, Yongzhen Chen, Byung-Seok Kim, Qinghua Zhou, Xindong Liu, Xiaohu Wang, Seon Hee Chang, Chen Dong
Summary: Forkhead box O transcription factors, especially FoxO1 and FoxO3a, play important roles in immune responses. This study reveals the inhibitory role of another member, FoxO4, in Th1 cell's production of interferon-gamma. Conditional deletion of FoxO4 enhances CD4+ T cell's response to Listeria monocytogenes infection. The study also highlights the importance of the FoxO4/DKK3 axis in Th1 cell differentiation.
JOURNAL OF CLINICAL INVESTIGATION
(2022)
Article
Biochemistry & Molecular Biology
Heather M. Froggatt, Alfred T. Harding, Ryan R. Chaparian, Nicholas S. Heaton
Summary: The study identified ETS variant transcription factor 7 (ETV7) as a negative regulator of the type I IFN response, specifically targeting a subset of antiviral ISGs important for IFN-mediated control of influenza viruses. This research assigns a function for ETV7 as an IFN response regulator and suggests ETV7 as a potential therapeutic target to enhance innate antiviral responses and IFN-based antiviral therapies.
Article
Immunology
Patrycja K. Thompson, Edward L. Y. Chen, Renee F. de Pooter, Catherine Frelin, Walter K. Vogel, Christina R. Lee, Thomas Venables, Divya K. Shah, Norman N. Iscove, Mark Leid, Michele K. Anderson, Juan Carlos Zuniga-Pflucker
Summary: GATA-3 is a crucial factor in early T cell development and differentiation. This study reveals its collaboration with the Notch signaling pathway in T lineage specification and commitment. GATA-3 deficiency leads to a block in T cell development and diversion towards myeloid lineage fate. Moreover, the absence of GATA-3, in the presence of Notch signaling, induces apoptosis in early T lineage cells.
JOURNAL OF IMMUNOLOGY
(2022)
Article
Oncology
Chao Song, Tianwei Chen, Lan He, Ning Ma, Jian-ang Li, Ye-Fei Rong, Yuan Fang, Mengmeng Liu, Dong Xie, Wenhui Lou
Article
Oncology
Qianzhi Ni, Pingping Chen, Bing Zhu, Jingjing Li, Dong Xie, Xingyuan Ma
Article
Oncology
QianZhi Ni, Zhenhua Chen, Qianwen Zheng, Dong Xie, Jing-Jing Li, Shuqun Cheng, Xingyuan Ma
Article
Hematology
Wenting Zheng, Jun Wei, Caitlin C. Zebley, Lindsay L. Jones, Yogesh Dhungana, Yong-Dong Wang, Jayadev Mavuluri, Lingyun Long, Yiping Fan, Ben Youngblood, Hongbo Chi, Terrence L. Geiger
Summary: This study demonstrates that the deficiency of Regnase-1 enhances CAR-T cell expansion and memory-like cell formation, leading to improved tumor clearance and sustained remission. Regnase-1 deficiency also reduces exhaustion and enhances the activity of CAR-T cells.
Article
Biochemistry & Molecular Biology
Hongling Huang, Peipei Zhou, Jun Wei, Lingyun Long, Hao Shi, Yogesh Dhungana, Nicole M. Chapman, Guotong Fu, Jordy Saravia, Jana L. Raynor, Shaofeng Liu, Gustavo Palacios, Yong-Dong Wang, Chenxi Qian, Jiyang Yu, Hongbo Chi
Summary: This study reveals that amino acid transporters play a role in dampening T-MEM differentiation, while Pofut1 is a key regulator for terminal effector differentiation of T-EFF cells. These findings highlight the importance of nutrient uptake and signaling in determining T cell fate.
Article
Multidisciplinary Sciences
Seon Ah Lim, Jun Wei, Thanh-Long M. Nguyen, Hao Shi, Wei Su, Gustavo Palacios, Yogesh Dhungana, Nicole M. Chapman, Lingyun Long, Jordy Saravia, Peter Vogel, Hongbo Chi
Summary: Regulatory T cells play a crucial role in immune tolerance and immunosuppression in the tumor microenvironment. Inhibiting lipid synthesis dependent on SREBPs in T-reg cells can enhance antitumor immune responses without autoimmune toxicity, and deletion of SCAP in these cells inhibits tumor growth and enhances immunotherapy. SCAP and SREBPs signaling regulate lipid synthesis and inhibitory receptor signaling in T-reg cells, pointing to new ways of targeting these cells for cancer therapy.
Article
Multidisciplinary Sciences
Guotong Fu, Clifford S. Guy, Nicole M. Chapman, Gustavo Palacios, Jun Wei, Peipei Zhou, Lingyun Long, Yong-Dong Wang, Chenxi Qian, Yogesh Dhungana, Hongling Huang, Anil KC, Hao Shi, Sherri Rankin, Scott A. Brown, Amanda Johnson, Randall Wakefield, Camenzind G. Robinson, Xueyan Liu, Anthony Sheyn, Jiyang Yu, Suzanne Jackowski, Hongbo Chi
Summary: The CDP-ethanolamine pathway plays a crucial role in coordinating the expression and localization of CXCR5 in T-FH cells, impacting humoral immunity. This discovery enhances our understanding of T-FH cell differentiation and humoral immunity.
Article
Multidisciplinary Sciences
Chan Yul Yoo, Jiangman He, Qing Sang, Yongjian Qiu, Lingyun Long, Ruth Jean-Ae Kim, Emily G. Chong, Joseph Hahm, Nicholas Morffy, Pei Zhou, Lucia C. Strader, Akira Nagatani, Beixin Mo, Xuemei Chen, Meng Chen
Summary: The study demonstrates that PIF3 possesses a p53-like transcription activation domain, and PHYB can suppress PIF3 transactivation activity by binding adjacent to the domain. This reveals a novel signaling mechanism of PHYB through direct interference of PIF3 transactivation activity.
NATURE COMMUNICATIONS
(2021)
Article
Multidisciplinary Sciences
Lingyun Long, Jun Wei, Seon Ah Lim, Jana L. Raynor, Hao Shi, Jon P. Connelly, Hong Wang, Cliff Guy, Boer Xie, Nicole M. Chapman, Guotong Fu, Yanyan Wang, Hongling Huang, Wei Su, Jordy Saravia, Isabel Risch, Yong-Dong Wang, Yuxin Li, Mingming Niu, Yogesh Dhungana, K. C. Anil, Peipei Zhou, Peter Vogel, Jiyang Yu, Shondra M. Pruett-Miller, Junmin Peng, Hongbo Chi
Summary: Nutrients play a crucial role in adaptive immunity regulation by interacting with mTORC1. This study identified regulatory modules in mouse regulatory T cells that mediate immune receptor- and nutrient-dependent signaling to mTORC1. Epigenetic and post-translational mechanisms of nutrient transporters, sensors, and transducers in immune signals were unraveled, revealing their pivotal roles in T cell immunity and immune tolerance.
Meeting Abstract
Hematology
Nicole L. Michmerhuizen, Masayuki Umeda, Ilaria Iacobucci, Bright Arthur, Danika Di Giacomo, Ryan Hiltenbrand, Pablo Portola, Sherif Abdelhamed, Hongling Huang, Peipei Zhou, Lingyun Long, Hao Shi, Yu Sun, Evangelia K. Papachristou, Chandra Chilamakuri, Clive S. D'Santos, Hongbo Chi, Jeffery M. Klco, Charles G. Mullighan
Article
Mathematics, Applied
Lingyun Long, Aichao Li, Lili Jin
Summary: This paper proposes a wireless English synchronous QoS control algorithm with low complexity and easy implementation to improve the quality of wireless English multimedia communication. The algorithm maps the wireless English RTP timestamp to the same absolute reference clock and establishes a synchronization detection decision rule based on the synchronization QoS requirements. The state space model is used to describe system behavior and enables real-time synchronization detection and judgment. Experimental results show that the algorithm outperforms the RTP/RTCP-based algorithm in terms of synchronization performance.
APPLIED MATHEMATICS AND NONLINEAR SCIENCES
(2022)
