Antimicrobial-Induced DNA Damage and Genomic Instability in Microbial Pathogens

Unraveling the Physiological Complexities of Antibiotic Lethality

(2015) Daniel J. Dwyer et al.   Annual Review of Pharmacology and Toxicology

The Production of Reactive Oxygen Species Is a Universal Action Mechanism of Amphotericin B against Pathogenic Yeasts and Contributes to the Fungicidal Effect of This Drug

(2014) Ana Cecilia Mesa-Arango et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Antibiotic-Induced Replication Stress Triggers Bacterial Competence by Increasing Gene Dosage near the Origin

(2014) Jelle Slager et al.   CELL

Reactive oxygen species and the bacterial response to lethal stress

(2014) Xilin Zhao et al.   CURRENT OPINION IN MICROBIOLOGY

Short-term exposure to fluconazole induces chromosome loss in Candida albicans: An approach to produce haploid cells

(2014) Fang-Mo Chang et al.   FUNGAL GENETICS AND BIOLOGY

Microbiological effects of sublethal levels of antibiotics

(2014) Dan I. Andersson et al.   NATURE REVIEWS MICROBIOLOGY

The cryptic sexual strategies of human fungal pathogens

(2014) Iuliana V. Ene et al.   NATURE REVIEWS MICROBIOLOGY

Antibiotics induce redox-related physiological alterations as part of their lethality

(2014) D. J. Dwyer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Tetraploid Intermediate Precedes Aneuploid Formation in Yeasts Exposed to Fluconazole

(2014) Benjamin D. Harrison et al.   PLOS BIOLOGY

Antimicrobials, Stress and Mutagenesis

(2014) Alexandro Rodríguez-Rojas et al.   PLoS Pathogens

DNA Repair Mechanisms and the Bypass of DNA Damage in Saccharomyces cerevisiae

(2013) S. Boiteux et al.   GENETICS

β-lactam antibiotics promote bacterial mutagenesis via an RpoS-mediated reduction in replication fidelity

(2013) A. Gutierrez et al.   Nature Communications

Fungicidal Drugs Induce a Common Oxidative-Damage Cellular Death Pathway

(2013) Peter Belenky et al.   Cell Reports

RpoS Plays a Central Role in the SOS Induction by Sub-Lethal Aminoglycoside Concentrations in Vibrio cholerae

(2013) Zeynep Baharoglu et al.   PLoS Genetics

The Yeast Environmental Stress Response Regulates Mutagenesis Induced by Proteotoxic Stress

(2013) Erika Shor et al.   PLoS Genetics

Balancing Stability and Flexibility within the Genome of the Pathogen Cryptococcus neoformans

(2013) Kate L. Ormerod et al.   PLoS Pathogens

Stress-induced mutation via DNA breaks inEscherichia coli: A molecular mechanism with implications for evolution and medicine

(2012) Susan M. Rosenberg et al.   BIOESSAYS

Antimicrobials as promoters of genetic variation

(2012) Jesús Blázquez et al.   CURRENT OPINION IN MICROBIOLOGY

In-feed antibiotic effects on the swine intestinal microbiome

(2012) T. Looft et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Oxidation of the Guanine Nucleotide Pool Underlies Cell Death by Bactericidal Antibiotics

(2012) J. J. Foti et al.   SCIENCE

Global Gene Deletion Analysis Exploring Yeast Filamentous Growth

(2012) O. Ryan et al.   SCIENCE

Adaptive mechanisms in pathogens: universal aneuploidy in Leishmania

(2012) An Mannaert et al.   TRENDS IN PARASITOLOGY

Aneuploidy and Drug Resistance in Pathogenic Fungi

(2012) Kyung J. Kwon-Chung et al.   PLoS Pathogens

Vibrio cholerae Triggers SOS and Mutagenesis in Response to a Wide Range of Antibiotics: a Route towards Multiresistance

(2011) Zeynep Baharoglu et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Horizontal gene transfer in fungi

(2011) David A. Fitzpatrick   FEMS MICROBIOLOGY LETTERS

Effect of recA inactivation on mutagenesis of Escherichia coli exposed to sublethal concentrations of antimicrobials

(2011) T. D. Thi et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Regulatory Circuitry Governing Fungal Development, Drug Resistance, and Disease

(2011) R. S. Shapiro et al.   MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS

Tolerance to drug-induced cell death favours the acquisition of multidrug resistance in Leishmania

(2011) W Moreira et al.   Cell Death & Disease

Deletion of Cryptococcus neoformans AIF Ortholog Promotes Chromosome Aneuploidy and Fluconazole-Resistance in a Metacaspase-Independent Manner

(2011) Camile P. Semighini et al.   PLoS Pathogens

Genomic Plasticity of the Human Fungal Pathogen Candida albicans

(2010) Anna Selmecki et al.   EUKARYOTIC CELL

Influence of ciprofloxacin and vancomycin on mutation rate and transposition of IS256 in Staphylococcus aureus

(2010) Michael Nagel et al.   INTERNATIONAL JOURNAL OF MEDICAL MICROBIOLOGY

Sublethal Antibiotic Treatment Leads to Multidrug Resistance via Radical-Induced Mutagenesis

(2010) Michael A. Kohanski et al.   MOLECULAR CELL

Cryptococcus neoformans Overcomes Stress of Azole Drugs by Formation of Disomy in Specific Multiple Chromosomes

(2010) Edward Sionov et al.   PLoS Pathogens

Engineered bacteriophage targeting gene networks as adjuvants for antibiotic therapy

(2009) T. K. Lu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Acquisition of Aneuploidy Provides Increased Fitness during the Evolution of Antifungal Drug Resistance

(2009) Anna M. Selmecki et al.   PLoS Genetics