Sequence-Specific Fidelity Alterations Associated with West Nile Virus Attenuation in Mosquitoes

A Crystal Structure of the Dengue Virus NS5 Protein Reveals a Novel Inter-domain Interface Essential for Protein Flexibility and Virus Replication

(2015) Yongqian Zhao et al.   PLoS Pathogens

RNA Virus Population Diversity, an Optimum for Maximal Fitness and Virulence

(2014) Victoria K. Korboukh et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structural Dynamics as a Contributor to Error-prone Replication by an RNA-dependent RNA Polymerase

(2014) Ibrahim M. Moustafa et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Ribavirin-Resistant Variants of Foot-and-Mouth Disease Virus: the Effect of Restricted Quasispecies Diversity on Viral Virulence

(2014) J. Zeng et al.   JOURNAL OF VIROLOGY

Alphavirus Mutator Variants Present Host-Specific Defects and Attenuation in Mammalian and Insect Models

(2014) Kathryn Rozen-Gagnon et al.   PLoS Pathogens

Variation in RNA Virus Mutation Rates across Host Cells

(2014) Marine Combe et al.   PLoS Pathogens

An increased replication fidelity mutant of foot-and-mouth disease virus retains fitness in vitro and virulence in vivo

(2013) Jianxiong Zeng et al.   ANTIVIRAL RESEARCH

Mutational and fitness landscapes of an RNA virus revealed through population sequencing

(2013) Ashley Acevedo et al.   NATURE

High-throughput DNA sequencing errors are reduced by orders of magnitude using circle sequencing

(2013) D. I. Lou et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A study of the virulence in mice of high copying fidelity variants of human enterovirus 71

(2013) Sara Sadeghipour et al.   VIRUS RESEARCH

Crystal Structure of the Full-Length Japanese Encephalitis Virus NS5 Reveals a Conserved Methyltransferase-Polymerase Interface

(2013) Guoliang Lu et al.   PLoS Pathogens

Cooperative interactions in the West Nile virus mutant swarm

(2012) Alexander T Ciota et al.   BMC EVOLUTIONARY BIOLOGY

A Polymerase Mechanism-based Strategy for Viral Attenuation and Vaccine Development

(2012) Spencer A. Weeks et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A live, impaired-fidelity coronavirus vaccine protects in an aged, immunocompromised mouse model of lethal disease

(2012) Rachel L Graham et al.   NATURE MEDICINE

Coxsackievirus B3 mutator strains are attenuated in vivo

(2012) N. F. Gnadig et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Molecular Dynamics Simulations of Viral RNA Polymerases Link Conserved and Correlated Motions of Functional Elements to Fidelity

(2011) Ibrahim M. Moustafa et al.   JOURNAL OF MOLECULAR BIOLOGY

Nonconsensus West Nile Virus Genomes Arising during Mosquito Infection Suppress Pathogenesis and Modulate Virus Fitness In Vivo

(2011) G. D. Ebel et al.   JOURNAL OF VIROLOGY

Arbovirus high fidelity variant loses fitness in mosquitoes and mice

(2011) L. L. Coffey et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Coronaviruses

(2011) Mark R. Denison et al.   RNA Biology

Long-Range Interaction Networks in the Function and Fidelity of Poliovirus RNA-Dependent RNA Polymerase Studied by Nuclear Magnetic Resonance

(2010) Xiaorong Yang et al.   BIOCHEMISTRY

Viral Mutation Rates

(2010) R. Sanjuan et al.   JOURNAL OF VIROLOGY

Population variation of West Nile virus confers a host-specific fitness benefit in mosquitoes

(2010) Kelly A. Fitzpatrick et al.   VIROLOGY

Insights into Arbovirus Evolution and Adaptation from Experimental Studies

(2010) Alexander T. Ciota et al.   Viruses-Basel

Fidelity Variants of RNA Dependent RNA Polymerases Uncover an Indirect, Mutagenic Activity of Amiloride Compounds

(2010) Laura I. Levi et al.   PLoS Pathogens

Dynamics: the missing link between structure and function of the viral RNA-dependent RNA polymerase?

(2009) Craig E Cameron et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Experimental Passage of St. Louis Encephalitis Virus In Vivo in Mosquitoes and Chickens Reveals Evolutionarily Significant Virus Characteristics

(2009) Alexander T. Ciota et al.   PLoS One

RNAi Targeting of West Nile Virus in Mosquito Midguts Promotes Virus Diversification

(2009) Doug E. Brackney et al.   PLoS Pathogens

Characterization of mosquito-adapted West Nile virus

(2008) A. T. Ciota et al.   JOURNAL OF GENERAL VIROLOGY

Genetic Interactions among the West Nile Virus Methyltransferase, the RNA-Dependent RNA Polymerase, and the 5' Stem-Loop of Genomic RNA

(2008) B. Zhang et al.   JOURNAL OF VIROLOGY

Determinants of RNA-Dependent RNA Polymerase (In)fidelity Revealed by Kinetic Analysis of the Polymerase Encoded by a Foot-and-Mouth Disease Virus Mutant with Reduced Sensitivity to Ribavirin

(2008) A. Arias et al.   JOURNAL OF VIROLOGY

Rates of evolutionary change in viruses: patterns and determinants

(2008) Siobain Duffy et al.   NATURE REVIEWS GENETICS

Genetic diversity and purifying selection in West Nile virus populations are maintained during host switching

(2008) Greta V.S. Jerzak et al.   VIROLOGY