Article
Cell Biology
Yasir Mohamud, Hui Tang, Yuan Chao Xue, Huitao Liu, Chen Seng Ng, Amirhossein Bahreyni, Honglin Luo
Summary: Coxsackievirus B3 targets TFEB for proteolytic processing to disrupt host lysosomal function and enhance viral infection.
Article
Multidisciplinary Sciences
Beatriz Alvarez-Rodriguez, Javier Buceta, Ron Geller
Summary: Despite limited understanding, a comprehensive analysis reveals significant variation in the neutralization sites targeted by polyclonal antibody responses to non-enveloped viruses in individual humans. This knowledge helps predict viral escape and identify key structural and evolutionary parameters. A minimum of two mutations is required for significant escape from multiple sera.
NATURE COMMUNICATIONS
(2023)
Article
Virology
Chengrui Niu, Wei Xu, Sidong Xiong
Summary: The appendix plays a role in regulating the composition of the intestinal microbiota and has an impact on cardiac infection and inflammation.
Article
Virology
Adelina Stoyanova, Angel S. Galabov
Summary: Chemotherapy is commonly used for enterovirus infections, while antivirals are not currently utilized in clinical practice. However, a consecutive alternating administration (CAA) treatment scheme combining enterovirus inhibitors has shown promising results in preventing drug resistance and increasing efficacy in treating enterovirus infections.
ARCHIVES OF VIROLOGY
(2021)
Article
Chemistry, Multidisciplinary
Jingzhe Wang, Tonggong Liu, Siyao Gu, Hui-hui Yang, Weidong Xie, Cheng Gao, Dayong Gu
Summary: This study introduces a novel cardiomyocyte sponge to trap and neutralize the virus causing viral myocarditis. The sponge effectively inhibits virus infection by maintaining cellular morphology. The most significant implication of this study is the development of a universal antivirus infection strategy for treating known and unknown virus outbreaks.
Article
Infectious Diseases
Zonghui Xiao, Feng He, Miao Feng, Zhuo Liu, Zhewei Liu, Sen Li, Wei Wang, Hailan Yao, Jianxin Wu
Summary: This study constructed an engineered CVB3 to reduce its virulence in muscles, pancreas, and brain by targeting specific tissue miRNA. The engineered CVB3 showed attenuated replication and reduced cytotoxicity, and provided complete protection in mice after lethal virus infection.
INFECTION GENETICS AND EVOLUTION
(2022)
Article
Microbiology
Yuxuan Fu, Sidong Xiong
Summary: This study found that exosomes can serve as vehicles for CVB3 virus, delivering the virus into cells and infecting receptor-negative cells. Exosomes carrying CVB3 virus have higher infection efficiency compared to free virus, and can overcome restrictions to viral tropism by accessing different routes.
Article
Virology
Siwen Bao, Hao Wang, Wang Li, Likai Ji, Xiaochun Wang, Quan Shen, Shixing Yang, Chenglin Zhou, Wen Zhang
Summary: Coxsackievirus B3 infection induces dynamic changes in the gut virome, with significant variations in the abundance of Caudovirales and Microviridae as potential biomarkers for the infection process. This study provides insights into the gut virome alterations following Enterovirus infection, offering implications for clinical treatment and prevention strategies.
JOURNAL OF MEDICAL VIROLOGY
(2022)
Article
Multidisciplinary Sciences
Paolo Carai, Giulia Ruozi, Alexandra Paye, Yannick Debing, Francesca Bortolotti, Julie Lecomte, Lorena Zentilin, Elizabeth A. Jones, Mauro Giacca, Stephane Heymans
Summary: Viral myocarditis is a significant cause of heart failure in both children and adults, and the molecular determinants and cardioprotective molecules involved in cardiac inflammation and cardiomyocyte necrosis are not well characterized. In this study, researchers used an in vivo method called functional selection to identify novel immunomodulatory molecules in a mouse model of Coxsackievirus B3-induced myocarditis. They found that IL9 and four other cytokines were cardioprotective factors in this model.
SCIENTIFIC REPORTS
(2022)
Article
Oncology
Amirhossein Bahreyni, Huitao Liu, Yasir Mohamud, Yuan Chao Xue, Jingchun Zhang, Honglin Luo
Summary: The study found that miR-CVB3-1.1 can safely infect and lyse breast cancer cells, significantly inhibiting tumor growth and metastasis. Mice treated with miR-CVB3-1.1 showed reduced toxicity and prolonged survival.
Review
Virology
Anja Geisler, Ahmet Hazini, Lisanne Heimann, Jens Kurreck, Henry Fechner
Summary: CVB3 as an oncolytic virus shows broad anti-tumor activity and enhances treatment efficacy by inducing an immune response against tumors. The toxicity in healthy tissues varies and can be reduced through genetic engineering. However, further efforts are needed to develop CVB3 as a therapeutic agent for cancer treatment in clinical practice.
Article
Virology
Sandra Pinkert, Meike Kespohl, Nicolas Kelm, Ziya Kaya, Arnd Heuser, Karin Klingel, Antje Beling
Summary: The study demonstrates that the use of tramadol in the CVB3 myocarditis mouse model does not have disruptive effects on viral pathogenicity or immune response in the heart. This supports the consideration of the demonstrated protocol as a general analgesic strategy for CVB3 infection.
Article
Plant Sciences
Bowen Sun, Lin Lin, Tian Yao, Jingchun Yao, Guimin Zhang, Yunlun Li, Chao Li
Summary: This study found that Jingfang Granules (JFG) significantly alleviated pathological damage in the cardiac tissues of coxsackievirus B3-induced viral myocarditis mice and attenuated the expression of inflammatory genes. JFG may exert its therapeutic effects by enhancing autophagy to suppress cell apoptosis, thereby reducing cell damage.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Microbiology
Tingjun Liu, Yuhan Li, Shengjie Chen, Lulu Wang, Xiaolan Liu, Qingru Yang, Yan Wang, Xiaorong Qiao, Jing Tong, Xintao Deng, Shihe Shao, Hua Wang, Hongxing Shen
Summary: This study identified a significantly decreased expression of circDDX17 after Coxsackievirus B3 (CVB3) infection. Further experiments demonstrated that circDDX17 enhanced CVB3 replication by downregulating the expression of miR-1248, which in turn regulated CVB3 replication through interacting with the gene coding for NOTCH Receptor 2 (NOTCH2).
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Virology
Lydia Phillips, William E. Tapprich
Summary: Coxsackievirus B3 (CVB3) is an enterovirus that causes diseases such as pancreatitis and myocarditis in humans. The highly structured 5' untranslated region (5' UTR) of CVB3 RNA genome contains important domains and elements for translation and replication. The comparative analysis of the 5' UTR from avirulent and virulent strains of CVB3 reveals significant structural differences, which may contribute to the virulence and persistence of the avirulent strain. Tertiary modeling suggests that the compact conformation of the 5' UTR in the virulent strain allows critical domains to come in close contact, while the extended conformation in the avirulent strain separates these domains.
JOURNAL OF VIROLOGY
(2023)
Article
Microbiology
Gonzalo Moratorio, Marco Vignuzzi
Article
Microbiology
Leen Delang, Pei-Shi Yen, Thomas Vallet, Marie Vazeille, Marco Vignuzzi, Anna-Bella Failloux
Article
Biochemical Research Methods
Tzipi Braun, Antonio Borderia, Cyril Barbezange, Marco Vignuzzi, Yoram Louzoun
Article
Virology
Lucia Carrau, Veronica V. Rezelj, Maria G. Noval, Laura Levi, Daniela Megrian, Herve Blanc, James Weger-Lucarelli, Gonzalo Moratorio, Kenneth A. Stapleford, Marco Vignuzzi
JOURNAL OF VIROLOGY
(2019)
Review
Virology
Ferdinand Roesch, Alvaro Fajardo, Gonzalo Moratorio, Marco Vignuzzi
Review
Microbiology
Marco Vignuzzi, Carolina B. Lopez
NATURE MICROBIOLOGY
(2019)
Article
Virology
Veronika Bernhauerova, Veronica V. Rezelj, Marco Vignuzzi
Article
Biochemistry & Molecular Biology
Colleen L. Watkins, Brian J. Kempf, Stephanie Beaucourt, David J. Barton, Olve B. Peersen
JOURNAL OF BIOLOGICAL CHEMISTRY
(2020)
Article
Virology
Vadim Sharov, Veronica V. Rezelj, Vladimir V. Galatenko, Avi Titievsky, Julia Panov, Konstantin Chumakov, Raul Andino, Marco Vignuzzi, Leonid Brodsky
Summary: The study found that the production of defective viral genomes (DVGs) of Zika virus is significantly higher in C6/36 cells compared to Vero cells during the infection process, which may lead to mosquito tolerance to ZIKV infection and drive the persistence of the mosquito vector. The model simulations showed that a higher activation of DVG-associated processes leads to a slower accumulation of infected cells, indicating a potential role of DVGs in virus attenuation.
JOURNAL OF VIROLOGY
(2021)
Article
Virology
Luca Murer, Anthony Petkidis, Thomas Vallet, Marco Vignuzzi, Urs F. Greber
Summary: The study reveals that by altering viral proteins, the virus can develop drug resistance, providing a deeper understanding of the drug resistance mechanisms against low pH in endolysosomes. This opens up new avenues for using endosomal acidification inhibitors as a strategy against RVs, especially if directly applied to the airways.
JOURNAL OF VIROLOGY
(2022)
Article
Microbiology
Noemie Berry, Rodolphe Suspene, Vincent Caval, Pierre Khalfi, Guillaume Beauclair, Stephane Rigaud, Herve Blanc, Marco Vignuzzi, Simon Wain-Hobson, Jean-Pierre Vartanian
Summary: HSV-1 impairs the mitochondrial network and releases mtDNA, leading to the upregulation of type I interferon and APOBEC3A expression. The RNA polymerase III/RIG-I pathway is crucial for interferon production. Released mtDNA causes mutations induced by APOBEC3A, resulting in DNA catabolism.
Article
Immunology
Ludivine Grzelak, Ferdinand Roesch, Amaury Vaysse, Anne Biton, Rachel Legendre, Francoise Porrot, Pierre-Henri Commere, Cyril Planchais, Hugo Mouquet, Marco Vignuzzi, Timothee Bruel, Olivier Schwartz
Summary: This study identified Interferon Regulatory Factor 8 (IRF8) as a gene involved in regulating the efficacy of anti-CD20 antibodies. The results demonstrated that IRF8 is necessary for efficient CD20 transcription, and its presence is positively correlated with CD20 expression and the depleting capacity of anti-CD20 antibodies.
EUROPEAN JOURNAL OF IMMUNOLOGY
(2022)
Article
Virology
R. Henningsson, G. Moratorio, A. V. Borderia, M. Vignuzzi, M. Fontes
Article
Virology
Valerie J. Morley, Maria Gabriela Noval, Rubing Chen, Scott C. Weaver, Marco Vignuzzi, Kenneth A. Stapleford, Paul E. Turner
Article
Marfa Jose Benitez-Galeano, Thomas Vallet, Lucia Carrau, Lester Hernandez-Rodriguez, Ana Bertalmio, Fernando Rivas, Leticia Rubio, Diego Maeso, Marco Vignuzzi, Gonzalo Moratorio, Rodney Colina
GENOME ANNOUNCEMENTS
(2018)