Human CD8+ T-cells Recognizing Peptides from Mycobacterium tuberculosis (Mtb) Presented by HLA-E Have an Unorthodox Th2-like, Multifunctional, Mtb Inhibitory Phenotype and Represent a Novel Human T-cell Subset

Progression of clinical tuberculosis is associated with a Th2 immune response signature in combination with elevated levels of SOCS3

(2014) Senait Ashenafi et al.   CLINICAL IMMUNOLOGY

CD8+ Regulatory T Cells, and Not CD4+ T Cells, Dominate Suppressive Phenotype and Function after In Vitro Live Mycobacterium bovis-BCG Activation of Human Cells

(2014) Mardi C. Boer et al.   PLoS One

Human Lung Epithelial Cells Contain Mycobacterium tuberculosis in a Late Endosomal Vacuole and Are Efficiently Recognized by CD8+ T Cells

(2014) Melanie J. Harriff et al.   PLoS One

Adequate Th2-Type Response Associates with Restricted Bacterial Growth in Latent Mycobacterial Infection of Zebrafish

(2014) Milka Marjut Hammarén et al.   PLoS Pathogens

TANDEM: understanding diabetes and tuberculosis

(2014) Reinout van Crevel et al.   Lancet Diabetes & Endocrinology

IL-13-producing BLT1-positive CD8 cells are increased in asthma and are associated with airway obstruction

(2013) A. Dakhama et al.   ALLERGY

The Immune Response in Tuberculosis

(2013) Anne O'Garra et al.   Annual Review of Immunology

Antibody-Mediated Immunity against Tuberculosis: Implications for Vaccine Development

(2013) Jacqueline M. Achkar et al.   Cell Host & Microbe

Differential gene expression of activating Fcγ receptor classifies active tuberculosis regardless of human immunodeficiency virus status or ethnicity

(2013) J.S. Sutherland et al.   CLINICAL MICROBIOLOGY AND INFECTION

CD39 is involved in mediating suppression byMycobacterium bovisBCG-activated human CD8+CD39+regulatory T cells

(2013) Mardi C. Boer et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

The next 10 years for tuberculosis vaccines: do we have the right plans in place?

(2013) Joel Meyer et al.   Expert Review of Vaccines

Polymorphism in Human Cytomegalovirus UL40 Impacts on Recognition of Human Leukocyte Antigen-E (HLA-E) by Natural Killer Cells

(2013) Susan L. Heatley et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Longitudinal Immune Responses and Gene Expression Profiles in Type 1 Leprosy Reactions

(2013) Annemieke Geluk et al.   JOURNAL OF CLINICAL IMMUNOLOGY

Safety and efficacy of MVA85A, a new tuberculosis vaccine, in infants previously vaccinated with BCG: a randomised, placebo-controlled phase 2b trial

(2013) Michele D Tameris et al.   LANCET

Intracellular antibody-bound pathogens stimulate immune signaling via the Fc receptor TRIM21

(2013) William A McEwan et al.   NATURE IMMUNOLOGY

An inside job for antibodies: tagging pathogens for intracellular sensing

(2013) Teunis B H Geijtenbeek et al.   NATURE IMMUNOLOGY

GATA-3 controls the maintenance and proliferation of T cells downstream of TCR and cytokine signaling

(2013) Yunqi Wang et al.   NATURE IMMUNOLOGY

Recombinant ESAT-6-CFP10 Fusion Protein Induction of Th1/Th2 Cytokines and FoxP3 Expressing Treg Cells in Pulmonary TB

(2013) Dolly Jackson-Sillah et al.   PLoS One

A Helicopter Perspective on TB Biomarkers: Pathway and Process Based Analysis of Gene Expression Data Provides New Insight into TB Pathogenesis

(2013) Simone A. Joosten et al.   PLoS One

Genetic disruption of CD8+ Treg activity enhances the immune response to viral infection

(2013) T. A. W. Holderried et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A nonsynonymous mutation atHLA-Edefines the newE*01:06allele in Brazilian individuals

(2013) L. C. Veiga-Castelli et al.   TISSUE ANTIGENS

Activated B Cells in the Granulomas of Nonhuman Primates Infected with Mycobacterium tuberculosis

(2012) Jia Yao Phuah et al.   AMERICAN JOURNAL OF PATHOLOGY

Interleukin-13-producing CD8+ T cells mediate dermal fibrosis in patients with systemic sclerosis

(2012) Patrizia Fuschiotti et al.   ARTHRITIS AND RHEUMATISM

T Cell Assays and MIATA: The Essential Minimum for Maximum Impact

(2012) C.M. Britten et al.   IMMUNITY

GATA-3 Regulates the Homeostasis and Activation of CD8+ T Cells

(2012) T.-S. Tai et al.   JOURNAL OF IMMUNOLOGY

Distinct Phases of Blood Gene Expression Pattern Through Tuberculosis Treatment Reflect Modulation of the Humoral Immune Response

(2012) Jacqueline M. Cliff et al.   JOURNAL OF INFECTIOUS DISEASES

CD8+ T Cells in the Lesional Skin of Atopic Dermatitis and Psoriasis Patients Are an Important Source of IFN-γ, IL-13, IL-17, and IL-22

(2012) DirkJan Hijnen et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Nonclassical MHC class Ib–restricted cytotoxic T cells monitor antigen processing in the endoplasmic reticulum

(2012) Niranjana A Nagarajan et al.   NATURE IMMUNOLOGY

Epstein-Barr virus Peptide Presented by HLA-E is Predominantly Recognized by CD8bright Cells in multiple Sclerosis Patients

(2012) Pernille B. Jørgensen et al.   PLoS One

HLA-E-Restricted Cross-Recognition of Allogeneic Endothelial Cells by CMV-Associated CD8 T Cells: A Potential Risk Factor following Transplantation

(2012) Mathilde Allard et al.   PLoS One

New pathways of protective and pathological host defense to mycobacteria

(2012) Tom H.M. Ottenhoff   TRENDS IN MICROBIOLOGY

Vaccines against Tuberculosis: Where Are We and Where Do We Need to Go?

(2012) Tom H. M. Ottenhoff et al.   PLoS Pathogens

GATA-3 up-regulation in CD8+ T cells as a biomarker of immune dysfunction in systemic sclerosis, resulting in excessive interleukin-13 production

(2011) Thomas A. Medsger et al.   ARTHRITIS AND RHEUMATISM

Identification of biomarkers for tuberculosis disease using a novel dual-color RT–MLPA assay

(2011) S A Joosten et al.   GENES AND IMMUNITY

An updated view on transcription factor GATA3-mediated regulation of Th1 and Th2 cell differentiation

(2011) R. Yagi et al.   INTERNATIONAL IMMUNOLOGY

Ex Vivo Kinetics of Early and Long-Term Multifunctional Human Leukocyte Antigen E-Specific CD8+ Cells in Volunteers Immunized with the Ty21a Typhoid Vaccine

(2010) R. Salerno-Goncalves et al.   Clinical and Vaccine Immunology

Human gene expression profiles of susceptibility and resistance in tuberculosis

(2010) J Maertzdorf et al.   GENES AND IMMUNITY

Genome-Based In Silico Identification of New Mycobacterium tuberculosis Antigens Activating Polyfunctional CD8+ T Cells in Human Tuberculosis

(2010) S. T. Tang et al.   JOURNAL OF IMMUNOLOGY

Control of T Cell Reactivation by Regulatory Qa-1-Restricted CD8+ T Cells

(2010) A. Varthaman et al.   JOURNAL OF IMMUNOLOGY

The other Janus face of Qa-1 and HLA-E: diverse peptide repertoires in times of stress

(2010) Thorbald van Hall et al.   MICROBES AND INFECTION

Mycobacterium tuberculosis Peptides Presented by HLA-E Molecules Are Targets for Human CD8+ T-Cells with Cytotoxic as well as Regulatory Activity

(2010) Simone A. Joosten et al.   PLoS Pathogens

Compartmentalization of Immune Responses in Human Tuberculosis

(2009) Sayma Rahman et al.   AMERICAN JOURNAL OF PATHOLOGY

Effector CD8+ T cells in systemic sclerosis patients produce abnormally high levels of interleukin-13 associated with increased skin fibrosis

(2009) Patrizia Fuschiotti et al.   ARTHRITIS AND RHEUMATISM

How B cells shape the immune response againstMycobacterium tuberculosis

(2009) Paul J. Maglione et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

The nonpolymorphic MHC Qa-1bmediates CD8+T cell surveillance of antigen-processing defects

(2009) Cláudia C. Oliveira et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The HLA‐ER/HLA‐ERGenotype Affects the Natural Course of Hepatitis C Virus (HCV) Infection and Is Associated with HLA‐E–Restricted Recognition of an HCV‐Derived Peptide by Interferon‐γ–Secreting Human CD8+T Cells

(2009) Daniela Schulte et al.   JOURNAL OF INFECTIOUS DISEASES

Analysis of Mycobacterium tuberculosis-Specific CD8 T-Cells in Patients with Active Tuberculosis and in Individuals with Latent Infection

(2009) Nadia Caccamo et al.   PLoS One

The Mycobacterium tuberculosis Phagosome Is a HLA-I Processing Competent Organelle

(2009) Jeff E. Grotzke et al.   PLoS Pathogens