Article
Agriculture, Dairy & Animal Science
Insaf Riahi, Antonio J. Ramos, Jog Raj, Zdenka Jakovcevic, Hunor Farkas, Marko Vasiljevic, Anna Maria Perez-Vendrell
Summary: The contamination of animal feed with mycotoxins is a global concern, leading to adverse effects on productivity and animal health. The addition of detoxifying agents, such as MMDA, to contaminated diets can alleviate the negative impact of mycotoxins on broiler chickens.
Article
Biochemistry & Molecular Biology
Hanrui Qing, Xueting Huo, Shimeng Huang, Lihong Zhao, Jianyun Zhang, Cheng Ji, Qiugang Ma
Summary: The study demonstrated that Bacillus subtilis ANSB168 could degrade OTA and its bioproduct could alleviate damages induced by OTA in laying hens, including reducing inflammation and oxidative stress.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Chemistry, Analytical
Zahra Khoshbin, Elham Sameiyan, Hamed Zahraee, Mohammad Ramezani, Mona Alibolandi, Khalil Abnous, Seyed Mohammad Taghdisi
Summary: In this study, a simple aptasensing approach was used to detect ochratoxin A (OTA), a dangerous mycotoxin with severe health effects. The aptasensor utilized the alteration of liquid crystal (LC) molecules at the surfactant-arranged interface to sensitively detect OTA. By perturbing the alignment of LCs, the presence of OTA induced a noticeable change in the polarized view of the aptasensor substrate. The aptasensor demonstrated high sensitivity and could detect OTA in various real samples.
ANALYTICA CHIMICA ACTA
(2023)
Article
Food Science & Technology
Majid Behfar, Ali Heshmati, Freshteh Mehri, Amin Mousavi Khaneghah
Summary: This study used the response surface methodology to achieve maximum removal of ochratoxin A (OTA) while minimizing reduction in antioxidant compounds during the grape juice clarification process. The results showed that the concentrations of bentonite, gelatin, and diatomite, as well as the clarification time, were correlated with the reduction amounts of OTA and antioxidant compounds. The study also found that the reduction amounts of OTA and antioxidant capacity followed a linear mode, while the decreased phenolic acid and flavonoid values followed a quadratic model.
Article
Food Science & Technology
Maria Izco, Ariane Vettorazzi, Maria de Toro, Yolanda Saenz, Lydia Alvarez-Erviti
Summary: The study showed that sub-chronic exposure to low doses of OTA significantly altered the structure and diversity of the gut microbiome in mice, with even more pronounced effects than in the high-dose OTA group.
Article
Food Science & Technology
Beyza H. Ulusoy, Canan Hecer, Serkan Sayiner, Fatma Kaya Yildirim
Summary: Dietary exposure to mycotoxins in samarella, a traditional meat product in Cyprus, poses a risk to public health, with some samples exceeding the safety limits for total aflatoxins and AFB1, while no contamination was found for OTA.
JOURNAL OF FOOD SCIENCE AND TECHNOLOGY-MYSORE
(2022)
Review
Chemistry, Applied
Abirami Ramu Ganesan, Kannan Mohan, Durairaj Karthick Rajan, Arti A. Pillay, Thavamani Palanisami, Palanivel Sathishkumar, Lorenza Conterno
Summary: Mycotoxins, such as OTA and DON, are widely distributed in food materials and have harmful effects on human health. Improper handling and practices during the production and processing of food can lead to the formation of these mycotoxins. Understanding their distribution, toxicity, and interaction with other contaminants is crucial for ensuring food safety and good agricultural practices.
Article
Biochemistry & Molecular Biology
Jelena Loncar, Barbara Bellich, Alessia Parroni, Massimo Reverberi, Roberto Rizzo, Slaven Zjalic, Paola Cescutti
Summary: The study evaluated oligosaccharides extracted from Trametes versicolor for controlling two mycotoxins, with heptasaccharides showing up to 90% inhibitory activity. These results suggest that these oligosaccharides could be natural alternatives for controlling mycotoxins.
Article
Spectroscopy
Qin Ma, Dongqin Nie, Xinyi Sun, Yaling Xu, Jingxian He, Li Yang, Lizhu Yang
Summary: A versatile Y shaped DNA nanostructure has been developed for simultaneous detection of aflatoxin B1 and ochratoxin A. The method is simple and rapid, utilizing self-powered DNA hybridization reaction to control the opening of DNA tweezers, allowing for quantitative detection of target mycotoxins.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2022)
Article
Biochemistry & Molecular Biology
Ana Lucia Leitao, Francisco J. Enguita
Summary: Through structure-based methods and proteome mining, potential enzymatic activity capable of degrading ochratoxins has been identified in filamentous fungi, offering a promising solution for detoxification of various food commodities.
Article
Pharmacology & Pharmacy
Riddhi Sharma, Sean M. Gettings, Gareth Hazell, Nora Bourbia
Summary: This study investigated the impact of Ochratoxin A (OTA) on neuronal survival and viability. The findings suggest that typical daily exposure to OTA may not trigger neuronal dysfunction, but increased OTA dose caused decreased BDNF expression, potentially leading to adverse effects on neuronal health.
Article
Biochemistry & Molecular Biology
Yexuan Ren, Ruwen Tian, Ting Wang, Junlin Cao, Jianguo Li, Anping Deng
Summary: A highly sensitive ELISA method using a newly produced monoclonal antibody was developed for the detection of OTA in food samples. The ELISA exhibited ultra-sensitivity with IC50 and LOD values of 34.8 pg mL(-1) and 1.5 pg mL(-1), respectively. The antibody showed no cross-reactivity with other mycotoxins, and the ELISA could also determine total levels of ochratoxins in food samples.
Review
Food Science & Technology
Houshmand Sharafi, Negar Alizadeh, Mehran Moradi, Kiomars Sharafi, Amin Mousavi Khaneghah
Summary: The prevalence of ochratoxin A (OTA) in meat, edible offal, and meat products (MOP) was assessed through systematic review and meta-analysis. A total of 75 articles comprising 8585 samples from global studies were analyzed. The overall prevalence of OTA in MOP was 39%, with the highest and lowest prevalence percentages recorded in Iraq (77%) and the USA (3%), respectively. The study also found variations in OTA concentration across different food types and countries.
FOOD AND CHEMICAL TOXICOLOGY
(2023)
Article
Food Science & Technology
Z. Dilek Heperkan, Ece Gunalan-Inci, Tugce Ceyhan
Summary: Fruit juices, dried fruits, and other fruit-based products contribute significantly to human exposure to mycotoxins. This study examined the contamination of patulin (PAT) and ochratoxin A (OTA) in homemade vinegar made from various fruits, with apples and grapes being the most contaminated. Analysis indicated that 61% of the vinegar samples were contaminated with PAT, and 12% with OTA. Interestingly, vinegar produced from fruits collected from the producers' own orchards showed the highest levels of mycotoxin contamination. This contamination poses a health risk, as 15% of the vinegar samples exceeded the European Union limit for PAT concentration.
Article
Biotechnology & Applied Microbiology
Meilin Wei, Solairaj Dhanasekaran, Guillaume Legrand Ngolong Ngea, Esa Abiso Godana, Xiaoyun Zhang, Qiya Yang, Xiangfeng Zheng, Hongyin Zhang
Summary: The study found that Cryptococcus podzolicus Y3 efficiently eliminated ochratoxin A (OTA) and converted it into non-toxic ochratoxin A (OTa) in different media. The elimination substances produced by the strain were heat stable and involved intracellular proteins. Additionally, C. podzolicus Y3 also had the ability to degrade citrinin (CIT), although the efficiency was lower than single mycotoxin degradation.
BIOLOGICAL CONTROL
(2022)
Article
Toxicology
Ozge Kose, Walid Rachidi, David Beal, Pinar Erkekoglu, Hussein Fayyad-Kazan, Belma Kocer Gumusel
JOURNAL OF APPLIED TOXICOLOGY
(2020)
Article
Environmental Sciences
Aylin Balci, Gizem Ozkemahli, Pinar Erkekoglu, Naciye Dilara Zeybek, Nilgun Yersal, Belma Kocer-Gumusel
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2020)
Article
Public, Environmental & Occupational Health
Dilek Tokac, Hatice Gul Anlar, Merve Bacanli, Sevtap Aydin Dilsiz, Servet Iritas, Nursen Basaran
TOXICOLOGY AND INDUSTRIAL HEALTH
(2020)
Article
Public, Environmental & Occupational Health
Naciye Dilara Zeybek, Unzile Sur, Ofcan Oflaz, Pinar Erkekoglu, Aylin Balci, Gizem Ozkemahli, Ali Asci, Murat Kizilgun, Oguz Han Edebal, Belma Kocer-Gumusel
ARHIV ZA HIGIJENU RADA I TOKSIKOLOGIJU-ARCHIVES OF INDUSTRIAL HYGIENE AND TOXICOLOGY
(2020)
Article
Food Science & Technology
Nursen Basaran, Yalcin Duydu, Merve Bacanli, Hatice Gul Anlar, Sevtap Aydin Dilsiz, Aylin Ustundag, Can Ozgur Yalcin, Tanja Schwerdtle, Hermann M. Bolt
FOOD AND CHEMICAL TOXICOLOGY
(2020)
Article
Environmental Sciences
Aylin Balci, Gizem Ozkemahli, Pinar Erkekoglu, Dilara Zeybek, Nilgun Yersal, Belma Kocer-Gumusel
Summary: This study evaluated the effects of single and combined exposures to BPA and/or DEHP during the prenatal and lactational period on the male reproductive system of rats in later stages of life. The results suggest that prenatal and lactational exposure to BPA and DEHP may have adverse effects on the male reproductive system in later stages of life, especially after combined exposure.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL HEALTH RESEARCH
(2022)
Article
Pharmacology & Pharmacy
Gamze Tilbe Sen, Gizem Ozkemahli, Reza Shahbazi, Pinar Erkekoglu, Kezban Ulubayram, Belma Kocer-Gumusel
INTERNATIONAL JOURNAL OF TOXICOLOGY
(2020)
Article
Environmental Sciences
Anil Yirun, Gizem Ozkemahli, Aylin Balci, Pinar Erkekoglu, Naciye Dilara Zeybek, Nilgun Yersal, Belma Kocer-Gumusel
Summary: This study aimed to investigate the toxicity of BPA and/or DEHP on the central nervous system and neuroendocrine system in Sprague-Dawley rats during prenatal and lactational periods. The results showed that early-life exposure to these chemicals caused significant changes in lipid peroxidation, neurotransmitter levels, and apoptosis in the hippocampus. This suggests that alterations in oxidant/antioxidant status and neurotransmitters may be the underlying mechanisms of neurotoxicity induced by BPA and DEHP.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Elcin Bakir, Tugbagul Cal, Sevtap Aydin Dilsiz, Hande Canpinar, Ayse Eken, Ulku Undeger Bucurgat
Summary: The study found that flurbiprofen has cytotoxic, genotoxic, and apoptotic effects in human cancer cells, potentially inducing apoptosis at the gene level.
JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY
(2021)
Article
Environmental Sciences
Merve Becit, Sule Cilekar, Mustafa Mert Basaran, Halit Bugra Koca, Sefa Celik, Sevtap Aydin Dilsiz
Summary: Workers in marble processing plants are at high risk of exposure to marble dust containing silica, which may result in immunotoxic and genotoxic effects. Oxidative stress and immune system parameters were significantly affected in workers exposed to marble dust.
ENVIRONMENTAL RESEARCH
(2021)
Review
Toxicology
Sonia Sanajou, Gonul Sahin, Terken Baydar
Summary: The use of aluminium in cosmetics and personal care products has raised concerns regarding potential harm to the body. The dermal absorption of aluminium and its potential link to diseases like Alzheimer's disease are not widely understood. Further research is needed to determine the long-term effects of exposure to aluminium-based products.
JOURNAL OF APPLIED TOXICOLOGY
(2021)
Review
Pharmacology & Pharmacy
Sonia Sanajou, Gonul Sahin
Summary: Biomarkers are crucial parameters in human health, with mechanistic biomarkers playing a key role in preventing toxic effects and diseases. They offer potential for diagnosis, prognosis, recurrence, and disease spread, as well as indicating exposure levels to various agents. Understanding the mechanisms behind biomarker production is essential for their development and application.
TURKISH JOURNAL OF PHARMACEUTICAL SCIENCES
(2021)
Article
Chemistry, Multidisciplinary
Busra Ozyurt, Gizem Ozkemahli, Anil Yirun, Aylin Balci Ozyurt, Merve Bacanli, Nursen Basaran, Belma Kocer-Gumusel, Pinar Erkekoglu
Summary: The potential toxic effects of BPA, BPS, and BPF were comparatively evaluated in HepG2 cells. These bisphenol derivatives showed similar toxicities, with BPS > BPF > BPA in terms of cytotoxicity, increased intracellular ROS production, imbalance in oxidant/antioxidant parameters, and significant DNA damage.
DRUG AND CHEMICAL TOXICOLOGY
(2023)
Review
Chemistry, Multidisciplinary
Sonia Sanajou, Pinar Erkekoglu, Gonul Sahin, Terken Baydar
Summary: Aluminum may play a role in the pathogenesis of Alzheimer's disease as a neurotoxin, possibly through the involvement of GSK3β. However, further research is needed to determine the exact mechanisms of its neurotoxicity.
DRUG AND CHEMICAL TOXICOLOGY
(2023)
Article
Pharmacology & Pharmacy
Tuba Sariaydin, Tugbagul Cal, Sevtap Aydin Dilsiz, Hande Canpinar, Ulku Undeger Bucurgat
Summary: Metformin exerts different cytotoxic and apoptotic effects on HepG2 and HeLa cells. Metformin mainly induces cytotoxicity in HeLa cells through apoptosis, while in HepG2 cells it inhibits cell viability by arresting the cell cycle in G0/G1 phase and inducing apoptosis.
ISTANBUL JOURNAL OF PHARMACY
(2021)
Article
Pharmacology & Pharmacy
Mohammadhossein Movassaghghazani, Nazanin Shabansalmani
Summary: The study revealed high levels of AFM1 in both breast milk and powdered milk samples in Tehran, with some samples exceeding the established limits. Therefore, monitoring and regulating toxin levels in these products is crucial for maternal and infant health.
Article
Pharmacology & Pharmacy
Defeng Wen, Wantong Han, Quan Chen, Guanhui Qi, Mengling Gao, Pu Guo, Yu Liu, Zhongyuan Wu, Shulin Fu, Qirong Lu, Yinsheng Qiu
Summary: Luteolin can inhibit FB1-induced intestinal inflammatory injury by inhibiting the activation of NF-kappa B and ERK signaling pathways, according to network pharmacology and in vitro experiments.
