Article
Food Science & Technology
Archana Molangiri, Saikanth Varma, M. Satyavani, Saikrishna Kambham, Asim K. Duttaroy, Sanjay Basak
Summary: Early exposure to bisphenol may result in adverse reproductive health issues in later life. This study investigated the effects of orally administered bisphenol S (BPS) and bisphenol A (BPA) on testicular development in rats. The results showed that prenatal exposure to BPS can lead to changes in plasma testosterone levels, testis histology, inflammation, oxidative stress, and sperm DNA damage, potentially affecting male reproductive functions.
FOOD AND CHEMICAL TOXICOLOGY
(2022)
Article
Environmental Sciences
Aylin Balci, Gizem Ozkemahli, Pinar Erkekoglu, Dilara Zeybek, Nilgun Yersal, Belma Kocer-Gumusel
Summary: This study evaluated the effects of single and combined exposures to BPA and/or DEHP during the prenatal and lactational period on the male reproductive system of rats in later stages of life. The results suggest that prenatal and lactational exposure to BPA and DEHP may have adverse effects on the male reproductive system in later stages of life, especially after combined exposure.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL HEALTH RESEARCH
(2022)
Article
Environmental Sciences
Xiang Zhou, Tongtong Zhang, Lebin Song, Yichun Wang, Qijie Zhang, Rong Cong, Chengjian Ji, Jiaochen Luan, Liangyu Yao, Wei Zhang, Ninghong Song, Shangqian Wang
Summary: The study found that prenatal exposure to DBP can lead to erectile dysfunction in male adult rats, potentially by activating the Akt/Bad/Bax/caspase-3 pathway and suppressing the NOS/cGMP pathway.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2021)
Article
Environmental Sciences
Tongtong Zhang, Xiang Zhou, Xu Zhang, Xiaohan Ren, Jiajin Wu, Zhongyuan Wang, Shangqian Wang, Zengjun Wang
Summary: Phthalate, an environmental endocrine disruptor, has been found to cause direct and intergenerational male reproductive damage. This study explored the effects of prenatal exposure to DBP on testicular injury and offspring gut microbiota, revealing a connection between gut dysbiosis and testicular damage in the offspring. Understanding the role of gut microbiota in reproductive function is crucial, and further research is needed to investigate the link between environmental pollution and human health.
Article
Environmental Sciences
Anil Yirun, Gizem Ozkemahli, Aylin Balci, Pinar Erkekoglu, Naciye Dilara Zeybek, Nilgun Yersal, Belma Kocer-Gumusel
Summary: This study aimed to investigate the toxicity of BPA and/or DEHP on the central nervous system and neuroendocrine system in Sprague-Dawley rats during prenatal and lactational periods. The results showed that early-life exposure to these chemicals caused significant changes in lipid peroxidation, neurotransmitter levels, and apoptosis in the hippocampus. This suggests that alterations in oxidant/antioxidant status and neurotransmitters may be the underlying mechanisms of neurotoxicity induced by BPA and DEHP.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2021)
Article
Environmental Sciences
Senlin Xue, Lianqin Liu, Mengmeng Dong, Wei Xue, Shenrui Zhou, Xiaotian Li, Sihui Guo, Wei Yan
Summary: This study found that prenatal exposure to Bisphenol AF (BPAF) can induce reproductive toxicity in adult male offspring, including testicular impairments and immunological responses through the Aim2-NF-kappa B-IFNs signaling pathway.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2023)
Article
Environmental Sciences
Yaping Mao, Dan Li, Qiaoqiao Yang, Xiucong Pei, Zhiwen Duan, Mingyue Ma
Summary: This study suggests that prenatal BPA exposure disrupts male reproductive functions and is associated with changes in GDNF expression and DNA methylation, highlighting the need for further investigation into the detailed mechanisms.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Article
Food Science & Technology
Wenjuan Zhang, Tao Huang, Zhangbei Sun, Haibin Kuang, Yangyang Yuan, Weiying Zou, Fangming Liu, Fan Zhang, Bei Yang, Lei Wu, Dalei Zhang
Summary: This study demonstrates that exposure to BPS can cause cytotoxicity to Leydig cells through inducing oxidative stress, mitochondrial impairment, autophagic disturbance, and apoptosis.
FOOD AND CHEMICAL TOXICOLOGY
(2022)
Article
Environmental Sciences
Rui Wang, Jingyue Chen, Zhaokang Cui, Yu Li, Qian Gao, Yilong Miao, Huili Wang, Bo Xiong
Summary: Diisononyl phthalate (DINP) exposure negatively affects the quality and fertilization ability of porcine oocytes, leading to meiotic arrest and impaired sperm binding. The mechanism involves oxidative phosphorylation, apoptosis, and autophagy pathways.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2023)
Article
Toxicology
Gizem Ozkemahli, Aylin Balci Ozyurt, Pinar Erkekoglu, Naciye Dilara Zeybek, Nilgun Yersal, Belma Kocer-Gumusel
Summary: BPA and DEHP, commonly used endocrine disrupting chemicals, can disrupt female reproductive hormones and ovarian follicle development when exposed prenatally and early postnatally. Combined exposure may lead to more serious adverse effects that cannot be predicted by individual toxicity profiles.
TOXICOLOGY MECHANISMS AND METHODS
(2022)
Article
Environmental Sciences
Ruijing Liu, Dongbao Cai, Xusheng Li, Boping Liu, Jiali Chen, Xinwei Jiang, Haiwei Li, Zhenhua Li, Katja Teerds, Jianxia Sun, Weibin Bai, Yulong Jin
Summary: This study investigates the impact of BPA on male reproductive toxicity and its potential link to gut microbiota dysbiosis. The results show that BPA exposure damages testicular histology, decreases sperm count, and increases sperm abnormalities. Additionally, BPA exposure induces oxidative stress and cell apoptosis in the testes.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2022)
Article
Obstetrics & Gynecology
S. S. Tottenborg, K. S. Hougaard, L. Deen, E. B. Pedersen, M. Frederiksen, A. B. B. Kofoed, K. U. Petersen, H. W. Meyer, N. E. Ebbehoj, J. P. E. Bonde
Summary: The study found marginal and inconsistent associations between maternal exposure to PCBs in indoor air and semen quality, testicular size, and reproductive hormones in adult offspring.
HUMAN REPRODUCTION
(2022)
Article
Environmental Sciences
Fangpeng Hou, Junyun Huang, Furong Qing, Tianfu Guo, Sijia Ouyang, Lu Xie, Yechun Ding, Jingge Yu, Yanmin Li, Xia Liu, Tian-Sheng He, Xiaona Fan, Zhiping Liu
Summary: China has the largest reserves of rare earth elements (REEs) in the world, but widespread mining and use of REEs have increased the risk of pollution. Yttrium (Y), the first heavy REEs to be discovered, poses a significant threat to human health. However, little attention has been given to the impact of Y on human reproductive health. This study investigated the toxic effects of YCl3 on mouse testes and four types of testicular cells. YCl3 exposure caused substantial damage to mouse testes and induced apoptosis and autophagy in testicular cells. The study revealed that YCl3 impairs the antioxidant stress signaling pathway and activates the calcium pathway through the ROS-Ca2+ axis, promoting testicular cell apoptosis and autophagy, thus impairing male reproductive function.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2023)
Article
Environmental Sciences
Wei-Chi Huang, Keng-Ying Liao, Sheng-Kuo Hsieh, Ping-Ho Pan, Yu-Hsiang Kuan, Su-Lan Liao, Chun-Jung Chen, Wen-Ying Chen
Summary: The study suggests that MLB may have therapeutic potential against metabolic diseases, including maternal exposure-induced metabolic abnormalities. MLB supplementation was found to improve metabolic abnormalities in BPA-exposed rats, reducing obesity, adiposity, hyperglycemia, insulin resistance, and other metabolic issues, as well as affecting liver and adipose tissue functions positively.
ENVIRONMENTAL TOXICOLOGY
(2021)
Article
Environmental Sciences
Shuanglin Jiang, Li Chen, Jianyun Shen, Di Zhang, Hai Wu, Rong Wang, Shangrong Zhang, Nan Jiang, Wenyong Li
Summary: This study investigates the effects of maternal exposure to oxidized black carbon on testicular development and steroid synthesis in male offspring. The results indicate that prenatal exposure to oxidized black carbon has detrimental effects on mouse spermatogenesis in adult offspring.
Article
Environmental Sciences
Aylin Balci, Gizem Ozkemahli, Pinar Erkekoglu, Dilara Zeybek, Nilgun Yersal, Belma Kocer-Gumusel
Summary: This study evaluated the effects of single and combined exposures to BPA and/or DEHP during the prenatal and lactational period on the male reproductive system of rats in later stages of life. The results suggest that prenatal and lactational exposure to BPA and DEHP may have adverse effects on the male reproductive system in later stages of life, especially after combined exposure.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL HEALTH RESEARCH
(2022)
Article
Chemistry, Multidisciplinary
Busra Ozyurt, Gizem Ozkemahli, Anil Yirun, Aylin Balci Ozyurt, Merve Bacanli, Nursen Basaran, Belma Kocer-Gumusel, Pinar Erkekoglu
Summary: The potential toxic effects of BPA, BPS, and BPF were comparatively evaluated in HepG2 cells. These bisphenol derivatives showed similar toxicities, with BPS > BPF > BPA in terms of cytotoxicity, increased intracellular ROS production, imbalance in oxidant/antioxidant parameters, and significant DNA damage.
DRUG AND CHEMICAL TOXICOLOGY
(2023)
Article
Environmental Sciences
Gizem Ozkemahli, Pinar Erkekoglu, Ayse Ercan, Naciye Dilara Zeybek, Nilgun Yersal, Belma Kocer-Gumusel
Summary: This study investigates the toxic effects of BPA and/or MEHP on the HepG2 cell line. The results suggest that combined exposure to these chemicals may cause serious toxicological outcomes.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Chnar Kakakhan, Cuneyt Turkes, Ozcan Gulec, Yeliz Demir, Mustafa Arslan, Gizem Ozkemahli, Sukru Beydemir
Summary: A series of novel inhibitors of human alpha-carbonic anhydrase (hCA) were designed using a tail approach. These inhibitors showed remarkable selectivity for tumor isoforms hCA IX and XII. Adding a lipophilic naphthyl tail to the analogues increased the inhibitory and selective activities against hCA XII. The compounds also exhibited inhibitory effects against a human lung adenocarcinoma cancer cell line.
BIOORGANIC & MEDICINAL CHEMISTRY
(2023)
Article
Environmental Sciences
Ozge Yesildemir, Yasemin Akdevelioglu, Selinay Basak Erdemli Kose, Deniz Arca Cakir, Anil Yirun, Aylin Balci Ozyurt, Suna Sabuncuoglu, Aysu Duyan Camurdan, Bahar Cuhaci Cakir, Pinar Erkekoglu
Summary: This study aimed to estimate the daily dietary intakes of melamine for human milk-fed (HMF) babies and mixed-fed (MF) babies. It was conducted in 70 mother-baby pairs, with 40 babies in the HMF group and 30 babies in the MF group. Samples of human milk, formula milk, and baby urine were collected for analysis. The results showed that melamine concentrations in human milk and formula milk samples were below the tolerable daily intake, indicating that Turkish babies (aged 0-6 months) are not at risk for high melamine exposure through the diet.
ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY
(2023)
Article
Environmental Sciences
Aylin Balci Ozyurt, Pinar Erkekoglu, Naciye Dilara Zeybek, Ali Asci, Unzile Yaman, Ofcan Oflaz, Murat Kizilgun, Evin Iscan, Tugce Batur, Mehmet Ozturk, Belma Kocer-Gumusel
Summary: Polychlorinated biphenyls (PCBs) were widely used in various industries but were later banned due to their high toxicity. Aroclor 1254 (A1254), a commercial PCB congener, accumulates in the environment, leading to high human exposure. A1254 has been found to cause hepatotoxicity, metabolic disorders, and endocrine disorders. Our study on male rats showed that A1254 resulted in histological changes, oxidative stress, and apoptosis in the liver. Selenium deficiency aggravated oxidative stress and apoptosis, while selenium supplementation provided partial protection. More mechanistic in vivo experiments are needed to further evaluate the hepatotoxicity of PCBs.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL HEALTH RESEARCH
(2023)
Article
Toxicology
Anil Yiruen, Deniz Arca Cakir, Sonia Sanajou, Selinay Basak Erdemli Kose, Aylin Balci Ozyurt, Dilara Zeybek, Ozlem Bozdemir, Terken Baydar, Pinar Erkekoglu
Summary: Alzheimer's disease (AD) is a neurodegenerative disorder characterized by decline in cognitive functions and caused by brain infections, particularly herpes simplex virus type-1 (HSV-1) infection. This study created two AD models (Tau and A beta) in SH-SY5Y cell line and applied HSV glycoprotein B (gB) to the cell line and models. The study found that HSV-gB increased levels of A beta and hyperphosphorylated Tau, similar to the AD models. The data confirmed the role of immune system, chronic inflammation, and HSV-1 infection in AD development.
JOURNAL OF APPLIED TOXICOLOGY
(2023)
Article
Toxicology
Aylin Balci-Ozyurt, Anil Yirun, Deniz Arca Cakir, N. Dilara Zeybek, Didem Oral, Suna Sabuncuoglu, Pinar Erkekoglu
Summary: Nanoparticles (NPs) between 1 to 100 nm in diameter have toxic effects on both humans and the environment. In this study, the effects of normal-sized and nano-sized titanium dioxide (TiO2) NPs on cells were compared. It was found that normal-sized TiO2 resulted in lower H3 acetylation and nano-sized TiO2 caused higher DNA damage and global DNA methylation. Melatonin showed partial protection against the toxicity of TiO2 NPs.
TOXICOLOGY MECHANISMS AND METHODS
(2023)
Article
Environmental Sciences
Merve Buke Sahin, Murat Cagan, Anil Yirun, Aylin Balci Ozyurt, Selinay Basak Erdemli Kose, Irem Iyigun, Melda Celik, Ozgur Ozyuncu, Pinar Erkekoglu, Cavit Isik Yavuz
Summary: This study assessed fetal exposure to Bisphenol derivatives and found a positive correlation between birth weight and cord blood Bisphenol A concentration. Further research on maternal exposure during the fetal and neonatal period is critical for public health.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL HEALTH RESEARCH
(2023)
Article
Environmental Sciences
Fatma Pinar Tabanli, Siddika Songuel Yalcin, Sedef Ramoglu, Sadiman Kiykac Altinbas, Anil Yirun, Aylin Balci Ozyurt, Funda Gucel, Pinar Erkekoglu, Kadriye Yurdakok
Summary: This study aimed to investigate the association between bisphenol A (BPA), 25-hydroxy vitamin D [25(OH)D], and 1 alpha,25 dihydroxy vitamin D [1,25( OH)(2)D] levels in cord blood of newborn babies. The results showed that both BPA exposure and insufficient vitamin D transfer via cord blood are common in newborns, but there is no correlation between BPA levels and vitamin D levels in cord blood.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Article
Environmental Sciences
Fatma Pinar Tabanli, Siddika Songul Yalcin, Sedef Ramoglu, Sadiman Kiykac Altinbas, Anil Yirun, Aylin Balci ozyurt, Funda Gucel, Pinar Erkekoglu, Kadriye Yurdakok
Summary: This study investigated the association between BPA, 25(OH)D, and 1,25(OH)(2)D levels in cord blood of newborn babies. The study found that both BPA exposure and insufficient vitamin D transfer via cord blood are common in newborns, but BPA levels were not correlated with vitamin D levels in cord blood.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Article
Toxicology
Mehmet Evren Ozturk, Anil Yirun, Selinay Basak Erdemli-Kose, Aylin Balci-Ozyurt, Deniz Arca cakir, Didem Oral, Pinar Erkekoglu
Summary: This study evaluated the toxic effects of thimerosal, aluminum, and their combination on SH-SY5Y cells. The results showed that both thimerosal and aluminum can alter the oxidant/antioxidant status, cause DNA damage, and change dopamine and DAT levels. The changes were more pronounced in cells treated with the combined exposure to aluminum and thimerosal.
HUMAN & EXPERIMENTAL TOXICOLOGY
(2022)
Article
Pharmacology & Pharmacy
Kazkayasi Inci, Telli Gokcen, Balci Aylin, Uma Serdar
Summary: This study investigates the effects of acute hyperglycemia on oxidative stress markers in healthy rabbits, and finds that vitamin E pretreatment can partially prevent the oxidative stress caused by acute hyperglycemia.
JOURNAL OF RESEARCH IN PHARMACY
(2022)