Article
Multidisciplinary Sciences
Stephanie Cerceo Page, Srinidhi Rao Sripathy, Federica Farinelli, Zengyou Ye, Yanhong Wang, Daniel J. Hiler, Elizabeth A. Pattie, Claudia Nguyen, Madhavi Tippani, Rebecca L. Moses, Huei-Ying Chen, Matthew Nguyen Tran, Nicholas J. Eagles, Joshua M. Stolz, Joseph L. I. I. I. I. Catallini, Olivia R. Soudry, Dwight Dickinson, Karen F. Berman, Jose A. Apud, Daniel R. Weinberger, Keri Martinowich, Andrew E. Jaffe, Richard E. Straub, Brady J. Maher
Summary: The study analyzed neurons derived from individuals with high polygenic risk scores for schizophrenia (SCZ) and neurotypical individuals, finding that patient-derived neurons exhibited altered electrophysiological measures related to Na+ channel function, action potential interspike interval, and gamma-aminobutyric acid-ergic neurotransmission. These electrophysiological measures predicted core clinical and cognitive features in SCZ patients, potentially offering critical insights for novel therapeutics.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Pharmacology & Pharmacy
Mark Estacion, Shujun Liu, Xiaoyang Cheng, Sulayman Dib-Hajj, Stephen G. Waxman
Summary: Chronic pain is a prevalent and unmet medical need globally. Through a genetic study, individuals with less pain were found to carry gain-of-function variants in Kv7.2 or Kv7.3 genes, suggesting that activating these potassium channels could reduce sensory neuron activity and provide potential pain relief.
FRONTIERS IN PHARMACOLOGY
(2023)
Review
Chemistry, Inorganic & Nuclear
Ulrich Schubert, Berthold Stoeger
Summary: This article reviews the chain-like and cyclic structures of compounds with a MIDLINE HORIZONTAL ELLIPSISTi-O-Ti-OMIDLINE HORIZONTAL ELLIPSIS backbone. These compounds involve the coordination octahedra of the titanium atoms sharing corners through mu 2-O atoms. The charge of the TiO2+ unit is balanced by organic or inorganic ligands, which also complete the coordination sphere of the titanium atoms. While there are limited structurally characterized chain structures, various types of cyclic compounds are known.
COORDINATION CHEMISTRY REVIEWS
(2024)
Article
Biology
David E. Saenz, Tingting Gu, Yue Ban, Kirk O. Winemiller, Michael R. Markham
Summary: The study found that the Brachyhypopomus species B. bennetti exhibits minimal EOD plasticity, but its electrocytes retain vestigial mechanisms of biphasic signaling. This suggests that this species may represent a transitional phenotypic state within a clade where signal complexity and plasticity were initially gained and then lost.
JOURNAL OF EXPERIMENTAL BIOLOGY
(2021)
Article
Neurosciences
Zhefu Que, Maria Olivero-Acosta, Jingliang Zhang, Muriel Eaton, Anke M. Tukker, Xiaoling Chen, Jiaxiang Wu, Junkai Xie, Tiange Xiao, Kyle Wettschurack, Layan Yunis, J. Marshall Shafer, James A. Schaber, Jean-Christophe Rochet, Aaron B. Bowman, Chongli Yuan, Zhuo Huang, Chang-Deng Hu, Darci J. Trader, William C. Skarnes, Yang Yang
Summary: The study reveals that the SCN2A gene variant L1342P can increase intrinsic excitability of neurons, leading to hyperexcitability phenotypes. Neuronal cultures carrying this variant exhibit some resistance to anticonvulsant medication but can be alleviated by a specific blocker, phrixotoxin-3 (PTx3), suggesting potential therapeutic interventions for patients with this genetic variant.
JOURNAL OF NEUROSCIENCE
(2021)
Article
Engineering, Biomedical
Marianne Wauchop, Naimeh Rafatian, Yimu Zhao, Wenliang Chen, Mark Gagliardi, Stephane Masse, Brian J. Cox, Patrick Lai, Timothy Liang, Shira Landau, Stephanie Protze, Xiao Dong Gao, Erika Yan Wang, Kelvin Chan Tung, Zachary Laksman, Rick Xing Ze Lu, Gordon Keller, Kumaraswamy Nanthakumar, Milica Radisic, Peter H. Backx
Summary: To better understand SCN5A-related cardiomyopathies, ventricular cardiomyocytes were generated from induced pluripotent stem cells of a patient with dilated cardiomyopathy and the R222Q mutation. Heart-on-a-chip biowires were created to study the effects of the mutation on myocardial maturation. The R222Q mutation not only altered cardiac electrophysiology and Na+ current, but also caused disruptions in sarcomere structure and mechanical destabilization.
Article
Anesthesiology
Jacob T. Beckley, Hassan Pajouhesh, George Luu, Sheri Klas, Anton Delwig, Dennis Monteleone, Xiang Zhou, Denise Giuvelis, Ian D. Meng, David C. Yeomans, John C. Hunter, John Mulcahy
Summary: The voltage-gated sodium channel Na(v)1.7 plays a crucial role in pain signal transmission, making it a promising target for analgesic therapy. The small molecule Na(v)1.7 inhibitor ST-2530 demonstrated high selectivity for human Na(v)1.7 and exhibited potent analgesic effects in various mouse pain models, without affecting motor function.
Article
Cardiac & Cardiovascular Systems
Molly O'Reilly, Laura C. Sommerfeld, C. O'Shea, S. Broadway-Stringer, S. Andaleeb, J. S. Reyat, S. N. Kabir, D. Stastny, A. Malinova, D. Delbue, L. Fortmueller, K. Gehmlich, D. Pavlovic, B. Skryabin, A. P. Holmes, P. Kirchhof, L. Fabritz
Summary: This study found that the point mutation M1875T in the SCN5A gene is associated with familial AF. A new mouse model was used to show that this mutation causes gain-of-function of the cardiac sodium channel, resulting in increased atrial excitability.
Review
Biochemistry & Molecular Biology
Cedric Vallee, Brendan Howlin, Rebecca Lewis
Summary: The Epithelial Sodium Channel/Degenerin (ENaC/DEG) family is a superfamily of sodium-selective channels with high homology in the pore region, playing important physiological roles in various animal species. The G/SxS selectivity filter and other conserved residues are crucial for ion selectivity, with different residues involved in ion permeability depending on the ion type. This review highlights new perspectives for further exploration of ion selectivity mechanisms.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemical Research Methods
Karoline Horgmo Jaeger, Samuel Wall, Aslak Tveito
Summary: Short QT (SQT) syndrome is a genetic cardiac disorder characterized by a shortened QT interval in the patient's electrocardiogram, associated with increased risk of arrhythmias and sudden cardiac death. Cardiomyocytes derived from induced pluripotent stem cells from SQT patients provide a platform for testing pharmacological treatments in human cardiac cells with specific mutations. A computational procedure is applied to translate measured drug effects from these cells to predict drug responses in adult patients, showing promising results in identifying drug effects and QT interval changes.
PLOS COMPUTATIONAL BIOLOGY
(2021)
Article
Chemistry, Inorganic & Nuclear
Felix J. de Zwart, Bente Reus, Annechien A. H. Laporte, Vivek Sinha, Bas de Bruin
Summary: The development of a metrical oxidation state model allows for accurate determination of oxidation states for redox-active ligands and metals, providing stable and practical structural information for a wide range of compounds.
INORGANIC CHEMISTRY
(2021)
Article
Chemistry, Multidisciplinary
Jun Ying, Baoyue Zhang, Aixiang Tian, Xiuli Wang
Summary: A series of new Anderson-based compounds modified by multi-nuclear metal clusters were synthesized and showed promising electrocatalytic and catalytic performances. Compound 3 exhibited the best photocatalytic activity among the synthesized compounds. The compounds also showed potential for catalyzing organic dyes and carbon dioxide.
Article
Chemistry, Organic
Rui-jun Peng, Yuan Chen, Xue-jing Zhang, Ming Yan
Summary: A Rh(iii)-catalyzed ortho C-H migratory insertion of N-nitrosoanilines with naphthoquinone carbenes has been developed, yielding the desired products in good yields under mild reaction conditions. Diverse elaborations of the products were also explored, making this method valuable for the synthesis of biarylamines and their derivatives.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2023)
Review
Biochemistry & Molecular Biology
Xin Wu, Liang Hong
Summary: Calmodulin (CaM) is a small protein that serves as a ubiquitous signal transducer, regulating neuronal plasticity, muscle contraction, and immune response. It interacts with ion channels and plays regulatory roles in cellular electrophysiology. Mutations in CaM-binding IQ domain can lead to various diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Chemistry, Applied
Jessica Margalef, Maria Biosca, Pol de la Cruz-Sanchez, Xisco Caldentey, Carles Rodriguez-Escrich, Oscar Pamies, Miquel A. Pericas, Montserrat Dieguez
Summary: A family of phosphite/phosphinite-thioether ligands has shown excellent catalytic performance in the Ir-catalyzed asymmetric hydrogenation of a variety of olefins. Their modular architecture allows for a broad substrate scope, covering different substitution patterns and functional groups. The catalytic performance of the Ir-ligand assemblies remains consistent when using environmentally friendly 1,2-propylene carbonate as a solvent.
ADVANCED SYNTHESIS & CATALYSIS
(2021)
Article
Evolutionary Biology
Juliette Gorson, Girish Ramrattan, Aida Verdes, Elizabeth M. Wright, Yuri Kantor, Ramakrishnan Rajaram Srinivasan, Raj Musunuri, Daniel Packer, Gabriel Albano, Wei-Gang Qiu, Mande Holford
GENOME BIOLOGY AND EVOLUTION
(2015)
Editorial Material
Multidisciplinary Sciences
Mande Holford, Rodney Nichols
Article
Multidisciplinary Sciences
Prachi Anand, Alison O'Neil, Emily Lin, Trevor Douglas, Mande Holford
SCIENTIFIC REPORTS
(2015)
Article
Environmental Sciences
Patrick Kelly, Prachi Anand, Alexander Uvaydov, Srinivas Chakravartula, Chhime Sherpa, Elena Pires, Alison O'Neil, Trevor Douglas, Mande Holford
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2015)
Article
Zoology
J. Gorson, M. Holford
INTEGRATIVE AND COMPARATIVE BIOLOGY
(2016)
Article
Food Science & Technology
John Moon, Juliette Gorson, Mary Elizabeth Wright, Laurel Yee, Samer Khawaja, Hye Young Shin, Yasmine Karma, Rajeeva Lochan Musunri, Michelle Yun, Mande Holford
Review
Food Science & Technology
Aida Verdes, Prachi Anand, Juliette Gorson, Stephen Jannetti, Patrick Kelly, Abba Leffler, Danny Simpson, Girish Ramrattan, Mande Holford
Article
Evolutionary Biology
Aida Verdes, Danny Simpson, Mande Holford
GENOME BIOLOGY AND EVOLUTION
(2018)
Article
Multidisciplinary Sciences
Abba E. Leffler, Alexander Kuryatov, Henry A. Zebroski, Susan R. Powell, Petr Filipenko, Adel K. Hussein, Juliette Gorson, Anna Heizmann, Sergey Lyskov, Richard W. Tsien, Sebastien F. Poget, Annette Nicke, Jon Lindstrom, Bernardo Rudy, Richard Bonneau, Mande Holford
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2017)
Article
Ornithology
Mark E. Hauber, Miri Dainson, Daniel T. Baldassarre, Marouf Hossain, Mande Holford, Christina Riehl
JOURNAL OF AVIAN BIOLOGY
(2018)
Article
Biochemistry & Molecular Biology
Miri Dainson, Melissa Mark, Marouf Hossain, Barney Yoo, Mande Holford, Shannon E. McNeil, Christina Riehl, Mark E. Hauber
JOURNAL OF CHEMICAL ECOLOGY
(2018)
Article
Multidisciplinary Sciences
Anders Eriksson, Prachi Anand, Juliette Gorson, Corina Grijuc, Elina Hadelia, James C. Stewart, Mande Holford, Adam Claridge-Chang
SCIENTIFIC REPORTS
(2018)
Article
Food Science & Technology
Giulia Fassio, Maria Vittoria Modica, Lou Mary, Paul Zaharias, Alexander E. Fedosov, Juliette Gorson, Yuri I. Kantor, Mande Holford, Nicolas Puillandre
Article
Food Science & Technology
Juliette Gorson, Giulia Fassio, Emily S. Lau, Mande Holford
Summary: The presence of a venom gland is strongly correlated with dietary breadth in terebrid snails, with species lacking a venom gland showing greater dietary diversity. A revision of the definition of venom complexity in conoidean snails is proposed to better capture the breadth of ecological influences. Prey diet is an important factor in terebrid venom evolution and diversification, indicating the need for further investigations into understudied organisms in this field.
Editorial Material
Zoology
Mande Holford, Benjamin B. Normark
INTEGRATIVE AND COMPARATIVE BIOLOGY
(2022)
Article
Pharmacology & Pharmacy
Mohammadhossein Movassaghghazani, Nazanin Shabansalmani
Summary: The study revealed high levels of AFM1 in both breast milk and powdered milk samples in Tehran, with some samples exceeding the established limits. Therefore, monitoring and regulating toxin levels in these products is crucial for maternal and infant health.
Article
Pharmacology & Pharmacy
Defeng Wen, Wantong Han, Quan Chen, Guanhui Qi, Mengling Gao, Pu Guo, Yu Liu, Zhongyuan Wu, Shulin Fu, Qirong Lu, Yinsheng Qiu
Summary: Luteolin can inhibit FB1-induced intestinal inflammatory injury by inhibiting the activation of NF-kappa B and ERK signaling pathways, according to network pharmacology and in vitro experiments.