Article
Genetics & Heredity
Lorenzo Lones, Aaron Di Antonio
Summary: The research found that enhancing glial cells' ability to regulate lithium ions can suppress seizures. The study also found that the Wnk kinase regulates the buffering of lithium ions in glial cells through the transcription factor Fray, and overexpression of the Fray gene can effectively suppress seizure behavior in multiple epilepsy models. Finally, the study identified cortex glia as a key cell type in the susceptibility to seizures.
Article
Biochemistry & Molecular Biology
Qian Dong, Michael Zavortink, Francesca Froldi, Sofya Golenkina, Tammy Lam, Louise Y. Cheng
Summary: This study investigates the non-autonomous regulation of neural stem cell proliferation by glial cells, revealing the crucial roles of lipid droplets and the Hedgehog signaling molecule in this process. By modulating Hh signaling, glial cells have the ability to influence the proliferation of neural stem cells and their neuron-producing capability.
Article
Biochemistry & Molecular Biology
Kevin P. Kelly, Kate L. J. Ellacott, Heidi Chen, Owen P. McGuinness, Carl Hirschie Johnson
Summary: Time-restricted feeding is crucial for weight management as it affects metabolism, but previous studies have often confused feeding time with fasting time; Researchers have introduced a new time-optimized feeding plan to better analyze the effects of meal timing on the body, and to more accurately simulate human eating patterns in the laboratory; According to the data, controlling the timing of carbohydrate and fat oxidation can effectively limit fat accumulation.
Article
Multidisciplinary Sciences
Akiko Maruko, Koichi M. Iijima, Kanae Ando
Summary: This study investigates the molecular pathways involved in the generation of daily feeding patterns in Drosophila. The results show that quasimodo (qsm) and CLK play important roles in regulating feeding rhythms, and the generation of feeding/fasting episodes is independent of the molecular clock machinery.
Article
Multidisciplinary Sciences
Soo Min Oh, Kyunghwa Jeong, Jeong Taeg Seo, Seok Jun Moon
Summary: Through studying fruit flies, we have found that multimodal sensory integration plays a role in feeding behavior, particularly the contributions of olfactory and mechanical inputs to taste-evoked feeding behavior. Controlled delivery of three different sensory cues can produce a supra-additive reflex. Fruit flies serve as a versatile model system for studying multisensory integration related to feeding, which likely also exists in vertebrates.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Review
Cell Biology
Lara Bideyan, Rohith Nagari, Peter Tontonoz
Summary: This passage discusses the complex changes in hepatic gene expression in mammals during fasting and feeding transitions, highlighting the factors influencing these changes and the regulatory effects of dietary modifications on hepatic gene expression programs.
GENES & DEVELOPMENT
(2021)
Review
Endocrinology & Metabolism
Yanghe Zhang, Qingfei Meng, Qianhui Sun, Zhi-Xiang Xu, Honglan Zhou, Yishu Wang
Summary: LKB1 plays a crucial role in tumor suppression and metabolic regulation, deficiency of LKB1 leads to metabolic alterations in cancer cells promoting tumorigenesis while causing metabolic fragility. LKB1 also influences immune cell function through lipid metabolic regulation.
MOLECULAR METABOLISM
(2021)
Article
Gastroenterology & Hepatology
Suehelay Acevedo-Acevedo, Megan L. Stefkovich, Sun Woo Sophie Kang, Rory P. Cunningham, Constance M. Cultraro, Natalie Porat-Shliom
Summary: This study reveals the important role of liver kinase B1 (LKB1) in the transition from feeding to fasting states in the liver. Knocking out LKB1 leads to significant changes in the hepatic lobule and metabolic inefficiency in the whole body.
HEPATOLOGY COMMUNICATIONS
(2022)
Article
Cell Biology
Alba Capelo-Diz, Sofia Lachiondo-Ortega, David Fernandez-Ramos, Jorge Canas-Martin, Naroa Goikoetxea-Usandizaga, Marina Serrano-Macia, Maria J. Gonzalez-Rellan, Laura Mosca, Joan Blazquez-Vicens, Alberto Tinahones-Ruano, Marcos F. Fondevila, Mason Buyan, Teresa C. Delgado, Virginia Gutierrez de Juan, Paula Ayuso-Garcia, Alejandro Sanchez-Rueda, Sergio Velasco-Aviles, Hector Fernandez-Susavila, Cristina Riobello-Suarez, Bartlomiej Dziechciarz, Cristina Montiel-Duarte, Fernando Lopitz-Otsoa, Maider Bizkarguenaga, Jon Bilbao-Garcia, Ganeko Bernardo-Seisdedos, Ana Senra, Mario Soriano-Navarro, Oscar Millet, Angel Diaz-Lagares, Ana B. Crujeiras, Aida Bao-Caamano, Diana Cabrera, Sebastiaan van Liempd, Miguel Tamayo-Caro, Luigi Borzacchiello, Beatriz Gomez-Santos, Xabier Buque, Diego Saenz de Urturi, Francisco Gonzalez-Romero, Jorge Simon, Ruben Rodriguez-Agudo, Asier Ruiz, Carlos Matute, Daniel Beiroa, Juan M. Falcon-Perez, Patricia Aspichueta, Juan Rodriguez-Cuesta, Marina Porcelli, Maria A. Pajares, Cristina Ameneiro, Miguel Fidalgo, Ana M. Aransay, Tomas Lama-Diaz, Miguel G. Blanco, Miguel Lopez, Ricardo Villa-Bellosta, Timo D. Mueller, Ruben Nogueiras, Ashwin Woodhoo, Maria Luz Martinez-Chantar, Marta Varela-Rey
Summary: This study reveals that hepatic S-adenosylmethionine (SAMe) acts as a metabolic sensor of nutrition and fine-tunes the fasting response by regulating various cellular processes in mice. It shows that SAMe modulates PEMT activity, ER-mitochondria contacts, lipid oxidation, ATP production in the liver, and FGF21-mediated lipolysis and thermogenesis in adipose tissues. Additionally, the study highlights the role of glucagon-induced SAMe synthesis in preventing excessive lipid oxidation and mitochondrial ATP synthesis, thereby protecting against ER stress and liver injury.
Article
Biochemistry & Molecular Biology
Meng Zhao, Ariel Quintana, Chen Zhang, Alexander Y. Andreyev, William Kiosses, Tomomi Kuwana, Anne Murphy, Patrick G. Hogan, Mitchell Kronenberg
Summary: The differentiation of NKT2 cells requires higher and sustained calcium signals compared to their NKT1 counterparts, which is connected with mitochondria and cellular metabolism.
Article
Oncology
Jennifer A. Jimenez, April A. Apfelbaum, Allegra G. Hawkins, Laurie K. Svoboda, Abhijay Kumar, Ramon Ocadiz Ruiz, Alessandra X. Garcia, Elena Haarer, Zeribe C. Nwosu, Joshua Bradin, Trupta Purohit, Dong Chen, Tomasz Cierpicki, Jolanta Grembecka, Costas A. Lyssiotis, Elizabeth R. Lawlor
Summary: Ewing sarcomas are driven by EWS-ETS fusions, with EWS-FLI1 being the most common fusion gene. Both EWS-FLI1 and menin regulate serine biosynthesis by modulating ATF4, a stress-response gene. Inhibition of EWS-FLI1 or menin leads to loss of ATF4 and downregulation of serine synthesis pathway genes.
MOLECULAR CANCER RESEARCH
(2021)
Review
Biochemistry & Molecular Biology
Christoph Heier, Svitlana Klishch, Olha Stilbytska, Uliana Semaniuk, Oleh Lushchak
Summary: The deposition of storage fat in the form of triacylglycerol (TAG) is a conserved strategy to cope with energy availability and metabolic stress. The fruit fly Drosophila melanogaster has been established as a model system to study TAG metabolism and the etiology of lipid-associated metabolic diseases, showing potential in understanding the genetic and dietary basis of TAG storage and related disorders.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
(2021)
Review
Food Science & Technology
Xue Li, Binbin Nian, Ruizhi Li, Xinyu Cao, Yanjun Liu, Yuanfa Liu, Yong-Jiang Xu
Summary: This article conducted a meta-analysis to assess the effects of fasting on patients with metabolic syndrome (MS). The results showed that fasting significantly reduced body weight, BMI, body fat percentage, insulin level, and HOMA-IR in patients with MS, while having no effect on glucose, blood pressure, and lipids profile.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2022)
Article
Biology
Yongjun Li, Paula Haynes, Shirley L. Zhang, Zhifeng Yue, Amita Sehgal
Summary: Steroid hormones, specifically ecdysone, act as long-range signals that enter the brain more at night through nuclear hormone receptors (NHRs) and regulate sleep in Drosophila. The ecdysone receptor (EcR) and its downstream NHR Eip75B (E75) were found to function in glia to affect the rhythm and amount of sleep. This suggests that ecdysone acts as a systemic secreted factor that modulates sleep by stimulating lipid metabolism in cortex glia.
Article
Gastroenterology & Hepatology
Colin R. Lickwar, James M. Davison, Cecelia Kelly, Gilberto Padilla Mercado, Jia Wen, Briana R. Davis, Matthew C. Tillman, Ivana Semova, Sarah F. Andres, Goncalo Vale, Jeffrey G. McDonald, John F. Rawls
Summary: This study reveals that the combination of microbiota and high-fat diet may suppress the expression of hepatocyte nuclear factor 4 alpha, leading to the preferential activation of intestinal epithelial cell proliferation programs, which in turn affects intestinal lipid absorption, epithelial cell renewal, and systemic energy balance.
CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY
(2022)
Article
Oncology
Jaeoh Park, David Eisenbarth, Wonyoung Choi, Hail Kim, Chan Choi, Dahye Lee, Dae-Sik Lim
Article
Biochemistry & Molecular Biology
Kyung-Hye Roh, Yeojin Lee, Je-Hyun Yoon, Danbi Lee, Eunju Kim, Eunchong Park, In Young Lee, Tae Sung Kim, Hyun Kyu Song, Jaekyoon Shin, Dae-Sik Lim, Eui-Ju Choi
Summary: MST1/STK4 acts as a negative regulator of the TLR4-NF-kappa B signaling pathway, inhibiting TRAF6 autoubiquitination and downstream signaling, thereby limiting inflammation induced by LPS. The research also suggests that MST1/STK4 can regulate the production of proinflammatory cytokines in macrophages.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2021)
Article
Dermatology
Aimee Flores, Sekyu Choi, Ya-Chieh Hsu, William E. Lowry
Summary: Inhibition of pyruvate entry into mitochondria has been found to accelerate the hair cycle, even in cases of refractory hair loss, leading to the formation of histologically normal hair follicles within a short period of time. This suggests a versatile treatment strategy for alopecia in humans.
EXPERIMENTAL DERMATOLOGY
(2021)
Article
Multidisciplinary Sciences
Sekyu Choi, Bing Zhang, Sai Ma, Meryem Gonzalez-Celeiro, Daniel Stein, Xin Jin, Seung Tea Kim, Yuan-Lin Kang, Antoine Besnard, Amelie Rezza, Laura Grisanti, Jason D. Buenrostro, Michael Rendl, Matthias Nahrendorf, Amar Sahay, Ya-Chieh Hsu
Summary: The study revealed that corticosterone regulates hair follicle stem cell (HFSC) quiescence and hair growth in mice, with chronic stress prolonging HFSC quiescence and maintaining hair follicles in an extended resting phase. The mechanism involves corticosterone suppressing the expression of Gas6 gene through acting on dermal papillae, and restoring Gas6 expression can overcome stress-induced inhibition of HFSC activation and hair growth.
Article
Multidisciplinary Sciences
Ting Yuan, Karthika Annamalai, Shruti Naik, Blaz Lupse, Shirin Geravandi, Anasua Pal, Aleksandra Dobrowolski, Jaee Ghawali, Marina Ruhlandt, Kanaka Durga Devi Gorrepati, Zahra Azizi, Dae-Sik Lim, Kathrin Maedler, Amin Ardestani
Summary: LATS2, a core component of the Hippo signaling pathway, is activated under diabetic conditions and induces beta-cell failure. Inhibiting LATS2 can improve beta-cell viability and insulin secretion, suggesting it as a potential therapeutic target for improving pancreatic beta-cell survival in diabetes.
NATURE COMMUNICATIONS
(2021)
Article
Multidisciplinary Sciences
Su Jin Ham, Daewon Lee, Wen Jun Xu, Eunjoo Cho, Sekyu Choi, Soohong Min, Sunghyouk Park, Jongkyeong Chung
Summary: The loss of UCHL1 destabilizes pyruvate kinase and mitigates PD-related phenotypes, activating AMPK to promote mitophagy. Additionally, UCHL1 interacts antagonistically with TRIM63 to regulate PD-related pathologies, suggesting a link between glycolysis and PD pathology.
Article
Biology
Daehee Hwang, Miju Kim, Soyeon Kim, Mi Ra Kwon, Ye-Seul Kang, Dahyun Kim, Ho-Chul Kang, Dae-Sik Lim
Summary: Contact inhibition is a crucial cellular phenomenon regulated by the Hippo signaling pathway, which controls cell growth and differentiation. Evidence suggests that WWP1 mono-ubiquitinates AMOTL2 and activates LATS at cell junctions under high cell density, emphasizing the importance of molecular mechanisms in responding to upstream cell density cues.
LIFE SCIENCE ALLIANCE
(2021)
Article
Biochemistry & Molecular Biology
Hae Yon Jeon, Jinwook Choi, Lianne Kraaier, Young Hoon Kim, David Eisenbarth, Kijong Yi, Ju-Gyeong Kang, Jin Woo Kim, Hyo Sup Shim, Joo-Hyeon Lee, Dae-Sik Lim
Summary: Lineage fidelity of stem cells is crucial for tissue homeostasis. This study reveals that activation of YAP/TAZ can reprogram airway secretory cells into squamous alveolar type 1 (AT1) fate, and identifies the cellular and molecular mechanisms involved in this cell fate conversion. Aberrant activation of the YAP/TAZ-mTORC1-ATF4 axis is observed in bronchiolitis obliterans syndrome patients, suggesting a potential therapeutic target for fibrotic lung diseases.
Article
Cell Biology
Hyun Ahm Sohn, Dong Chul Lee, Anna Park, Minho Kang, Byoung-Ha Yoon, Chul-Ho Lee, Yong-Hoon Kim, Kyoung-Jin Oh, Cha Yeon Kim, Seong-Hwan Park, Han Koo, Hyoung-Chin Kim, Won Kee Yoon, Dae-Sik Lim, Daesoo Kim, Kyung Chan Park, Young Il Yeom
Summary: NDRG3 plays an important role in the regulation of liver cell metabolism, and its loss of function leads to excessive glycogen accumulation, hypoglycemia, elevated liver triglyceride content, and perturbation of the methionine cycle. These findings suggest therapeutic potential for regulating NDRG3 in disorders related to metabolic pathways.
Article
Immunology
Sergi Masgrau-Alsina, Lou Martha Wackerbarth, Dae-sik Lim, Markus Sperandio
Summary: This study identifies MST1 as a critical regulator of neutrophil homeostasis and mobilization from the bone marrow, shedding light on its complex role in regulating innate immunity.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Sixian Qi, Zhenxing Zhong, Yuwen Zhu, Yebin Wang, Mingyue Ma, Yu Wang, Xincheng Liu, Ruxin Jin, Zhihan Jiao, Rui Zhu, Zhao Sha, Kyvan Dang, Ying Liu, Dae-Sik Lim, Junhao Mao, Lei Zhang, Fa-Xing Yu
Summary: This study reveals that the HPO1 and HPO2 modules together regulate the activity of LATS1/2 kinases and YAP/TAZ transcriptional co-activators in the Hippo pathway. Inactivation of either HPO1 or HPO2 module leads to partial activation of YAP/TAZ, bile duct hyperplasia, and hepatocellular carcinoma (HCC) in mice livers. On the other hand, inactivation of both HPO1 and HPO2 modules results in full activation of YAP/TAZ, rapid development of intrahepatic cholangiocarcinoma (iCCA), and early lethality.
Article
Multidisciplinary Sciences
Anna Park, Kwang-eun Kim, Isaac Park, Sang Heon Lee, Kun-Young Park, Minkyo Jung, Xiaoxu Li, Maroun Bou Sleiman, Su Jeong Lee, Dae-Soo Kim, Jaehoon Kim, Dae-Sik Lim, Eui-Jeon Woo, Eun Woo Lee, Baek Soo Han, Kyoung-Jin Oh, Sang Chul Lee, Johan Auwerx, Ji Young Mun, Hyun-Woo Rhee, Won Kon Kim, Kwang-Hee Bae, Jae Myoung Suh
Summary: LETMD1 is a mitochondrial matrix protein that is crucial for maintaining respiratory function and thermogenesis in brown adipose tissue (BAT) upon cold stimulus. Knockout of LETMD1 leads to deficiency in OXPHOS complex proteins and impaired mitochondrial respiration in BAT. BAT-specific Letmd1 deficient mice exhibit the same phenotypes as Letmd1 knockout mice.
NATURE COMMUNICATIONS
(2023)
Review
Biochemistry & Molecular Biology
Hansaem Jang, Yemin Jo, Jung Hyun Lee, Sekyu Choi
Summary: Hair follicles in the skin undergo cyclic rounds of regeneration, degeneration, and rest throughout life. Stem cells residing in hair follicles play a pivotal role in maintaining tissue homeostasis and hair growth cycles. This review summarizes our understanding of how age-associated HFSC intrinsic and extrinsic mechanisms can induce HFSC aging and hair loss. In addition, we discuss approaches developed to attenuate age-associated changes in HFSCs and their niches, thereby promoting hair regrowth.
Review
Biochemistry & Molecular Biology
Chaeryeong Lim, Jooyoung Lim, Sekyu Choi
Summary: Mammalian skin has the ability to regenerate hair follicles after injury, similar to embryonic hair follicle development. Stem cells, immune cells, mesenchymal cells, and signaling pathways play essential roles in the process of wound induced hair follicle neogenesis (WIHN). WIHN represents a promising therapeutic approach for hair follicle regeneration and scar prevention.
MOLECULES AND CELLS
(2023)
Article
Biochemical Research Methods
Jiwon Kim, Kun-Young Park, Sungwoo Choi, Ung Hyun Ko, Dae-Sik Lim, Jae Myoung Suh, Jennifer H. Shin
Summary: Adipocyte dedifferentiation is a complex process that involves dynamic actin remodeling and regulation by multiple signaling pathways, and the study reveals that adipocytes are highly dynamic.