Article
Biochemistry & Molecular Biology
Gian Marco Tosi, Daniela Giustarini, Lorenzo Franci, Alberto Minetti, Francesco Imperatore, Elena Caldi, Paolo Fiorenzani, Anna Maria Aloisi, Anna Sparatore, Ranieri Rossi, Mario Chiariello, Maurizio Orlandini, Federico Galvagni
Summary: Oxidative stress is crucial in the pathophysiology of retinal diseases, with NACET showing potential as a more efficient alternative to NAC in preventing and treating AMD, by increasing intracellular GSH levels and enhancing oxidative stress resistance in RPE cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Ola Gutziet, Roee Iluz, Hila Ben Asher, Linoy Segal, Dikla Ben Zvi, Yuval Ginsberg, Nizar Khatib, Osnat Zmora, Michael G. Ross, Zeev Weiner, Ron Beloosesky
Summary: Perinatal hypoxia can cause infant brain damage, neurological disability, and mortality. N-Acetyl-Cysteine (NAC) acts as an antioxidant to protect offspring brains from hypoxic brain damage. NAC treatment can reduce brain protein levels, apoptosis, and acute sensorimotor dysfunction caused by hypoxia.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Fahimeh Abedini Bajgiran, Zeinab Khazaei Koohpar, Ali Salehzadeh
Summary: This study found that continuous exposure to lead induced apoptosis in testicular cells, caused oxidative stress, and decreased sperm quality and morphological changes in testis cells. However, NAC treatment showed protective effects on testicular tissue mainly through rebalancing of antioxidant capacity and downregulation of apoptosis-related genes.
BIOLOGICAL TRACE ELEMENT RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Ozlem Coskun, Ozlem Oztopuz, Basak Buyuk
Summary: The study revealed that NAC administered along with CP can mitigate CP-induced liver damage by reducing liver enzyme activities, alleviating inflammation, decreasing oxidative stress, improving liver morphology, and influencing apoptotic signaling pathways.
MOLECULAR BIOLOGY REPORTS
(2021)
Article
Biology
Yulan Zhao, Yu Zhuang, Yan Shi, Zheng Xu, Changming Zhou, Lianying Guo, Ping Liu, Cong Wu, Ruiming Hu, Guoliang Hu, Xiaoquan Guo, Lanjiao Xu
Summary: The study demonstrates the protective effects of N-acetyl-l-cysteine on heat stress-induced oxidative stress and inflammation in the hypothalamus of hens, suggesting its potential as a candidate for treating and preventing hypothalamic injury caused by heat stress.
JOURNAL OF THERMAL BIOLOGY
(2021)
Article
Agriculture, Dairy & Animal Science
Laryssa G. Barrozo, Lais R. F. M. Paulino, Bianca R. Silva, Efigenia C. Barbalho, Danisvania R. Nascimento, Miguel F. Lima Neto, Jose R. Silva
Summary: NAC, as an antioxidant, plays a crucial role in promoting GSH biosynthesis and regulating cell proliferation. Studies on in vitro culture, oocyte maturation, embryonic development, and cryopreservation show beneficial effects of NAC in protecting cells from oxidative stress damage.
ANIMAL REPRODUCTION SCIENCE
(2021)
Article
Psychiatry
Richard A. Kanaan, Gina Oliver, Anita Dharan, Shahbaz Sendi, Alice Maier, Mohammadreza Mohebbi, Chee Ng, Sudie E. Back, Peter Kalivas, Michael Berk
Summary: This study investigated the efficacy of adjuvant N-acetylcysteine (NAC) treatment in patients with treatment-resistant PTSD. The results showed that there were no significant differences between NAC and placebo groups in CAPS-5 scores at 12 weeks, but significant differences were observed in craving duration and resistance at 64 weeks. Further research is needed to determine the efficacy of NAC for treatment-resistant PTSD.
PSYCHIATRY RESEARCH
(2023)
Article
Medicine, Research & Experimental
Yonela Ntamo, Khanyisani Ziqubu, Nireshni Chellan, Bongani B. Nkambule, Tawanda M. Nyambuya, Sithandiwe E. Mazibuko-Mbeje, Kwazikwakhe B. Gabuza, Patrick Orlando, Luca Tiano, Phiwayinkosi V. Dludla
Summary: Liver transplantation is the definitive treatment for complete liver failure, but oxidative stress and inflammation contribute to the damage caused during the procedure. N-acetyl cysteine (NAC) has been studied as a potential therapeutic drug to counteract oxidative stress and inflammation. Clinical evidence suggests that NAC can improve liver function by enhancing endogenous antioxidants and attenuating inflammation, but some studies have shown conflicting results.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Review
Biochemistry & Molecular Biology
Daniela Giustarini, Aldo Milzani, Isabella Dalle-Donne, Ranieri Rossi
Summary: Glutathione (GSH) has special antioxidant properties due to its high concentration, ubiquity, and reactivity. In diseases where oxidative stress plays a role, GSH concentration is reduced, making cells more prone to damage. This review discusses strategies for increasing cellular GSH, including GSH itself, derivatives, activators, prodrugs, foods, and diets, as well as their mechanisms and advantages/disadvantages.
Article
Biochemistry & Molecular Biology
MohammadMahdi Jaafarzadeh, Roham Mahjoob Khaligh, Zhaleh Mohsenifar, Aida Shabani, MohammadMahdi Rezvani Gilkalaei, Sara Rajabi Keleshteri, Asghar Beigi Harchegani
Summary: Chronic exposure to cadmium and lead is associated with accumulation of these heavy metals in the brain, morphological changes, antioxidants depletion, oxidative stress, and brain cells apoptosis. NAC supplementation can protect brain tissue against toxicity of lead and cadmium by improving antioxidant capacity, mitigating oxidative stress, apoptosis, and down-regulating PD-related genes.
BIOLOGICAL TRACE ELEMENT RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Zahra Azarmehr, Najmeh Ranji, Zeinab Khazaei Koohpar, Hadi Habibollahi
Summary: The study demonstrated that N-acetylcysteine (NAC) protects liver tissue against cadmium (Cd) toxicity by increasing antioxidant capacity, reducing oxidative stress, inflammation, apoptosis, and up-regulating FXR, LXR, and SIRT1 genes.
MOLECULAR BIOLOGY REPORTS
(2021)
Article
Hematology
Sezaneh Haghpanah, Nader Cohan, Mohammadreza Bordbar, Asghar Bazrafshan, Mehran Karimi, Soheila Zareifar, Sanaz Safaei, Azam Aramesh, Mohamad Moghadam, Saeid Amiri Zadeh Fard, Omid Reza Zekavat
Summary: Oxidative stress plays a significant role in the progression of beta-thalassemia, and the study found that vitamin E can effectively reduce TOS in patients with TDT. Both NAC and vitamin E supplements led to a decrease in TAC, but no significant change in hemoglobin levels was observed. Further research is needed to determine the long-term effects of antioxidant supplementation in TDT patients.
ANNALS OF HEMATOLOGY
(2021)
Article
Pharmacology & Pharmacy
Ana Lopes-Rocha, Thiago Ohno Bezerra, Roberta Zanotto, Inda Lages Nascimento, Angela Rodrigues, Cristiane Salum
Summary: The disruption of neurodevelopment hypothesis for schizophrenia is supported by evidence of redox imbalance and glutathione deficit in this disorder. The present study found that treatment with the GSH precursor NAC could reverse behavioral deficits in MAM rats through a mechanism involving nitric oxide. Furthermore, ongoing inflammatory processes were observed in MAM rats, and NAC exhibited a potential antipsychotic effect.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Clinical Neurology
Cansu Bilister Egilmez, Burcu Azak Pazarlar, Mumin Alper Erdogan, Oytun Erbas
Summary: This study found that N-acetyl cysteine (NAC) reduced the stage of convulsions and prolonged the onset time of myoclonic jerks in a dose-dependent manner in a rat model of epilepsy. NAC also decreased the percentage of spikes in EEG recordings and improved oxidative stress biomarkers in a dose-dependent manner. The results suggest that NAC has a beneficial effect in reducing seizures and preventing oxidative stress in epilepsy, with the effect being dose-dependent.
Article
Obstetrics & Gynecology
Osnat Zmora, Ola Gutziet, Linoy Segal, Sari Boulos, Zvika Millo, Yuval Ginsberg, Nizar Khatib, Ofer Fainaru, Michael G. Ross, Zeev Weiner, Ron Beloosesky
Summary: NAC treatment can attenuate the inflammatory response syndrome in newborns and decrease neuroapoptosis and inflammation in the brains of offspring in a rat model of NEC through inhibition of NF-kappa B, nNOS, and Caspase 3 pathways.
ACTA OBSTETRICIA ET GYNECOLOGICA SCANDINAVICA
(2021)
Article
Plant Sciences
Yadu Nandan Dey, Manish M. Wanjari, Dharmendra Kumar, Vinay Lomash, Ankush D. Jadhav
JOURNAL OF ETHNOPHARMACOLOGY
(2016)
Article
Plant Sciences
Yadu Nandan Dey, Garima Sharma, Manish M. Wanjari, Dharmendra Kumar, Vinay Lomash, Ankush D. Jadhav
PHARMACEUTICAL BIOLOGY
(2017)
Article
Environmental Sciences
Anupama Ojha, Santosh Kumar Yaduvanshi, Satish Chnadra Pant, Vinay Lomash, Nalini Srivastava
ENVIRONMENTAL TOXICOLOGY
(2013)
Article
Environmental Sciences
Utsab Deb, Vinay Lomash, Suchita Raghuvanshi, S. C. Pant, R. Vijayaraghavan
ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY
(2012)
Article
Food Science & Technology
Rahul Bhattacharya, Pooja Rao, Poonam Singh, Shiv Kumar Yadav, Preeti Upadhyay, Sandhya Malla, Niranjan Laxman Gujar, Vinay Lomash, Satish Chandra Pant
FOOD AND CHEMICAL TOXICOLOGY
(2014)
Article
Toxicology
R. Satpute, V. Lomash, M. Kaushal, R. Bhattacharya
HUMAN & EXPERIMENTAL TOXICOLOGY
(2013)
Article
Biotechnology & Applied Microbiology
Abhishek Yadav, Rashi Mathur, Mohammed Samim, Vinay Lomash, Pramod Kushwaha, Uma Pathak, Anil Kumar Babbar, Swaran Jeet Singh Flora, Anil Kumar Mishra, Mahabir Parshad Kaushik
Article
Multidisciplinary Sciences
Rekha Dhanwani, Mohsin Khan, Vinay Lomash, Putcha Venkata Lakshmana Rao, Hinh Ly, Manmohan Parida
Article
Public, Environmental & Occupational Health
Pravin Kumar, Vinay Lomash, P. C. Jatav, A. Kumar, S. C. Pant
TOXICOLOGY AND INDUSTRIAL HEALTH
(2016)
Article
Cell Biology
Vinay Lomash, Satish C. Pant
WOUND REPAIR AND REGENERATION
(2014)
Article
Dermatology
Vinay Lomash, Sunil E. Jadhav, Rajagopalan Vijayaraghavan, Satish C. Pant
INTERNATIONAL WOUND JOURNAL
(2013)
Article
Toxicology
S. J. S. Flora, Nidhi Dwivedi, Utsab Deb, Pramod Kushwaha, Vinay Lomash
TOXICOLOGY RESEARCH
(2014)
Article
Public, Environmental & Occupational Health
R. M. Satpute, Y. D. Bhutia, V. Lomash, R. Bhattacharya
TOXICOLOGY AND INDUSTRIAL HEALTH
(2019)
Article
Pharmacology & Pharmacy
Yadu Nandan Dey, Manish M. Wanjari, Dharmendra Kumar, Vinay Lomash, Sudesh N. Gaidhani, Ankush D. Jadhav
JOURNAL OF PHARMACY & PHARMACOGNOSY RESEARCH
(2017)