Article
Cell Biology
Sumaiah S. Al-Asmari, Aleksandra Rajapakse, Tomalika R. Ullah, Genevieve Pepin, Laura V. Croft, Michael P. Gantier
Summary: Activation of the STING pathway in cancer cells upon genotoxic treatment leads to the production of interferon-beta and anti-tumoral effects. However, it is also associated with the expression of pro-tumorigenic genes. In this study, it was found that genotoxic DNA damage rapidly increased the expression of IL-6 in STING-expressing cancer cells, independent of type-I interferon responses. The production of IL-6 was driven through both canonical and non-canonical STING signaling pathways. Inhibition of ERK1/2 could inhibit IL-6 production induced by DNA damage.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Orthopedics
R. Wiegertjes, N. G. M. Thielen, A. P. M. van Caam, M. van Laar, H. M. van Beuningen, M. I. Koenders, P. L. E. M. van Lent, P. M. van der Kraan, F. A. J. van de Loo, E. N. Blaney Davidson
Summary: The study indicates that aging leads to increased expression of IL-6 receptor and enhanced IL-6-induced p-STAT3 signaling in articular cartilage, which may be caused by age-related loss of protective TGF-β3 signaling and suppression of IL-6R. This mechanism could contribute to age-related osteoarthritis development.
OSTEOARTHRITIS AND CARTILAGE
(2021)
Article
Chemistry, Medicinal
Tianzhi Dai, Lan Lin, Huan Chen, Wenyu Lu, Xuelian Yang, Li Yang, Ying Liu, Jichun Cui, Dequn Sun
Summary: The incidence of various types of cancers is increasing every year, with leukemia being particularly common. Developing new drugs to combat leukemia is crucial. In this study, several hybrids were designed and synthesized, resulting in a new lead molecule 5a that demonstrated a strong therapeutic effect on leukemia. Further experiments showed that 5a effectively inhibited the growth of various cancer cells and had lower toxicity to normal cells. Mechanistic investigations revealed that 5a downregulated Bcl-2 and induced genotoxic stress responses. The results suggest that 5a should be further investigated as a potential therapeutic compound against leukemia.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2022)
Article
Clinical Neurology
Yuki Kageyama, Yasuhiko Deguchi, Takaoki Kasahara, Munehide Tani, Kenji Kuroda, Koki Inoue, Tadafumi Kato
Summary: Patients with bipolar disorder have elevated plasma IL-6 levels, higher in depressed patients than in remitted patients. However, the study did not find a significant difference in plasma circulating cell-free mitochondrial DNA levels between depressed and remitted BD patients.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Article
Toxicology
Xi Cheng, Changcai Liu, Yang Yang, Longhui Liang, Bo Chen, Huilan Yu, Junmei Xia, Shilei Liu, Yihe Li
Summary: Sulfur mustard (SM) is a blister chemical warfare agent with severe cytotoxicity and genotoxicity, mainly causing damage through alkylation-induced DNA lesions and oxidative stress from glutathione depletion. Liquid chromatography-tandem mass spectrometry (LC-MS/MS) technology plays a key role in analyzing DNA damage caused by SM.
TOXICOLOGY LETTERS
(2021)
Article
Biochemistry & Molecular Biology
Zengming Zhao, Xiabei Yan, Lizhong Li, Yulei Shu, Jun He, Lili Wang, Qingzhen Huang, Jianwei Xie, Jun Zhao, Shuangqing Peng
Summary: Sulfur mustard (SM), a chemical warfare agent, can cause DNA damage and is toxic to cells. Our study found that dividing cells are more sensitive to SM and that stem cells, in particular, are more prone to DNA damage. The DNA repair pathways involved in stem cells and somatic cells were also different.
DNA AND CELL BIOLOGY
(2022)
Article
Gastroenterology & Hepatology
Kazuma Sekiba, Motoyuki Otsuka, Kazuyoshi Funato, Yu Miyakawa, Eri Tanaka, Takahiro Seimiya, Mari Yamagami, Takeya Tsutsumi, Kazuya Okushin, Kei Miyakawa, Akihide Ryo, Kazuhiko Koike
Summary: The HBV X protein degrades the Smc5/6 complex, impairing DNA double-strand break repair and promoting cellular transformation. Nitazoxanide (NTZ) restores the function of the Smc5/6 complex, repairing HR in HBx-expressing cells and promoting colony formation.
JOURNAL OF HEPATOLOGY
(2022)
Article
Oncology
Marco Carlo Merlano, Matteo Paccagnella, Nerina Denaro, Andrea Abbona, Danilo Galizia, Dario Sangiolo, Loretta Gammaitoni, Erika Fiorino, Silvia Minei, Paolo Bossi, Lisa Licitra, Ornella Garrone
Summary: This study found that IL-6 and TGF-beta play a prognostic role in head and neck cancer patients with poor clinical characteristics. Nivolumab treatment positively modulates some Th1 cytokines, but it does not correlate with the outcome.
Article
Cell Biology
Kristina Riegel, Hajime Yurugi, Janine Schloeder, Helmut Jonuleit, Manuel Kaulich, Friederike Kirschner, Danielle Arnold-Schild, Stefan Tenzer, Hansjorg Schild, Krishnaraj Rajalingam
Summary: Tumors suppress antitumor immune responses by secreting IL-6, which inhibits the production of IL-12p70 in dendritic cells. The classical mitogen-activated protein kinase ERK5/MAPK7 is essential for IL-6 production in tumor cells, suggesting a potential target for enhancing antitumor immune responses.
CELL DEATH & DISEASE
(2021)
Article
Biochemistry & Molecular Biology
Dina M. Metwally, Tahani T. Al-Otaibi, Abdelhabib Semlali, Reem A. Alajmi
Summary: Sarcocystis spp. are intracellular protozoan parasites that can cause inflammation in different organs of camels. The study showed that infection with Sarcocystis spp. in camels, particularly those from the Al-flassim region, increased inflammation through stimulation of IL-6 expression.
BIOSCIENCE REPORTS
(2021)
Article
Cell Biology
Chao Cao, Baoping Tian, Xinwei Geng, Hongbin Zhou, Zhiwei Xu, Tianwen Lai, Yanping Wu, Zhengqiang Bao, Zhihua Chen, Wen Li, Huahao Shen, Songmin Ying
Summary: Chronic inflammation has been identified as a risk factor for human cancer, and this study showed that cigarette smoke-induced genomic instability may be partially attributed to IL-17-mediated inflammation. Higher levels of IL-17 and DDR were observed in smokers' lung tissues compared to non-smokers, as well as in mice exposed to cigarette smoke. These findings suggest that IL-17 could play a crucial role in the development of lung cancer.
Review
Biochemistry & Molecular Biology
Eva Ramos, Emilio Gil-Martin, Cristobal de los Rios, Javier Egea, Francisco Lopez-Munoz, Rene Pita, Antonio Juberias, Juan J. J. Torrado, Dolores R. R. Serrano, Russel J. J. Reiter, Alejandro Romero
Summary: In this review, melatonin is proposed as a therapeutic option to counteract the toxicological mechanisms and pathways activated after exposure to sulfur and nitrogen mustards. Additionally, the metabolites of melatonin are predicted to have a scavenger action and neutralize the damage induced by these blister agents. The anti-inflammatory action and NLRP3 inflammasome modulation of melatonin can also provide protection against sulfur and nitrogen mustard-induced injury.
Article
Neurosciences
Faezeh-sadat Khorram, Ali Mehdipour, Amir Moghadam-Ahmadi, Habib Farahmand, Azadeh Askari, Seyed Mohsen Moosavi, Ahmad Shabanizadeh, Masoumeh Parsi, Mohammad Kazemi Arababadi
Summary: This study showed that brain MRI without contrast can increase protein levels of IL-6 in the peripheral serum, but has no effect on IL-10, IL-17A, and TGF-beta levels. Participants with mild anxiety had higher IL-6 mRNA levels after MRI compared to those without anxiety.
Article
Biochemistry & Molecular Biology
Nerea Cuesta-Gomez, Laura Medina-Ruiz, Gerard J. Graham, John D. M. Campbell
Summary: Mesenchymal stromal cells (MSC) are potential cellular therapeutics for psoriasis, a chronic inflammatory skin and joint disease. MSC adoptive cellular therapy can modulate the immune response and suppress the hyperactivation of effector T cells underlying the disease. In this study, we investigated the therapeutic potential of bone marrow and adipose tissue-derived MSCs in a psoriasis-like inflammation model. We found that both unlicensed and licensed MSCs accelerated the healing of psoriatic lesions, but unlicensed MSCs were more efficient in resolving skin inflammation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
I-Ting Lin, Yu-Han Lin, Wei-Shiung Lian, Feng-Sheng Wang, Re-Wen Wu
Summary: Spinal epidural fibrosis is characterized by excessive scar formation in the dura and nerve roots, contributing to the failed back surgery syndrome. The microRNA-29a (miR-29a) has been found to inhibit fibrotic matrix production in various tissues, but its role in spinal epidural scarring remained unclear. This study showed that miR-29a attenuated fibrogenic activity and reduced fibrotic matrix formation in the epidural tissue of transgenic mice. Furthermore, miR-29aTg also protected against laminectomy-induced damage and could assess walking patterns and movement activity. Immunohistochemistry staining indicated reduced expression of IL-6, TGF-beta1, and Dnmt3b in miR-29aTg mice compared to wild-type mice. These findings highlight the epigenetic regulation of miR-29a in reducing spinal epidural fibrosis and preserving spinal cord integrity.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Medicine, Research & Experimental
Lakshmi Thangavelu, Sri Renukadevi Balusamy, Senthilkumar Sivanesan, Haribalan Perumalsamy, R. Parameshwari, Vijayaraghavan Rajagopalan, Rajeshkumar Shanmugam
BIOMEDICINE & PHARMACOTHERAPY
(2018)
Article
Public, Environmental & Occupational Health
R. M. Satpute, Y. D. Bhutia, V. Lomash, R. Bhattacharya
TOXICOLOGY AND INDUSTRIAL HEALTH
(2019)
Article
Biochemistry & Molecular Biology
Burhan Ud Din Shafi, Ravindra Kumar, S. E. Jadhav, Junaid Kar
BIOLOGICAL TRACE ELEMENT RESEARCH
(2020)
Review
Medicine, Research & Experimental
Rajagopalan Vijayaraghavan
JOURNAL OF INTERNATIONAL MEDICAL RESEARCH
(2020)
Article
Infectious Diseases
Nagaraju Bankan, Fathimunnisa Koka, Rajagopalan Vijayaraghavan, Sreekanth Reddy Basireddy, Selvaraj Jayaraman
Summary: Acinetobacter species, especially Acinetobacter baumannii, exhibit multidrug resistance through efflux pump mechanisms. The natural compound (+)Usnic acid shows better efficacy as an efflux pump inhibitor compared to conventional inhibitors in lowering the minimum inhibitory concentration of tigecycline-resistant Acinetobacter baumannii isolates.
Article
Biotechnology & Applied Microbiology
Mokshata Gupta, Ashok Kumar Pattanaik, Asmita Singh, Shalini Sharma, Sunil Ekanath Jadhav, Avneesh Kumar, Ashok Kumar Verma
Summary: The study aimed to isolate lactic acid bacteria strains from newborn calves for the development of a potential probiotic for calf nutrition. Among the strains isolated, CPN60 exhibited better resistance to adverse conditions in the gastrointestinal tract and superior co-aggregation and antagonistic activity against pathogenic strains of Escherichia coli. In vivo assessment in Wistar rats showed improved nutrient utilization efficiency, growth performance, fecal lactate concentration, short-chain fatty acids production, and cell-mediated immune response in the group supplemented with L. salivarius CPN60.
JOURNAL OF BIOSCIENCE AND BIOENGINEERING
(2021)
Article
Biochemistry & Molecular Biology
Karunakaran Balaji, Jagadish Vijayakumar, Ponnusamy Kasirajan Sankaran, Sivanesan Senthilkumar, Rajagopalan Vijayaraghavan, Jayaraman Selvaraj, Maria Francis Yuvaraj
Summary: Extract from Celastrus paniculatus seed can inhibit lead-acetate-induced kidney damage by regulating the PI3K/AKT signaling pathways, alleviating adverse changes caused by lead acetate.
Article
Medicine, Research & Experimental
Zareena Begum, Vijayalakshmi Subramanian, Gunapriya Raghunath, Karthikeyan Gurusamy, Rajagopalan Vijayaraghavan, Senthilkumar Sivanesan
Summary: This study investigates the effects of exercise of varying intensity on the nervous system in multiple sclerosis. The findings demonstrate that a combination of preconditioning exercise and high-intensity exercise can provide neuroprotection and promote remyelination.
ADVANCES IN CLINICAL AND EXPERIMENTAL MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
P. Thamizhan, Sunil Ekanath Jadhav, Pranav Sunil Jadhav, Pramod Chaudhary, Pankaj Kumar Choubey, Vijay Kumar Singh, Narayan Dutta
Summary: This study evaluated the effects of incremental levels of select dietary trace minerals on the growth performance, nutrient utilization, and mineral balance of male goats. The results showed that feeding higher levels of zinc, copper, manganese, and selenium improved the digestibility of non-fiber carbohydrates and the retention of zinc, manganese, and selenium, leading to subtle beneficial effects on the growth performance of male goats.
BIOLOGICAL TRACE ELEMENT RESEARCH
(2023)
Article
Medicine, General & Internal
Rajagopalan Vijayaraghavan, Sivanesan Senthilkumar, Anitha Roy, Durairajan Sheela, Royapuram Veeraragavan Geetha, Anitha Magesh
Summary: The study evaluated the safety and tolerability of autoinjector devices (AIDS) in rabbits by intramuscular administration of amikacin and buprenorphine. The results showed that the AIDs were safe and suitable for further experimentation, recommended for self-administration in emergency situations for adults, children, as well as farm and pet animals.
SAGE OPEN MEDICINE
(2022)
Article
Anatomy & Morphology
Santhi Chillakuru, Subhadra Devi Velichety, Vijayaraghavan Rajagopalan
ANATOMY & CELL BIOLOGY
(2020)
Article
Biotechnology & Applied Microbiology
S. Mohammed Shahid, Siddesh B. Sirwar, R. Vijayaraghavan
JOURNAL OF PURE AND APPLIED MICROBIOLOGY
(2018)
Proceedings Paper
Physics, Condensed Matter
R. K. Chandunika, R. Vijayaraghavan, Niroj Kuinar Sahu
62ND DAE SOLID STATE PHYSICS SYMPOSIUM
(2018)
Article
Pharmacology & Pharmacy
Bhima Uma Maheswari, Rajagopalan Vijayaraghavan, Thuppil Venkatesh
PAKISTAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2018)
Article
Biology
R. Vijayaraghavan, Sonia Johari, Sangeetha Shukla
INDIAN JOURNAL OF EXPERIMENTAL BIOLOGY
(2018)