Review
Psychiatry
Kelly A. Knowles, David F. Tolin
Summary: This review article discusses the application and mechanisms of exposure therapy in the treatment of anxiety-related disorders. The findings suggest that cognitive and behavioral mechanisms play important roles in exposure therapy, and neural activation mechanisms contribute to its effectiveness. Improved understanding of the biological mechanisms offers promising directions for clinical research.
CURRENT PSYCHIATRY REPORTS
(2022)
Article
Biochemistry & Molecular Biology
Yue Zheng, Xian-Wen Yang, Dominique Schols, Mattia Mori, Bruno Botta, Andy Chevigne, Martin Mulinge, Andre Steinmetz, Jean-Claude Schmit, Carole Seguin-Devaux
Summary: The study demonstrates that compounds from Cassia abbreviata block HIV-1 entry into cells and may have potential antiviral properties, with piceatannol showing promise in inhibiting HIV-1 infection in a model of the female genital tract. The structure-activity relationships (SAR) highlight the importance of pharmacophoric groups in piceatannol for inhibiting HIV-1 entry.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Chemistry, Medicinal
Maya Rima, Jeanne Trognon, Laure Latapie, Asma Chbani, Christine Roques, Fatima El Garah
Summary: This study evaluated the antibiofilm activity of extracts from three seaweeds and found that the extract from green Ulva lactuca showed promising antibiofilm activity and exhibited a synergistic effect with tobramycin. Preliminary chemical composition analysis also provided some insights into the active compounds.
Article
Microbiology
Ifeanyichukwu E. Eke, John T. Williams, Elizabeth R. Haiderer, Veronica J. Albrecht, Heather M. Murdoch, Bassel J. Abdalla, Robert B. Abramovitch
Summary: Nitro-containing compounds are important agents in controlling tuberculosis. Several nitro-containing compounds have been identified and characterized for their mechanism of action against Mycobacterium tuberculosis. These compounds show different activities, targets, and bactericidal capabilities.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2023)
Article
Microbiology
Kristina Kovacikova, Marina Gorostiola Gonzalez, Rhian Jones, Juan Reguera, Alba Gigante, Maria-Jesus Perez-Perez, Gerhard Puerstinger, Julia Moesslacher, Thierry Langer, Lak Shin Jeong, Leen Delang, Johan Neyts, Eric J. Snijder, Gerard J. P. van Westen, Martijn J. van Hemert
Summary: This study compared the antiviral efficacy of nsP1 inhibitors and found that CHVB and MADTP series had similar modes of action while differing from the FHNA series. Molecular-docking studies revealed the binding sites and potential actions of different series of inhibitors within the nsP1 structure.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2021)
Article
Biochemistry & Molecular Biology
Carmen Costas-Ferreira, Rafael Duran, Lilian Ferreira Faro
Summary: The main objective of this study was to evaluate the effects and mechanisms of action of glyphosate and a glyphosate-based herbicide on dopaminergic neurotransmission in the rat striatum. Findings showed that glyphosate increased dopamine release and impaired motor control, as well as decreased acetylcholinesterase activity and antioxidant capacity. Two possible mechanisms, increased dopamine release and inhibition of dopamine transporter, were suggested to explain the effects of glyphosate.
PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Yoshihisa Ozoe, Yoshiki Matsubara, Yuji Tanaka, Yasuhide Yoshioka, Fumiyo Ozoe, Takahiro Shiotsuki, Kazuki Nomura, Toshifumi Nakao, Shinichi Banba
Summary: Dinotefuran is a unique insecticide that acts on specific nicotinic acetylcholine receptor (nAChR) subtypes, leading to differences in its insecticidal activity compared to imidacloprid.
PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY
(2023)
Article
Toxicology
Yu-Teng Jheng, Denise Utami Putri, Hsiao-Chi Chuang, Kang-Yun Lee, Hsiu-Chu Chou, San-Yuan Wang, Chia-Li Han
Summary: This study identified potential molecular features associated with early lung damage in response to traffic-related air pollution, which could be used to screen individuals more susceptible to air pollution.
PARTICLE AND FIBRE TOXICOLOGY
(2021)
Article
Forestry
Luana M. Luz, Ediane C. Alves, Nariane Q. Vilhena, Tamires B. Oliveira, Zara G. B. Silva, Joze M. N. Freitas, Candido F. O. Neto, Roberto C. L. Costa, Lucas C. Costa
Summary: This study investigated the physiological mechanisms associated with growth rehydration in two species of Hymenaea plants under short-term drought stress. It was found that Hymenaea courbaril tends to invest in nitrogen and adjust root growth, while Hymenaea stigonocarpa utilizes higher water potential and lower net photosynthesis to support aboveground growth. This suggests that different species have distinct ways of controlling water status and growth.
JOURNAL OF FORESTRY RESEARCH
(2023)
Review
Psychology, Multidisciplinary
Aikaterini Grimani, Alexander Moog, Ivo Vlaev
Summary: The aim of this study is to evaluate the effects of music exposure on prosocial behaviour, identify the behaviour change techniques (BCTs) used, and examine the mechanisms of action (MoAs) that mediate the relationship. The review included 15 articles with 19 relevant studies, but many of them lacked sufficient information for coding. The most commonly used BCTs were instruction on how to perform a behavior, salience of consequences, reduce negative emotions, and identification of self as a role model. Emotion was found to be the most significant MoA, but there were too few coded BCTs to draw conclusions about BCT-MoA relationships.
CURRENT PSYCHOLOGY
(2023)
Article
Psychology, Clinical
Kati Roesmann, Elisabeth J. Leehr, Joscha Boehnlein, Bettina Gathmann, Martin J. Herrmann, Markus Junghoefer, Hanna Schwarzmeier, Fabian R. Seeger, Niklas Siminski, Thomas Straube, Udo Dannlowski, Ulrike Lueken
Summary: This study aimed to elucidate the mechanisms of action for immediate and sustained treatment response of virtual-reality exposure treatment (VRET) for spider phobia. The study found that higher within-session fear reductions predicted better treatment outcomes, and lower initial fear activation tended to be associated with better long-term results. The findings highlight the importance of fear reduction in VRET for short-and long-term treatment success.
JOURNAL OF ANXIETY DISORDERS
(2023)
Article
Microbiology
Simona Di Blasio, Maria Clarke, Charlotte K. K. Hind, Masanori Asai, Louis Laurence, Angelica Benvenuti, Mahnoor Hassan, Dorothy Semenya, DeDe Kwun-Wai Man, Victoria Horrocks, Giorgia Manzo, Sarah van der Lith, Carolyn Lam, Eugenio Gentile, Callum Annette, Janine Bosse, Yanwen Li, Barry Panaretou, Paul R. R. Langford, Brian D. D. Robertson, Jenny K. W. Lam, J. Mark Sutton, Michael McArthur, A. James Mason
Summary: A structure-activity-relationship study was conducted to modify a bolalipid antiseptic, resulting in new analogues with broader antibacterial activity. Synergistic relationships with aminoglycosides were identified, particularly against Acinetobacter baumannii and Pseudomonas aeruginosa. The study provides insights for the further adaptation of this class of antimicrobials.
Article
Toxicology
Leon Earl Gray, Justin M. Conley, Christy S. Lambright, Johnathan R. Furr
Summary: Administration of individual chemicals and mixtures during sexual differentiation can disrupt the androgen signaling pathway and induce reproductive abnormalities in male rats. This study coadministered the pesticides pyrifluquinazon (PFQ) and dibutyl phthalate (DBP) to pregnant rats and observed a reduction in male anogenital distance, reproductive organ weights, sperm counts, and the occurrence of hypospadias in male offspring. The results support the hypothesis that chemicals that disrupt the androgen signaling pathway can induce dose-additive male reproductive abnormalities.
TOXICOLOGICAL SCIENCES
(2022)
Review
Ophthalmology
Ryan T. Barrett, Jordan P. Hastings, Yasmyne C. Ronquillo, Phillip C. Hoopes, Majid Moshirfar
Summary: Palytoxin is a deadly natural toxin found in marine animals, including zoanthid corals. Exposure to this toxin can lead to various symptoms, with an increasing incidence of ocular exposure in recent years.
CLINICAL OPHTHALMOLOGY
(2021)
Article
Psychology, Social
Theofilos Gkinopoulos, Silvia Mari
Summary: This article explores the relationship between exposure to conspiracy theories and normative, nonnormative collective action, and political engagement, as well as the emotional underpinnings of these effects. The findings suggest that exposure to conspiracy theories can decrease normative collective action but increase nonnormative collective action, negative emotions, and political engagement.
JOURNAL OF APPLIED SOCIAL PSYCHOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Qingquan Kong, Yuji Nakai, Nanae Kuroda, Akiko Shiratsuchi, Kaz Nagaosa, Yoshinobu Nakanishi
JOURNAL OF BIOCHEMISTRY
(2015)
Article
Immunology
Firzan Nainu, Yumiko Tanaka, Akiko Shiratsuchi, Yoshinobu Nakanishi
JOURNAL OF IMMUNOLOGY
(2015)
Article
Immunology
Akiko Shiratsuchi, Mao Nitta, Ayumi Kuroda, Chiharu Komiyama, Mitsuko Gawasawa, Naoto Shimamoto, Tran Quoc Tuan, Teppei Morita, Hiroji Aiba, Yoshinobu Nakanishi
JOURNAL OF IMMUNOLOGY
(2016)
Article
Biochemistry & Molecular Biology
Saori Nonaka, Yuki Ando, Takuto Kanetani, Chiharu Hoshi, Yuji Nakai, Firzan Nainu, Kaz Nagaosa, Akiko Shiratsuchi, Yoshinobu Nakanishi
JOURNAL OF BIOLOGICAL CHEMISTRY
(2017)
Article
Multidisciplinary Sciences
Saori Nonaka, Aki Hori, Yoshinobu Nakanishi, Takayuki Kuraishi
JOVE-JOURNAL OF VISUALIZED EXPERIMENTS
(2017)
Review
Immunology
Firzan Nainu, Akiko Shiratsuchi, Yoshinobu Nakanishi
FRONTIERS IN IMMUNOLOGY
(2017)
Article
Neurosciences
J. Malmevik, M-L. Rogers, M. Nilsson, Y. Nakanishi, R. A. Rush, N. R. Sirns, H. Muyderman
Article
Immunology
Akiko Shiratsuchi, Naoto Shimamoto, Mao Nitta, Tran Quoc Tuan, Afwa Firdausi, Mitsuko Gawasawa, Kaneyoshi Yamamoto, Akira Ishihama, Yoshinobu Nakanishi
JOURNAL OF IMMUNOLOGY
(2014)
Article
Biochemistry & Molecular Biology
Saori Nonaka, Koichiro Kawamura, Aki Hori, Emil Salim, Kazuki Fukushima, Yoshinobu Nakanishi, Takayuki Kuraishi
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2018)
Article
Virology
Dini Rahmatika, Nanae Kuroda, Zhang Min, Firzan Nainu, Kaz Nagaosa, Yoshinobu Nakanishi
Article
Oncology
Saori Nonaka, Mai Sono, Chiharu Hoshi, Takuto Kanetani, Hiroshi Nakayama, Naoshi Dohmae, Yoshinobu Nakanishi
EXPERIMENTAL CELL RESEARCH
(2019)
Article
Cell Biology
Min Zhang, Kaz Nagaosa, Yuji Nakai, Tetsuo Yasugi, Masako Kushihiki, Dini Rahmatika, Makoto Sato, Akiko Shiratsuchi, Yoshinobu Nakanishi
Article
Pharmacology & Pharmacy
Heny Ekowati, Junko Arai, Ayu Sekarani Damana Putri, Firzan Nainu, Akiko Shiratsuchi, Yoshinobu Nakanishi
DRUG DISCOVERIES AND THERAPEUTICS
(2017)
Review
Pharmacology & Pharmacy
Saori Nonaka, Akiko Shiratsuchi, Kaz Nagaosa, Yoshinobu Nakanishi
BIOLOGICAL & PHARMACEUTICAL BULLETIN
(2017)