期刊
VIROLOGY
卷 528, 期 -, 页码 48-53出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.virol.2018.12.008
关键词
Cancer; Drosophila; Viral infection
类别
资金
- Hokkoku Cancer Foundation
- KAKENHI grant from the Japan Society for the Promotion of Science [18K19395, 25440044, 16K07726]
- Grants-in-Aid for Scientific Research [25440044, 18K19395, 16K07726] Funding Source: KAKEN
Immune responses evoked on viral infections prevent the dissemination of infection that otherwise leads to the development of diseases in host organisms. In the present study, we investigated whether viral infection influences tumorigenesis in cancer-bearing animals using a Drosophila model of cancer. Cancer was induced in the posterior part of wing imaginal discs through the simultaneous inhibition of apoptosis and cell-cycle checkpoints. The larvae and embryos of cancer-induced flies were infected with Drosophila C virus, a natural pathogen to Drosophila, and larval wing discs and adult wings were morphologically examined for cancer characteristics relative to uninfected controls. We found that viral infections brought about an approximately 30% reduction in the rate of cancer development in both wing discs and wings. These inhibitory effects were not observed when growth-defective virus was used to infect animals. These results indicate that productive viral infections repress tumorigenesis in Drosophila.
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