Review
Environmental Sciences
Luis Daniel Martinez-Razo, Alejandra Martinez-Ibarra, Edgar Ricardo Vazquez-Martinez, Marco Cerbon
Summary: DEHP, considered an endocrine disruptor chemical (EDC), is widely used in the plastic industry and can have negative effects on placental development and function, potentially impacting fetal growth. Research indicates that DEHP and MEHP can impair key processes in placental development and affect various placental functions. Clinical evidence also supports the connection between DEHP exposure and adverse pregnancy outcomes and pathologies.
ENVIRONMENT INTERNATIONAL
(2021)
Article
Environmental Sciences
Nuran Cikcikoglu Yildirim, Tuba Parlak Ak, Omer Samasas
Summary: This study revealed the toxic characteristics of DEHP in Gammarus pulex by examining biochemical and histopathological changes. Changes in SOD, CAT, and GST activities were identified as potential sensitive biomarkers for environmental risk assessment, and increased immunoreactivity in G. pulex due to DEHP exposure was observed.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2021)
Article
Chemistry, Multidisciplinary
Kuo-Cheng Lan, Te- Weng, Wei-Che Chiang, Chen-Yuan Chiu, Ding-Cheng Chan, Rong-Sen Yang, Shing-Hwa Liu
Summary: DEHP and its metabolite MEHP have been found to inhibit myogenesis in vitro, suggesting their potential role as environmental risk factors affecting muscle differentiation.
APPLIED SCIENCES-BASEL
(2022)
Article
Engineering, Environmental
Huiyan Yang, Mingsheng Li, Cui Zhang, Na Li, Xiangfeng Yao, Xianxu Li, Fang Li, Jun Wang
Summary: This study investigated the ecotoxicological effects of DEHP on wheat seedlings by exposing them to DEHP-contaminated soil for 30 days. The results showed that DEHP reduced wheat germination rate and inhibited root length. There was no effect on plant height. At the biochemical level, photosynthetic pigments and soluble sugar content were initially promoted and then inhibited. The antioxidant enzymes displayed different trends, and corresponding genes were upregulated or downregulated. The study also demonstrated the dose-dependent nature of DEHP toxicity to wheat seedlings and identified potential binding targets of DEHP. Overall, this study provided valuable insights for assessing the toxicity risk of DEHP to wheat.
JOURNAL OF HAZARDOUS MATERIALS
(2023)
Article
Biochemistry & Molecular Biology
Jian Xu, Liming Wang, Lihuan Zhang, Fang Zheng, Fang Wang, Jianhang Leng, Keyi Wang, Paul Heroux, Han-Ming Shen, Yihua Wu, Dajing Xia
Summary: MEHP exacerbates cytotoxicity by amplifying the PINK1-Parkin-mediated mitophagy pathway, leading to increased mitochondrial damage and robust mitophagy. Co-treatment with N-acetyl cysteine (NAC) counteracted the effects of MEHP-CCCP, suggesting that mitochondrial ROS played a vital role in this process. The findings provide insights into the potential roles of endocrine disrupting chemicals (EDCs) in human diseases such as Parkinson's disease.
Article
Environmental Sciences
Rui-jing Liu, Yong-jian He, Huan Liu, Dong-dong Zheng, Shao-wen Huang, Chun-hong Liu
Summary: Lycium barbarum polysaccharide (LBP) showed protective effects against DEHP-induced liver toxicity in rats by attenuating oxidative stress and down-regulating detoxification enzymes expression. This suggests that LBP could be a potential natural ingredient for auxiliary therapeutic use in health food.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2021)
Article
Engineering, Environmental
Xia Li, Jianpeng Li, Sijia Hao, Ailing Han, Yayu Yang, Guozhen Fang, Jifeng Liu, Shuo Wang
Summary: A enzyme mimic material inspired by serine proteases was developed to degrade DEHP, which was then immobilized onto RC membranes for continuous recycling degradation. This biocatalytic membrane showed effective DEHP degradation and good stability, offering a promising biomaterial for water decontamination and liquid food depollution.
JOURNAL OF HAZARDOUS MATERIALS
(2021)
Article
Chemistry, Applied
Yuting Liang, Zhi Jiang, Wenfeng Shangguan
Summary: This study investigated the photocatalytic reaction behavior of DEHP over surface platinized TiO2, with the oxidation state of platinum found to be crucial in determining the photocatalytic activity. Platinized titania with oxidized Pt species showed higher photocatalytic activity compared to metallic Pt. Photocatalysis coupled with thermal catalysis can enhance the degradation of DEHP, and Pt oxide, particularly PtO, can improve the photocatalytic oxidation efficiency by promoting the separation efficiency of photo generated carriers.
Article
Biology
Yukiko Tando, Hitoshi Hiura, Asuka Takehara, Yumi Ito-Matsuoka, Takahiro Arima, Yasuhisa Matsui
Summary: Maternal exposure to DEHP induces DNA hypermethylation of spermatogenesis-related gene promoters in fetal testicular germ cells in F1 mice, leading to downregulation of gene expression in spermatogonia and subsequent defects in spermatogenesis.
Article
Environmental Sciences
Hyunki Cho, Yohan Seol, Seungyun Baik, Baeckkyoung Sung, Chang Seon Ryu, Young Jun Kim
Summary: The effects of MEHP exposure on Daphnia magna were investigated, revealing that MEHP exposure increased lipid droplet numbers and the reproduction rate of adult female daphnids. Furthermore, MEHP exposure enhanced lipid metabolism and altered the expression levels of ecdysone receptor and vitellogenin.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2022)
Article
Biotechnology & Applied Microbiology
Shivani Popli Goyal, Tripti Agarwal, Vijendra Mishra, Ankur Kumar, Chakkaravarthi Saravanan
Summary: This study identified two strains of Lactobacillus (Lactobacillus rhamnosus GG and Lactobacillus plantarum MTCC 25,433) that can rapidly adsorb over 85% of DEHP. The adsorption of DEHP was affected by cell wall polysaccharides, proteins, lipids, and peptidoglycan. These findings suggest that these Lactobacillus strains could be potential strategies for detoxification of DEHP-contaminated foods.
PROBIOTICS AND ANTIMICROBIAL PROTEINS
(2023)
Review
Environmental Sciences
Wing Sum Kwan, Vellaisamy A. L. Roy, Kwan Ngok Yu
Summary: DEHP, widely used as a plasticizer in consumer products, has been linked to adverse health effects, prompting the need for toxicological assessment. Zebrafish embryos have become a popular in vivo model for studying DEHP toxicity, aiming to assess both acute and chronic effects on different developmental stages.
Article
Environmental Sciences
Abd El-Zaher M. A. Mustafa, Jawaher Alkahtani, Mohamed Soliman Elshikh, Manal M. Al Shaqhaa, Mona S. Alwahibi
Summary: DEHP, a widely used plasticizer and endocrine disrupting pollutant, has been extensively studied for its environmental and toxicological effects on human health. Citric acid was found to significantly enhance the uptake of DEHP by plants, showing great potential for phytoremediation of contaminated soil.
Article
Environmental Sciences
Krishna Ghosh, Biji Chatterjee, KiranKumar Nalla, Bablu Behera, Amit Mukherjee, Santosh R. Kanade
Summary: This study aimed to assess the impact of DEHP exposure on human breast cancer cells and found that DEHP can induce DNA hypermethylation and alter the expression of DNA methylation regulators. Additionally, DEHP significantly reduces p53 protein levels, increases SP1 and E2F1 transcription factor levels, and silences the p21 promoter through DNA methylation.
Article
Biodiversity Conservation
Xianxu Li, Qian Wang, Can Wang, Zhongkang Yang, Jinhua Wang, Lusheng Zhu, Dexin Zhang, Jun Wang
Summary: This study investigated the acute and chronic toxicity of DEHP on zebrafish, focusing on oxidative damage, neurotoxicity, and DNA damage in the liver. The results showed that DEHP enhanced oxidative stress, lipid peroxidation, and cytotoxicity in zebrafish liver, leading to DNA damage. The severity of the effects was positively correlated with the concentration of DEHP.
ECOLOGICAL INDICATORS
(2022)
Article
Biochemistry & Molecular Biology
Sahin Takci, Ali Asci, Pinar Erkekoglu, Sule Yigit, Belma Kocer-Gumusel, Murat Yurdakok
BIOLOGICAL TRACE ELEMENT RESEARCH
(2019)
Article
Public, Environmental & Occupational Health
Pinar Erkekoglu, Ming-Wei Chao, Chia-Yi Tseng, Bevin P. Engelward, Ozge Kose, Belma Kocer-Gumusel, Gerald N. Wogan, Steven R. Tannenbaum
ARHIV ZA HIGIJENU RADA I TOKSIKOLOGIJU-ARCHIVES OF INDUSTRIAL HYGIENE AND TOXICOLOGY
(2019)
Article
Biochemistry & Molecular Biology
Elodie Clain, Juliano G. Haddad, Andrea C. Koishi, Laura Sinigaglia, Walid Rachidi, Philippe Despres, Claudia N. Duarte dos Santos, Pascale Guiraud, Nolwenn Jouvenet, Chaker El Kalamouni
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2019)
Article
Nanoscience & Nanotechnology
Dalel Askri, Valerie Cunin, David Beal, Sylvie Berthier, Benoit Chovelon, Josiane Arnaud, Walid Rachidi, Mohsen Sakly, Salem Amara, Michel Seve, Sylvia G. Lehmann
Article
Toxicology
Ozge Kose, Walid Rachidi, David Beal, Pinar Erkekoglu, Hussein Fayyad-Kazan, Belma Kocer Gumusel
JOURNAL OF APPLIED TOXICOLOGY
(2020)
Article
Environmental Sciences
Aylin Balci, Gizem Ozkemahli, Pinar Erkekoglu, Naciye Dilara Zeybek, Nilgun Yersal, Belma Kocer-Gumusel
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2020)
Article
Public, Environmental & Occupational Health
Naciye Dilara Zeybek, Unzile Sur, Ofcan Oflaz, Pinar Erkekoglu, Aylin Balci, Gizem Ozkemahli, Ali Asci, Murat Kizilgun, Oguz Han Edebal, Belma Kocer-Gumusel
ARHIV ZA HIGIJENU RADA I TOKSIKOLOGIJU-ARCHIVES OF INDUSTRIAL HYGIENE AND TOXICOLOGY
(2020)
Article
Environmental Sciences
Aylin Balci, Gizem Ozkemahli, Pinar Erkekoglu, Dilara Zeybek, Nilgun Yersal, Belma Kocer-Gumusel
Summary: This study evaluated the effects of single and combined exposures to BPA and/or DEHP during the prenatal and lactational period on the male reproductive system of rats in later stages of life. The results suggest that prenatal and lactational exposure to BPA and DEHP may have adverse effects on the male reproductive system in later stages of life, especially after combined exposure.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL HEALTH RESEARCH
(2022)
Article
Pharmacology & Pharmacy
Gamze Tilbe Sen, Gizem Ozkemahli, Reza Shahbazi, Pinar Erkekoglu, Kezban Ulubayram, Belma Kocer-Gumusel
INTERNATIONAL JOURNAL OF TOXICOLOGY
(2020)
Article
Gastroenterology & Hepatology
Umur Keles, Evin Iscan, Huriye Erbak Yilmaz, Gokhan Karakulah, Asli Suner, Erhan Bal, Nilgun Tasdemir, Ayse Derya Cavga, Umut Ekin, Zeynep Mutlu, Sila Kahyaoglu, Muhittin A. Serdar, Nese Atabey, Mehmet Ozturk
AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY
(2020)
Article
Environmental Sciences
Anil Yirun, Gizem Ozkemahli, Aylin Balci, Pinar Erkekoglu, Naciye Dilara Zeybek, Nilgun Yersal, Belma Kocer-Gumusel
Summary: This study aimed to investigate the toxicity of BPA and/or DEHP on the central nervous system and neuroendocrine system in Sprague-Dawley rats during prenatal and lactational periods. The results showed that early-life exposure to these chemicals caused significant changes in lipid peroxidation, neurotransmitter levels, and apoptosis in the hippocampus. This suggests that alterations in oxidant/antioxidant status and neurotransmitters may be the underlying mechanisms of neurotoxicity induced by BPA and DEHP.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2021)
Article
Oncology
Evin Iscan, Umut Ekin, Gokhan Yildiz, Ozden Oz, Umur Keles, Asli Suner, Gulcin Cakan-Akdogan, Gunes Ozhan, Marta Nekulova, Borivoj Vojtesek, Hamdiye Uzuner, Gokhan Karakulah, Hani Alotaibi, Mehmet Ozturk
Summary: The study reveals that TAp73 beta is overexpressed in hepatocellular carcinoma (HCC) and can promote malignant dedifferentiation of liver cancer cells. This suggests that TAp73 beta may play a significant role in the development of HCC.
Article
Chemistry, Multidisciplinary
Busra Ozyurt, Gizem Ozkemahli, Anil Yirun, Aylin Balci Ozyurt, Merve Bacanli, Nursen Basaran, Belma Kocer-Gumusel, Pinar Erkekoglu
Summary: The potential toxic effects of BPA, BPS, and BPF were comparatively evaluated in HepG2 cells. These bisphenol derivatives showed similar toxicities, with BPS > BPF > BPA in terms of cytotoxicity, increased intracellular ROS production, imbalance in oxidant/antioxidant parameters, and significant DNA damage.
DRUG AND CHEMICAL TOXICOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Tugce Batur, Ayse Argundogan, Umur Keles, Zeynep Mutlu, Hani Alotaibi, Serif Senturk, Mehmet Ozturk
Summary: The study reveals that AXL is highly expressed in advanced hepatocellular carcinoma and is closely associated with a mesenchymal phenotype. By using gene knockout and pharmacological inhibition, it was found that loss of AXL leads to drastic phenotypic changes in HCC cells, resulting in loss of tumorigenicity in vivo.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Chemistry, Medicinal
Gunes Y. Akdeniz, Hulya Akgun, Ozlem B. Ozakpinar, Merve Duracik, Mehmet Ozturk, Evin Iscan, Faika Basoglu
Summary: In this study, a series of phenylurenyl chalcone derivatives were synthesized and evaluated for their anticancer and antimicrobial activity. Some of these compounds showed good cytotoxic activity against Huh-7 cell line and exhibited inhibitory effects against bacteria and fungi.
LETTERS IN DRUG DESIGN & DISCOVERY
(2022)