Article
Environmental Sciences
A. Amala Lourthuraj, Mohammad Rafe Hatshan, Dina S. Hussein
Summary: This study aimed to identify pesticide degrading bacteria and localize organophosphate hydrolase activity. Results showed that two bacteria isolated from contaminated samples were able to efficiently remove chlorpyrifos and utilize pesticides as a source of carbon and energy.
ENVIRONMENTAL RESEARCH
(2022)
Article
Food Science & Technology
Mingming Li, Xin Zhang, Jiapeng Li, Linggao Liu, Qiujin Zhu, Chao Qu, Yunhan Zhang, Shouwei Wang
Summary: This study investigated the isolation, purification, and identification of potential cardioprotective bioactive peptides from dry-cured pork coppa. The results showed that M1F2 peptide had a higher inhibitory effect on cardiovascular inflammation compared to M2F2. Nano-liquid chromatography-tandem mass spectrometry identified a total of 30 peptides, among which LTDKPFL, VEAPPAKVP, KVPVPAPK, IPVPKK, and PIKRSP were found to be promising platelet-activating factor acetyl hydrolase inhibitory peptides. Overall, bioactive peptides produced during the processing of dry-cured pork coppa have positive effects on human health.
Article
Medicine, General & Internal
Jordi Roca-Ferrer, Maria Perez-Gonzalez, Isam Alobid, Valeria Tubita, Mireya Fuentes, Marina Bantula, Rosa Munoz-Cano, Antonio Valero, Inaki Izquierdo, Joaquim Mullol, Jacopo Galli
Summary: This study aimed to assess the role of the Platelet-Activating Factor (PAF)/receptor (PAFR) system in chronic rhinosinusitis with nasal polyps (CRSwNP). The study found that PAFR protein was expressed in nasal mucosa and nasal polyps, and Lyso-PAF concentrations were higher in nasal polyps of asthmatic patients. These findings suggest that the PAF/PAFR system may play a role in CRSwNP pathogenesis.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Environmental Sciences
Grazielle Castagna Cezimbra Weis, Charles Elias Assmann, Vitor Bastianello Mostardeiro, Audrei de Oliveira Alves, Jessica Righi da Rosa, Micheli Mainardi Pillat, Cinthia Melazzo de Andrade, Maria Rosa Chitolina Schetinger, Vera Maria Melchiors Morsch, Ivana Beatrice Manica da Cruz, Ijoni Hilda Costabeber
Summary: The study revealed that exposure to chlorpyrifos (CPF) can induce oxidative and inflammatory responses in murine microglial cells. At lower concentrations, CPF promoted a pro-oxidative and pro-inflammatory state in microglial cells.
Article
Biotechnology & Applied Microbiology
Aswathi Aswathi, Ashok Pandey, Aravind Madhavan, Rajeev K. Sukumaran
Summary: A highly efficient chlorpyrifos-degrading Pseudomonas nitroreducens was found to remodel its proteome and induce global response pathways in response to the compound, with up-regulated proteins mainly involved in carbohydrate metabolism and chemical degradation pathways.
ENVIRONMENTAL TECHNOLOGY & INNOVATION
(2021)
Article
Toxicology
Shreesh Raj Sammi, Tauqeerunnisa Syeda, Kendra D. Conrow, Maxwell C. K. Leung, Jason R. Cannon
Summary: Organophosphate (OP) pesticides, like CPF, have irreversible neurotoxic effects on dopaminergic neurons. CPF reduces mitochondrial content and is associated with specific genes, cyp-35A2 and cyp-35A3. Mitochondria may be a common target for all OP pesticide parent compounds.
TOXICOLOGICAL SCIENCES
(2023)
Article
Environmental Sciences
Thitipa Thosapornvichai, Chananya Huangteerakul, Amornrat Naranuntarat Jensen, Laran T. Jensen
Summary: Toxicity resulting from off-target effects of widely used organophosphate insecticides, chlorpyrifos and malathion, was investigated using yeast and nematode models. The study showed that these insecticides caused mitochondrial damage and dysfunction, induced the mitochondrial unfolded protein response pathway, and led to neurodegeneration in GABAergic neurons. Impaired movement was also observed in nematodes exposed to these insecticides, potentially due to motor neuron damage.
ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY
(2022)
Review
Nutrition & Dietetics
Rajendran Harishkumar, Sakshi Hans, Janelle E. Stanton, Andreas M. Grabrucker, Ronan Lordan, Ioannis Zabetakis
Summary: This review discusses the role of platelet-activating factor (PAF) and its receptor in inflammatory diseases and atherosclerotic cardiovascular diseases, with a focus on how inhibiting PAF-R can reduce cardiovascular disease risk. Research suggests that dietary factors may modulate PAF metabolism and PAF-R function to regulate disease development.
Article
Toxicology
SandeepReddy Kondakala, Lucie Henein, Erin McDevitt, Matthew K. Ross, George Eli Howell
Summary: This study found that the inhibition of non-cholinergic enzyme targets in the liver is more pronounced under steatotic conditions following exposure to chlorpyrifos (CPS). The results suggest that steatotic conditions may enhance the inhibitory effects of CPS on hepatic enzymes, which may be related to the alterations in hepatic lipid metabolism following OP exposures.
TOXICOLOGY IN VITRO
(2022)
Article
Chemistry, Applied
Jakkrit Suwannachat, Apichart Saenchoopa, Wonn Shweyi Thet Tun, Rina Patramanon, Sakda Daduang, Jureerat Daduang, Sirinan Kulchat
Summary: An enzymatic electrochemical biosensor was developed for the indirect detection of organophosphates by measuring the inhibition of acetylcholinesterase. The biosensor showed enhanced performance with the use of a copper nanowires/reduced graphene oxide composite on a screen-printed carbon electrode. This sensor is useful for reliable analysis of chlorpyrifos.
Article
Engineering, Environmental
Yuxue Liu, Tao Tang, Linson Lonappan, Shengmao Yang, Satinder Kaur Brar
Summary: In this study, laccase extracted from the fungus Trametes versicolor using apple pomace as culture medium was found to effectively degrade chlorpyrifos under acid conditions. The findings have important implications for the biodegradation of organophosphate pesticides and the practical application of laccase in remediating chlorpyrifos-contaminated soil and water.
JOURNAL OF WATER PROCESS ENGINEERING
(2023)
Article
Biochemistry & Molecular Biology
Haiyuan Teng, Yayun Zuo, Zeng Jin, Yidong Wu, Yihua Yang
Summary: High level resistance to chlorpyrifos has been found in the beet armyworm in China. The resistance is primarily due to insensitivity of the acetylcholinesterase in the beet armyworm. A specific amino acid substitution is tightly linked to this resistance. These findings provide a basis for resistance management in the beet armyworm population.
PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY
(2022)
Article
Genetics & Heredity
Vaishali Chakravarty, Libi Anandi, K. A. Ashiq, K. Abhijith, Rintu Umesh, Mayurika Lahiri
Summary: Lipid species have diverse biological functions based on structural differences, some of which interact with proteins as second messengers. The accumulation of phospholipid mediator PAF in the tumor microenvironment disrupts cellular homeostasis and increases metastatic potential.
FRONTIERS IN GENETICS
(2021)
Review
Biochemistry & Molecular Biology
Palgan Krzysztof, Tretyn Andrzej
Summary: Anaphylaxis is a life-threatening hypersensitivity reaction, often caused by drugs and food. Factors such as physical exercise, acute infections, drugs, alcohol, and menstruation can exacerbate the severity of the reaction. This review highlights the role of platelet-activating factor in the development of severe anaphylactic reactions, including anaphylactic shock.
Article
Allergy
Julia E. M. Upton, Jennifer A. Hoang, Matilde Leon-Ponte, Yaron Finkelstein, Yue (Jennifer) Du, Khosrow Adeli, Thomas Eiwegger, Eyal Grunebaum, Peter Vadas
Summary: This study found that decreased serum PAF-AH activity is a biomarker of severe anaphylaxis and levels of this enzyme do not change during acute anaphylaxis. The results suggest that PAF-AH may modulate susceptibility to severe anaphylaxis.