A Common Cancer Risk-Associated Allele in the hTERT Locus Encodes a Dominant Negative Inhibitor of Telomerase

Two-step mechanism involving active-site conformational changes regulates human telomerase DNA binding

(2015) Christopher G. Tomlinson et al.   BIOCHEMICAL JOURNAL

Prescribing splicing

(2015) R. Guigo et al.   SCIENCE

Inactive C-terminal telomerase reverse transcriptase insertion splicing variants are dominant-negative inhibitors of telomerase

(2014) Shusen Zhu et al.   BIOCHIMIE

Variants near TERT and TERC influencing telomere length are associated with high-grade glioma risk

(2014) Kyle M Walsh et al.   NATURE GENETICS

A Genome-Wide Association Study Identifies a Locus on TERT for Mean Telomere Length in Han Chinese

(2014) Yun Liu et al.   PLoS One

Microenvironmental Regulation of Telomerase Isoforms in Human Embryonic Stem Cells

(2014) Lida Radan et al.   STEM CELLS AND DEVELOPMENT

Alternative splicing regulation of telomerase: a new paradigm?

(2014) Mandy S. Wong et al.   TRENDS IN GENETICS

The Major Reverse Transcriptase-Incompetent Splice Variant of the Human Telomerase Protein Inhibits Telomerase Activity but Protects from Apoptosis

(2013) I. Listerman et al.   CANCER RESEARCH

Fine-mapping identifies multiple prostate cancer risk loci at 5p15, one of which associates with TERT expression

(2013) Zsofia Kote-Jarai et al.   HUMAN MOLECULAR GENETICS

A genome-wide association scan (GWAS) for mean telomere length within the COGS project: identified loci show little association with hormone-related cancer risk

(2013) Karen A. Pooley et al.   HUMAN MOLECULAR GENETICS

Telomeres and human health

(2013) S. E. Bojesen   JOURNAL OF INTERNAL MEDICINE

An Investigation of the Effects of the Core Protein Telomerase Reverse Transcriptase on Wnt Signaling in Breast Cancer Cells

(2013) I. Listerman et al.   MOLECULAR AND CELLULAR BIOLOGY

A genome-wide association study identifies multiple susceptibility loci for chronic lymphocytic leukemia

(2013) Helen E Speedy et al.   NATURE GENETICS

Genome-wide association study identifies multiple risk loci for chronic lymphocytic leukemia

(2013) Sonja I Berndt et al.   NATURE GENETICS

Multiple independent variants at the TERT locus are associated with telomere length and risks of breast and ovarian cancer

(2013) Stig E Bojesen et al.   NATURE GENETICS

Identification of seven loci affecting mean telomere length and their association with disease

(2013) Veryan Codd et al.   NATURE GENETICS

Structure of active dimeric human telomerase

(2013) Anselm Sauerwald et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Regulation of Telomerase Alternative Splicing: A Target for Chemotherapy

(2013) Mandy S. Wong et al.   Cell Reports

Enhanced isolation of fibroblasts from human skin explants

(2012) Lily Huschtscha et al.   BIOTECHNIQUES

TERT polymorphisms modify the risk of acute lymphoblastic leukemia in Chinese children

(2012) Xiaojing Sheng et al.   CARCINOGENESIS

Telomerase Reverse Transcriptase Locus Polymorphisms and Cancer Risk: A Field Synopsis and Meta-Analysis

(2012) Simone Mocellin et al.   JNCI-Journal of the National Cancer Institute

Alternatively Spliced Telomerase Reverse Transcriptase Variants Lacking Telomerase Activity Stimulate Cell Proliferation

(2012) R. Hrdlickova et al.   MOLECULAR AND CELLULAR BIOLOGY

The telomere syndromes

(2012) Mary Armanios et al.   NATURE REVIEWS GENETICS

Five dysfunctional telomeres predict onset of senescence in human cells

(2011) Zeenia Kaul et al.   EMBO REPORTS

Efficientin VivoManipulation of Alternative Pre-mRNA Splicing Events Using Antisense Morpholinos in Mice

(2010) Marilyn K. Parra et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Direct involvement of the TEN domain at the active site of human telomerase

(2010) Julie Jurczyluk et al.   NUCLEIC ACIDS RESEARCH

Cancer in dyskeratosis congenita

(2009) B. P. Alter et al.   BLOOD

Control of telomere length by a trimming mechanism that involves generation of t-circles

(2009) Hilda A Pickett et al.   EMBO JOURNAL

Telomerase modulates Wnt signalling by association with target gene chromatin

(2009) Jae-Il Park et al.   NATURE

An RNA-dependent RNA polymerase formed by TERT and the RMRP RNA

(2009) Yoshiko Maida et al.   NATURE

Sequence variants at the TERT-CLPTM1L locus associate with many cancer types

(2009) Thorunn Rafnar et al.   NATURE GENETICS

Spontaneous occurrence of telomeric DNA damage response in the absence of chromosome fusions

(2009) Anthony J Cesare et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

How Shelterin Protects Mammalian Telomeres

(2008) Wilhelm Palm et al.   Annual Review of Genetics

A sensitive direct human telomerase activity assay

(2008) Scott B Cohen et al.   NATURE METHODS