Antisense Oligonucleotide Therapies

Preclinical Evaluation of the Toxicological Effects of a Novel Constrained Ethyl Modified Antisense Compound Targeting Signal Transducer and Activator of Transcription 3 in Mice and Cynomolgus Monkeys

(2015) Sebastien A. Burel et al.   Nucleic Acid Therapeutics

Sequence motifs associated with hepatotoxicity of locked nucleic acid—modified antisense oligonucleotides

(2014) Andrew D. Burdick et al.   NUCLEIC ACIDS RESEARCH

Targeted delivery of antisense oligonucleotides to hepatocytes using triantennaryN-acetyl galactosamine improves potency 10-fold in mice

(2014) Thazha P. Prakash et al.   NUCLEIC ACIDS RESEARCH

Acute Kidney Injury During Therapy With an Antisense Oligonucleotide Directed Against PCSK9

(2013) Eveline P. van Poelgeest et al.   AMERICAN JOURNAL OF KIDNEY DISEASES

Complex formation with nucleic acids and aptamers alters the antigenic properties of platelet factor 4

(2013) M. E. Jaax et al.   BLOOD

Species-specific Inflammatory Responses as a Primary Component for the Development of Glomerular Lesions in Mice and Monkeys Following Chronic Administration of a Second-generation Antisense Oligonucleotide

(2013) Kendall S. Frazier et al.   TOXICOLOGIC PATHOLOGY

Comparison of Hepatic Transcription Profiles of Locked Ribonucleic Acid Antisense Oligonucleotides: Evidence of Distinct Pathways Contributing to Non-target Mediated Toxicity in Mice

(2013) Satoko Kakiuchi-Kiyota et al.   TOXICOLOGICAL SCIENCES

Hepatotoxic Potential of Therapeutic Oligonucleotides Can Be Predicted from Their Sequence and Modification Pattern

(2013) Peter H. Hagedorn et al.   Nucleic Acid Therapeutics

Assessing unintended hybridization-induced biological effects of oligonucleotides

(2012) Morten Lindow et al.   NATURE BIOTECHNOLOGY

Proliferative and Nonproliferative Lesions of the Rat and Mouse Urinary System

(2012) Kendall S. Frazier et al.   TOXICOLOGIC PATHOLOGY

Peptide-mediated Cell and In Vivo Delivery of Antisense Oligonucleotides and siRNA

(2012) Peter Järver et al.   Molecular Therapy-Nucleic Acids

Silencing of microRNA families by seed-targeting tiny LNAs

(2011) Susanna Obad et al.   NATURE GENETICS

Association of Long-term Administration of the Survivin mRNA-Targeted Antisense Oligonucleotide LY2181308 With Reversible Kidney Injury in a Patient With Metastatic Melanoma

(2010) William G. Herrington et al.   AMERICAN JOURNAL OF KIDNEY DISEASES

Targeted nanoparticles enhanced flow electroporation of antisense oligonucleotides in leukemia cells

(2010) Shengnian Wang et al.   BIOSENSORS & BIOELECTRONICS

Newly identified CpG ODNs, M5-30 and M6-395, stimulate mouse immune cells to secrete TNF-α and enhance Th1-mediated immunity

(2010) Sun-Shim Choi et al.   JOURNAL OF MICROBIOLOGY

Targeted Delivery of RNAi Therapeutics With Endogenous and Exogenous Ligand-Based Mechanisms

(2010) Akin Akinc et al.   MOLECULAR THERAPY

Topical Application of Antisense Oligonucleotide-Loaded Chitosan Nanoparticles to Rats

(2010) Suna Özbaş-Turan et al.   OLIGONUCLEOTIDES

Crosstalk pathways between Toll-like receptors and the complement system

(2010) George Hajishengallis et al.   TRENDS IN IMMUNOLOGY

Stimulation of the Immune System by Therapeutic Antisense Oligodeoxynucleotides and Small Interfering RNAs via Nucleic Acid Receptors

(2009) Denise Richardt-Pargmann et al.   Annals of the New York Academy of Sciences

CpG-ODNs induces up-regulated expression of chemokine CCL9 in mouse macrophages and microglia

(2009) C. Ravindran et al.   CELLULAR IMMUNOLOGY

Peptide-conjugated antisense oligonucleotides for targeted inhibition of a transcriptional regulator in vivo

(2008) Erik Henke et al.   NATURE BIOTECHNOLOGY

Therapeutic RNAi targeting PCSK9 acutely lowers plasma cholesterol in rodents and LDL cholesterol in nonhuman primates

(2008) M. Frank-Kamenetsky et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA