The siRNA Non-seed Region and Its Target Sequences Are Auxiliary Determinants of Off-Target Effects

A Dynamic Search Process Underlies MicroRNA Targeting

(2015) Stanley D. Chandradoss et al.   CELL

Interactions between the non-seed region of siRNA and RNA-binding RLC/RISC proteins, Ago and TRBP, in mammalian cells

(2014) Tomoko Takahashi et al.   NUCLEIC ACIDS RESEARCH

Specific inhibition of diverse pathogens in human cells by synthetic microRNA-like oligonucleotides inferred from RNAi screens

(2014) A. Franceschini et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural basis for microRNA targeting

(2014) N. T. Schirle et al.   SCIENCE

Mapping the Human miRNA Interactome by CLASH Reveals Frequent Noncanonical Binding

(2013) Aleksandra Helwak et al.   CELL

miRTarBase update 2014: an information resource for experimentally validated miRNA-target interactions

(2013) Sheng-Da Hsu et al.   NUCLEIC ACIDS RESEARCH

Transcriptome-wide miR-155 Binding Map Reveals Widespread Noncanonical MicroRNA Targeting

(2012) Gabriel B. Loeb et al.   MOLECULAR CELL

Ensembl 2013

(2012) Paul Flicek et al.   NUCLEIC ACIDS RESEARCH

The Crystal Structure of Human Argonaute2

(2012) N. T. Schirle et al.   SCIENCE

Thermodynamic Control of Small RNA-Mediated Gene Silencing

(2012) Kumiko Ui-Tei et al.   Frontiers in Genetics

siRNA Off-Target Effects Can Be Reduced at Concentrations That Match Their Individual Potency

(2011) Daniel R. Caffrey et al.   PLoS One

Structural insights into RNA interference

(2010) Dipali G. Sashital et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Structural basis for 5′-nucleotide base-specific recognition of guide RNA by human AGO2

(2010) Filipp Frank et al.   NATURE

Recognizing and avoiding siRNA off-target effects for target identification and therapeutic application

(2009) Aimee L. Jackson et al.   NATURE REVIEWS DRUG DISCOVERY

Structural determinants of miRNAs for RISC loading and slicer-independent unwinding

(2009) Tomoko Kawamata et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Structure of the guide-strand-containing argonaute silencing complex

(2008) Yanli Wang et al.   NATURE

Thermodynamic stability and Watson–Crick base pairing in the seed duplex are major determinants of the efficiency of the siRNA-based off-target effect

(2008) Kumiko Ui-Tei et al.   NUCLEIC ACIDS RESEARCH

Argonaute proteins: key players in RNA silencing

(2007) Gyorgy Hutvagner et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY