Article
Rheumatology
Alexandra Kachaner, Elisabeth Berge, Frederic Desmoulins, Christine Le Pajolec, Antoine Rousseau, Marc Labetoulle, Gaetane Nocturne, Xavier Mariette, Raphaele Seror
Summary: This study describes primary Sjogren's disease patients who do not have or have a low level of dryness, and compares them with Sjogren's disease patients who have oral or ocular dryness features.
Article
Rheumatology
Sherri Longobardi, Charmaine Lopez-Davis, Bhuwan Khatri, Constantin Georgescu, Cherilyn Pritchett-Frazee, Christina Lawrence, Astrid Rasmussen, Lida Radfar, Robert Hal Scofield, Alan N. Baer, Susan A. Robinson, Erika Darrah, Robert C. Axtell, Gabriel Pardo, Jonathan D. Wren, Kristi A. Koelsch, Joel M. Guthridge, Judith A. James, Christopher J. Lessard, Amy Darise Farris
Summary: This study identified autoantibodies in anti-Ro/SS-A negative primary Sjogren's syndrome (SS), providing a new approach for diagnosing Ro-negative SS.
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Article
Rheumatology
Manuel Ramos-Casals, Nihan Acar-Denizli, Arjan Vissink, Pilar Brito-Zeron, Xiaomei Li, Francesco Carubbi, Roberta Priori, Natasa Toplak, Chiara Baldini, Enrique Faugier-Fuentes, Aike A. Kruize, Thomas Mandl, Minako Tomiita, Saviana Gandolfo, Kunio Hashimoto, Gabriela Hernandez-Molina, Benedikt Hofauer, Samara Mendieta-Zeron, Astrid Rasmussen, Pulukool Sandhya, Damien Sene, Virginia Fernandes Moca Trevisani, David Isenberg, Erik Sundberg, Sandra G. Pasoto, Agata Sebastian, Yasunori Suzuki, Soledad Retamozo, Bei Xu, Roberto Giacomelli, Angelica Gattamelata, Masa Bizjak, Stefano Bombardieri, Richard-Eduardo Loor-Chavez, Anneline Hinrichs, Peter Olsson, Hendrika Bootsma, Scott M. Lieberman
Summary: Childhood-onset primary Sjogren's syndrome is characterized by sicca features, parotid enlargement, and systemic disease, with age at diagnosis influencing the phenotypic expression of the disease. Symptom presentation includes dry mouth, dry eyes, positive ANA, anti-Ro/La antibodies, and positive RF, among others.
Article
Rheumatology
Katrine Braekke Norheim, Juliana Imgenberg-Kreuz, Andrei Alexsson, Svein Joar Auglaend Johnsen, Kjetil Bardsen, Johan Gorgas Brun, Rezvan Kiani Dehkordi, Elke Theander, Thomas Mandl, Roland Jonsson, Wan-Fai Ng, Christopher J. Lessard, Astrid Rasmussen, Kathy Sivilis, Lars Ronnblom, Roald Omdal
Summary: Genetic variations at the RTP4/MASP1 locus are associated with fatigue in Scandinavian patients with pSS, indicating a potential genetic influence on fatigue in pSS.
Article
Immunology
Giacomo Cafaro, Carlo Perricone, Francesco Carubbi, Chiara Baldini, Luca Quartuccio, Roberta Priori, Onorina Berardicurti, Francesco Ferro, Saviana Gandolfo, Angelica Gattamelata, Roberto Giacomelli, Salvatore De Vita, Roberto Gerli, Elena Bartoloni
Summary: The prevalence of PNS involvement in pSS is relatively rare but prognostically relevant. Patients with SMP exhibit main adverse prognostic features, while those with pure sensory neuropathies typically have a milder clinical picture.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Rheumatology
Valentina Pucino, Jason D. Turner, Saba Nayar, Florian Kollert, Saaeha Rauz, Andrea Richards, Jon Higham, Ana Poveda-Gallego, Simon J. Bowman, Francesca Barone, Benjamin A. Fisher
Summary: This study aimed to compare clinical and proteomic predictors of primary Sjogren's syndrome (SjS) and non-SjS sicca syndrome (sicca), and identify the key predictors of symptoms. The results showed that obesity-related metabolic factors may regulate symptoms in sicca, while further research is needed to explore the non-inflammatory drivers of high symptom burden in SjS.
Article
Rheumatology
Qing Zheng, Lingyu Liu, Bin Wang, Yan He, Mengqin Zhang, Guixiu Shi
Summary: The key pathogenic pathway in primary Sjogren's syndrome (SjS) is the activation of the interferon (IFN) pathway, which was identified through bioinformatics analysis. The phosphorylated signal transducer and activator of transcription proteins 1 (p-STAT1) was found to be a valuable biomarker for diagnosing SjS, particularly in salivary gland samples with negative lymphatic foci.
Article
Biochemistry & Molecular Biology
Jose Antonio Garcia-Espinoza, Jose Francisco Munoz-Valle, Mariel Garcia-Chagollan, Jorge Hernandez-Bello, Claudia Azucena Palafox-Sanchez, Erika Fabiola Lopez-Villalobos, Gabriela Athziri Sanchez-Zuno, Gloria Esther Martinez-Bonilla, Sergio Cerpa-Cruz, Francisco Josue Carrillo-Ballesteros, Edith Oregon-Romero
Summary: This study found that the IVS1 + 173 polymorphism of the ICOS gene is not a genetic marker for the development of pSS, while the c.1624 C>T polymorphism is associated with a reduced risk. Additionally, increased membranal-ICOS expression was observed in pSS patients with high lymphocytic infiltration. These findings suggest that ICOS may play an important role in the pathogenesis of pSS and should be further studied as a possible disease marker in T cell subsets of pSS patients.
CURRENT ISSUES IN MOLECULAR BIOLOGY
(2022)
Article
Rheumatology
Ivan Giovannini, Michele Lorenzon, Valeria Manfre, Sara Zandonella Callegher, Enrico Pegolo, Chiara Zuiani, Rossano Girometti, Alojzija Hocevar, Christian Dejaco, Quartuccio Luca, Salvatore De Vita, Alen Zabotti
Summary: This study evaluated the safety, patient tolerance, and diagnostic accuracy of US-guided CNB in managing salivary gland enlargement among pSS patients. The results showed that the procedure was safe, well-tolerated by patients, and had no long-term complications.
Article
Rheumatology
S. H. Kim, H. K. Min, S. -H. Lee, K. -A. Lee, H. -R. Kim
Summary: This study aimed to differentiate primary Sjogren's syndrome (pSS) from idiopathic sicca syndrome by examining the ultrasonographic findings of lacrimal glands. A semi-quantitative scoring system for lacrimal gland ultrasonography (LGUS) was established for diagnosing pSS. The study found that patients with pSS had higher proportions of intraglandular branch of lacrimal artery, inhomogeneity, and hyperechoic bands compared to patients with idiopathic sicca syndrome. The combination of intraglandular branch of lacrimal artery and inhomogeneity was the most suitable criteria for classifying pSS using LGUS.
CLINICAL AND EXPERIMENTAL RHEUMATOLOGY
(2022)
Article
Immunology
Tian Sun, Shanshan Liu, Guangxia Yang, Rujie Zhu, Zutong Li, Genhong Yao, Hongwei Chen, Lingyun Sun
Summary: This study investigates the role of the inhibitory receptor Tim-3 in Sjogren's syndrome (SS) and mesenchymal stem cell (MSC) treatment. The results show that Tim-3 is downregulated in T cells of SS patients and mice, and MSC transplantation can ameliorate SS-like symptoms and pathological changes by modulating Tim-3 expression. Tim-3 is also crucial for the inhibitory effect of MSCs on PBMC proliferation. These findings provide a novel mechanism of MSC treatment and suggest a potential combination therapy for SS targeting the inhibitory receptor.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Rheumatology
Viktoria Fana, U. M. Dohn, Simon Krabbe, L. Terslev
Summary: This study demonstrated the effectiveness of the OMERACT Ultrasound Scoring System in evaluating salivary gland involvement in patients suspected of Sjogren's syndrome, with good sensitivity and excellent specificity for diagnosing primary SS and fulfilling the 2016 ACR/EULAR criteria. The findings support the use of ultrasound in diagnosing pSS and endorse the incorporation of ultrasound in the classification criteria.
Article
Geriatrics & Gerontology
Nan Duan, Zhiyan Li, Yong Fan, Yaping Jiang, Haixia Li
Summary: This study investigated the clinical data and laboratory markers associated with renal function damage or renal involvement in pSS patients. The results showed that age, urea, chlorine, and anti-SSA were highly associated with renal injury in pSS. Early screening for autoantibodies would be meaningful for evaluation and prevention of renal injury in pSS.
Article
Immunology
Tian-Ping Zhang, Jing Dou, Li Wang, Shan Wang, Ping Wang, Xiao-Hui Zhou, Chun-Mei Yang, Xiao-Mei Li
Summary: Exposure to PM2.5 and PM10 is significantly associated with an elevated risk of hospitalizations for Sjogren's syndrome (SS). Female patients and those aged 65 and above are more susceptible to the effects of PM2.5 and PM10. Exposure to PM2.5 and PM10 in colder seasons also increases the risk of SS-related hospitalizations.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Rheumatology
Kerry Gairy, Claudia Knight, Papa Anthony, Ben Hoskin
Summary: This study described the classification and clustering of patients with primary SS and systemic organ involvement in routine practice. It identified the heterogeneity of patients with pSS through cluster analysis and highlighted the importance of pain, fatigue, and organ involvement in determining disease burden. The study revealed five clusters based on key clinical characteristics, with a minority of patients showing multiple organ involvement and the highest frequency of pain and fatigue.
Review
Allergy
Ji-Qing Chen, Peter Szodoray, Margit Zeher
CLINICAL REVIEWS IN ALLERGY & IMMUNOLOGY
(2016)
Article
Immunology
Aniko Rentka, Jolan Harsfalvi, Gabriella Szucs, Zoltan Szekanecz, Peter Szodoray, Krisztina Koroskenyi, Adam Kemeny-Beke
IMMUNOLOGIC RESEARCH
(2016)
Review
Immunology
Ji-Qing Chen, Gabor Papp, Peter Szodoray, Margit Zeher
AUTOIMMUNITY REVIEWS
(2016)
Article
Allergy
Peter Szodoray, Stephanie M. Stanford, Oyvind Molberg, Ludvig A. Munthe, Nunzio Bottini, Britt Nakken
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2016)
Article
Immunology
Melinda Zsuzsanna Szabo, Peter Szodoray, Emese Kiss
IMMUNOLOGIC RESEARCH
(2017)
Article
Immunology
Britt Nakken, Gabor Papp, Vidar Bosnes, Zeher Margit, Nagy Gyorgy, Peter Szodoray
IMMUNOLOGY LETTERS
(2017)
Article
Rheumatology
Aniko Rentka, Annamaria Nagy, Jolan Harsfalvi, Gabriella Szucs, Zoltan Szekanecz, Rudolf Gesztelyi, Peter Szodoray, Adam Kemeny-Beke
RHEUMATOLOGY INTERNATIONAL
(2017)
Review
Medical Laboratory Technology
Aniko Rentka, Krisztina Koroskenyi, Jolan Harsfalvi, Zoltan Szekanecz, Gabriella Szucs, Peter Szodoray, Adam Kemeny-Beke
ANNALS OF CLINICAL BIOCHEMISTRY
(2017)
Article
Rheumatology
A. Dioszegi, T. Tarr, M. Nagy-Vincze, M. Nanasy-Vass, R. Veisz, L. Bidiga, B. Dezso, J. Balla, P. Szodoray, Z. Szekanecz, P. Soltesz
Article
Ophthalmology
Annamaria Nagy, Aniko Rentka, Gabor Nemeth, Hassan Ziad, Gabriella Szucs, Zoltan Szekanecz, Rudolf Gesztelyi, Judit Zsuga, Zsuzsa Aszalos, Peter Szodoray, Adam Kemeny-Beke
OCULAR IMMUNOLOGY AND INFLAMMATION
(2019)
Article
Multidisciplinary Sciences
Ji-Qing Chen, Gabor Papp, Szilard Poliska, Krisztina Szabo, Tunde Tarr, Balint Laszlo Balint, Peter Szodoray, Margit Zeher
Article
Ophthalmology
Zoltan Griger, Katalin Danko, Levente Bodoki, Zsuzsa Aszalos, Gabor Nemeth, Hassan Ziad, Rudolf Gesztelyi, Judit Zsuga, Peter Szodoray, Adam Kemeny-Beke
OCULAR IMMUNOLOGY AND INFLAMMATION
(2020)
Article
Biotechnology & Applied Microbiology
Katalin Szabo, Levente Bodoki, Melinda Nagy-Vincze, Anett Vincze, Erika Zilahi, Peter Szodoray, Katalin Danko, Zoltan Griger
BIOMED RESEARCH INTERNATIONAL
(2018)
Review
Immunology
Margit Zeher, Gabor Papp, Britt Nakken, Peter Szodoray
AUTOIMMUNITY REVIEWS
(2017)
Review
Immunology
Gabor Papp, Peter Boros, Britt Nakken, Peter Szodoray, Margit Zeher
AUTOIMMUNITY REVIEWS
(2017)