Review
Medicine, General & Internal
Jiaxi Liu, Jinfang Gao, Zewen Wu, Liangyu Mi, Na Li, Yajing Wang, Xinyue Peng, Ke Xu, Fengping Wu, Liyun Zhang
Summary: ACPAs are autoantibodies commonly found in patients with RA, with most of the mechanisms of formation and bone destruction well-understood. Despite advances in clinical applications and targeted therapies related to ACPAs, the presence of different subtypes poses a limitation.
FRONTIERS IN MEDICINE
(2022)
Article
Rheumatology
Laura C. Cappelli, Clifton O. Bingham, Patrick M. Forde, Valsamo Anagnostou, Julie Brahmer, Evan J. Lipson, Jennifer Mammen, Megan Schollenberger, Ami A. Shah, Erika Darrah
Summary: Anti-RA33 antibodies are present in a subset of patients with ICI-induced IA, but absent in other patients treated with immune checkpoint inhibitors. Anti-RA33 antibodies may be a biomarker for developing inflammatory arthritis.
Article
Rheumatology
Nienke Oskam, Pleuni Ooijevaar-De Heer, Dorien Kos, Jorn Jeremiasse, Laurette van Boheemen, Gwenny M. Verstappen, Frans G. M. Kroese, Dirkjan van Schaardenburg, Gertjan Wolbink, Theo Rispens
Summary: This study identified specific epitopes associated with rheumatoid arthritis and healthy individuals. The study also found that IgM-RFs have the ability to activate complement or inhibit IgG-mediated complement activation, depending on the epitopes they bind to. These results demonstrate the need to redefine 'RF' into pathological and physiological autoantibody subtypes.
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Article
Immunology
Karen Yu, Luna Dillemans, Mieke Gouwy, Helena Bessa, Mieke Metzemaekers, Erik Martens, Patrick Matthys, Xavier Bossuyt, Patrick Verschueren, Carine Wouters, Lien De Somer, Paul Proost
Summary: In this study, a fluorescent in vitro assay was improved to characterize endogenous PAD activity in complex samples. The results showed similar levels of PAD activity in synovial fluids of rheumatoid arthritis (RA) and juvenile idiopathic arthritis (JIA) patients, while citrullination was limited in joints of patients with gout or Lyme's disease. Interestingly, a higher level of extracellular citrullination was only found in blood of anti-CCP-positive RA patients.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Cell Biology
Brianna Hurysz, Nunzio Bottini
Summary: Rheumatoid arthritis (RA) is a common autoimmune disease associated with dysregulation of proteoglycans. Modulating the function and signaling of proteoglycans, as well as targeting citrullinated aggrecan with tolerizing agents, may provide a potential approach to improve current RA therapy.
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
(2022)
Article
Rheumatology
Achilleas Floudas, Conor M. Smith, Orla Tynan, Nuno Neto, Vinod Krishna, Sarah M. Wade, Megan Hanlon, Clare Cunningham, Viviana Marzaioli, Mary Canavan, Jean M. Fletcher, Ronan H. Mullan, Suzanne Cole, Ling-Yang Hao, Michael G. Monaghan, Sunil Nagpal, Douglas J. Veale, Ursula Fearon
Summary: This study provides a global transcriptomic analysis of the synovial joints in rheumatoid arthritis (RA) and psoriatic arthritis (PsA), revealing the immune-stromal cell interactions in synovial inflammation. The findings highlight the differential transcription profiles and interactions between cell subsets in RA and PsA, suggesting potential targets for targeted therapeutic intervention in these diseases.
ANNALS OF THE RHEUMATIC DISEASES
(2022)
Review
Immunology
Johan Ronnelid, Carl Turesson, Alf Kastbom
Summary: Measurement of autoantibodies like RF and ACPA is crucial in the diagnosis and treatment of RA, but lack of harmonization between different commercial tests poses a challenge. It is recommended that all RF and ACPA tests should have a diagnostic specificity of 98-99%, and the introduction of test result-specific likelihood ratios can provide more precise information for clinical decision-making. Detection of autoantibodies can also be used to predict future arthritis development and prognosis in at-risk patients.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Biochemical Research Methods
Carina Villacres, Victor Spicer, Oleg Krokhin
Summary: The study investigated the chromatographic behavior of peptides with citrulline and homocitrulline residues in LC-MS experiments, with the goal of differentiating between different modifications based on retention data. Various separation modes were tested, with SCX demonstrating the most differentiating power due to its ability to amplify the effect of charge loss upon citrullination. The study aimed to improve the confidence of MS-based identifications by understanding the chromatographic conditions for arginine citrullination and asparagine deamidation.
JOURNAL OF PROTEOME RESEARCH
(2021)
Article
Immunology
Maya F. Amjadi, Maxwell H. Parker, Ryan R. Adyniec, Zihao Zheng, Alex M. Robbins, S. Janna Bashar, Michael F. Denny, Sara S. Mccoy, Irene M. Ong, Miriam A. Shelef
Summary: Rheumatoid factors (RFs) are polyreactive antibodies that can bind disease-specific epitopes. Recent studies have found that RFs in COVID-19 can bind novel IgG epitopes, which provides new insights into the mechanism of RFs.
JOURNAL OF AUTOIMMUNITY
(2024)
Review
Biochemistry & Molecular Biology
Tsvetelina Batsalova, Balik Dzhambazov
Summary: Collagen type II (COL2) is significantly affected by autoimmune responses in rheumatoid arthritis (RA), and posttranslational modifications (PTMs) of COL2 have been implicated in RA autoimmunity. The discovery of anti-citrullinated protein response in RA has led to improved diagnostic assays and classification criteria for the disease. Immunological tolerance induced by modified COL2 peptides is considered as a potential strategy for RA therapy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Rheumatology
Francesca Motta, Nicola Bizzaro, Davide Giavarina, Franco Franceschini, Maria Infantino, Boaz Palterer, Gian Domenico Sebastiani, Carlo Selmi
Summary: This study analyzed the role of rheumatoid factor (RF) isotypes in the diagnosis and prognosis of rheumatoid arthritis (RA). The results showed that testing all RF isotypes with latex test or nephelometry provides the highest sensitivity, while determination of IgA isotype provides the highest specificity and positive likelihood ratio. However, RF isotypes do not provide relevant prognostic information due to limited and conflicting data.
Review
Environmental Sciences
Wanitcha Gumtorntip, Nuntana Kasitanon, Worawit Louthrenoo, Nipon Chattipakorn, Siriporn C. Chattipakorn
Summary: This review summarizes and discusses the association between air pollutants and the development or aggravation of rheumatoid arthritis (RA). The findings suggest that air pollutants can stimulate immunological processes and inflammatory mediators and autoantibodies productions. Furthermore, air pollutants can induce and aggravate RA disease activity. However, discrepancies in the results highlight the need for future studies to elucidate these mechanisms and identify reliable biomarkers for individual susceptibility and disease activity assessment.
ENVIRONMENTAL POLLUTION
(2023)
Article
Nutrition & Dietetics
Kayo Masuko
Summary: Glucose metabolism may be altered in rheumatoid arthritis and other autoimmune diseases, impacting the pathophysiology of these diseases. Research on glucose and its metabolism contributes to a better understanding of the role of carbohydrates in the occurrence and duration of these diseases.
Article
Immunology
Nozima Aripova, Michael J. Duryee, Bryant R. England, Carlos D. Hunter, Jack E. Mordeson, Evan M. Ryan, Eric C. Daubach, Debra J. Romberger, Geoffrey M. Thiele, Ted R. Mikuls
Summary: The purpose of this study was to evaluate the downstream effects of macrophage released soluble mediators, following stimulation with modified fibrinogen antigens, on human fibroblast-like synoviocytes. The results showed that the released PDGF-BB from macrophages can induce fibroblast activation and promote an aggressive phenotype. The effects were most pronounced with dually modified fibrinogen.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Medicine, General & Internal
Gabriel D. Roman-Melendez, Daniel R. Monaco, Janelle M. Montagne, Rachel S. Quizon, Maximilian F. Konig, Mekbib Astatke, Erika Darrah, H. Benjamin Larman
Summary: The study successfully utilized phage display technology to profile antibody reactivities in rheumatoid arthritis patients and quantify differences among patients, identifying specific antibody profiles. This provides a powerful tool for research on autoimmune diseases.
Review
Immunology
Cristina Belizna, Ljudmila Stojanovich, Jan Willem Cohen-Tervaert, Celine Fassot, Daniel Henrion, Laurent Loufrani, Gyorgy Nagy, Christian Muchardt, Milena Hasan, Marie Noelle Ungeheuer, Laurent Arnaud, Jaume Alijotas-Reig, Enrique Esteve-Valverde, Ferdinando Nicoletti, Patrick Saulnier, Alban Godon, Pascal Reynier, Jean Marie Chretien, Laura Damian, Loukman Omarjee, Guillaume Mahe, Marc Antoine Pistorius, Pier Luigi Meroni, Katrien Devreese
AUTOIMMUNITY REVIEWS
(2018)
Review
Rheumatology
Gyorgy Nagy, Nora Nemeth, Edit I. Buzas
CURRENT OPINION IN RHEUMATOLOGY
(2018)
Article
Biochemistry & Molecular Biology
Eszter Szarka, Petra Aradi, Krisztina Huber, Judit Pozsgay, Lili Vegh, Anna Magyar, Gergo Gyulai, Gyorgy Nagy, Bernadette Rojkovich, Eva Kiss, Ferenc Hudecz, Gabriella Sarmay
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2018)
Article
Rheumatology
A. Dioszegi, T. Tarr, M. Nagy-Vincze, M. Nanasy-Vass, R. Veisz, L. Bidiga, B. Dezso, J. Balla, P. Szodoray, Z. Szekanecz, P. Soltesz
Article
Ophthalmology
Annamaria Nagy, Aniko Rentka, Gabor Nemeth, Hassan Ziad, Gabriella Szucs, Zoltan Szekanecz, Rudolf Gesztelyi, Judit Zsuga, Zsuzsa Aszalos, Peter Szodoray, Adam Kemeny-Beke
OCULAR IMMUNOLOGY AND INFLAMMATION
(2019)
Article
Immunology
Eszter Baricza, Nikolett Marton, Panna Kiralyhidi, Orsolya Tuende Kovacs, Ilona Kovacsne Szekely, Eszter Lajko, Laszo Kohidai, Bernadett Rojkovich, Barbara Ersek, Edit Iren Buzas, Gyoergy Nagy
FRONTIERS IN IMMUNOLOGY
(2018)
Article
Rheumatology
Nadia M. T. Roodenrijs, Maria J. H. de Hair, Marlies C. van der Goes, Johannes W. G. Jacobs, Paco M. J. Welsing, Desiree van der Heijde, Daniel Aletaha, Maxime Dougados, Kimme L. Hyrich, Iain B. McInnes, Ulf Mueller-Ladner, Ladislav Senolt, Zoltan Szekanecz, Jacob M. van Laar, Gyorgy Nagy
ANNALS OF THE RHEUMATIC DISEASES
(2018)
Review
Immunology
Cristina Belizna, Francesca Pregnolato, Sebastien Abad, Jaume Alijotas-Reig, Howard Amital, Zahir Amoura, Laura Andreoli, Emmanuel Andres, Achile Aouba, Sule Apras Bilgen, Laurent Arnaud, Boris Bienvenu, Viktoria Bitsadze, Patrick Blanco, Miri Blank, Maria Orietta Borghi, Antonia Caligaro, Elisabeta Candrea, Valentina Canti, Laurent Chiche, Jean Marie Chretien, Jan Willem Cohen Tervaert, Laura Damian, Teresa Delross, Emmanuelle Dernis, Katrien Devreese, Aleksandra Djokovic, Enrique Esteve-Valverde, Maria Favaro, Celine Fassot, Raquel Ferrer-Oliveras, Alban Godon, Mohamed Hamidou, Milena Hasan, Daniel Henrion, Bernard Imbert, Pierre Yves Jeandel, Pascale Jeannin, Patrick Jego, Noemie Jourde-Chiche, Jamilya Khizroeva, Olivier Lambotte, Cedric Landron, Jose Omar Latino, Estibaliz Lazaro, Karina de Leeuw, Thomas Le Gallou, Levent Kilic, Maarten Limper, Laurent Loufrani, Romain Lubin, Nadine Magy-Bertrand, Guillaume Mahe, Alexander Makatsariya, Thierry Martin, Christian Muchardt, Gyorgy Nagy, Loukman Omarjee, Pieter Van Paasen, Gilles Pernod, Florence Perrinet, Gilberto Pires Rosa, Marc Antoine Pistorius, Amelia Ruffatti, Fatma Said, Patrick Saulnier, Damien Sene, Loic Sentilhes, Ova Shovman, Jean Sibilia, Crina Sinescu, Natasa Stanisavljevic, Ljudmila Stojanovich, Lai Shan Tam, Angela Tincani, Frederic Tollis, Sebastian Udry, Marie Noelle Ungeheuer, Mathilde Versini, Ricard Cervera, Pier Luigi Meroni
AUTOIMMUNITY REVIEWS
(2018)
Article
Ophthalmology
Zoltan Griger, Katalin Danko, Levente Bodoki, Zsuzsa Aszalos, Gabor Nemeth, Hassan Ziad, Rudolf Gesztelyi, Judit Zsuga, Peter Szodoray, Adam Kemeny-Beke
OCULAR IMMUNOLOGY AND INFLAMMATION
(2020)
Article
Biotechnology & Applied Microbiology
Katalin Szabo, Levente Bodoki, Melinda Nagy-Vincze, Anett Vincze, Erika Zilahi, Peter Szodoray, Katalin Danko, Zoltan Griger
BIOMED RESEARCH INTERNATIONAL
(2018)
Meeting Abstract
Rheumatology
Zsolt Karoly Mangel, Gyorgy Nagy, Margit Szentesi
ANNALS OF THE RHEUMATIC DISEASES
(2019)
Meeting Abstract
Rheumatology
P. Kiralyhidi, E. S. Molnar, E. J. Baricza, N. Marton, E. Buzas, G. Nagy
ANNALS OF THE RHEUMATIC DISEASES
(2019)
Meeting Abstract
Rheumatology
N. M. T. Roodenrijs, M. J. H. de Hair, J. W. G. Jacobs, P. M. J. Welsing, D. M. F. M. van der Heijde, J. M. van Laar, G. Nagy
ANNALS OF THE RHEUMATIC DISEASES
(2018)
Meeting Abstract
Rheumatology
M. Kedves, J. Gal, K. Torocsik, D. Balaton, J. Csitos, N. Megyes, G. Nagy
ANNALS OF THE RHEUMATIC DISEASES
(2018)
Meeting Abstract
Rheumatology
E. Baricza, N. Marton, P. Kiralyhidi, O. T. Kovacs, I. K. Szekely, E. Lajko, L. Kohidai, B. Rojkovich, E. Barbara, E. I. Buzas, G. Nagy
ANNALS OF THE RHEUMATIC DISEASES
(2018)