Review
Biochemistry & Molecular Biology
Maria Amparo Blanch-Ruiz, Raquel Ortega-Luna, Maria Angeles Martinez-Cuesta, Angeles Alvarez
Summary: Cardiovascular diseases are a leading cause of death, with blood-cell interactions and endothelial dysfunction playing a key role in thrombus formation. Neutrophil extracellular vesicles (EVs) and neutrophil extracellular traps (NETs) have been reported to contribute to thrombosis through various mechanisms, requiring exhaustive analysis of their structure and composition to clarify their role in pathological thrombus formation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Hematology
Jun Yong, Simon T. Abrams, Guozheng Wang, Cheng-Hock Toh
Summary: The cell-based model of coagulation has advanced our understanding of clinical hemostasis and thrombosis, allowing for the development of new treatments. Recent evidence has highlighted the procoagulant properties of extracellular histones, which can contribute to both adverse coagulation outcomes and physiological clot formation. These findings hold promise for the development of targeted therapies for immunothrombotic pathologies in acute critical illnesses.
JOURNAL OF THROMBOSIS AND HAEMOSTASIS
(2023)
Review
Immunology
Zhaoyuan Chen, Hao Zhang, Mengdi Qu, Ke Nan, Hanzhong Cao, Juan P. Cata, Wankun Chen, Changhong Miao
Summary: Patients with sepsis often have coagulation dysfunction and the formation of thrombus, with neutrophil extracellular traps (NETs) playing a key role in sepsis. Clinical evaluation of NETs function could be a valuable biomarker for early diagnosis of sepsis. The interaction of NETs with platelets, complement, and endothelium mediates the formation of immunothrombosis in sepsis, and inhibiting NETs formation is considered a potential treatment for sepsis.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2021)
Article
Cell Biology
Iwona Cichon, Weronika Ortmann, Michal Santocki, Malgorzata Opydo-Chanek, Elzbieta Kolaczkowska
Summary: Obese individuals have a higher survival rate during sepsis, but their white blood cell response in liver vasculature is suppressed; the study found that platelets in obese mice have a limited impact on neutrophil formation, suggesting that their dysfunctional state may affect immune responses.
Review
Immunology
Andrea Herrero-Cervera, Oliver Soehnlein, Ellinor Kenne
Summary: Chronic inflammation is a common feature of many diseases and is especially prevalent in the aging population. The role of neutrophils in chronic inflammation is still not well understood, with conflicting evidence suggesting both beneficial and detrimental effects. However, emerging evidence indicates that neutrophils play a significant role in several chronic diseases.
CELLULAR & MOLECULAR IMMUNOLOGY
(2022)
Article
Multidisciplinary Sciences
Joram Huckriede, Sara Bulow Anderberg, Albert Morales, Femke de Vries, Michael Hultstrom, Anders Bergqvist, Jose T. Ortiz-Perez, Jan Willem Sels, Kanin Wichapong, Miklos Lipcsey, Marcel van de Poll, Anders Larsson, Tomas Luther, Chris Reutelingsperger, Pablo Garcia de Frutos, Robert Frithiof, Gerry A. F. Nicolaes
Summary: This study investigated the levels and changes of DAMPS and immune modulators in severe COVID-19 patients, revealing elevated levels of cfDNA, H3, NE, GAS6 and AXL associated with clinical events and ICUAW, as well as correlating with patient survival. Decreases in cfDNA and GAS6 over time were observed in survivors, while markers such as H3, NE and cfDNA correlated well with tissue damage and neutrophil counts.
SCIENTIFIC REPORTS
(2021)
Article
Hematology
Matthew Locke, Colin Longstaff
Summary: Histones released into circulation can promote coagulation and enhance clot stability, but can also hinder fibrinolysis. They crosslink to fibrin molecules through FXIIIa, resulting in resistant fibrin networks. Low-molecular-weight heparin can prevent covalent interactions between histones and fibrin, reducing their effects on fibrinolysis.
THROMBOSIS AND HAEMOSTASIS
(2021)
Article
Biochemistry & Molecular Biology
Remo Poto, Leonardo Cristinziano, Luca Modestino, Amato de Paulis, Gianni Marone, Stefania Loffredo, Maria Rosaria Galdiero, Gilda Varricchi
Summary: Human neutrophils play a significant role in the host response against pathogens, and recent research has revealed their functional plasticity and involvement in cancer and angiogenesis. Neutrophils release angiogenic factors and form NETs, which promote tumor growth and metastasis through various mechanisms. Understanding the functions of NETs in cancer and angiogenesis could be important for early diagnosis, prevention, and treatment of tumors.
Article
Biochemistry & Molecular Biology
Somanathapura K. NaveenKumar, Mahadevappa Hemshekhar, Bidare N. Sharathbabu, Kempaiah Kemparaju, Govindasamy Mugesh, Kesturu S. Girish
Summary: Cell-free heme (CFH) is a product of hemoglobin, myoglobin, and hemoprotein degradation and plays a key role in the progression of lung disease pathology. Heme-induced platelet activation and ferroptosis lead to neutrophil aggregation and NET formation, causing pulmonary damage. Redox modulators and ferroptosis inhibitors may be potential therapies for respiratory distress-associated complications.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2023)
Review
Hematology
Xiangbo Xu, Yuting Wu, Shixue Xu, Yue Yin, Walter Ageno, Valerio De Stefano, Qingchun Zhao, Xingshun Qi
Summary: This review comprehensively examines the changes in NETs biomarkers associated with thrombosis and their role in thrombus formation. Studies have shown significant alterations in levels of NETs biomarkers in thrombotic patients, highlighting their importance in the development and prognostic assessment of thrombotic diseases. The paper also explores the potential therapeutic implications of NETs and discusses limitations of existing biomarker detection methods.
THROMBOSIS JOURNAL
(2022)
Article
Oncology
Muhammad H. Shahzad, Lixuan Feng, Xin Su, Ariane Brassard, Iqraa Dhoparee-Doomah, Lorenzo E. Ferri, Jonathan D. Spicer, Jonathan J. Cools-Lartigue
Summary: Neutrophils play a role in cancer by releasing neutrophil extracellular traps (NETs) that interact with cancer cells, driving resistance to therapy. NETs are involved in various mechanisms of therapy resistance, including T-cell exhaustion, drug detoxification, angiogenesis, and extracellular matrix remodeling. Therefore, understanding and targeting NETs is crucial for effective cancer treatment.
Editorial Material
Oncology
Phei Er Saw, Jianing Chen, Erwei Song
Summary: Neutrophil extracellular traps (NETs) are involved in both infection control and tumor metastasis. The study by Mousset et al. published in Cancer Cell reveals that chemotherapy-induced inflammation promotes NETosis in malignant tumors, leading to chemoresistance. This finding highlights the potential of targeting inflammatory NETs for cancer treatment.
Article
Immunology
Carlos Blanco-Camarillo, Omar Rafael Aleman, Carlos Rosales
Summary: The article discusses the different phenotypes and functional states of neutrophils in healthy and pathological conditions, with a focus on the presence and cellular functions of low-density neutrophils (LDN) in the blood of healthy individuals.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Alexander A. Fields, Elizabeth Andraska, Christof A. Kaltenmeier, Zachary Matthay, Kimberly Herrera, Brenda M. Nunez-Garcia, Chayse D. Jones, Katherine Wick, Silvia Liu, Jian-Hua Luo, Yan-Ping A. Yu, Michael M. Matthay, Carolyn J. Hendrickson, Roland J. Bainton, Tessa S. Barrett, Jeffrey D. Berger, Matthew Z. Neal, Lucy Kornblith
Summary: This study found that plasma from COVID-19 patients can induce abnormal platelet function and promote inflammatory response in neutrophils. The soluble components in plasma had an impact on the behavior of platelets and neutrophils, which may contribute to the thromboinflammatory complications observed in COVID-19.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Lanlan Li, Yongchang Ma, Yi Hu, Pengfei Wang, Songling Han, Xiangjun Zhang, Jianxiang Zhang
Summary: This article reports a targeted treatment method for asthma using a cyclic oligosaccharide-derived nanotherapy. The treatment effectively alleviates oxidative stress, suppresses inflammatory responses, reverses airway remodelling, and improves pulmonary function. The method shows promising results for the treatment of eosinophilic and neutrophilic asthma.
Article
Cell Biology
Agostina Carestia, Tomas Kaufman, Leonardo Rivadeneyra, Veronica Ines Landoni, Roberto Gabriel Pozner, Soledad Negrotto, Lina Paola D'Atri, Ricardo Martin Gomez, Mirta Schattner
JOURNAL OF LEUKOCYTE BIOLOGY
(2016)
Article
Hematology
H. A. Mena, A. Carestia, L. Scotti, F. Parborell, M. Schattner, S. Negrotto
JOURNAL OF THROMBOSIS AND HAEMOSTASIS
(2016)
Review
Immunology
Agostina Carestia, Tomas Kaufman, Mirta Schattner
FRONTIERS IN IMMUNOLOGY
(2016)
Article
Biochemistry & Molecular Biology
Lina Paola D'Atri, Mirta Schattner
FRONTIERS IN BIOSCIENCE-LANDMARK
(2017)
Article
Oncology
Amandeep S. Taggar, Kenneth L. Pitter, Gil'ad N. Cohen, Mark Schattner, Hans Gerdes, Arnold J. Markowitz, David Ilson, Paul Brady, John J. Cuaron, Karyn A. Goodman, Abraham J. Wu
Article
Multidisciplinary Sciences
Julia Etulain, Hebe A. Mena, Roberto P. Meiss, Gustavo Frechtel, Susana Gutt, Soledad Negrotto, Mirta Schattner
SCIENTIFIC REPORTS
(2018)
Article
Cell & Tissue Engineering
Hebe Agustina Mena, Paula Romina Zubiry, Blandine Dizier, Mirta Schattner, Catherine Boisson-Vidal, Soledad Negrotto
STEM CELL RESEARCH & THERAPY
(2018)
Article
Multidisciplinary Sciences
Agostina Carestia, Gustavo Frechtel, Gloria Cerrone, Maria A. Linari, Claudio D. Gonzalez, Patricia Casais, Mirta Schattner
Review
Cell Biology
Mirta Schattner
JOURNAL OF LEUKOCYTE BIOLOGY
(2019)
Article
Cardiac & Cardiovascular Systems
Leonardo Rivadeneyra, Nancy Charo, Denise Kviatcovsky, Silvia de la Barrera, Ricardo Martin Gomez, Mirta Schattner
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
(2018)
Article
Immunology
Maria F. Ferrer, Emilia Scharrig, Nancy Charo, Ana L. Ripodas, Ricardo Drut, Eugenio A. Carrera Silva, Ariel Nagel, Jarlath E. Nally, Daniela P. Montes de Oca, Mirta Schattner, Ricardo M. Gomez
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2018)
Article
Cell Biology
Agostina Carestia, Hebe A. Mena, Cinthia M. Olexen, Juan M. Ortiz Wilczynski, Soledad Negrotto, Andrea E. Errasti, Ricardo M. Gomez, Craig N. Jenne, Eugenio A. Carrera Silva, Mirta Schattner
Article
Hematology
Hebe Agustina Mena, Paula Romina Zubiry, Blandine Dizier, Virginie Mignon, Fernanda Parborell, Mirta Schattner, Catherine Boisson-Vidal, Soledad Negrotto
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2019)
Editorial Material
Medicine, General & Internal
Federico Rodriguez Lucci, Mirta Schattne
Article
Immunology
Tomas Kaufman, Debora Magosevich, Maria Carolina Moreno, Maria Alejandra Guzman, Lina Paola D'Atri, Agostina Carestia, Maria Eugenia Fandino, Carlos Fondevila, Mirta Schattner
CLINICAL IMMUNOLOGY
(2017)