Article
Materials Science, Multidisciplinary
M. Chethan, Asha Rajiv
Summary: This study investigates the bioactivity of strontium doped phosphate glasses by immersing the glass samples in simulated body fluid. The analysis of the samples includes XRD, FTIR, SEM, and EDX evaluations. The results confirm the formation of a hydroxyapatite layer on the glass surface after immersion in the body fluid and the observation of crystal agglomerates.
MATERIALS TODAY COMMUNICATIONS
(2023)
Article
Materials Science, Multidisciplinary
Swarnima Singh, Krishna Kant Pandey, Anup Kumar Keshri
Summary: By increasing the plasma power from 20 to 35 kW, the hydroxyapatite coating on titanium alloys became denser, leading to improved corrosion resistance due to reduced pores and voids in the coatings.
METALS AND MATERIALS INTERNATIONAL
(2021)
Article
Materials Science, Coatings & Films
Srikant Tiwari, S. B. Mishra
Summary: Pure hydroxyapatite, pure titanium, and titanium-hydroxyapatite composite coatings with different titanium contents were deposited on 254 SMO steel. The Ti40-HAp composite coating exhibited the highest microhardness and adhesion strength due to its low porosity and low coefficient of thermal expansion. The bioactivity of the coatings decreased as the titanium content increased. The formation of rutile TiO2 and CaTiO3 phases significantly enhanced the performance of the coatings.
SURFACE & COATINGS TECHNOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Hiroki Miyajima, Hiroki Touji, Kazutoshi Iijima
Summary: Bone-like hydroxyapatite (HAp) was prepared from 1.5SBF with different pH values, resulting in micro-sized particles with higher Ca/P ratio and crystallinity at pH 7.4, and nano-sized particles at pH 8.0 and 8.4. A mixture of micro-sized and nano-sized particles was obtained at pH 7.7. Monitoring Ca2+ concentrations showed a drastic decrease at pH 7.4, slightly decreased at higher pH, and higher at pH 7.7. The cytotoxicity of the obtained precipitates to mesenchymal stem cells was lower than that of synthetic HAp.
Article
Materials Science, Coatings & Films
Fatih Sargin, Garip Erdogan, Kursat Kanbur, Ahmet Turk
Summary: Orthopedic implants are widely used in modern medicine to enhance the quality of human life, with PEEK emerging as a high-performance alternative to metallic implants. Coating PEEK implants with bioactive materials such as HA has been shown to improve their bioactivity and osteointegration behavior, effectively addressing the shortcomings of PEEK's biological inertness and low bioactivity.
SURFACE & COATINGS TECHNOLOGY
(2021)
Article
Materials Science, Coatings & Films
S. Bano, A. Rincon Romero, D. M. Grant, A. Nommeots-Nomm, C. Scotchford, I Ahmed, T. Hussain
Summary: ICIE16 and 13-93 bioactive glasses were coated using a high-velocity oxy-fuel thermal spraying technique, with higher flame power resulting in denser, harder, and rougher coatings. The 13-93 coating showed higher stability and cell proliferation in simulated body fluid.
SURFACE & COATINGS TECHNOLOGY
(2021)
Article
Materials Science, Ceramics
Yuxing He, Fuwei Peng, Jinwen Du, Liangfeng Li, Bing Xue, Meng Dong, Pengfei Gao
Summary: A 100 mT magnetic field was applied during plasma spraying of hydroxyapatite (HA) coating on Ti6Al4V substrate. The impact of the magnetic field on microstructure, bonding strength, and bioactivity of the coating was investigated. Compared to the as-sprayed coating, the magnetic field treated coating exhibited reduced porosity, microcracks, and residual stress, as well as significantly improved bonding strength.
JOURNAL OF THE EUROPEAN CERAMIC SOCIETY
(2023)
Article
Chemistry, Physical
Piotr Prochor, Zaneta Anna Mierzejewska
Summary: Scientists have identified two main paths for orthopedic implant fabrication, either searching for new materials with properties closest to natural bone or creating individually adapted geometry with Rapid Prototyping methods. PEEK GRF30 and Ti6Al4V SLM are materials of interest, but further research is needed to fully understand their bioactivity. The study found that both materials exhibited bioactivity comparable to Ti6Al4V, showing promising potential for orthopedic implants.
Article
Chemistry, Physical
Awatef Abidi, Zahra Jokar, Seyedmahmoodreza Allahyari, Fereshteh Kolahi Sadigh, S. Mohammad Sajadi, Payam Firouzi, Dumitru Baleanu, Ferial Ghaemi, Arash Karimipour
Summary: This study investigated the heat transfer properties of Zinc Oxide nanofluid in Simulated-Body-Fluid, and found that adding Hydroxyapatite and Carbon Nanotube can enhance heat transfer performance. Computational methods can be used to optimize heat transfer measurements of nanofluids for cost reduction.
JOURNAL OF MOLECULAR LIQUIDS
(2021)
Article
Chemistry, Multidisciplinary
Brid Murphy, Mick A. Morris, Jhonattan Baez
Summary: This study is the second part of a two-part research on the generation of hydroxyapatite coatings using supersaturated solutions. The study analyzes the characteristics of hydroxyapatite in powder form and as a film on orthopaedic implants, and tracks its growth mechanism. The results demonstrate a clear propensity of the process to grow hydroxyapatite films and the successful formation of the desired coatings.
Article
Chemistry, Multidisciplinary
Pedro R. Prezas, Manuel J. Soares, Joao P. Borges, Jorge C. Silva, Filipe J. Oliveira, Manuel Pedro F. Graca
Summary: Conventional methods fail to achieve electrical charging of atmospheric plasma spray (APS) hydroxyapatite (Hap) coatings, but a new non-contact, electrode-free method - corona charging achieves this goal. Charged coatings show higher bioactivity compared to non-charged coatings, promoting osteoblastic cell proliferation and increased intake of calcium and phosphorus. The results of this study indicate the promising potential of corona charging in orthopedics and dental implantology.
Article
Chemistry, Physical
Mehmet Topuz
Summary: In this research, a hydroxyapatite-Al2O3 reinforced poly (lactic acid) hybrid coating was synthesized on magnesium to improve interface strength, corrosion properties, and dissolution rate. The coatings were produced using the spin-coating technique of the synthesized solutions. The characterization, mechanical properties, and in-vitro bioactivity of the hybrid coatings were investigated.
SURFACES AND INTERFACES
(2023)
Article
Materials Science, Multidisciplinary
Jingyuan Huang, Markus Voigt, Steffen Wackenrohr, Christoph Ebbert, Adrian Keller, Hans Juergen Maier, Guido Grundmeier
Summary: Surface corrosion and fatigue behavior of pure iron were studied in a modified simulated body fluid, revealing a correlation between surface corrosion progression and fatigue life.
MATERIALS AND CORROSION-WERKSTOFFE UND KORROSION
(2022)
Article
Materials Science, Coatings & Films
Xiaomei Liu, Dingyong He, Zheng Zhou, Xingye Guo, Yi Liu, Wenjia Hou, Hua Li
Summary: HA coatings fabricated by atmospheric plasma spraying exhibit high crystallinity, phase purity, and c-axis crystalline orientation, showing enhanced proliferation of osteoblasts cells and antibacterial properties. These findings suggest the potential applications of HA coatings in orthopedic and dental implantation fields.
SURFACE & COATINGS TECHNOLOGY
(2021)
Article
Nanoscience & Nanotechnology
Xitong Cheng, Xiao Yang, Chengde Liu, Yizheng Li, Yangyang Zhang, Jinyan Wang, Xingdong Zhang, Xigao Jian
Summary: Apatite coatings play a critical role in enhancing the surface bioactivity and osteogenic activity of implant materials. This study proposes a strategy to improve the bonding ability between apatite coatings and substrates by constructing a three-dimensional nanoporous structure and introducing a polydopamine coating. The enhanced apatite coating exhibits better bioactivity and osteogenic differentiation, as confirmed by in vitro and in vivo experiments. This research shows great potential for the clinical application of orthopedic implants.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Chemistry, Multidisciplinary
Qiang Chu, Linhua Liao, Bin Liu, Gaorong Han, Xiang Li
Summary: This study synthesized composite nanosheets with controllable SO2 gas release capability, which can induce oxidative damages to tumor cells by utilizing the glycolysis effect of GOx. At the same time, the nanosheets deplete the energy supply of tumor cells, effectively inhibiting tumor growth both in vitro and in vivo in a synergistic manner.
ADVANCED FUNCTIONAL MATERIALS
(2021)
Article
Chemistry, Multidisciplinary
Hanjing Kong, Qiang Chu, Chao Fang, Guodong Cao, Gaorong Han, Xiang Li
Summary: The study successfully designed and synthesized fine CaO2 nanoparticles with Cu-ferrocene molecules on the surface, which release Ca2+ ions and H2O2 under acidic conditions and promote the production of (OH)-O-center dot. The enhanced (OH)-O-center dot induction and intracellular calcium overload contribute significantly to antitumor effects in vitro and in vivo.
Article
Materials Science, Biomaterials
Tong Chen, Yike Fu, Ruoyu Zhang, Gaorong Han, Xiang Li
Summary: Electrodynamic therapy using platinum nanoparticles for tumor treatment generates ROS under an electric field, with increased chloride ion concentration being beneficial for ROS production. The combination of potassium chloride nanocrystals, amorphous calcium carbonate nanoclusters, and platinum nanoparticles can enhance intracellular ROS generation and lead to agitated tumor inhibition through a cycle of mutual promotion and self-amplification between excessive calcium ions and ROS.
BIOMATERIALS SCIENCE
(2022)
Article
Chemistry, Multidisciplinary
Peipei Zhu, Cheng Zhou, Jiafei Chen, Qiang Chu, Feiyu Li, Yike Fu, Xiang Li
Summary: The combination of precise tumor depletion and immunotherapy has great potential to eradicate cancer. In this study, anaerobic bacteria were integrated with ZnAl layered double hydroxides (LDHs) to construct an effective system for inhibiting tumor growth and metastasis. The biohybrid P. acnes@LDHs demonstrated remarkable anticancer outcomes in both in vitro and in vivo experiments.
ADVANCED FUNCTIONAL MATERIALS
(2023)
Article
Chemistry, Multidisciplinary
Zijie Lu, Linming Zhou, Yingpei Yao, Feiyu Li, Zijian Hong, Yongjun Wu, Xiang Li
Summary: Electrodynamic therapy (EDT) is an emerging alternative approach for tumor treatment, based on the electrocatalytic activation of water dissociation on platinum nanoparticles (PtNPs) to produce hydroxyl radicals. However, the mechanism of EDT remains controversial, particularly when PtNPs are not in direct contact with electrodes. This study reveals the fundamental mechanism of EDT, identifying the crucial reactant as free chlorine generated during electrolysis. Experimental examinations and calculations confirm the catalytic activation of HOCl by PtNPs, resulting in the production of oxygen anion radicals and the corrosion of PtNPs. Cytotoxicity and intracellular abnormalities further support these findings, offering new insight into the in vitro anti-cancer mechanism of EDT.
ADVANCED FUNCTIONAL MATERIALS
(2023)
Article
Chemistry, Multidisciplinary
Feiyu Li, Qiang Chu, Zefeng Hu, Zijie Lu, Chao Fang, Gaorong Han, Yike Fu, Xiang Li
Summary: A biohybrid therapeutic system combining responsive materials and living microorganisms was developed for tumor treatment, showing significant efficacy in tumor ablation and inhibition of recurrence.
Article
Nanoscience & Nanotechnology
Cheng Zhou, Jiafei Chen, Bingzhu Zheng, Peipei Zhu, Qiang Chu, Feiyu Li, Yike Fu, Xiang Li, Jun Luo
Summary: The combination of targeted therapy and immunotherapy using a biohybrid system consisting of NO3--intercalated LDH and PA shows promising results in eliminating solid tumors and inhibiting tumor metastasis.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Chemistry, Multidisciplinary
Qiang Chu, Congkun Xie, Guodong Cao, Zefeng Hu, Feiyu Li, Yike Fu, Gaorong Han, Xiang Li
Summary: A hybrid platform, constructed via the surface armoring of living yeasts by a manganese silicate compound (MS@Yeast), is investigated for combinational cancer treatment. The intrinsic characteristics of living yeasts, in both acidophilic and anaerobic conditions, empower the hybrid platform with activated selected colonization in tumors. The integration of biologically active microorganisms and functional materials provides distinctive perspectives in the exploration of potential therapeutics for tackling cancer.
Article
Materials Science, Biomaterials
Jiafei Chen, Shiqi Wan, Yike Fu, Yi Zhou, Xiang Li, Huiming Wang
Summary: In this study, an implantable system with combined functions of tumor therapy and tissue repair was developed. The system utilized tannic acid/Fe3+ nanoparticles with Fenton catalytic activity and GSH inhibitor BSO drug to achieve amplified chemodynamic tumor treatment. Additionally, bioactive glass fibers loaded with vascular endothelial growth factor (VEGF) were used as drug carriers for tissue repair. This work is inspiring for postoperative tumor treatment and recovery.
JOURNAL OF MATERIALS CHEMISTRY B
(2023)
Article
Materials Science, Biomaterials
Xi Xiao, Bingzhu Zheng, Qiang Zheng, Zijie Lu, Dong Cen, Xiujun Cai, Xiang Li, Renren Deng
Summary: This study presents a heterostructure nanocomposite containing ZnO-coated lanthanide nanoparticles, which can efficiently generate peroxynitrite anion (ONOO-) at targeted tumor sites, thereby promoting cancer cell apoptosis and inhibiting tumor growth.
JOURNAL OF MATERIALS CHEMISTRY B
(2022)
Article
Materials Science, Biomaterials
Congkun Xie, Dong Cen, Huiyang Wang, Yifan Wang, Yongjun Wu, Gaorong Han, Xiang Li
Summary: Hierarchical manganese silicate nanoclusters modified with triphenylphosphonium disassemble in an acidic tumor microenvironment into ultrasmall nanocapsules, enabling deep tumor penetration and mitochondria targeting, exhibiting considerable antitumor effect.
BIOMATERIALS SCIENCE
(2021)
Article
Materials Science, Biomaterials
Linhua Liao, Qiang Chu, Chao Fang, Xiang Li, Gaorong Han
Summary: Fine hollow nanocapsules of NiFe hydroxides were designed and synthesized for delivering anticancer drug and tumor depletion. The system showed significant Fenton activity and pH-responsive drug release, inducing hydroxyl radicals in tumor cells to achieve remarkable antitumor properties.
BIOMATERIALS SCIENCE
(2021)
Article
Materials Science, Biomaterials
Qiang Chu, Huimin Zhu, Bin Liu, Guodong Cao, Chao Fang, Yulian Wu, Xiang Li, Gaorong Han
JOURNAL OF MATERIALS CHEMISTRY B
(2020)
Article
Materials Science, Biomaterials
Huimin Zhu, Guodong Cao, Chu Qiang, YiKe Fu, Yulian Wu, Xiang Li, Gaorong Han
BIOMATERIALS SCIENCE
(2020)
Article
Materials Science, Biomaterials
Linhua Liao, Dong Cen, Yike Fu, Bin Liu, Chao Fang, Yifan Wang, Xiujun Cai, Xiang Li, Hao Bin Wu, Gaorong Han
JOURNAL OF MATERIALS CHEMISTRY B
(2020)
