Role of Indoxyl Sulfate in the Progression of Chronic Kidney Disease and Cardiovascular Disease: Experimental and Clinical Effects of Oral Sorbent AST-120

Spherical Carbon Adsorbent (AST-120) Protects Deterioration of Renal Function in Chronic Kidney Disease Rats through Inhibition of Reactive Oxygen Species Production from Mitochondria and Reduction of Serum Lipid Peroxidation

(2010) Shigeru Owada et al.   NEPHRON EXPERIMENTAL NEPHROLOGY

Effect of a Carbonaceous Oral Adsorbent on the Progression of CKD: A Multicenter, Randomized, Controlled Trial

(2009) Tadao Akizawa et al.   AMERICAN JOURNAL OF KIDNEY DISEASES

An Oral Sorbent, AST-120, Increases Klotho Expression and Inhibits Cell Senescence in the Kidney of Uremic Rats

(2009) Ayinuer Adijiang et al.   AMERICAN JOURNAL OF NEPHROLOGY

The Uremic Toxin 3-Indoxyl Sulfate Is a Potent Endogenous Agonist for the Human Aryl Hydrocarbon Receptor

(2009) Jennifer C. Schroeder et al.   BIOCHEMISTRY

Oral adsorbent AST-120 ameliorates endothelial dysfunction independent of renal function in rats with subtotal nephrectomy

(2009) Tamehachi Namikoshi et al.   HYPERTENSION RESEARCH

Oral charcoal adsorbent (AST-120) prevents progression of cardiac damage in chronic kidney disease through suppression of oxidative stress

(2009) H. Fujii et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

AST-120 (Kremezin®) initiated in early stage chronic kidney disease stunts the progression of renal dysfunction in type 2 diabetic subjects

(2008) Kazunori Konishi et al.   DIABETES RESEARCH AND CLINICAL PRACTICE

Indoxyl sulphate promotes aortic calcification with expression of osteoblast-specific proteins in hypertensive rats

(2008) A. Adijiang et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

AST-120 Treatment in Pre-Dialysis Period Affects the Prognosis in Patients on Hemodialysis

(2008) Haruhiko Ueda et al.   RENAL FAILURE

Oral Sorbent AST-120 Increases Renal NO Synthesis in Uremic Rats

(2007) Zohra Tumur et al.   JOURNAL OF RENAL NUTRITION