Review
Biochemistry & Molecular Biology
Chien-Lin Lu, Cai-Mei Zheng, Kuo-Cheng Lu, Min-Tser Liao, Kun-Lin Wu, Ming-Chieh Ma
Summary: The uremic toxin IS leads to oxidative stress in CKD patients, causing organ damage and complications such as cardiovascular diseases, renal osteodystrophy, muscle wasting, and anemia. IS-induced ROS production impairs glomerular filtration and triggers vascular smooth muscle cells transformation, contributing to muscle atrophy and bone abnormalities.
Article
Geriatrics & Gerontology
Ran-hui Cha, Seok Hui Kang, Mi Yeun Han, Won Suk An, Su-Hyun Kim, Jun Chul Kim
Summary: The addition of AST-120 to standard treatment in chronic kidney disease patients did not result in a significant difference in gait speed, but showed modest beneficial effects on gait speed change and quality of life, indicating potential to improve sarcopenia.
JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE
(2022)
Article
Nutrition & Dietetics
Miyuki Kobara, Nessa Naseratun, Hiroe Toba, Tetsuo Nakata
Summary: The study found that preconditioning with short-term dietary restriction can attenuate chronic pressure overload-induced cardiac hypertrophy and associated oxidative stress, ultimately improving heart function.
Article
Biochemistry & Molecular Biology
Julia Wollenhaupt, Janina Frisch, Eva Harlacher, Dickson W. L. Wong, Han Jin, Corinna Schulte, Sonja Vondenhoff, Julia Moellmann, Barbara Mara Klinkhammer, Li Zhang, Adelina Baleanu-Curaj, Elisa A. Liehn, Thimoteus Speer, Andrey Kazakov, Christian Werner, Emiel P. C. van der Vorst, Simina-Ramona Selejan, Mathias Hohl, Michael Bohm, Rafael Kramann, Erik A. L. Biessen, Michael Lehrke, Nikolaus Marx, Joachim Jankowski, Christoph Maack, Peter Boor, Leticia Prates Roma, Heidi Noels
Summary: CKD increases cardiac oxidative stress responses in the heart, but additional hits are required to induce uremic cardiomyopathy.
Article
Biochemistry & Molecular Biology
Sunil Bhandari
Summary: Uraemia leads to changes in cardiac and mitochondrial function, while intravenous iron therapy can improve oxidative stress and mitochondrial function.
FRONTIERS IN BIOSCIENCE-LANDMARK
(2021)
Article
Multidisciplinary Sciences
Shuangtao Ma, Donna H. Wang
Summary: Knocking out Trpa1 accelerates age-related myocardial fibrosis, ventricular dilation, and cardiac dysfunction.
Review
Biochemistry & Molecular Biology
Yi-Ling Cao, Ji-Hong Lin, Hans-Peter Hammes, Chun Zhang
Summary: This review summarizes the function and beneficial properties of common flavonoids for the treatment of CKD and renal fibrosis, including preventing renal dysfunction and improving renal function by blocking or suppressing deleterious pathways such as oxidative stress and inflammation.
Article
Biochemistry & Molecular Biology
Cheng-Kai Hsu, Shih-Chi Su, Lun-Ching Chang, Kai-Jie Yang, Chin-Chan Lee, Heng-Jung Hsu, Yih-Ting Chen, Chiao-Yin Sun, I-Wen Wu
Summary: This study aimed to assess the effects of AST-120 on the gut microbiota, related functional capability, and metabolomic profiling in advanced CKD patients. The results showed that AST-120 can partially restore the gut microbiota and intervene in the metabolism of short- and medium-chain fatty acids.
Article
Biochemistry & Molecular Biology
Sen Guo, Bin-Bin Zhang, Lu Gao, Xiao-Yue Yu, Ji-Hong Shen, Fan Yang, Wen-Cai Zhang, Ya-Ge Jin, Gang Li, Yan-Ge Wang, Zhan-Ying Han, Yuan Liu
Summary: Heart failure severely impairs human health, and cardiac hypertrophy is one of the main causes. This study found that RNF13 plays a protective role in cardiac hypertrophy by activating the p62-NRF2 axis.
FREE RADICAL BIOLOGY AND MEDICINE
(2023)
Review
Nutrition & Dietetics
Scott E. Liebman, Thu H. Le
Summary: This article discusses the impact of oxidative stress in chronic kidney disease and the role of the Nrf2 pathway in kidney disease, as well as the promising therapeutic potential of sulforaphane.
Article
Medicine, Research & Experimental
Moustafa Fathy, Rania Abdel-latif, Yasmeen M. Abdelgwad, Othman Ali Othman, Abdel-Razik H. Abdel-Razik, Thomas Dandekar, Eman M. Othman
Summary: The study showed that eugenol has a potential protective effect against CCl4-induced chronic kidney damage in an experimental model, mainly through its antioxidant, anti-inflammatory, and anti-fibrotic activities.
Article
Biochemistry & Molecular Biology
Yue Xiong, Jie Xu, Wenli Cao, Jiawei Zhang, Zhihui Feng, Ke Cao, Jiankang Liu
Summary: This study explored the beneficial effects of hydroxytyrosol (HT) on strenuous exercise-induced pathological changes in the heart. HT improved heart weight and morphology, decreased cardiac hypertrophy markers and oxidative stress. It also improved mitochondrial biogenesis, mitochondrial complex activity, expression of mitochondrial dynamics-related proteins, and activated apoptotic pathway. In an in vitro model, HT reduced reactive oxygen species level, promoted mitochondrial biogenesis, and inhibited apoptosis and cardiomyocyte hypertrophy. Knockdown of key regulator PPARGC1A partially abolished the benefits of HT, indicating its involvement in mitochondrial homeostasis.
Article
Nutrition & Dietetics
Nur Elena Zaaba, Suhail Al-Salam, Sumaya Beegam, Ozaz Elzaki, Javed Yasin, Abderrahim Nemmar
Summary: Catalpol, an active compound in traditional Chinese medicine Rehmannia glutinosa, has shown significant protective effects against adenine-induced chronic kidney disease (CKD) in mice. It reduces inflammation, oxidative stress, and fibrosis in the kidneys, and improves renal function. This study suggests that catalpol may be a potential nephroprotective agent for CKD.
Article
Cardiac & Cardiovascular Systems
Linda Hagmayer, Christina Mayer, Nadja Ebert, Kerstin Amann, Christoph Daniel
Summary: Chronic kidney disease (CKD) often leads to congestive heart failure (CHF) and left ventricular hypertrophy (LVH), contributing to increased mortality in CKD patients. This study investigated whether cardiovascular changes in CKD could be reversed by kidney transplantation. The results showed that while renal function normalized after transplantation, heart load and hypertrophy did not decrease. However, left ventricular wall thickness, fractional shortening, and ejection fraction were restored to normal levels.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Review
Biochemistry & Molecular Biology
Tina Levstek, Katarina Trebusak Podkrajsek
Summary: Telomeres are dynamic DNA nucleoprotein structures located at the end of chromosomes that maintain genomic stability. Shortened telomeres contribute to cellular senescence and degenerative diseases such as chronic kidney diseases (CKDs). Oxidative stress also accelerates telomere shortening. This review examines the association between telomere length and CKDs, particularly in patients receiving kidney replacement therapy. Understanding the relationship between telomere attrition and kidney disease can contribute to new strategies for managing CKDs.
Article
Endocrinology & Metabolism
Yukihiro Kohara, Riko Kitazawa, Ryuma Haraguchi, Yuuki Imai, Sohei Kitazawa
Summary: Macrophages play a crucial role in bone regeneration by promoting angiogenesis and wound healing. Through RNA-seq analysis, TGFBI, uPA, and TGF-beta 1 secreted by macrophages were identified as genes mediating angiogenesis and wound healing. Treatment with uPA inhibitor or TGF-beta receptor inhibitors confirmed their importance in bone regeneration.
Article
Peripheral Vascular Disease
Daisuke Kanai, Hideki Fujii, Kentaro Nakai, Keiji Kono, Kentaro Watanabe, Shunsuke Goto, Shinichi Nishi
Summary: This study found that the use of statins in patients with peripheral arterial diseases (PAD) may help prevent the occurrence of acute kidney injury (AKI) after angiography and/or intervention for PAD.
JOURNAL OF ATHEROSCLEROSIS AND THROMBOSIS
(2022)
Article
Hematology
Mao Shimizu, Hideki Fujii, Keiji Kono, Kentaro Watanabe, Shunsuke Goto, Kandai Nozu, Kimitoshi Nakamura, Shinichi Nishi
Summary: This study did not identify any Fabry disease patients among male hemodialysis patients in Awaji Island, Japan, despite some patients having a family history of kidney and cardiovascular diseases. Although a few patients had low levels of alpha-galactosidase A activity, none of them tested positive in secondary screening.
THERAPEUTIC APHERESIS AND DIALYSIS
(2022)
Article
Cell Biology
Sohei Kitazawa, Ryuma Haraguchi, Yuki Takaoka, Riko Kitazawa
Summary: This article introduces a novel histochemical technique that allows for the observation of sequence-specific DNA methylation status while maintaining tissue architecture. By optimizing the treatment conditions, it is possible to selectively detect the presence of a single methylated cytosine in individual cells.
HISTOCHEMISTRY AND CELL BIOLOGY
(2023)
Letter
Pathology
Sohei Kitazawa, Riko Kitazawa
PATHOLOGY INTERNATIONAL
(2023)
Letter
Pathology
Sohei Kitazawa, Riko Kitazawa
PATHOLOGY INTERNATIONAL
(2023)
Article
Urology & Nephrology
Shunsuke Goto, Hideki Fujii, Kentaro Watanabe, Mao Shimizu, Hidehisa Okamoto, Kazuo Sakamoto, Keiji Kono, Shinichi Nishi
Summary: This study suggests that astragalus root can slow the progression of chronic kidney disease by suppressing oxidative stress and the renin-angiotensin system.
CLINICAL AND EXPERIMENTAL NEPHROLOGY
(2023)
Article
Medicine, General & Internal
Masao Iwagami, Yuka Kanemura, Naru Morita, Toshitaka Yajima, Masafumi Fukagawa, Shuzo Kobayashi
Summary: This study examined hemodialysis patients in Japan with dyskalemia and analyzed their characteristics and clinical outcomes. The study found that dyskalemia was associated with adverse outcomes such as increased mortality and major adverse cardiovascular events. Older age and malnutrition were associated with hypokalemia, while a longer duration of dialysis was associated with hyperkalemia. Optimizing serum potassium levels is important for hemodialysis patients.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Nobumichi Saito, Masao Toyoda, Masumi Kondo, Makiko Abe, Noriyuki Sanechika, Moritsugu Kimura, Kaichiro Sawada, Masafumi Fukagawa
Summary: This study reveals that phosphorylation of β1-integrin inhibits the expression of renin, while dephosphorylation promotes its expression. Knockdown of β1-integrin and connexin-40 both enhance the expression of renin. Pneumatic pressurization and hypotonic medium culture decrease renin expression, which can be restored by β1-integrin knockdown.
Article
Urology & Nephrology
Shunsuke Goto, Hideki Fujii, Makiko Mieno, Takashi Yagisawa, Masanori Abe, Kosaku Nitta, Shinichi Nishi
Summary: This study found that living donor kidney transplantation (LKT) is associated with a lower risk of mortality and an increase in life expectancy compared to hemodialysis (HD), with larger benefits observed in female and older patients.
CLINICAL AND EXPERIMENTAL NEPHROLOGY
(2023)
Article
Transplantation
Shunsuke Goto, Takayuki Hamano, Hideki Fujii, Masatomo Taniguchi, Masanori Abe, Kosaku Nitta, Shinichi Nishi
Summary: This study investigated the association between serum calcium levels and cardiovascular mortality in calcimimetics users using a nationwide Japanese registry for dialysis patients.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2023)
Article
Urology & Nephrology
Ryohei Yamamoto, Enyu Imai, Shoichi Maruyama, Hitoshi Yokoyama, Hitoshi Sugiyama, Asami Takeda, Tatsuo Tsukamoto, Shunya Uchida, Kazuhiko Tsuruya, Tatsuya Shoji, Hiroki Hayashi, Yasuhiro Akai, Megumu Fukunaga, Tsuneo Konta, Saori Nishio, Shunsuke Goto, Hirofumi Tamai, Kojiro Nagai, Ritsuko Katafuchi, Kosuke Masutani, Takashi Wada, Tomoya Nishino, Arimasa Shirasaki, Hiroshi Sobajima, Kosaku Nitta, Kunihiro Yamagata, Junichiro J. Kazama, Keiju Hiromura, Hideo Yasuda, Makoto Mizutani, Toshiyuki Akahori, Tomohiko Naruse, Takeyuki Hiramatsu, Kunio Morozumi, Tetsushi Mimura, Yosuke Saka, Eiji Ishimura, Hajime Hasegawa, Daisuke Ichikawa, Takashi Shigematsu, Hiroshi Sato, Ichiei Narita, Yoshitaka Isaka
Summary: This study found that the time to remission is an important predictor of relapse in steroid-sensitive patients.
JOURNAL OF NEPHROLOGY
(2022)
Article
Endocrinology & Metabolism
Kohei Okamoto, Hideki Fujii, Kentaro Watanabe, Shunsuke Goto, Keiji Kono, Shinichi Nishi
Summary: Serum fibroblast growth factor 23 (FGF23) levels and the renin-angiotensin-aldosterone system (RAAS) are elevated in chronic kidney disease (CKD) patients, and their association with left ventricular hypertrophy (LVH) has been reported. Cardiac expression of FGF23 shows a close correlation with LVH and RAAS-related factors, indicating a potential link between local FGF23 levels and LVH and RAAS activation.
JOURNAL OF THE ENDOCRINE SOCIETY
(2022)