Highly stereoselective biocatalytic reduction of alpha-halo ketones

The use of recombinant carbonyl reductase biocatalysts for the reduction of alpha-halo ketone intermediates to their corresponding alpha-halo alcohols has been investigated. The alpha-halo alcohol is obtained in good yield from the corresponding ketone in a stereoselective manner. (C) 2009 Elsevier Ltd. All rights reserved.