Green and scalable procedure for extremely fast ligandless Suzuki-Miyaura cross-coupling reactions in aqueous IPA using solid-supported Pd in continuous flow

An environmentally friendly continuous-flow protocol for the Suzuki coupling of boronic acids and aryl halides under ligand-free conditions using solid-supported Pd is presented. The process described herein uses very simple reaction conditions and equipment setup and can be readily scaled up to provide multigram quantities of products containing low levels of residual Pd. (C) 2014 Elsevier Ltd. All rights reserved.