Review
Plant Sciences
Ali Ghanbari, Nasim Akhshi, Seyed Ershad Nedaei, Adriano Mollica, Ina Yosifova Aneva, Yaping Qi, Pan Liao, Sara Darakhshan, Mohammad Hosein Farzaei, Jianbo Xiao, Javier Echeverria
Summary: This review discussed the beneficial impact of Tribulus terrestris and its secondary metabolites on the female reproductive system, including improvements in polycystic ovary syndrome patients, normal ovaries, postmenopausal syndrome patients' sexual desire, and ovarian and breast cancers. These studies showed that the positive effect of T. terrestris on the female reproductive system was attributed to the presence of a secondary metabolite called protodioscin.
Review
Food Science & Technology
Rasika Gunarathne, Harshani Nadeeshani, Anni Lu, Jinyao Li, Baohong Zhang, Tianlei Ying, Jun Lu
Summary: This article provides an overview of the nutraceutical potential of Tribulus terrestris (T. terrestris) in promoting human health. Studies have shown that this herb has antioxidant, anti-inflammatory, anticancer, antidiabetic, testosterone boosting, and cardio, renal and liver protective properties, making it a promising nutraceutical for preventing and managing prevalent human diseases. However, further clinical studies are needed to broaden its potential applications.
FOOD REVIEWS INTERNATIONAL
(2023)
Article
Plant Sciences
A. G. Klyushin, S. V. Tomilova, D. V. Kochkin, B. A. Galishev, A. M. Nosov
Summary: This study focuses on the effect of synthetic phytohormones on the growth and biosynthetic parameters of a suspension culture of Tribulus terrestris L., as well as the influence of cytokinins on these characteristics. The results show that the type and concentration of cytokinins can modulate their action, thus optimizing the growth and biosynthetic characteristics of the plant cell cultures.
RUSSIAN JOURNAL OF PLANT PHYSIOLOGY
(2022)
Article
Plant Sciences
Xiao-Chen Sun, Xiao Song, Fei Guo, Yao-Hui Yuan, Shu-Yue Wang, Shuai Wang, Kun-Lin Liu, Xi-Yu Lv, Bing Han, Chao Zhang, Jiang-Ting Liu
Summary: Terrestrosin D (TED), a major spirostanol saponin isolated from Fructus Tribuli (FT), exhibits potential hepatorenal toxicity, which is reversible after withdrawal. Toxicokinetic study reveals an accumulation phenomenon of TED in rats, while tissue distribution study shows targeted distribution of TED in liver and kidneys.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Article
Plant Sciences
Ruxandra Stefanescu, Lenard Farczadi, Adina Hutanu, Binca E. Osz, Marius Marusteri, Ancuta Negroiu, Camil E. Vari
Summary: The study evaluated the mechanisms of action of Tribulus terrestris extracts in diabetes, finding that they can lower blood glucose levels and increase follicle-stimulating hormone and testosterone levels.
Article
Genetics & Heredity
Parul Tyagi, Mrinalini Prasad, Shivangi Mathur, Rajiv Ranjan
Summary: This study aimed to identify candidate genes associated with diosgenin biosynthesis in Tribulus terrestris through whole transcriptome profiling. The majority of unigenes related to the biosynthesis of diosgenin exhibited up-regulation in the fruit, leaf, and root tissues. The differential expression of selected genes was validated through qRT-PCR. Additionally, the study discovered a large number of unigenes related to transcription factors and containing simple sequence repeats (SSR).
Article
Chemistry, Medicinal
Bui Huu Tai, Bui Hai Ninh, Pham Hai Yen, Duong Thi Dung, Nguyen Huy Hoang, Nguyen Xuan Nhiem, Nguyen Van Tuyen, Le Tuan Anh, Phan Van Kiem
Summary: Three undescribed triterpene glycosides and fourteen known compounds were isolated from the leaves of Syzygium bullockii, including six triterpene glycosides, four phenolics, four megastigmanes, and three flavonoids. The structures were elucidated through spectroscopic analysis. Compounds 1-10 and 12-17 exhibited inhibitory activity against nitric oxide production in activated RAW264.7 cells, with IC50 values ranging from 1.30 to 13.70 μM, lower than that of the positive control compound L-NMMA (IC50 = 33.8 μM).
JOURNAL OF NATURAL MEDICINES
(2023)
Article
Biochemistry & Molecular Biology
Nguyen Duc Duy, Ngo Anh Bang, Pham Hai Yen, Do Thi Trang, Bui Thi Nha Trang, Nguyen Thi Kim Thuy, Nguyen Thi Cuc, Nguyen Xuan Nhiem, Phan Van Kiem, Ninh Khac Ban, Bui Huu Tai
Summary: Four undescribed pentacyclic triterpenene glycosides and five known pentacyclic triterpenenes were isolated from the methanol extract of Cryptolepis buchananii fruits. Their structures were determined through various spectroscopic analyses. These compounds showed significant inhibition of NO production in LPS-activated RAW264.7 cells.
CHEMISTRY & BIODIVERSITY
(2023)
Article
Biochemistry & Molecular Biology
Phan Van Kiem, Bui Hai Ninh, Bui Huu Tai, Nguyen Xuan Nhiem, Pham Hai Yen, Nguyen Huy Hoang, Do Thi Trang, Duong Thi Dung, Nguyen Van Tuyen, Le Tuan Anh
Summary: Four undescribed phenolic glycosides including three stilbene derivatives and a chalcone glycoside, as well as thirteen known compounds, were isolated from the leaves of Syzygium attopeuense. Their chemical structures were determined and compounds 1-3, 5, and 6 showed significant inhibition of NO production in LPS-activated RAW264.7 cells.
CHEMISTRY & BIODIVERSITY
(2023)
Article
Biochemistry & Molecular Biology
Hoang Thi Tuyet Lan, Nguyen Thi Mai, Bui Thi Mai Anh, Duong Thi Dung, Phan Van Kiem, Bui Huu Tai
Summary: A chemical study of the methanol extract of Achyranthes aspera revealed the presence of four new flavonoid C-glycosides (1-4) and eight known analogs (5-12). Their structures were determined using spectroscopic data analysis, HR-ESI-MS, and 1D and 2D NMR spectra. The isolates were evaluated for their inhibitory activity on NO production in LPS-activated RAW264.7 cells. Compounds 2, 4, and 8-11 showed significant inhibition with IC50 values ranging from 25.06 to 45.25 μM, compared to the positive control compound L-NMMA with an IC50 value of 32.24 μM, while the remaining compounds exhibited weak inhibitory activity with IC50 values over 100 μM. This study represents the first report of compound 7 from the Amaranthaceae family and compound 11 from the genus Achyranthes.
CHEMISTRY & BIODIVERSITY
(2023)
Article
Biochemistry & Molecular Biology
Apurva Patel, Mital Bhatt, Anjali Soni, Preeti Sharma
Summary: Tribulus terrestris possesses pharmacological properties with anticancer activities due to its rich steroidal saponins. Nuatigenin saponin, identified in the active fraction of seed extract, shows high binding affinity with multiple cellular targets proteins, indicating its potential as a therapeutic drug for breast cancer treatment.
JOURNAL OF CELLULAR BIOCHEMISTRY
(2021)
Article
Chemistry, Applied
Tomoki Iguchi, Minpei Kuroda, Mai Ishihara, Hiroshi Sakagami, Yoshihiro Mimaki
Summary: Several new bioactive compounds were isolated from the seeds of Withania somnifera, with only one showing significant cytotoxic activity against human cancer cell lines. These compounds hold potential therapeutic value for the treatment of cancer.
NATURAL PRODUCT RESEARCH
(2021)
Article
Plant Sciences
Tamami Shimazaki, Tomoki Iguchi, Aki Kanda, Kie Yamamoto, Naoki Takahashi, Yoshihiro Mimaki
Summary: This study investigated the structures of nine steroidal glycosides isolated from Allium atropurpureum bulbs and their cytotoxicity against small-cell lung cancer cells. Three of the compounds showed moderate cytotoxicity.
PHYTOCHEMISTRY LETTERS
(2023)
Article
Food Science & Technology
Wenjun Guo, Jingxuan Yang, Jifeng Wang, Xiaohang Xu, Jinghan Huang, Yue Liu, Shengxu Xie, Yajuan Xu
Summary: This study uncovers the mechanisms behind the therapeutic impact of Tribulus terrestris extract in treating ischemic stroke, expanding its potential medicinal applications and confirming its potential as a dietary supplement.
MOLECULAR NUTRITION & FOOD RESEARCH
(2023)
Article
Chemistry, Medicinal
Nguyen Chi Mai, Ninh Khac Ban, Truong Quang Trung, Dinh Thien Hoang, Bui Van Thanh, Do Thi Trang, Bui Huu Tai, Phan Van Kiem
Summary: This study isolated three new compounds and four known compounds from the stems and leaves of Strychnos vanprukii. The chemical structures were determined using various spectroscopic techniques. The compounds showed inhibitory effects on NO production in stimulated cells.
NATURAL PRODUCT COMMUNICATIONS
(2022)
Article
Oncology
Ji-Hye Joo, Seong-Su Hong, Young-Rak Cho, Dong-Wan Seo
Article
Biochemistry & Molecular Biology
Sang-Jin Lee, Miran Yoo, Ga-Yeon Go, Do Hee Kim, Hyunmo Choi, Young-Eun Leem, Yong Kee Kim, Dong-Wan Seo, Jae-Ha Ryu, Jong-Sun Kang, Gyu-Un Bae
CHEMICO-BIOLOGICAL INTERACTIONS
(2016)
Article
Oncology
Jae-Kyung In, Jin-Kyu Kim, Joa Sub Oh, Dong-Wan Seo
INTERNATIONAL JOURNAL OF ONCOLOGY
(2016)
Article
Oncology
Miran Yoo, Sang-Jin Lee, Yong Kee Kim, Dong-Wan Seo, Nam-In Baek, Jae-Ha Ryu, Jong-Sun Kang, Gyu-Un Bae
MOLECULAR MEDICINE REPORTS
(2016)
Article
Cell Biology
Sang-Jin Lee, Jeongmi Hwang, Hyeon-Ju Jeong, Miran Yoo, Ga-Yeon Go, Jae-Rin Lee, Young-Eun Leem, Jong Woo Park, Dong-Wan Seo, Yong Kee Kim, Myong-Joon Hahn, Jeung-Whan Han, Jong-Sun Kang, Gyu-Un Bae
CELL DEATH & DISEASE
(2016)
Article
Food Science & Technology
Sang-Jin Lee, Tuan Anh Vuong, Ga-Yeon Go, Yoo-Jin Song, Seulah Lee, Soo-Yeon Lee, Shin-Woong Kim, Jaecheol Lee, Yong Kee Kim, Dong-Wan Seo, Ki Hyun Kim, Jong-Sun Kang, Gyu-Un Bae
JOURNAL OF FUNCTIONAL FOODS
(2017)
Article
Oncology
Young-Rak Cho, Kyuhee Park, Jae-Shin Kang, Hye-Woo Byun, Joa Sub Oh, Dong-Wan Seo, Eun-Kyung Ahn
Article
Plant Sciences
Ga-Yeon Go, Sang-Jin Lee, Ayoung Jo, Jaecheol Lee, Dong-Wan Seo, Jong-Sun Kang, Si-Kwan Kim, Su-Nam Kim, Yong Kee Kim, Gyu-Un Bae
JOURNAL OF GINSENG RESEARCH
(2017)
Article
Plant Sciences
Soo-Yeon Lee, Ga-Yeon Go, Tuan Anh Vuong, Jee Won Kim, Sullim Lee, Ayoung Jo, Jun Min An, Su-Nam Kim, Dong-Wan Seo, Jin-Seok Kim, Yong Kee Kim, Jong-Sun Kang, Sang-Jin Lee, Gyu-Un Bae
JOURNAL OF GINSENG RESEARCH
(2018)
Article
Multidisciplinary Sciences
Sang-Jin Lee, Young-Eun Leem, Ga-Yeon Go, Younhee Choi, Yoo Jin Song, Insol Kim, Do Yoon Kim, Yong Kee Kim, Dong-Wan Seo, Jong-Sun Kang, Gyu-Un Bae
Article
Plant Sciences
Ga-Yeon Go, Ayoung Jo, Dong-Wan Seo, Woo Young Kim, Yong Kee Kim, Eui-Young So, Qian Chen, Jong-Sun Kang, Gyu-Un Bae, Sang-Jin Lee
JOURNAL OF GINSENG RESEARCH
(2020)
Article
Cell Biology
Min Su Kim, Jae Hyeon Kim, Eun-Kyung Ahn, Young-Rak Cho, Surim Han, Choong-Hyun Lee, Gyu-Un Bae, Joa Sub Oh, Kyu-Bong Kim, Dong-Wan Seo
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2020)
Article
Cell Biology
Jae Hyeon Kim, Sunho Kim, Surim Han, Eun-Kyung Ahn, Young-Rak Cho, Wonsik Jeong, Sung Joon Kim, Gyu-Un Bae, Joa Sub Oh, Dong-Wan Seo
Summary: In this study, the regulatory effects and mechanism of broussonin A and B on endothelial cell responses and angiogenesis were investigated. The results showed that broussonin A and B suppressed VEGF-A-stimulated endothelial cell proliferation and angiogenic responses through the regulation of cell cycle-related proteins and downstream signaling pathways. Furthermore, broussonin A and B inhibited the growth and invasion of lung and ovarian cancer cells. These findings suggest the potential pharmacological use of broussonin A and B in the regulation of angiogenesis and cancer cell growth.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2022)
Review
Toxicology
Jung Dae Lee, Joo Young Lee, Seung Jun Kwack, Chan Young Shin, Hyun-Jun Jang, Hyang Yeon Kim, Min Kook Kim, Dong-Wan Seo, Byung-Mu Lee, Kyu-Bong Kim
TOXICOLOGICAL RESEARCH
(2019)
Article
Biochemistry & Molecular Biology
Hee Doo Yang, Jung Woo Eun, Kyung-Bun Lee, Qingyu Shen, Hyung Seok Kim, Sang Yean Kim, Dong-Wan Seo, Won Sang Park, Jung Young Lee, Suk Woo Nam
EXPERIMENTAL AND MOLECULAR MEDICINE
(2018)
Article
Chemistry, Organic
Geeta Devi Yadav, Pooja Chaudhary, Balaram Pani, Surendra Singh
Summary: Chiral transition metal complexes with privileged ligands are efficient catalysts for various asymmetric organic transformations. Transition metal complexes of C1-symmetric pyrrolidine-based ligands have been widely used in asymmetric organic reactions. However, a comprehensive review article on the transition metal complexes of chiral C1-symmetric pyrrolidine-based ligands derived from (L)-proline has not been published.
TETRAHEDRON LETTERS
(2024)
