Article
Biochemistry & Molecular Biology
Jael R. Neyra Recky, M. Laura Dantola, Carolina Lorente
Summary: This study aims to evaluate the effect of adding DOPA on the oxidation process of biomolecules in acidic aqueous solutions. The results suggest that DOPA can decrease the consumption rate of biomolecules, possibly through electron transfer reactions between DOPA and biomolecule radicals.
PHOTOCHEMISTRY AND PHOTOBIOLOGY
(2023)
Article
Chemistry, Inorganic & Nuclear
Hassan Abul-Futouh, Daniel Costabel, Konrad Hotzel, Phil Liebing, Helmar Goeris, Wolfgang Weigand, Kalina Peneva
Summary: This report presents the synthesis and characterization of a mimic of [FeFe]-hydrogenase, named [Fe-2(CO)(6){μ-bdtf}] (2, bdtf = 3,4-dimercaptobenzaldehyde), obtained from the reaction between 3,4-dimercaptobenzaldehyde and Fe-3(CO)(12). Different ligands, such as PPh3 and P(OMe)(3), were used to modify complex 2, resulting in mono- and disubstituted complexes [Fe-2(CO)(5)PPh3{μ-bdtf}] (3), [Fe-2(CO)(4)(PPh3)(2){μ-bdtf}] (4), and [Fe-2(CO)(4)(P(OMe)(3))(2){μ-bdtf}] (5). The structures of complexes 2-5 were determined by X-ray diffraction analysis. The electrochemistry and catalytic activity of these mimics towards proton reduction were evaluated by cyclic voltammetry, with all complexes showing potential for hydrogen formation in the presence of weak acid, such as acetic acid (AcOH).
INORGANICA CHIMICA ACTA
(2023)
Article
Biotechnology & Applied Microbiology
Emi Yumoto, Naohisa Yanagihara, Masashi Asahina
Summary: L-3,4-dihydroxyphenylalanine (L-DOPA) is an important secondary metabolite in plants, with various biological roles such as stress response and metabolism. This paper describes an improved method for the quantification of L-DOPA content in plants, which is simple and rapid and can be done with a small amount of plant tissue.
PLANT BIOTECHNOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Yun-Gang He, Yong-Kang Huang, Qi-Qi Fan, Bo Zheng, Yong-Qiang Luo, Xing-Liang Zhu, Xiao-Xin Shi
Summary: This article presents a novel oxidation method for 1-Bn-DHIQs, efficiently and selectively converting them to 1-Bz-DHIQs while avoiding excessive oxidation. This method has been successfully applied in the total synthesis of the alkaloid canelillinoxine.
Article
Chemistry, Applied
Fabio Mastrogiovanni, Annalisa Romani, Luca Santi, Nicola Lacetera, Roberta Bernini
Summary: The study demonstrated that pomegranate peel extracts have a protective effect on bovine peripheral blood mononuclear cells and are not cytotoxic at certain concentrations. Additionally, the extracts show significant anti-proliferative activity.
NATURAL PRODUCT RESEARCH
(2021)
Article
Chemistry, Applied
Elisa Pannucci, Rocco Caracciolo, Annalisa Romani, Francesco Cacciola, Paola Dugo, Roberta Bernini, Leonardo Varvaro, Luca Santi
Summary: An extract enriched with hydroxytyrosol (HTyr) obtained from olive mill wastewaters was tested on olive tree pathogens Pss and At, showing potent antioxidant and antimicrobial activity, highlighting the potential application in olive cultivation.
NATURAL PRODUCT RESEARCH
(2021)
Article
Chemistry, Applied
Elisa Pannucci, Donatella D'Eliseo, Francesca Ieri, Annalisa Romani, Luca Santi, Roberta Bernini, Maurizio Sabatti, Francesca Velotti
Summary: The hydroalcoholic extracts obtained from buds of P. nigra, P. deltoides and P. trichocarpa showed antioxidant and anti-inflammatory activities, with P. nigra demonstrating the highest antioxidant activity and all extracts suppressing the production of key pro-inflammatory cytokines. These results highlight the potential of these extracts as therapeutic agents.
NATURAL PRODUCT RESEARCH
(2022)
Article
Multidisciplinary Sciences
Annalisa Romani, Gabriele Simone, Margherita Campo, Lorenzo Moncini, Roberta Bernini
Summary: The antifungal activities of tannins-rich commercial sweet chestnut wood and green tea leaf extracts were evaluated against various filamentous fungi, showing higher inhibitory effects with increasing concentrations.
Article
Biochemistry & Molecular Biology
Francesca Luzi, Elisa Pannucci, Mariangela Clemente, Edoardo Grande, Silvia Urciuoli, Annalisa Romani, Luigi Torre, Debora Puglia, Roberta Bernini, Luca Santi
Summary: This study utilized a sustainable process to extract antioxidants from olive oil wastes and by-products, preparing novel PVA-based films with promising antioxidant properties. The films showed potential for use in active food packaging to protect oxidative-sensitive food products. This research demonstrates a valuable example of reusing and valorizing agro-industrial wastes and by-products in accordance with the circular economy model.
Article
Agronomy
Mounira Inas Drais, Elisa Pannucci, Rocco Caracciolo, Roberta Bernini, Annalisa Romani, Luca Santi, Leonardo Varvaro
Summary: The study revealed that hydroxytyrosol enriched extracts from olive mill waste products have antifungal activity against Verticillium dahliae, with HTE1 showing higher efficacy. This suggests the potential of these compounds as an eco-friendly control measure for Verticillium wilt in olive production.
PHYTOPATHOLOGIA MEDITERRANEA
(2021)
Editorial Material
Nutrition & Dietetics
Annalisa Noce, Annalisa Romani, Roberta Bernini
Article
Biochemistry & Molecular Biology
Manuela Leo, Livio Muccillo, Laura Dugo, Roberta Bernini, Luca Santi, Lina Sabatino
Summary: Olive oil production generates waste products rich in water-soluble polyphenols, which can pose environmental problems. However, these waste products can be exploited for their bioactive properties. This study chemically characterized the polyphenolic extracts from the waste products and investigated their biological activities in normal and colorectal cancer cells. The extracts showed anti-inflammatory effects and can potentially ameliorate inflammation associated with diseases and tumors.
Article
Chemistry, Applied
Loredana Basirico, Fabio Mastrogiovanni, Nicola Lacetera, Luca Santi, Roberta Bernini, Umberto Bernabucci
Summary: This in vitro study evaluated for the first time the antioxidant and anti-inflammatory effect of an Oleuropein-enriched extract on bovine mammary epithelial cells. The extract showed no cytotoxic effect on the cells and reduced ROS production induced by hydrogen peroxide. It also downregulated the expression of pro-inflammatory cytokines. These findings confirm the antioxidant and anti-inflammatory properties of the extract.
NATURAL PRODUCT RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Valentina Laghezza Masci, Roberta Bernini, Noemi Villanova, Mariangela Clemente, Vittoria Cicaloni, Laura Tinti, Laura Salvini, Anna Rita Taddei, Antonio Tiezzi, Elisa Ovidi
Summary: The antitumor activity of hydroxytyrosyl oleate (HTyr-OL) against neuroblastoma cells was evaluated in this study. Results showed that the biological activity of HTyr was maintained in HTyr-OL treatments at lower dosages. Additionally, HTyr-OL exhibited antioxidant, anti-proliferative, and anti-inflammatory activities.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Andrea Lombardi, Andrea Fochetti, Pamela Vignolini, Margherita Campo, Alessandra Durazzo, Massimo Lucarini, Debora Puglia, Francesca Luzi, Marco Papalini, Monia Renzi, Andrea Cavallo, Roberta Bernini
Summary: This review article summarizes the current research status of the activation technology of poly (lactic acid) (PLA)-based materials in food and biomedical applications using natural compounds and extracts from plant sources. It discusses the synthesis and properties of PLA, as well as the chemical properties and unconventional extraction technologies of active ingredients (AIs) used for PLA activation. The innovative techniques for incorporating AIs into PLA, characterization of the novel materials, and their antioxidant and antimicrobial properties are also discussed. The study highlights the need for further joint research between academia and industry, following green chemistry principles and circular economy strategies.
Article
Biochemistry & Molecular Biology
Andrea Lombardi, Margherita Campo, Pamela Vignolini, Marco Papalini, Mirco Pizzetti, Roberta Bernini
Summary: This study characterized phenolic-rich extracts from olive, chestnut, pomegranate, and grape residues through HPLC-MS-DAD analysis. The results showed that these extracts exhibited significant growth inhibition against fungi, especially pathogenic dermatophytes. These extracts have potential applications as antifungal agents in the agri-food and biomedical fields.
Review
Nutrition & Dietetics
Laura Micheli, Laura Bertini, Agnese Bonato, Noemi Villanova, Carla Caruso, Maurizia Caruso, Roberta Bernini, Felice Tirone
Summary: Aging is a complex process caused by cellular damage accumulation and reduction in physiological activities, leading to increased incidence of age-related diseases. The Mediterranean diet, particularly the bioactive compounds in extra virgin olive oil like hydroxytyrosol and oleuropein, has been associated with longevity and protection against age-related disorders. This review focuses on the effects of these compounds on the brain, skeletal muscle, and gut microbiota, discussing their role in neurodegenerative diseases, neurogenesis, senescence, muscle disorders, and gut microbiota composition.
Review
Nutrition & Dietetics
Francesca Velotti, Roberta Bernini
Summary: Inflammaging refers to chronic low-grade inflammation caused by immune and non-immune cells stimulated by endogenous/self, misplaced or altered molecules, belonging to physiological aging. This inflammatory status is characterized by increased inflammation and decreased autophagy, and predisposes to age-related diseases. Phenolic compounds, particularly hydroxytyrosol (HTyr) found in extra-virgin olive oil, have antioxidant and anti-inflammatory properties that may counteract inflammaging and contribute to healthy aging.
Article
Computer Science, Information Systems
Giorgia Perelli, Roberta Bernini, Massimo Lucarini, Alessandra Durazzo
Summary: This study provides an update to the Dietary Supplement Label Database in Italy focused on dietary supplements coding. The updated dataset serves as a valuable resource for applying classification coding systems to dietary supplements and for various applications such as epidemiological investigations, exposure studies, and dietary assessment.
Article
Chemistry, Organic
Geeta Devi Yadav, Pooja Chaudhary, Balaram Pani, Surendra Singh
Summary: Chiral transition metal complexes with privileged ligands are efficient catalysts for various asymmetric organic transformations. Transition metal complexes of C1-symmetric pyrrolidine-based ligands have been widely used in asymmetric organic reactions. However, a comprehensive review article on the transition metal complexes of chiral C1-symmetric pyrrolidine-based ligands derived from (L)-proline has not been published.
TETRAHEDRON LETTERS
(2024)
