Article
Chemistry, Analytical
Raquel B. R. Mesquita, Christina Klima, H. Martinez-Perez-Cejuela, Ana R. Monforte, A. C. Silva Ferreira, Antonio O. S. S. Rangel
Summary: During the winemaking process, the exposure of wine to oxygen can affect its color and flavor. Iron ions, specifically Fe(III) and Fe(II), play a significant role in the oxidation of phenolic compounds in wine. Speciation analysis based on the oxidation state is crucial for evaluating the risk of wine oxidation. A microfluidic paper-based analytical device was developed for iron speciation analysis in wine samples, using a colorimetric reaction and hydroxylamine for the oxidation of Fe(III) to Fe(II). This device successfully analyzed iron speciation in both white and red wines.
MICROCHEMICAL JOURNAL
(2023)
Review
Chemistry, Multidisciplinary
Jiayi Li, Hien M. Nguyen
Summary: This study investigates the catalytic control and mechanism of glycosylation reactions. It finds that phenanthroline can serve as a nucleophilic catalyst for highly diastereoselective glycosylation. This method has potential applications in the synthesis of biologically important oligosaccharides and glycopeptides.
ACCOUNTS OF CHEMICAL RESEARCH
(2022)
Article
Chemistry, Multidisciplinary
Hengfu Xu, Richard N. Schaugaard, Jiayi Li, H. Bernhard Schlegel, Hien M. Nguyen
Summary: This study reports a new stereoselective method for the formation of the 1,2-cis furanosidic linkage using phenanthroline catalysts. The method operates under mild conditions and provides good yields and high selectivities for biologically relevant oligosaccharides and polysaccharides. NMR experiments and density functional theory calculations support an associative mechanism, and the reaction is applicable to various furanosyl bromide donors.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2022)
Article
Chemistry, Applied
Andreia R. Rodrigues, Iara S. Nunes, Julys Pablo A. Fernandes, Stefani Iury E. Andrade, Amalia Gama G. Pessoa, Ricardo Alexandre C. de Lima
Summary: A digital image-based flow-batch analyzer (DIB-FBA) was developed for determining the chemical speciation of iron in tomato samples. The Fe(II)/1,10-phenanthroline reaction was used for Fe(II) determination and Fe(III) was calculated by subtracting Fe(II) from total iron. The DIB-FBA, which utilized a webcam and software for image analysis, showed satisfactory performance in analyzing different tomato types and certified reference material. The combination of digital image and flow automation provided by DIB-FBA can have further applications in speciating other metals in diverse food samples.
JOURNAL OF FOOD COMPOSITION AND ANALYSIS
(2023)
Article
Dermatology
Yuping Zhang, Jingli Li, Zizhen Zhao, Xiaoxi Yang, Dongmei You, Xiaorong Li, Zhigang Fan, Ailing Fu
Summary: This study discovers that a compound called ph-ph+ has inhibitory effects on the fungus causing dermatophytosis and kills the fungi by inducing cell apoptosis. The results show that the ph-ph+ gel can effectively eliminate the pathogen without any side effects. This research not only provides a potential new treatment for fungal infections, but also reveals a new approach of inducing cell apoptosis through iron ion.
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2023)
Article
Chemistry, Organic
Bo-Xi Liu, Fei Wang, Ying Chen, Wei-Dong Rao, Shu-Su Shen, Shun-Yi Wang
Summary: A visible-light-promoted regioselective denitrogenative cross-coupling between benzotriazinones and selenosulfonates has been developed for the synthesis of ortho-selenylated benzamides. The reaction provides good yields and demonstrates a general substrate scope. Furthermore, this protocol has been successfully employed for the one-pot two-step synthesis of a series of ebselen and its analogs.
ORGANIC CHEMISTRY FRONTIERS
(2022)
Article
Chemistry, Inorganic & Nuclear
Svetlana V. Gutorova, Petr I. Matveev, Pavel S. Lemport, Daniil A. Novichkov, Igor P. Gloriozov, Nane A. Avagyan, Alexey O. Gudovannyy, Yulia V. Nelyubina, Vitaly A. Roznyatovsky, Vladimir G. Petrov, Konstantin A. Lyssenko, Yuri A. Ustynyuk, Stepan N. Kalmykov, Valentine G. Nenajdenko
Summary: Phenanthroline diamides (L) have the unique ability to extract uranium from nitric acid solutions and form 1:2 stoichiometry complexes as tight ion pairs {[UO2LNO3]+[UO2(NO3)3]-} in a polar organic solvent. This extraction mechanism combines solvation and ion-pair anion exchange, and was confirmed by UV-vis study and chemical synthesis. The structure of the complexes in the solid state was unambiguously determined through chemical synthesis and single crystal growth.
INORGANIC CHEMISTRY
(2023)
Article
Medicine, Research & Experimental
Priyadharshini Sivasubramaniam, Nadarra Stokes, Ameya Patil, Lindsey Smith, Christopher P. Hartley, Rondell P. Graham, Roger K. Moreira
Summary: Currently, tissue hepatic iron content (HIC) evaluation requires destructive laboratory testing. To improve this, an AI model was developed for the recognition and measurement of iron in liver samples using routine histologic stains. The AI model showed strong correlation with HIC and other histologic scoring systems, and offered advantages over standard quantitative methods in terms of spatial resolution and nondestructive testing.
LABORATORY INVESTIGATION
(2023)
Article
Chemistry, Multidisciplinary
Aleksandr Denisenko, Pavel Garbuz, Yelyzaveta Makovetska, Oleh Shablykin, Dmytro Lesyk, Galeb Al-Maali, Rodion Korzh, Iryna V. Sadkova, Pavel K. Mykhailiuk
Summary: Bicyclo[2.1.1]hexanes have been synthesized and used as saturated bioisosteres of the ortho-substituted benzene ring. Incorporating the bicyclo[2.1.1]hexane core into the structure of fungicides resulted in patent-free analogs with high antifungal activity.
Article
Chemistry, Multidisciplinary
Sumit Ghosh, Sudip Laru, Alakananda Hajra
Summary: C-H activation and functionalization have shown promise as a versatile method for bond formations, while imidazopyridine, especially 2-arylImidazo[1,2-a]pyridine, has garnered attention for its coordination with metal catalysts in forming ortho-substituted products. This review summarizes articles on ortho C-H functionalization of 2-arylImidazo[1,2-a]pyridines up to August 2021.
Article
Chemistry, Multidisciplinary
Sumit Ghosh, Sudip Laru, Alakananda Hajra
Summary: C-H activation and functionalization is a promising strategy for synthetic versatility, while the fused bicycle of imidazole with pyridine, 2-arylImidazo[1,2-a]pyridine, has profound impact in medicinal and material chemistry. The N-1 atom in 2-arylImidazo[1,2-a]pyridine facilitates coordination with metal catalysts for ortho-substituted product formation. This review summarizes the research articles on ortho C-H functionalization of 2-arylImidazo[1,2-a]pyridines published until August 2021.
Article
Engineering, Biomedical
Bastien Eydan, Baptiste Pierrat, Nicolas Curt, Hassan Zahouani, Jerome Molimard
Summary: The aim of this study was to develop a new device to study the mechanical interaction between medical devices and skin, and its effects on shear strain and friction behavior. The experiment results showed that skin surface conditioning had a significant impact on friction properties.
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
(2022)
Article
Chemistry, Physical
Paul M. DeMent, Chenlu Liu, Joseph Wakpal, Richard N. Schaugaard, H. Bernhard Schlegel, Hien M. Nguyen
Summary: Phenanthroline is a commonly used bidentate ligand in coordination chemistry, which can be tuned to develop efficient and stereoselective catalysts. By activating 2-deoxy-2-fluoro glycosyl halides with phenanthroline-based catalysts, glycosylations with high levels of alpha-selectivities and moderate to high yields can be achieved. The proposed mechanism for this catalytic glycosylation system involves double S(N)2 displacement pathways with phenanthroline catalysts, ensuring stereoselective formation of alpha-1,2-cis-2-fluoro glycosides.
Article
Chemistry, Analytical
Geandre de Carvalho Oliveira, Caio Cesar Souza Machado, Dayane Karine Inacio, Joao Flavio da Silveira Petruci, Sidnei G. Silva
Summary: In this study, an RGB color sensor was used for quantitative optical analysis of colored solutions. The sensor's ability to respond to different colored solutions was evaluated, and the spectral bands processed by each sensor channel were investigated. The results showed that the sensor achieved similar analytical performance to a commercial spectrophotometer and did not require image processing. This research is significant for quantitative analysis of colored solutions.
Article
Mechanics
Thomas Duminy, Aurelien Doitrand, Sylvain Meille
Summary: This study conducted in situ wedge splitting tests on millimeter-size PMMA samples and proposed a method to determine the material tensile strength and critical energy release rate using digital image correlation and a full finite element implementation of the coupled criterion.
ENGINEERING FRACTURE MECHANICS
(2024)
Article
Biochemistry & Molecular Biology
Alexsandro Sozar Martins, Batista Pereira Junior Joao, Adriano de Araujo Gomes, Fabio Israel Martins Carvalho, Adonias Dantas Filho Heronides, Kelly Das Gracas Fernandes Dantas
BIOLOGICAL TRACE ELEMENT RESEARCH
(2020)
Article
Food Science & Technology
Adilson S. Santos, Cheilane T. de Souza, Danilo J. Leao, Felipo O. Correia, Tarcisio S. Almeida, Sergio L. C. Ferreira
FOOD ANALYTICAL METHODS
(2020)
Article
Chemistry, Analytical
Emanuella Santos Sousa, Mateus P. Schneider, Licarion Pinto, Mario Cesar Ugulino de Araujo, Adriano de Araujo Gomes
MICROCHEMICAL JOURNAL
(2020)
Article
Chemistry, Analytical
Kaewta Danchana, Piyawan Phansi, Cheilane T. de Souza, Sergio L. C. Ferreira, Victor Cerda
Article
Environmental Sciences
Juliana Bazzan Arsand, Rodrigo Barcellos Hoff, Louise Jank, Roberta Bussamara, Alexsandro Dallegrave, Fatima Menezes Bento, Livia Kmetzsch, Daiane Acosta Falcao, Maria do Carmo Ruaro Peralba, Adriano de Araujo Gomes, Tania Mara Pizzolato
SCIENCE OF THE TOTAL ENVIRONMENT
(2020)
Article
Chemistry, Physical
Eder C. Lima, Adriano A. Gomes, Hai Nguyen Tran
JOURNAL OF MOLECULAR LIQUIDS
(2020)
Article
Chemistry, Applied
Cynthia Giselle Reile, Maria Susana Rodriguez, David Douglas de Sousa Fernandes, Adriano de Araujo Gomes, Paulo Henrique Goncalves Dias Diniz, Carolina Vanesa Di Anibal
Article
Automation & Control Systems
Aline S. Pontes, Alisson Araujo, Weverton Marinho, Paulo H. Goncalves Dias Diniz, Adriano de Araujo Gomes, Hector C. Goicoechea, Edvan C. Silva, Mario C. U. Araujo
JOURNAL OF CHEMOMETRICS
(2020)
Article
Chemistry, Analytical
Federico Belen, Federico Danilo Vallese, Lisa G. T. Leist, Marco Flores Ferrao, Adriano de Araujo Gomes, Marcelo Fabian Pistonesi
MICROCHEMICAL JOURNAL
(2020)
Article
Chemistry, Analytical
Odiane C. Balieiro, Mayra Suelen da Silva Pinheiro, Simone Y. S. Silva, Marilene Nunes Oliveira, Sebastiao C. Silva, Adriano A. Gomes, Licarion Pinto
MICROCHEMICAL JOURNAL
(2020)
Article
Chemistry, Applied
Ravena Souza de Almeida Azevedo, Joao Honorato Santos Neto, Liz Oliveira Dos Santos, Adriano de Araujo Gomes, Debora de Andrade Santana, Ana Maria Pinto Dos Santos
Summary: This study proposes a preliminary assessment of the homogeneity and stability of mechanically processed pumpkin seed meal reference material using digital image acquisition and texture characteristics analysis. The results indicated low homogeneity, with most samples being considered stable.
Review
Chemistry, Analytical
Sergio L. C. Ferreira, Victor Cerda, Lindomar A. Portugal, Lucas B. Goncalves, Joao H. Santos Neto, Joao B. Pereira Junior, Edwin Palacio
Summary: This study discusses the methods for selenium speciation analysis using CVG-AFS and their advantages and drawbacks.
TRAC-TRENDS IN ANALYTICAL CHEMISTRY
(2022)
Article
Chemistry, Analytical
Caio S. A. Felix, Joao B. Pereira Junior, Jucelino B. da Silva Junior, Allan S. Cruz, Kelly G. F. Dantas, Sergio L. C. Ferreira
Summary: This study reports the mercury levels in fish samples purchased at a public market in Belem City, Brazil. The results showed that consuming 25g of these fish daily does not pose a risk to the local population's health.
Article
Chemistry, Analytical
Lindomar A. Portugal, Edwin Palacio, Rejane Frizzarin, Joao H. Santos Neto, Victor Cerda, Sergio L. C. Ferreira
Summary: This work proposes an automated strategy for the speciation of inorganic selenium in infusion tea samples. The system utilizes an MSFIA-CVG-AFS system and sodium tetrahydroborate for chemical vapor generation. The method involves an online prereduction step to convert selenium (VI) to selenium (IV) before determining the total selenium concentration. The chemical parameters were optimized using a fractional factorial design. The method exhibited low detection and quantification limits, with a linear range and good precision. This method was successfully applied to analyze inorganic selenium speciation in commercially purchased tea samples.
Article
Chemistry, Analytical
Qian Wu, Li Tian, Xiangyu Shan, Huiling Li, Chao Li, Juan Lu
Summary: A novel ECL sensor was developed by modifying Fe3CuO4-Ru(bpy)3+ and GO-CdS@ZnS on the electrode for the detection of permethrin. The sensor exhibited high sensitivity and a wide detection range.
Article
Chemistry, Analytical
Tingting Gong, Lei Liao, Bingying Jiang, Ruo Yuan, Yun Xiang
Summary: In this study, a fluorescent biosensing system for high sensitivity detection of MT was established using a new Ag+-stabilized DNA triplex probe (Ag+-SDTP) combined with catalytic hairpin assembly (CHA) and CRISPR/Cas12a signal enhancements. The sensing method is able to selectively detect MT from other non-specific molecules and can achieve low level detection of MT in diluted human serums, demonstrating its potential for monitoring disease-specific MT biomarker at trace levels.
Article
Chemistry, Analytical
Estrella Sanz Rodriguez, Kyra Wood, Paul R. Haddad, Brett Paull
Summary: This study presents a simple, rapid, and reliable method for determining boron in aqueous solutions using suppressed ion chromatography coupled to electrospray ionisation-triple quadrupole mass spectrometry. The method achieved a low limit of detection and demonstrated excellent analytical performance.
Article
Chemistry, Analytical
Aline Cournut, Paul Moustiez, Yannick Coffinier, Christine Enjalbal, Claudia Bich
Summary: Alzheimer's disease is a major cause of senile dementia and is characterized by the aggregation of neurofibrillary tangles and amyloid plaques in the brain. The A beta 1-42 peptide is considered the primary cause of neurotoxicity due to its insolubility and subsequent aggregation. A beta 1-42 and A beta 1-40 have been identified as relevant biomarkers for AD diagnosis, and SurfaceAssisted Laser Desorption/Ionization Mass Spectrometry (SALDI-MS) was used to monitor the A beta 1-42/A beta 1-40 ratio without prior sample treatment.
Article
Chemistry, Analytical
Dotse Selali Chormey, Buse Tugba Zaman, Tulay Borahan Kustanto, Sezin Erarpat Bodur, Suleyman Bodur, Elif Ozturk Er, Sezgin Bakirdere
Summary: This review provides an overview of the harmful effects of endocrine disrupting chemicals (EDCs) on human health and introduces the methods for analyzing EDCs. Recent research has focused on using green chemicals, such as deep eutectic solvents (DESs), for microextraction to ensure environmental safety.
Article
Chemistry, Analytical
Yan Zhang, Renfeng Xu, Jingjing Wu, Zhenghong Zhang, Yuhuang Wang, Hongqin Yang, Sheng Zhang
Summary: This study visualized the pore-like structures in prostate cancer cell membranes after treatment with the anticancer drug paclitaxel, demonstrating its mechanism of action related to oxidative damage.
Article
Chemistry, Analytical
Chihong Ma, Qin Zhou, Jinjin Shi, Hua Gao, Di Huang, Huimin Xue, Han Wang, Zhenzhong Zhang, Sen Yang, Junli Zhang, Kaixiang Zhang
Summary: We developed a CRISPR-empowered electrochemical biosensor, named PER-E-CRISPR, for amplification-free and sensitive detection of miR-21. The biosensor combines the advantages of CRISPR/Cas13a and primer exchange reaction (PER) for target amplification. Under optimized conditions, the PER-E-CRISPR assay exhibits a linear range from 10-13 to 10-7 M and a limit of detection of 30.2 fM. The biosensor shows excellent performance in actual plasma, indicating promising prospects for miRNA detection in molecular diagnosis.
Article
Chemistry, Analytical
Gang Liang, Jie Zhao, Yufei Gao, Tao Xie, Jianhui Zhen, Ligang Pan, Wenwen Gong
Summary: Molecular docking (MD) analysis is widely used for studying the interaction between aptamers and small molecules. This study established steady-state aptamers of tertiary structures (SATS) using specific aptamers of tetracycline antibiotics as docking models. Molecular docking results revealed multiple binding sites in the SATS of aptamers, with significant variations in binding free energy (BFE) and docking score (DS). The study also proposed a method for MD analysis based on SATS, providing insights into binding mode and predicting binding sites.
Article
Chemistry, Analytical
Yixuan Xu, Changchang Teng, Huiping Dang, Dalong Yin, Lifeng Yan
Summary: Stable organic radical molecules with high NIR fluorescence quantum efficiency have been synthesized and encapsulated into nanoparticles, which show great potential for both photodynamic therapy (PDT) and photothermal therapy (PTT) of tumors.
Article
Chemistry, Analytical
Yu Su, Dandan Yang, Yanjie Wang, Jie Ding, Lan Ding, Daqian Song
Summary: In this study, a highly selective molecularly imprinted polymer Cu-MIPs@CS was designed and synthesized for bisphenol A (BPA). Cu-MIPs@CS showed significantly enhanced imprinting factor and selective factor towards BPA compared to MIPs@CS. It also exhibited superior discrimination ability between BPA and its structural analogue. Additionally, Cu-MIPs@CS were successfully applied as a solid phase extraction adsorbent for the determination of BPA in drinking water samples.
Article
Chemistry, Analytical
Yi Qiao, Qiongdan Zhang, Yukun He, Tianguang Cheng, Jing Tu
Summary: Single cell heterogeneity plays an important role in many biological phenomena, and distinguishing cells with specific mutations is beneficial for clinical diagnosis and drug screening. This study introduces a gel plate platform that can distinguish cell types based on their phenotypes, with low equipment requirement. The gel platform has potential in point-of-care circumstances and single-cell stimulation responses that prioritize efficiency and simplicity.
Article
Chemistry, Analytical
Chengke Wang, Shuyang Sun, Ping Wang, Huawei Zhao, Wenling Li
Summary: The food safety of aquatic products is a global concern. Nanotechnology-based analyses have advantages in the detection of bacteria, metal ions, and small molecule contaminants. This review summarizes the recent advances in biosensing strategies for aquatic products and highlights the application of nanomaterials, lateral flow-based biosensors, surface-enhanced Raman scattering, microfluidic chips, and molecular imprinting technologies.
Article
Chemistry, Analytical
Liping Zhu, Zeng Tang, Xuemei Zhang, Li Zhu, Tian Meng, Linying Yu, Ting Xiao, Shasha Lu, Xiaoli Xiong, Xiurong Yang
Summary: A sensitive off-on electrochemiluminescence DNA sensor was developed using Exo III-assisted cascade amplification system. The sensor achieved high selectivity and ultra-high sensitivity in detecting target DNA by utilizing ECL and SPR effects. This study provides a new perspective for designing highly sensitive and programmable ECL biosensors.
Article
Chemistry, Analytical
Tong Li, Mengxu Sun, Suping Xia, Ting Huang, Rong-Tian Li, Chunrong Li, Zong Dai, Jin-Xiang Chen, Jun Chen, Nuan Jia
Summary: Here, we developed a binary system based on DNA tetrahedron and fluorogenic RNA aptamers for highly specific and label-free mRNA imaging in living cells. This system achieved high specificity label-free detection of nucleic acids with a detection limit of 1.34 nM. The method has potential applications in early disease diagnosis and new drug development.
Article
Chemistry, Analytical
Yao Zhao, Shu Zhang, Wang Yao, Yuxuan Zhu, Jing Qian, Juan Yang, Nianjun Yang
Summary: A new hierarchical nanostructured composite with high conductivity and catalytic activity is synthesized. The sensor exhibits significant catalytic effect and high sensitivity for monitoring the environmental endocrine disruptor bisphenol A (BPA).