Article
Chemistry, Analytical
Yina Sun, Chuan Huang, Xiujin Sun, Qian Wang, Peini Zhao, Shenguang Ge, Jinghua Yu
Summary: By utilizing MoS2-GQDs nanocomposite and enzyme-assisted DNA signal amplification, a novel on-off switch ECL biosensor was developed for sensitive detection of specific DNA sequences. The biosensor showed a good linear relationship in the range from 1 nM to 100 aM with a detection limit of 25.1 aM, providing a powerful strategy for biomedical research and clinical analysis.
Article
Biochemistry & Molecular Biology
Xinying Zhang, Xialing Hou, Decheng Lu, Yingying Chen, Lingyan Feng
Summary: A novel and efficient carbon nanocomposite material, Porphyrin (TMPyP) functionalized carbon quantum dots (CQDs-TMPyP), was developed as a luminescent material for the sensitive detection of copper ions (Cu2+) by quenching the luminescence of functionalized carbon quantum dots. A sensitive signal off electrochemiluminescence (ECL) biosensor was constructed for the detection of Cu2+. The sensor showed sensitive response to copper ions in the range of 10 nM to 10 mu M, with a detection limit of 2.78 nM. It exhibited good selectivity, stability, and a favorable response in complex systems. This proposed ECL biosensor provides an efficient and ultrasensitive method for Cu2+ detection.
Article
Chemistry, Analytical
Shuangtian Dong, Dongyang Wang, Xuwen Gao, Li Fu, Jingna Jia, Yuqi Xu, Bin Zhang, Guizheng Zou
Summary: This study proposes a method to achieve chemiluminescence with different wavelengths and intensities by adjusting triggering agents, which shows promising potential for applications in immunoassays and other fields.
ANALYTICAL CHEMISTRY
(2022)
Article
Chemistry, Analytical
Xiang Hu, Ying Wang, Xiong Zuping, Pei Song, Ai-Jun Wang, Zhaosheng Qian, Pei-Xin Yuan, Tiejun Zhao, Jiu-Ju Feng
Summary: In this study, an aggregation-enhanced PEC photosensitizer PPIX-[BMIm] was prepared by electrostatic bonding, and its PEC performance in a binary solvent of water and DMSO was studied. A label-free PEC cytosensor was built using PPIX-[BMIm], which showed a wide linear range and low limit of detection for detecting leukemia cells.
ANALYTICAL CHEMISTRY
(2022)
Article
Chemistry, Analytical
Jing Wen, Ding Jiang, Xueling Shan, Wenchang Wang, Fangmin Xu, Zhidong Chen
Summary: A new monitoring method for kanamycin (KAN) was developed using black phosphorus quantum dots (BPQDs) and a sensitive electrochemiluminescence (ECL) aptasensor based on HLPNs@Ag. The sensor showed superior performance in detecting KAN sensitively and selectively within a wide linear range. This ultra-sensitive and rapid ECL aptasensor-based KAN detection system has great potential for environmental safety monitoring.
Article
Chemistry, Analytical
Xiangyu Shan, Juan Lu, Qian Wu, Chao Li, Huiling Li, Shuning Yang, Li Tian
Summary: A novel and simple electrochemiluminescent sensor based on ZIFs electrospun carbon fiber and carbon quantum dots (CQDs) was developed for the detection of malathion. The sensor exhibited high sensitivity and selectivity, offering a convenient method for the detection of malathion in fruits and vegetables in real life.
MICROCHEMICAL JOURNAL
(2023)
Article
Chemistry, Analytical
Li-Ping Zong, Junji Li, Guofang Shu, Xinye Liu, Robert S. Marks, Xue-Ji Zhang, Serge Cosnier, Dan Shan
Summary: A novel ECL amplification strategy was established by designing Fe-N-C nanosheets with exceptional catalytic activity for O-2 activation. The material was successfully applied for antibiotic detection, indicating promising prospects for biological analysis and environmental monitoring.
ANALYTICAL CHEMISTRY
(2022)
Review
Chemistry, Analytical
Manickam Ramesh, Ravichandran Janani, Chinnaiyan Deepa, Lakshminarasimhan Rajeshkumar
Summary: Biosensors are modern engineering tools widely used for various applications,including industrial process control, environmental monitoring, and healthcare. Nanotechnology integration enhances their performance and sensing ability. Nanomaterials like nanoparticles and nanowires are commonly used in manufacturing nano-biosensors.
Article
Chemistry, Analytical
Ali Firoozbakhtian, Morteza Hosseini, Mahsa Naghavi Sheikholeslami, Foad Salehnia, Guobao Xu, Hodjattallah Rabbani, Ebtesam Sobhanie
Summary: The rapid spread of SARS-CoV-2 has raised the need for efficient and rapid diagnostic tools. In this study, an electrochemiluminescence (ECL)-based detection system was developed and trained using machine learning algorithms to accurately diagnose COVID-19 with over 90% accuracy. The system provides a cost-effective and time-saving alternative to traditional testing methods.
ANALYTICAL CHEMISTRY
(2022)
Article
Chemistry, Analytical
Li Wang, Wei-Jia Zeng, Xia Yang, Ruo Yuan, Wen-Bin Liang, Ying Zhuo
Summary: In this work, luminescent groups rich carbon dots (Lu-CDs) were synthesized by incorporating luminol into the CDs, resulting in a significantly enhanced electrochemiluminescent (ECL) performance. The ECL emission of Lu-CDs showed excellent consistency with its fluorescence emission, unlike other surface state-dominated CDs. Furthermore, Lu-CDs were used to develop an ECL biosensor for tumor cell analysis, demonstrating a wide detection range and low detection limit.
ANALYTICAL CHEMISTRY
(2023)
Article
Chemistry, Analytical
Qi Yue, Xuan Li, Jinglong Fang, Min Li, Jingjing Zhang, Guanhui Zhao, Wei Cao, Qin Wei
Summary: Here, a dual-mode quenched electrochemiluminescence immunosensor based on PtPd@PDA was proposed, which provides a new approach for detecting aflatoxin B1.
ANALYTICAL CHEMISTRY
(2022)
Review
Chemistry, Physical
Yemataw Addis Alemu, Enrico Rampazzo, Francesco Paolucci, Luca Prodi, Giovanni Valenti
Summary: Nanomaterials play an important role in enhancing the analytical performance of electrochemiluminescence by modifying the photophysical properties of the excited state through processes like metal-enhanced fluorescence and resonance energy transfer.
CURRENT OPINION IN COLLOID & INTERFACE SCIENCE
(2022)
Article
Materials Science, Multidisciplinary
Qing-Feng Li, Hongjun Xia, Erqing Li, Jin-Tao Wang, Zhenling Wang
Summary: This study successfully synthesized a hybrid material that can control luminescence through light stimuli, achieving the switching of luminescence of Eu3+ ions between ON and OFF states through repeated cycles of UV and visible light irradiation. This opens the possibility of developing lanthanide-based photoswitches for optical anti-counterfeiting and data storage.
JOURNAL OF MATERIALS CHEMISTRY C
(2022)
Article
Engineering, Environmental
Linlei Liu, Yuanqi Xu, Yidan Zhu, Haijun Wang, Yaqin Chai, Ruo Yuan
Summary: In this study, carbon nitride quantum dots (CNQDs) with efficient near-infrared electrochemiluminescence (NIR-ECL) and excellent biocompatibility were prepared as an emitter to construct an ultrasensitive regenerative biosensing platform for detection of microRNA-222 (miRNA-222). The introduction of electron-rich pyrimidine effectively increased the conjugation effect of electrons on triazine ring in CNQDs, resulting in red shift of ECL emission wavelength. An improved circular DNA walker was assembled by the catalytic ligation of T4 DNA ligase to enhance its stability and walking efficiency. By utilizing CNQDs as emitter and circular DNA walker as signal amplifier, a regenerative biosensor platform was developed for ultrasensitive detection of miRNA-222 with high sensitivity and successfully applied for detection in cancer cells lysate. This work opens up a promising approach for synthesizing efficient NIR-ECL CNQDs, reducing damage to organisms and achieving deeper tissue penetration, and provides a new method for biomarker detection and disease diagnosis.
CHEMICAL ENGINEERING JOURNAL
(2023)
Article
Biochemistry & Molecular Biology
Siobhan O'Connor, Lynn Dennany, Emmet O'Reilly
Summary: This review focuses on the innovations and applications of low toxicity semi-conductor quantum dots (SCQDs) utilised as ECL luminophores within biosensors. These materials have the advantages of tunable emission, low toxicity, and good water dispersibility. The review also explores the functionalization and multiplexing potential of these materials.
BIOELECTROCHEMISTRY
(2023)
Review
Chemistry, Analytical
Huipu Liu, Yunlong Chen, Huangxian Ju
Summary: This article introduces the important issue of cytosensing, which is the detection or imaging of biomolecules in situ or cells themselves in life science. Functional DNA structures have been widely used in cytosensing and have made significant progress in researching life mechanisms at the cell level. The article presents various functional DNA structures and their characteristics, as well as their applications in different scenes, such as detecting biological molecules, tumor imaging and therapy, cellular physics properties and interactions, and super-resolution imaging. The future challenges in this field are also discussed and further research is encouraged.
TRAC-TRENDS IN ANALYTICAL CHEMISTRY
(2023)
Article
Chemistry, Multidisciplinary
Yuru Wang, Yuanjiao Yang, Jingxing Guo, Huangxian Ju, Yunlong Chen
Summary: A dual gold nanoprobe system was developed for in vivo portable Raman detection of sialic acid (SA) in tumor xenografted mice. The system utilized two gold nanoprobes, Au10-DTTC/PEG-PBA and Au40-PEG-SA, which emitted strong SERS signals of DTTC upon specific recognition of SA in the tumor region. This method provides a convenient and portable approach for SA detection in tumor xenografted mice, with applications in tumor identification and clinical tumor cleavage.
Article
Materials Science, Biomaterials
Ying An, Weiwei Chen, Yiran Li, Hongxia Zhao, Deju Ye, Huipu Liu, Kun Wu, Huangxian Ju
Summary: Albumin-manganese-based nanocomposites (AMNs) with simple preparation and good biocompatibility have been widely used for in vivo T-1-weighted magnetic resonance imaging (MRI) and cancer theranostics. In this study, an aggregation and crosslinking assembly strategy was proposed to enhance the T-1 relaxivity of the AMN. The synthesized C-BM/ICG nanocomposite showed remarkable performance in in vivo multimodal imaging of tumors and cancer phototherapy, providing a promising multifunctional nanoprobe for cancer theranostics.
JOURNAL OF MATERIALS CHEMISTRY B
(2023)
Article
Chemistry, Analytical
Dawei Fan, Jing Luo, Zhengxing Gong, Huan Wang, Hongmin Ma, Dan Wu, Qin Wei, Huangxian Ju
Summary: In this paper, a novel photoelectrochemical immunosensor based on a ZnO/CdSe semiconductor composite material was developed for the super-sensitive and quantitative detection of neuron-specific enolase (NSE). The antifouling interface composed of polyacrylic acid (PAA) and polyethylene glycol (PEG) effectively prevented non-specific protein adsorption. Ascorbic acid (AA) served as an electron donor, enhancing the stability and intensity of photocurrent by scavenging photogenerated holes. The PEC antifouling immunosensor exhibited a wide linear range (0.10 pg mL-1-100 ng mL-1) and a low detection limit (34 fg mL-1), making it a potential tool for clinical diagnosis of small cell lung cancer.
ANALYTICA CHIMICA ACTA
(2023)
Article
Chemistry, Analytical
Xue Dong, Hanyu Wang, Xiang Ren, Hongmin Ma, Dawei Fan, Dan Wu, Qin Wei, Huangxian Ju
Summary: In this study, a mesoporous silica nanospheres (MSNs)-assisted split-type photoelectrochemical (PEC) aptasensor with in situ generation of Bi2S3 was proposed for reliable detection of prostate-specific antigen (PSA). The release of Na2S, induced by the reaction between PSA and aptamer, led to the formation of BiOI/BiOBr/Bi2S3 composite, altering the electron-hole transfer pathway and decreasing the photocurrent response. The sensor exhibited a linear range of 10 pg·mL-1-1 μg·mL-1 and a detection limit of 1.23 pg·mL-1, demonstrating satisfactory stability and anti-interference.
ANALYTICA CHIMICA ACTA
(2023)
Article
Chemistry, Analytical
Xiangfu Hu, Siqi Yu, Chao Wang, Xiaobo Zhang, Jianbin Pan, Huangxian Ju
Summary: In this study, we demonstrate the diffusion-induced acceleration of charge transfer from Ru(bpy)32+-doped silica nanoparticles (RDSNs) to the electrode via electrochemiluminescence (ECL) imaging. The presence of Ru(bpy)32+ in the electrolyte enhances the ECL emission of RDSNs, and the emission intensity is amplified by 478 times when the free Ru(bpy)32+ concentration is 10 μM. The diffusion of Ru(bpy)33+ near a single RDSN enables faster charge transfer to the electrode than electron hopping in RDSN, as demonstrated by spatial and temporal interaction imaging of the RDSN and the Ru(III) diffusion layer.
ANALYTICAL CHEMISTRY
(2023)
Article
Chemistry, Analytical
Junjie Hu, Fei Liu, Yunlong Chen, Jia Fu, Huangxian Ju
Summary: This work proposed a signal-on mass spectrometric biosensing strategy with a phospholipid-structured mass-encoded microplate for assessment of multiplex MMP activities, which is of great importance for cancer diagnosis and staging.
ANALYTICAL CHEMISTRY
(2023)
Article
Chemistry, Analytical
Ze-Rui Zhou, Da-Wei Li, Ruo-Can Qian, Huangxian Ju
Summary: We developed a DNAzyme-powered DNA walker to visualize the cooperative expression of mutant p53 and telomerase in living cells. The DNA walker allows for real-time monitoring of mutant p53 and active telomerase expression in cancer cells, providing new insights into the study of cancer pathway-relevant biomarkers.
ANALYTICAL CHEMISTRY
(2023)
Article
Chemistry, Analytical
Siqi Yu, Xiangfu Hu, Jianbin Pan, Jianping Lei, Huangxian Ju
Summary: In this study, a novel confinement system was proposed for the self-enhanced electrochemiluminescence (ECL) by codoping ECL emitter and coreactant in silica nanoparticles. The obtained nanoparticles showed stronger ECL emission and were used for the monitoring of glycoprotein on living cell membranes.
ANALYTICAL CHEMISTRY
(2023)
Article
Chemistry, Analytical
Xue Dong, Qingze Zeng, Li Dai, Xiang Ren, Wei Cao, Huangxian Ju, Qin Wei
Summary: In this study, a novel signal on-amplified-off detection mode for progesterone (P4) was proposed, utilizing hafnium oxide (HfO2) as an electrochemiluminescence (ECL) emitter and Ni-doped ZnO (Ni-ZnO) as a coreaction accelerator. The P4 analysis using this strategy significantly improved sensitivity and specificity, offering a practical method for biomolecule detection beyond the scope of this study.
ANALYTICAL CHEMISTRY
(2023)
Article
Chemistry, Analytical
Weisu Kong, Zhiyuan Xu, Tianrui Liu, Jianping Lei, Huangxian Ju
Summary: In this study, a PEC sensor with photocurrent polarity reversal was constructed using ascorbic acid as an electron donor and a zirconium metal-organic framework as a photoactive material. By introducing a detection tag and utilizing rolling cycle amplification, the reversed photocurrent showed an enhanced response to the target protein, enabling highly sensitive detection. This strategy demonstrated good specificity, a wide linear range, and a low detection limit for the detection of vascular endothelial growth factor 165.
ANALYTICAL CHEMISTRY
(2023)
Article
Biophysics
Xue Dong, Xiaoyue Zhang, Yu Du, Jiajun Liu, Qingze Zeng, Wei Cao, Qin Wei, Huangxian Ju
Summary: In this study, a self-enhanced ECL emitter, ZrO2-TiO2-Au composite, was introduced for dual-quenching ECL immunosensor. The anodic luminescence of ZrO2 was explored in the presence of TPrA as a co-reagent. TiO2 was designed as a co-reaction accelerator to amplify the ECL signal of the emitter. The dual-quenching strategy with Cu2O-APF as the quencher effectively enhanced the sensitivity of the immunosensor.
BIOSENSORS & BIOELECTRONICS
(2023)
Article
Chemistry, Multidisciplinary
Yuanjiao Yang, Yuru Wang, Zhicong Chao, Yuhui Yang, Yanyun Fang, Ying Liu, Lin Ding, Yunlong Chen, Huangxian Ju
Summary: A triply enhanced immunotherapy drug (TEID) is designed to ingeniously integrate in situ dual glycan reforming with perforation on cell membrane. It can simultaneously promote immune activation, weaken immune inhibition, and stimulate cytokines secretion for effective immunotherapy.
Article
Chemistry, Multidisciplinary
Shiya Zhao, Yuanjiao Yang, Yuru Wang, Huipu Liu, Huangxian Ju, Yunlong Chen
Summary: This study presents a functional dendrimer probe that can conveniently detect newly generated sialic acid groups in vivo using a dual-color imaging strategy. It enables the in situ semiquantitative evaluation of sialylation differences between tumor and normal tissues, allowing the investigation of sialylation-related biological events and facilitating clinical tumor diagnosis.
CHEMICAL COMMUNICATIONS
(2023)
Article
Chemistry, Analytical
Jiajun Liu, Yu Du, Aiping Guo, Nuo Zhang, Lei Liu, Dawei Fan, Xue Dong, Qin Wei, Huangxian Ju
Summary: In this study, a sandwich sensing platform was developed using silica-coated silver nanoparticles as a luminescent material and cerium dioxide as a signal quencher for sensitive neuro-specific enolase detection. The core-shell structure protected the silver nanoparticles and improved their luminescence properties. Amino-functionalized cerium dioxide efficiently diminished the luminescence signal, resulting in a highly sensitive and accurate detection mode. This detection strategy showed a powerful capability for biomolecule detection.
Article
Chemistry, Analytical
Qian Wu, Li Tian, Xiangyu Shan, Huiling Li, Chao Li, Juan Lu
Summary: A novel ECL sensor was developed by modifying Fe3CuO4-Ru(bpy)3+ and GO-CdS@ZnS on the electrode for the detection of permethrin. The sensor exhibited high sensitivity and a wide detection range.
Article
Chemistry, Analytical
Tingting Gong, Lei Liao, Bingying Jiang, Ruo Yuan, Yun Xiang
Summary: In this study, a fluorescent biosensing system for high sensitivity detection of MT was established using a new Ag+-stabilized DNA triplex probe (Ag+-SDTP) combined with catalytic hairpin assembly (CHA) and CRISPR/Cas12a signal enhancements. The sensing method is able to selectively detect MT from other non-specific molecules and can achieve low level detection of MT in diluted human serums, demonstrating its potential for monitoring disease-specific MT biomarker at trace levels.
Article
Chemistry, Analytical
Estrella Sanz Rodriguez, Kyra Wood, Paul R. Haddad, Brett Paull
Summary: This study presents a simple, rapid, and reliable method for determining boron in aqueous solutions using suppressed ion chromatography coupled to electrospray ionisation-triple quadrupole mass spectrometry. The method achieved a low limit of detection and demonstrated excellent analytical performance.
Article
Chemistry, Analytical
Aline Cournut, Paul Moustiez, Yannick Coffinier, Christine Enjalbal, Claudia Bich
Summary: Alzheimer's disease is a major cause of senile dementia and is characterized by the aggregation of neurofibrillary tangles and amyloid plaques in the brain. The A beta 1-42 peptide is considered the primary cause of neurotoxicity due to its insolubility and subsequent aggregation. A beta 1-42 and A beta 1-40 have been identified as relevant biomarkers for AD diagnosis, and SurfaceAssisted Laser Desorption/Ionization Mass Spectrometry (SALDI-MS) was used to monitor the A beta 1-42/A beta 1-40 ratio without prior sample treatment.
Article
Chemistry, Analytical
Dotse Selali Chormey, Buse Tugba Zaman, Tulay Borahan Kustanto, Sezin Erarpat Bodur, Suleyman Bodur, Elif Ozturk Er, Sezgin Bakirdere
Summary: This review provides an overview of the harmful effects of endocrine disrupting chemicals (EDCs) on human health and introduces the methods for analyzing EDCs. Recent research has focused on using green chemicals, such as deep eutectic solvents (DESs), for microextraction to ensure environmental safety.
Article
Chemistry, Analytical
Yan Zhang, Renfeng Xu, Jingjing Wu, Zhenghong Zhang, Yuhuang Wang, Hongqin Yang, Sheng Zhang
Summary: This study visualized the pore-like structures in prostate cancer cell membranes after treatment with the anticancer drug paclitaxel, demonstrating its mechanism of action related to oxidative damage.
Article
Chemistry, Analytical
Chihong Ma, Qin Zhou, Jinjin Shi, Hua Gao, Di Huang, Huimin Xue, Han Wang, Zhenzhong Zhang, Sen Yang, Junli Zhang, Kaixiang Zhang
Summary: We developed a CRISPR-empowered electrochemical biosensor, named PER-E-CRISPR, for amplification-free and sensitive detection of miR-21. The biosensor combines the advantages of CRISPR/Cas13a and primer exchange reaction (PER) for target amplification. Under optimized conditions, the PER-E-CRISPR assay exhibits a linear range from 10-13 to 10-7 M and a limit of detection of 30.2 fM. The biosensor shows excellent performance in actual plasma, indicating promising prospects for miRNA detection in molecular diagnosis.
Article
Chemistry, Analytical
Gang Liang, Jie Zhao, Yufei Gao, Tao Xie, Jianhui Zhen, Ligang Pan, Wenwen Gong
Summary: Molecular docking (MD) analysis is widely used for studying the interaction between aptamers and small molecules. This study established steady-state aptamers of tertiary structures (SATS) using specific aptamers of tetracycline antibiotics as docking models. Molecular docking results revealed multiple binding sites in the SATS of aptamers, with significant variations in binding free energy (BFE) and docking score (DS). The study also proposed a method for MD analysis based on SATS, providing insights into binding mode and predicting binding sites.
Article
Chemistry, Analytical
Yixuan Xu, Changchang Teng, Huiping Dang, Dalong Yin, Lifeng Yan
Summary: Stable organic radical molecules with high NIR fluorescence quantum efficiency have been synthesized and encapsulated into nanoparticles, which show great potential for both photodynamic therapy (PDT) and photothermal therapy (PTT) of tumors.
Article
Chemistry, Analytical
Yu Su, Dandan Yang, Yanjie Wang, Jie Ding, Lan Ding, Daqian Song
Summary: In this study, a highly selective molecularly imprinted polymer Cu-MIPs@CS was designed and synthesized for bisphenol A (BPA). Cu-MIPs@CS showed significantly enhanced imprinting factor and selective factor towards BPA compared to MIPs@CS. It also exhibited superior discrimination ability between BPA and its structural analogue. Additionally, Cu-MIPs@CS were successfully applied as a solid phase extraction adsorbent for the determination of BPA in drinking water samples.
Article
Chemistry, Analytical
Yi Qiao, Qiongdan Zhang, Yukun He, Tianguang Cheng, Jing Tu
Summary: Single cell heterogeneity plays an important role in many biological phenomena, and distinguishing cells with specific mutations is beneficial for clinical diagnosis and drug screening. This study introduces a gel plate platform that can distinguish cell types based on their phenotypes, with low equipment requirement. The gel platform has potential in point-of-care circumstances and single-cell stimulation responses that prioritize efficiency and simplicity.
Article
Chemistry, Analytical
Chengke Wang, Shuyang Sun, Ping Wang, Huawei Zhao, Wenling Li
Summary: The food safety of aquatic products is a global concern. Nanotechnology-based analyses have advantages in the detection of bacteria, metal ions, and small molecule contaminants. This review summarizes the recent advances in biosensing strategies for aquatic products and highlights the application of nanomaterials, lateral flow-based biosensors, surface-enhanced Raman scattering, microfluidic chips, and molecular imprinting technologies.
Article
Chemistry, Analytical
Liping Zhu, Zeng Tang, Xuemei Zhang, Li Zhu, Tian Meng, Linying Yu, Ting Xiao, Shasha Lu, Xiaoli Xiong, Xiurong Yang
Summary: A sensitive off-on electrochemiluminescence DNA sensor was developed using Exo III-assisted cascade amplification system. The sensor achieved high selectivity and ultra-high sensitivity in detecting target DNA by utilizing ECL and SPR effects. This study provides a new perspective for designing highly sensitive and programmable ECL biosensors.
Article
Chemistry, Analytical
Tong Li, Mengxu Sun, Suping Xia, Ting Huang, Rong-Tian Li, Chunrong Li, Zong Dai, Jin-Xiang Chen, Jun Chen, Nuan Jia
Summary: Here, we developed a binary system based on DNA tetrahedron and fluorogenic RNA aptamers for highly specific and label-free mRNA imaging in living cells. This system achieved high specificity label-free detection of nucleic acids with a detection limit of 1.34 nM. The method has potential applications in early disease diagnosis and new drug development.
Article
Chemistry, Analytical
Yao Zhao, Shu Zhang, Wang Yao, Yuxuan Zhu, Jing Qian, Juan Yang, Nianjun Yang
Summary: A new hierarchical nanostructured composite with high conductivity and catalytic activity is synthesized. The sensor exhibits significant catalytic effect and high sensitivity for monitoring the environmental endocrine disruptor bisphenol A (BPA).
