Review
Chemistry, Physical
Borhan Bin Mohamad Sultan, Oumaima Gharbi, Kevin Ogle, Junsoo Han
Summary: This article summarizes recent research activities using electrochemical techniques coupled with inductively coupled plasma atomic emission spectrometry for in-line electrolyte analyses. This methodology allows for direct measurement of elemental dissolution rates in real-time and complementary element-resolved electrochemical studies. It provides insights into element-specific reaction mechanisms at the part-per-billion level resolution, with applications in various domains of corrosion science and interfacial reactivity.
CURRENT OPINION IN ELECTROCHEMISTRY
(2023)
Article
Multidisciplinary Sciences
E. Ph. Galay, R. V. Dorogin, A. Z. Temerdashev
Summary: This paper discusses the presence and control methods of cobalt and nickel in human biological fluids, compares different sample preparation methods, and evaluates their measurement characteristics. The study shows that taking vitamin complexes in therapeutic concentrations does not lead to a significant increase in trace element concentrations in urine, while elevated concentrations can be detected using ICP-AES.
Article
Chemistry, Analytical
Tom Van Helden, Simone Braeuer, Thibaut Van Acker, Olivier Leroux, Dominique Van Der Straeten, Frank Vanhaecke
Summary: This study investigates the effects of instrumental setup on the response duration of elements, such as Hg and Se, in biological tissue. By optimizing the setup, significant improvement in the response duration is achieved. However, caution should be taken when selecting instrument settings and data acquisition conditions for accurate elemental mapping to avoid smearing effects.
JOURNAL OF ANALYTICAL ATOMIC SPECTROMETRY
(2022)
Article
Chemistry, Medicinal
Xiaodong Dou, Qi Sun, Guofeng Xu, Yameng Liu, Caifang Zhang, Bingding Wang, Yangbin Lu, Zheng Guo, Lingyu Su, Tongyu Huo, Xinyi Zhao, Chen Wang, Zhongtian Yu, Song Song, Liangren Zhang, Zhenming Liu, Luhua Lai, Ning Jiao
Summary: This study reported novel non-peptidomimetic inhibitors of SARS-CoV-2 Mpro developed through in-house library screening and biological evaluation. The compounds showed high inhibitory activity and low cytotoxicity, providing a promising starting point for further drug development and optimization.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2022)
Article
Chemistry, Analytical
Ioanna P. Paktsevanidou, N. Manousi, G. A. Zachariadis
Summary: This study successfully developed a simple and rapid method for elemental analysis of vinegar samples using ICP-AES, avoiding issues associated with sample dilution and acidic digestion. The method was validated for accuracy and precision on 10 different commercially available vinegar samples under optimum analysis conditions.
ANALYTICAL LETTERS
(2021)
Article
Biotechnology & Applied Microbiology
Jelena Milinovic, Carla Rodrigues, Mario Diniz, Joao Paulo Noronha
Summary: Iodine is essential for thyroid hormone synthesis, and its deficiency is a common global issue. Edible seaweed is a rich source of iodine, but consumption must be balanced to avoid exceeding the recommended intake levels.
ALGAL RESEARCH-BIOMASS BIOFUELS AND BIOPRODUCTS
(2021)
Article
Chemistry, Analytical
Jelena Mrmosanin, Aleksandra Pavlovic, Ivana Rasic Misic, Snezana Tosic, Stefan Petrovic, Zorica Mitic, Emilija Pecev-Marinkovic, Biljana Arsic
Summary: This study aimed at optimizing the ICP-AES conditions for the determination of macro and microelements in Trifolium species flowers and leaves. Plasma robustness was achieved after the optimization of instrumental parameters. The most abundant microelement in leaves was Ca, while in flowers it was K. The average contents of microelements were then determined and chemometrics were used for sample grouping based on elemental contents.
ANALYTICAL LETTERS
(2023)
Article
Spectroscopy
N. S. Medvedev, A. V. Volzhenin, A. Saprykin
Summary: A new method using mass spectrometry with inductively coupled plasma (ICP-MS) and electrothermal vaporization (ETV) was proposed for the analysis of high-purity molybdenum. The method allowed to determine the concentrations of 28 trace elements in high-purity molybdenum with a purity of 6N (99.9999% wt.) and provided LODs from 0.3 to 200 ng g(-1). Validation of the method was performed by spike experiments, and the results were compared with other analytical techniques.
ATOMIC SPECTROSCOPY
(2021)
Article
Chemistry, Analytical
N. Manousi, N. P. Kalogiouri, L. Kokokiris, A. Anthemidis, G. A. Zachariadis
Summary: Flower waters, considered by-products of essential oils, have various applications in the food industry due to their bioactive content. This study utilized ICP-AES to assess the elemental composition of several flower waters, with an optimized and validated method.
ANALYTICAL LETTERS
(2022)
Article
Chemistry, Multidisciplinary
Zhizhong Li, Madjid Hadioui, Kevin J. J. Wilkinson
Summary: This study investigated the analysis of Si-NPs in soil using single-particle ICP-MS. A size detection limit of 29 +/- 3 nm was achieved in Milli-Q water. Na4P2O7 was found to be the best extractant for Si-NP, preserving their size distribution for at least one month.
Article
Chemistry, Analytical
Anna Pekou, Natalia Manousi, George A. Zachariadis
Summary: In this study, a simple and rapid method was developed for the determination of metals and trace elements in maternal breast milk. The method used inductively coupled plasma - atomic emission spectrometry (ICP-AES) to analyze samples collected from lactating mothers at different stages of breastfeeding. The method showed good repeatability, linearity, and accuracy.
ANALYTICAL LETTERS
(2023)
Article
Chemistry, Physical
Hu Luo, Khan Muhammad Ajmal, Wang Liu, Kazuya Yamamura, Hui Deng
Summary: This study focused on highly efficient and damage-free diamond polishing enhanced by atmospheric pressure inductively coupled plasma (ICP) modified silicon plate. The results showed a significant decrease in surface roughness and the achievement of an atomically smooth, high-quality diamond surface.
Article
Biochemistry & Molecular Biology
Adil Hussain, Muhammad Sajid, Daniel Potter, Hassam Rasheed, Mujtaba Hassan, Naeem Akhtar, Bashir Ahmad, Syed Ali Imran Bokhari
Summary: Diversity in eleven Artemisia species from northern Pakistan was assessed based on elemental contents. Cluster analysis divided the species into two groups, while PCA analysis revealed maximum species diversity in the second axis. The study highlights the importance of precautionary measures to avoid metal toxicity when using Artemisia as medication.
BIOLOGICAL TRACE ELEMENT RESEARCH
(2023)
Article
Environmental Sciences
Mashael K. Bin Ateeq, Nouf M. Bin Durayhim, Meral M. Sulayem, Waad A. Al-Qahtani, Nezar H. Khdary, Ahmed M. Alhassan, Fatimah Mohammed A. Alzahrani, Khadijah Mohammedsaleh M. Katubi, Norah Salem Alsaiari
Summary: This study presents a novel method for ultra-trace Hg(II) determination in water based on a flexible extraction and preconcentration technique, which involves functionalizing carbon fibers. The use of gold nanoparticles is shown to enhance Hg(II) detection precision and eliminate memory effects in the results.
Article
Chemistry, Analytical
Yihuan Song, Feng Guo, Pingxiu Zeng, Jinhua Liu, Yuanchao Wang, Heyong Cheng
Summary: In this study, an analytical method integrating online solid phase extraction with high-performance liquid chromatography and inductively coupled plasma mass spectrometry (ICP-MS) was developed to simultaneously preconcentrate and quantify forms of Cr, Cd, Hg, and Pb in water. The method showed low limits of detection, good linearities, and low variability, and was validated by analyzing reference materials and real water samples.
ANALYTICA CHIMICA ACTA
(2022)
Article
Chemistry, Analytical
Qian Wu, Li Tian, Xiangyu Shan, Huiling Li, Chao Li, Juan Lu
Summary: A novel ECL sensor was developed by modifying Fe3CuO4-Ru(bpy)3+ and GO-CdS@ZnS on the electrode for the detection of permethrin. The sensor exhibited high sensitivity and a wide detection range.
Article
Chemistry, Analytical
Tingting Gong, Lei Liao, Bingying Jiang, Ruo Yuan, Yun Xiang
Summary: In this study, a fluorescent biosensing system for high sensitivity detection of MT was established using a new Ag+-stabilized DNA triplex probe (Ag+-SDTP) combined with catalytic hairpin assembly (CHA) and CRISPR/Cas12a signal enhancements. The sensing method is able to selectively detect MT from other non-specific molecules and can achieve low level detection of MT in diluted human serums, demonstrating its potential for monitoring disease-specific MT biomarker at trace levels.
Article
Chemistry, Analytical
Estrella Sanz Rodriguez, Kyra Wood, Paul R. Haddad, Brett Paull
Summary: This study presents a simple, rapid, and reliable method for determining boron in aqueous solutions using suppressed ion chromatography coupled to electrospray ionisation-triple quadrupole mass spectrometry. The method achieved a low limit of detection and demonstrated excellent analytical performance.
Article
Chemistry, Analytical
Aline Cournut, Paul Moustiez, Yannick Coffinier, Christine Enjalbal, Claudia Bich
Summary: Alzheimer's disease is a major cause of senile dementia and is characterized by the aggregation of neurofibrillary tangles and amyloid plaques in the brain. The A beta 1-42 peptide is considered the primary cause of neurotoxicity due to its insolubility and subsequent aggregation. A beta 1-42 and A beta 1-40 have been identified as relevant biomarkers for AD diagnosis, and SurfaceAssisted Laser Desorption/Ionization Mass Spectrometry (SALDI-MS) was used to monitor the A beta 1-42/A beta 1-40 ratio without prior sample treatment.
Article
Chemistry, Analytical
Dotse Selali Chormey, Buse Tugba Zaman, Tulay Borahan Kustanto, Sezin Erarpat Bodur, Suleyman Bodur, Elif Ozturk Er, Sezgin Bakirdere
Summary: This review provides an overview of the harmful effects of endocrine disrupting chemicals (EDCs) on human health and introduces the methods for analyzing EDCs. Recent research has focused on using green chemicals, such as deep eutectic solvents (DESs), for microextraction to ensure environmental safety.
Article
Chemistry, Analytical
Yan Zhang, Renfeng Xu, Jingjing Wu, Zhenghong Zhang, Yuhuang Wang, Hongqin Yang, Sheng Zhang
Summary: This study visualized the pore-like structures in prostate cancer cell membranes after treatment with the anticancer drug paclitaxel, demonstrating its mechanism of action related to oxidative damage.
Article
Chemistry, Analytical
Chihong Ma, Qin Zhou, Jinjin Shi, Hua Gao, Di Huang, Huimin Xue, Han Wang, Zhenzhong Zhang, Sen Yang, Junli Zhang, Kaixiang Zhang
Summary: We developed a CRISPR-empowered electrochemical biosensor, named PER-E-CRISPR, for amplification-free and sensitive detection of miR-21. The biosensor combines the advantages of CRISPR/Cas13a and primer exchange reaction (PER) for target amplification. Under optimized conditions, the PER-E-CRISPR assay exhibits a linear range from 10-13 to 10-7 M and a limit of detection of 30.2 fM. The biosensor shows excellent performance in actual plasma, indicating promising prospects for miRNA detection in molecular diagnosis.
Article
Chemistry, Analytical
Gang Liang, Jie Zhao, Yufei Gao, Tao Xie, Jianhui Zhen, Ligang Pan, Wenwen Gong
Summary: Molecular docking (MD) analysis is widely used for studying the interaction between aptamers and small molecules. This study established steady-state aptamers of tertiary structures (SATS) using specific aptamers of tetracycline antibiotics as docking models. Molecular docking results revealed multiple binding sites in the SATS of aptamers, with significant variations in binding free energy (BFE) and docking score (DS). The study also proposed a method for MD analysis based on SATS, providing insights into binding mode and predicting binding sites.
Article
Chemistry, Analytical
Yixuan Xu, Changchang Teng, Huiping Dang, Dalong Yin, Lifeng Yan
Summary: Stable organic radical molecules with high NIR fluorescence quantum efficiency have been synthesized and encapsulated into nanoparticles, which show great potential for both photodynamic therapy (PDT) and photothermal therapy (PTT) of tumors.
Article
Chemistry, Analytical
Yu Su, Dandan Yang, Yanjie Wang, Jie Ding, Lan Ding, Daqian Song
Summary: In this study, a highly selective molecularly imprinted polymer Cu-MIPs@CS was designed and synthesized for bisphenol A (BPA). Cu-MIPs@CS showed significantly enhanced imprinting factor and selective factor towards BPA compared to MIPs@CS. It also exhibited superior discrimination ability between BPA and its structural analogue. Additionally, Cu-MIPs@CS were successfully applied as a solid phase extraction adsorbent for the determination of BPA in drinking water samples.
Article
Chemistry, Analytical
Yi Qiao, Qiongdan Zhang, Yukun He, Tianguang Cheng, Jing Tu
Summary: Single cell heterogeneity plays an important role in many biological phenomena, and distinguishing cells with specific mutations is beneficial for clinical diagnosis and drug screening. This study introduces a gel plate platform that can distinguish cell types based on their phenotypes, with low equipment requirement. The gel platform has potential in point-of-care circumstances and single-cell stimulation responses that prioritize efficiency and simplicity.
Article
Chemistry, Analytical
Chengke Wang, Shuyang Sun, Ping Wang, Huawei Zhao, Wenling Li
Summary: The food safety of aquatic products is a global concern. Nanotechnology-based analyses have advantages in the detection of bacteria, metal ions, and small molecule contaminants. This review summarizes the recent advances in biosensing strategies for aquatic products and highlights the application of nanomaterials, lateral flow-based biosensors, surface-enhanced Raman scattering, microfluidic chips, and molecular imprinting technologies.
Article
Chemistry, Analytical
Liping Zhu, Zeng Tang, Xuemei Zhang, Li Zhu, Tian Meng, Linying Yu, Ting Xiao, Shasha Lu, Xiaoli Xiong, Xiurong Yang
Summary: A sensitive off-on electrochemiluminescence DNA sensor was developed using Exo III-assisted cascade amplification system. The sensor achieved high selectivity and ultra-high sensitivity in detecting target DNA by utilizing ECL and SPR effects. This study provides a new perspective for designing highly sensitive and programmable ECL biosensors.
Article
Chemistry, Analytical
Tong Li, Mengxu Sun, Suping Xia, Ting Huang, Rong-Tian Li, Chunrong Li, Zong Dai, Jin-Xiang Chen, Jun Chen, Nuan Jia
Summary: Here, we developed a binary system based on DNA tetrahedron and fluorogenic RNA aptamers for highly specific and label-free mRNA imaging in living cells. This system achieved high specificity label-free detection of nucleic acids with a detection limit of 1.34 nM. The method has potential applications in early disease diagnosis and new drug development.
Article
Chemistry, Analytical
Yao Zhao, Shu Zhang, Wang Yao, Yuxuan Zhu, Jing Qian, Juan Yang, Nianjun Yang
Summary: A new hierarchical nanostructured composite with high conductivity and catalytic activity is synthesized. The sensor exhibits significant catalytic effect and high sensitivity for monitoring the environmental endocrine disruptor bisphenol A (BPA).