Review
Chemistry, Analytical
Jagannath Mondal, Jeong Man An, Sachin S. Surwase, Kushal Chakraborty, Sabuj Chandra Sutradhar, Joon Hwang, Jaewook Lee, Yong-Kyu Lee
Summary: The development of accurate diagnosis and monitoring of diseases has become more important after the COVID-19 pandemic. Carbon nanomaterials such as graphene and carbon nanotubes have been considered as important candidates for biosensing channels due to their excellent physical properties. Various sensing methods, including electrochemical, optical, and electrical approaches, have been used in carbon nanotube-based biosensing systems, showing excellent sensitivity and selectivity against viruses and virus DNA structures. These biosensing platforms have great potential in improving healthcare and public health.
Article
Chemistry, Analytical
Monica Mediavilla, Monica Revenga-Parra, Cristina Gutierrez-Sanchez, Lourdes Hernandez-Apaolaza, Felix Pariente, Encarnacion Lorenzo
Summary: A new fluorescent assay for total polyphenol determination based on the bioconjugate formed between laccase enzyme and carbon nanodots has been developed. The study showed that bioconjugation does not inhibit enzymatic activity and the decrease in fluorescence is mainly due to electron transfer processes.
Article
Chemistry, Multidisciplinary
Hyeongho Min, Sangyul Baik, Jinhyung Kim, Jihyun Lee, Bo-Gyu Bok, Jin Ho Song, Min-Seok Kim, Changhyun Pang
Summary: The study introduces a diving beetle-inspired electro-adhesive patch that offers high reliability and flexibility for real-time diagnostics of the human body. Utilizing nanowire-implanted conductive multiscale architectures, the device provides a skin-adaptable and stretchable interface.
ADVANCED FUNCTIONAL MATERIALS
(2022)
Article
Electrochemistry
Merih Zeynep Cetin, Roxana-Mihaela Apetrei, Nese Guven, Pinar Camurlu
Summary: In this study, novel biosensing matrices based on electrospun nanofibers coated with conducting polymers (PEDOT or PPy) were used for immobilization of Tyrosinase enzyme and evaluated for phenol detection. The results showed that the biosensors developed using PEDOT and PPy exhibited high sensitivity and low detection limits.
JOURNAL OF THE ELECTROCHEMICAL SOCIETY
(2023)
Article
Chemistry, Physical
Sumit Kumar, Anamika Sindhu, Pannuru Venkatesu
Summary: Inspired by the biocompatibility and dexterity of ionic liquids in preserving enzyme structure and activity, this study investigated the interactions between Cyt-c and naked AuNPs as well as four IL-mediated AuNPs. The results showed that IL-AuNPs significantly enhanced the peroxidase activity and exhibited preference in counteracting temperature gradient change and long-term solvent preservation effects. The study also revealed the dominance of IL anions in modulating the interactions between IL-mediated AuNPs and Cyt-c. These findings suggest the promising potential of sulfur-containing IL-mediated AuNPs for Cyt-c immobilization and for applications in drug delivery and therapeutics.
PHYSICAL CHEMISTRY CHEMICAL PHYSICS
(2022)
Article
Chemistry, Multidisciplinary
Azat Abdullatypov, Pavel Oskin, Veronika Fedina, Liubov Trubitsina, Sofiya Yakimovich, Ekaterina Shuvalova, Pradeep Verma, Tatyana Dyachkova, Olga Ponamoreva, Sergey Alferov, Ioannis V. Yentekakis, Ying Zheng
Summary: This study assessed several modifications of carbon nanotube-based nanomaterials for their applications in laccase electrodes and model biofuel cells. The modified MWCNTs were used as adapters for immobilizing laccase from Catenuloplanes japonicus VKM Ac-875 onto graphite rod and graphite paste electrodes. The electrochemical properties and potential practical applications of the electrodes and biofuel cells were investigated.
Article
Chemistry, Multidisciplinary
Julia Ackermann, Jan Stegemann, Tim Smola, Eline Reger, Sebastian Jung, Anne Schmitz, Svenja Herbertz, Luise Erpenbeck, Karsten Seidl, Sebastian Kruss
Summary: Optical nanosensors based on single-wall carbon nanotubes are able to capture the dynamics of biochemical processes. A one-step phase separation approach has been developed to isolate monochiral (6,4)-SWCNTs from mixed SWCNT samples, enabling high-resolution imaging in the near-infrared spectrum using standard Si-based cameras. (6,4)-SWCNTs modified with (GT)(10)-ssDNA become highly sensitive to the neurotransmitter dopamine, allowing for fast and high-resolution imaging of dopamine release from cells.
Article
Chemistry, Multidisciplinary
Carmen Mihaela Tilmaciu, Bhimareddy Dinesh, Morgan Pellerano, Sebastien Diot, Melanie Guidetti, Julien Vollaire, Alberto Bianco, Cecilia Menard-Moyon, Veronique Josserand, May C. Morris
Summary: The novel CDK1 activity reporter, utilizing the sensitivity of a fluorescent biosensor and the properties of carbon nanotubes, allows for sensitive and dose-dependent measurement of CDK1 activity, monitoring of intracellular kinases, and direct fluorescence imaging within tumor xenografts in mice.
Article
Physics, Fluids & Plasmas
Quinn Parker, Dilina Perera, Ying Wai Li, Thomas Vogel
Summary: Using machine learning, we successfully identified configurational phases and structural transitions in a polymer nanotube composite, eliminating the need for human intuition or bias.
Article
Chemistry, Analytical
Michael Holzinger, Paulo Henrique M. Buzzetti, Serge Cosnier
Summary: Biosensors are crucial tools in the health and environmental sectors for fast and reliable diagnostics. Utilizing a combination of polymers and nanomaterials can enhance the performance of biosensors, potentially leading to more reliable health monitoring.
SENSORS AND ACTUATORS B-CHEMICAL
(2021)
Review
Chemistry, Analytical
Constanza J. Venegas, Soledad Bollo, Paulina Sierra-Rosales
Summary: This review provides a summary of the methods and results using carbon-based electrochemical (bio)sensors for detecting carbendazim in environmental and food samples. The focus is on the role of carbon nanotubes, carbon nitride, graphene, and its derivatives, and carbon-based materials as modifiers, along with the evaluation of analytical performance.
Article
Chemistry, Analytical
Mengying Li, Guo Wang, Jing Dai, Zhiqiang Zhao, Yadong Zhe, Huan Yang, Yuqing Lin
Summary: This study discovered a carbon nanomaterial CuZn-N/C with an active site structure that can function as an efficient laccase mimic for selectively catalyzing epinephrine oxidation. A sensitive and selective online optical detection platform was also constructed for real-time measurement of epinephrine release in the rat brain following ischemia. This work has implications for designing efficient laccase mimics and understanding the drug action for ischemic cerebrovascular illnesses and brain function exploration.
ANALYTICAL CHEMISTRY
(2023)
Article
Chemistry, Multidisciplinary
Robert Nissler, Andrea T. Mueller, Frederike Dohrman, Larissa Kurth, Han Li, Eric G. Cosio, Benjamin S. Flavel, Juan Pablo Giraldo, Axel Mithofer, Sebastian Kruss
Summary: The study developed molecular sensors based on near-infrared fluorescent single-wall carbon nanotubes for imaging plant polyphenols, providing a new tool for studying plant immune defense. These sensors can real-time report changes in total polyphenol level after herbivore or pathogen challenge in crop plants.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Article
Chemistry, Multidisciplinary
Xinzhao Xu, Benjamin J. Bowen, Rebecca E. A. Gwyther, Mark Freeley, Bella Grigorenko, Alexander V. Nemukhin, Johnas Eklof-Osterberg, Kasper Moth-Poulsen, D. Dafydd Jones, Matteo Palma
Summary: The study presents the construction of nanoscale protein-based sensing devices, demonstrating the ability to modulate the conductance gating effect by controlling the presentation of proteins. Furthermore, experimental results show that local electrostatic properties act as the key driving force for electrostatic gating.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Review
Chemistry, Multidisciplinary
Julia Ackermann, Justus T. Metternich, Svenja Herbertz, Sebastian Kruss
Summary: Biosensors are important tools in modern basic research and biomedical diagnostics. NIR fluorescent molecular sensors based on SWCNTs have great potential in analyte detection, and the research on chemical design strategies and molecular recognition contributes to their further development.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Article
Chemistry, Applied
Sara Guizzo, Cristina Tortolini, Federico Pepi, Francesca Leonelli, Franco Mazzei, Francesca Di Turo, Gabriele Favero
NATURAL PRODUCT RESEARCH
(2019)
Article
Archaeology
Francesca Di Turo, Pietro Matricardi, Chiara Di Meo, Franco Mazzei, Gabriele Favero, Daniela Zane
JOURNAL OF CULTURAL HERITAGE
(2019)
Article
Chemistry, Multidisciplinary
Deborah Quaglio, Laura Mangiardi, Giulia Venditti, Cristina Del Plato, Francesca Polli, Francesca Ghirga, Gabriele Favero, Marco Pierini, Bruno Botta, Franco Mazzei
CHEMISTRY-A EUROPEAN JOURNAL
(2020)
Article
Chemistry, Analytical
Giulia Calitri, Paolo Bollella, Leonardo Ciogli, Cristina Tortolini, Franco Mazzei, Riccarda Antiochia, Gabriele Favero
MICROCHEMICAL JOURNAL
(2020)
Article
Electrochemistry
Leonardo Ciogli, Rosaceleste Zumpano, Andrey A. Poloznikov, Dmitry M. Hushpulian, Vladimir I. Tishkov, Rafael Andreu, Lo Gorton, Franco Mazzei, Gabriele Favero, Paolo Bollella
Summary: A novel electrode platform for H2O2 detection was developed by immobilizing r-TOP on p-PD/MWCNTs/G modified graphite electrodes, enhancing sensitivity, stability, and selectivity while preventing enzyme inactivation due to the electro-Fenton reaction. The electrode exhibited a lower limit of detection of 1.8 mu M H2O2, an extended linear range between 6 and 900 mu M H2O2, and increased sensitivity compared to previous work based on TOP.
Article
Biochemical Research Methods
Rosaceleste Zumpano, Manuela Manghisi, Francesca Polli, Cristine D'Agostino, Federica Ietto, Gabriele Favero, Franco Mazzei
Summary: This study developed a label-free electrochemical immunosensor for the quick, cheap, and straightforward determination of atrazine, achieving detection through a technological platform and specific treatment methods. Under optimal experimental conditions, the immunosensor exhibited good linearity range, limit of detection, reproducibility, and stability, making it suitable for successful application in the detection and monitoring of atrazine in real water samples.
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
(2022)
Article
Physics, Atomic, Molecular & Chemical
Chiara Salvitti, Anna Troiani, Franco Mazzei, Cristine D'Agostino, Rosaceleste Zumpano, Chiara Baldacchini, Anna Rita Bizzarri, Alessandra Tata, Federico Pepi
Summary: This study demonstrates that an unmodified ESI Z-spray source can successfully carry out ambient ion soft landing, showing its potential in studying accelerated microdroplet reactions.
INTERNATIONAL JOURNAL OF MASS SPECTROMETRY
(2021)
Article
Chemistry, Multidisciplinary
Deborah Quaglio, Francesca Polli, Cristina Del Plato, Gabriele Cianfoni, Carola Tortora, Franco Mazzei, Bruno Botta, Andrea Calcaterra, Francesca Ghirga
Summary: Calix[n]arenes are cyclic oligomers with a unique three-dimensional structure, allowing interaction with size-matched guest molecules. They have attracted attention as versatile scaffolds for sensitive detection and site-oriented immobilisation in biosensor development.
SUPRAMOLECULAR CHEMISTRY
(2021)
Article
Chemistry, Analytical
Francesca Polli, Cristine D'Agostino, Rosaceleste Zumpano, Viviana De Martino, Gabriele Favero, Luciano Colangelo, Salvatore Minisola, Franco Mazzei
Summary: We report a new sensitive label-free electrochemical immunosensor that can accurately detect Vitamin D-3 in untreated serum samples. The immunosensor showed high sensitivity and a wide linear range, and showed good agreement with the reference method, suggesting its potential use for rapid monitoring of low Vitamin D levels.
Article
Biochemical Research Methods
Andrea Calcaterra, Francesca Polli, Lara Lamelza, Cristina Del Plato, Silvia Cammarone, Francesca Ghirga, Bruno Botta, Franco Mazzei, Deborah Quaglio
Summary: Recent efforts have focused on the development of selective, sensitive, fast response, and miniaturized immunosensors for analyte monitoring. However, the complexity of immobilizing antibodies to the sensor surface remains a challenge. Supramolecular chemistry has emerged as a suitable tool to preorganize artificial receptors and improve the properties of self-assembled monolayers, enabling the development of sensitive label-free electrochemical immunosensors.
BIOCONJUGATE CHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Francesca Polli, Gabriele Cianfoni, Rem Elnahas, Laura Mangiardi, Francesca A. Scaramuzzo, Silvia Cammarone, Deborah Quaglio, Andrea Calcaterra, Marco Pierini, Franco Mazzei, Robertino Zanoni, Bruno Botta, Francesca Ghirga
Summary: A practical supramolecular Ab conjugation strategy based on resorc[4]arene modifiers was developed to immobilize antibodies onto the surface of carbon nanotubes (CNTs) for selective binding to target antigens (Ags). The study utilized host-guest approach and synthesized resorc[4]arene linkers R1 and R2 to improve the orientation of antibodies on CNTs and optimize the Ab/Ag interaction, showing potential applicability in label-free immunosensor development.
Article
Biochemistry & Molecular Biology
Cristine D'Agostino, Claudia Chillocci, Francesca Polli, Luca Surace, Federica Simonetti, Marco Agostini, Sergio Brutti, Franco Mazzei, Gabriele Favero, Rosaceleste Zumpano
Summary: This study aimed to develop a user-friendly smartphone-based electrochemical biosensor for the rapid assessment of total polyphenols content in coffee blends. The biosensor, based on modified carbon-based screen-printed electrode, demonstrated high sensitivity and a wide linear range, and was validated for quantifying polyphenols in coffee blends.
Article
Electrochemistry
Juan Pinuela-Noval, Daniel Fernandez-Gonzalez, Sergio Brutti, Marta Suarez, Franco Mazzei, Maria Assunta Navarra, Luis Felipe Verdeja, Adolfo Fernandez, Marco Agostini
Summary: This study proposes for the first time the use of molybdenum and chromium carbides as additives to stabilize graphite/silicon composites. Spark plasma sintering technology is utilized to sinter the electrode powders. It is demonstrated that the presence of molybdenum or chromium carbides enhances the performance of C/Si electrodes, improving the cycling stability in lithium cells.
Article
Chemistry, Physical
Rosaceleste Zumpano, Laura Lambertini, Cristina Tortolini, Paolo Bollella, Gabriele Favero, Riccarda Antiochia, Franco Mazzei
JOURNAL OF POWER SOURCES
(2020)
Article
Chemistry, Multidisciplinary
Eliana Capecchi, Davide Piccinino, Elisabetta Tomaino, Bruno Mattia Bizzarri, Francesca Polli, Riccarda Antiochia, Franco Mazzei, Raffaele Saladino
Article
Chemistry, Analytical
Qian Wu, Li Tian, Xiangyu Shan, Huiling Li, Chao Li, Juan Lu
Summary: A novel ECL sensor was developed by modifying Fe3CuO4-Ru(bpy)3+ and GO-CdS@ZnS on the electrode for the detection of permethrin. The sensor exhibited high sensitivity and a wide detection range.
Article
Chemistry, Analytical
Tingting Gong, Lei Liao, Bingying Jiang, Ruo Yuan, Yun Xiang
Summary: In this study, a fluorescent biosensing system for high sensitivity detection of MT was established using a new Ag+-stabilized DNA triplex probe (Ag+-SDTP) combined with catalytic hairpin assembly (CHA) and CRISPR/Cas12a signal enhancements. The sensing method is able to selectively detect MT from other non-specific molecules and can achieve low level detection of MT in diluted human serums, demonstrating its potential for monitoring disease-specific MT biomarker at trace levels.
Article
Chemistry, Analytical
Estrella Sanz Rodriguez, Kyra Wood, Paul R. Haddad, Brett Paull
Summary: This study presents a simple, rapid, and reliable method for determining boron in aqueous solutions using suppressed ion chromatography coupled to electrospray ionisation-triple quadrupole mass spectrometry. The method achieved a low limit of detection and demonstrated excellent analytical performance.
Article
Chemistry, Analytical
Aline Cournut, Paul Moustiez, Yannick Coffinier, Christine Enjalbal, Claudia Bich
Summary: Alzheimer's disease is a major cause of senile dementia and is characterized by the aggregation of neurofibrillary tangles and amyloid plaques in the brain. The A beta 1-42 peptide is considered the primary cause of neurotoxicity due to its insolubility and subsequent aggregation. A beta 1-42 and A beta 1-40 have been identified as relevant biomarkers for AD diagnosis, and SurfaceAssisted Laser Desorption/Ionization Mass Spectrometry (SALDI-MS) was used to monitor the A beta 1-42/A beta 1-40 ratio without prior sample treatment.
Article
Chemistry, Analytical
Dotse Selali Chormey, Buse Tugba Zaman, Tulay Borahan Kustanto, Sezin Erarpat Bodur, Suleyman Bodur, Elif Ozturk Er, Sezgin Bakirdere
Summary: This review provides an overview of the harmful effects of endocrine disrupting chemicals (EDCs) on human health and introduces the methods for analyzing EDCs. Recent research has focused on using green chemicals, such as deep eutectic solvents (DESs), for microextraction to ensure environmental safety.
Article
Chemistry, Analytical
Yan Zhang, Renfeng Xu, Jingjing Wu, Zhenghong Zhang, Yuhuang Wang, Hongqin Yang, Sheng Zhang
Summary: This study visualized the pore-like structures in prostate cancer cell membranes after treatment with the anticancer drug paclitaxel, demonstrating its mechanism of action related to oxidative damage.
Article
Chemistry, Analytical
Chihong Ma, Qin Zhou, Jinjin Shi, Hua Gao, Di Huang, Huimin Xue, Han Wang, Zhenzhong Zhang, Sen Yang, Junli Zhang, Kaixiang Zhang
Summary: We developed a CRISPR-empowered electrochemical biosensor, named PER-E-CRISPR, for amplification-free and sensitive detection of miR-21. The biosensor combines the advantages of CRISPR/Cas13a and primer exchange reaction (PER) for target amplification. Under optimized conditions, the PER-E-CRISPR assay exhibits a linear range from 10-13 to 10-7 M and a limit of detection of 30.2 fM. The biosensor shows excellent performance in actual plasma, indicating promising prospects for miRNA detection in molecular diagnosis.
Article
Chemistry, Analytical
Gang Liang, Jie Zhao, Yufei Gao, Tao Xie, Jianhui Zhen, Ligang Pan, Wenwen Gong
Summary: Molecular docking (MD) analysis is widely used for studying the interaction between aptamers and small molecules. This study established steady-state aptamers of tertiary structures (SATS) using specific aptamers of tetracycline antibiotics as docking models. Molecular docking results revealed multiple binding sites in the SATS of aptamers, with significant variations in binding free energy (BFE) and docking score (DS). The study also proposed a method for MD analysis based on SATS, providing insights into binding mode and predicting binding sites.
Article
Chemistry, Analytical
Yixuan Xu, Changchang Teng, Huiping Dang, Dalong Yin, Lifeng Yan
Summary: Stable organic radical molecules with high NIR fluorescence quantum efficiency have been synthesized and encapsulated into nanoparticles, which show great potential for both photodynamic therapy (PDT) and photothermal therapy (PTT) of tumors.
Article
Chemistry, Analytical
Yu Su, Dandan Yang, Yanjie Wang, Jie Ding, Lan Ding, Daqian Song
Summary: In this study, a highly selective molecularly imprinted polymer Cu-MIPs@CS was designed and synthesized for bisphenol A (BPA). Cu-MIPs@CS showed significantly enhanced imprinting factor and selective factor towards BPA compared to MIPs@CS. It also exhibited superior discrimination ability between BPA and its structural analogue. Additionally, Cu-MIPs@CS were successfully applied as a solid phase extraction adsorbent for the determination of BPA in drinking water samples.
Article
Chemistry, Analytical
Yi Qiao, Qiongdan Zhang, Yukun He, Tianguang Cheng, Jing Tu
Summary: Single cell heterogeneity plays an important role in many biological phenomena, and distinguishing cells with specific mutations is beneficial for clinical diagnosis and drug screening. This study introduces a gel plate platform that can distinguish cell types based on their phenotypes, with low equipment requirement. The gel platform has potential in point-of-care circumstances and single-cell stimulation responses that prioritize efficiency and simplicity.
Article
Chemistry, Analytical
Chengke Wang, Shuyang Sun, Ping Wang, Huawei Zhao, Wenling Li
Summary: The food safety of aquatic products is a global concern. Nanotechnology-based analyses have advantages in the detection of bacteria, metal ions, and small molecule contaminants. This review summarizes the recent advances in biosensing strategies for aquatic products and highlights the application of nanomaterials, lateral flow-based biosensors, surface-enhanced Raman scattering, microfluidic chips, and molecular imprinting technologies.
Article
Chemistry, Analytical
Liping Zhu, Zeng Tang, Xuemei Zhang, Li Zhu, Tian Meng, Linying Yu, Ting Xiao, Shasha Lu, Xiaoli Xiong, Xiurong Yang
Summary: A sensitive off-on electrochemiluminescence DNA sensor was developed using Exo III-assisted cascade amplification system. The sensor achieved high selectivity and ultra-high sensitivity in detecting target DNA by utilizing ECL and SPR effects. This study provides a new perspective for designing highly sensitive and programmable ECL biosensors.
Article
Chemistry, Analytical
Tong Li, Mengxu Sun, Suping Xia, Ting Huang, Rong-Tian Li, Chunrong Li, Zong Dai, Jin-Xiang Chen, Jun Chen, Nuan Jia
Summary: Here, we developed a binary system based on DNA tetrahedron and fluorogenic RNA aptamers for highly specific and label-free mRNA imaging in living cells. This system achieved high specificity label-free detection of nucleic acids with a detection limit of 1.34 nM. The method has potential applications in early disease diagnosis and new drug development.
Article
Chemistry, Analytical
Yao Zhao, Shu Zhang, Wang Yao, Yuxuan Zhu, Jing Qian, Juan Yang, Nianjun Yang
Summary: A new hierarchical nanostructured composite with high conductivity and catalytic activity is synthesized. The sensor exhibits significant catalytic effect and high sensitivity for monitoring the environmental endocrine disruptor bisphenol A (BPA).
