期刊
HUMAN VACCINES & IMMUNOTHERAPEUTICS
卷 11, 期 4, 页码 1010-1021出版社
TAYLOR & FRANCIS INC
DOI: 10.1080/21645515.2015.1009817
关键词
bacteriophage; CIM monolithic column; DSP; gene therapy vector; PAT; purification; USP; vaccine; VLP; virus
Downstream processing of nanoplexes (viruses, virus-like particles, bacteriophages) is characterized by complexity of the starting material, number of purification methods to choose from, regulations that are setting the frame for the final product and analytical methods for upstream and downstream monitoring. This review gives an overview on the nanoplex downstream challenges and chromatography based analytical methods for efficient monitoring of the nanoplex production.
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