Recent Strategies in the Synthesis of Spiroindole and Spirooxindole Scaffolds

An overview of spirooxindole as a promising scaffold for novel drug discovery

(2020) Li-Ming Zhou et al.   Expert Opinion on Drug Discovery

Efficient Multicomponent Synthesis of Spirooxindole Derivatives Catalyzed by Copper Triflate

(2020) Chunlei Wu et al.   POLYCYCLIC AROMATIC COMPOUNDS

Recent investigations in the synthesis of spirooxindole derivatives by Iranian researchers

(2020) Leila Youseftabar-Miri et al.   Journal of the Iranian Chemical Society

Facile Diastereoselective Synthesis of Highly Substituted Alkylene-oxetanes from 3-Alkyl Allenoates and Diaryl 1,2-Diones/α-Ketoamides Mediated by DBU

(2019) Jagadeesh Krishnan et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

A simple and environmentally benign synthesis of novel spiro[indoline-3,5′-pyrano[2,3-d]pyrimidine] derivatives in water

(2019) Sakineh Ghadiri et al.   MONATSHEFTE FUR CHEMIE

Design and synthesis of new substituted spirooxindoles as potential inhibitors of the MDM2–p53 interaction

(2019) Assem Barakat et al.   BIOORGANIC CHEMISTRY

Synthesis of Spirooxindole Oxetanes via a Domino Reaction of 3-Hydroxyoxindoles and Phenyl Vinyl Selenone

(2019) Martina Palomba et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Synthesis of Spiro[indole-3,5'-isoxazoles] with Anticancer Activity via a Formal (4+1)-Spirocyclization of Nitroalkenes to Indoles

(2019) Alexander V. Aksenov et al.   JOURNAL OF ORGANIC CHEMISTRY

Synthesis of heterocycle appended spiro(oxindole-3,2’-pyrrolidine) derivatives from heterocyclic ylidenes and azomethine ylide through 1,3-dipolar cycloaddition reactions

(2019) S. Vidya et al.   SYNTHETIC COMMUNICATIONS

Rhodium(III)-Catalyzed C-H Activation/Carbene Insertion/Lossen Rearrangement Sequence: Efficient Synthesis of Spirooxindole Pyrrolones

(2019) Huixiong Dai et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Catalytic Asymmetric and Divergent Synthesis of Tricyclic and Tetracyclic Spirooxindoles: Controllable Site-Selective Electrophilic Halocyclization of 1,6-Enynes

(2019) Taochun Zha et al.   ORGANIC LETTERS

Synthesis of 7′-Arylidenespiro[indoline-3,1′-pyrrolizines] and 7′-Arylidenespiro[indene-2,1′-pyrrolizines] via [3 + 2] Cycloaddition and β-C–H Functionalized Pyrrolidine

(2019) Ying Huang et al.   JOURNAL OF ORGANIC CHEMISTRY

β-Cyclodextrin Mediated Multicomponent Synthesis of Spiroindole Derivatives in Aqueous Medium

(2019) Vishwa Deepak Tripathi   ASIAN JOURNAL OF CHEMISTRY

Catalytic asymmetric synthesis of spirooxindoles: recent developments

(2018) Guang-Jian Mei et al.   CHEMICAL COMMUNICATIONS

Recent advances in spirocyclization of indole derivatives

(2018) Jitender Bariwal et al.   CHEMICAL SOCIETY REVIEWS

Highly Diastereoselective Synthesis of Tetralin-fused Spirooxindoles via Lewis Acid-catalyzed C(sp3)–H Bond Functionalization

(2018) Mizuki Machida et al.   CHEMISTRY LETTERS

Synthesis of Multifunctional Spirocyclic Azetidines and Their Application in Drug Discovery

(2018) Alexander A. Kirichok et al.   CHEMISTRY-A EUROPEAN JOURNAL

Asymmetric Catalytic Double Michael Additions for the Synthesis of Spirooxindoles

(2018) Tengfei Kang et al.   CHEMISTRY-A EUROPEAN JOURNAL

Synthesis of Spirooxindoles through Cyclocondensation of Isatin and Cyclic 1,3-Diones

(2018) Rahul Joshi et al.   JOURNAL OF HETEROCYCLIC CHEMISTRY

Diastereo- and Enantioselective Synthesis of Spirooxindoles with Contiguous Tetrasubstituted Stereocenters via Catalytic Coupling of Two Tertiary Radicals

(2018) Zhi-Yong Song et al.   JOURNAL OF ORGANIC CHEMISTRY

Spirooxindole-fused pyrazolo pyridine derivatives: NiO–SiO2 catalyzed one-pot synthesis and antimicrobial activities

(2018) Swetha Yagnam et al.   SYNTHETIC COMMUNICATIONS

Iodine-promoted three-component reaction for the synthesis of spirooxindoles

(2018) Min Zhang et al.   TETRAHEDRON

Design, synthesis and anticancer activity of trifluoromethylphenylamino substituted spiroindoles

(2018) Mariana Budovská et al.   JOURNAL OF FLUORINE CHEMISTRY

Iodide/H2O2 Catalyzed Intramolecular Oxidative Amination for the Synthesis of 3,2′-Pyrrolidinyl Spirooxindoles

(2018) Yu-Ting Gao et al.   MOLECULES

Facile one-pot synthesis of spirooxindole-pyrrolidine derivatives and their antimicrobial and acetylcholinesterase inhibitory activities

(2018) Ying Huang et al.   NEW JOURNAL OF CHEMISTRY

Synthesis of polycyclic spirooxindoles via an asymmetric catalytic one-pot stepwise Aldol/chloroetherification/aromatization procedure

(2018) Yan Jiang et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Synthesis of benzosuberone-tethered spirooxindoles: 1-3-dipolar cycloaddition of azomethine ylides and arylidene benzosuberones

(2018) Sundaravel Vivek Kumar et al.   MOLECULAR DIVERSITY

Regio- and Stereoselective Synthesis of Spirooxindoles via Mizoroki–Heck Coupling of Aryl Iodides

(2018) Mats Larhed et al.   SYNLETT

Double-slit photoelectron interference in strong-field ionization of the neon dimer

(2018) Maksim Kunitski et al.   Nature Communications

Spirooxindoles as Potential Pharmacophores

(2017) Siva S. Panda et al.   MINI-REVIEWS IN MEDICINAL CHEMISTRY

Regio- and Stereoselective Synthesis of Functionalized Cyclopentene Derivatives via Mizoroki–Heck Reactions

(2017) Alexander Wetzel et al.   ORGANIC LETTERS

Asymmetric Organocatalytic Cascade Synthesis of Tetrahydro­furanyl Spirooxindoles

(2017) Tõnis Kanger et al.   SYNTHESIS-STUTTGART

Sodium Iodide/Hydrogen Peroxide-Mediated Oxidation/Lactonization for the Construction of Spirocyclic Oxindole-Lactones

(2016) Guofeng Li et al.   ADVANCED SYNTHESIS & CATALYSIS

Review of synthesis and various biological activities of spiro heterocyclic compounds comprising oxindole and pyrrolidine moities

(2016) Pankaj Saraswat et al.   SYNTHETIC COMMUNICATIONS

Molecular diversity of spirooxindoles. Synthesis and biological activity

(2015) Tetyana L. Pavlovska et al.   MOLECULAR DIVERSITY

Halogenated Organic Molecules of Rhodomelaceae Origin: Chemistry and Biology

(2013) Bin-Gui Wang et al.   CHEMICAL REVIEWS

Multicomponent 1,3-Dipolar Cycloaddition Reactions in the Construction of Hybrid Spiroheterocycles

(2013) Natarajan Arumugam et al.   CURRENT ORGANIC CHEMISTRY

Recent Progress on Routes to Spirooxindole Systems Derived from Isatin

(2013) Min Xia et al.   JOURNAL OF HETEROCYCLIC CHEMISTRY

Metal-free reactions of alkynes via electrophilic iodocarbocyclizations

(2012) Adeline Palisse et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Strategies for the enantioselective synthesis of spirooxindoles

(2012) Nicolas R. Ball-Jones et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

The asymmetric Heck and related reactions

(2011) Dennis Mc Cartney et al.   CHEMICAL SOCIETY REVIEWS

2-(Substituted phenyl)amino analogs of 1-methoxyspirobrassinol methyl ether: Synthesis and anticancer activity

(2009) Peter Kutschy et al.   BIOORGANIC & MEDICINAL CHEMISTRY

A highly atom economic, chemo-, regio- and stereoselective synthesis and evaluation of spiro-pyrrolothiazoles as antitubercular agents

(2009) Subramanian Vedhanarayanan Karthikeyan et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS