Article
Chemistry, Organic
Xiao Xiao, Jessica M. Roth, Nathaniel S. Greenwood, Maria K. Velopolcek, Jordan Aguirre, Mona Jalali, Alireza Ariafard, Sarah E. Wengryniuk
Summary: Bi(N)-HVIs, a newly emerging class of I(V) reagents, demonstrate favorable safety profiles, improved solubility, and comparable to superior oxidative reactivity compared to common I(V) reagents. By incorporating datively bound bidentate nitrogen ligands, these reagents provide a novel and convenient screening platform for the development of I(V) reagents and reactions.
JOURNAL OF ORGANIC CHEMISTRY
(2021)
Article
Electrochemistry
G. Balkourani, A. Brouzgou, C. Lo Vecchio, A. S. Arico, V Baglio, P. Tsiakaras
Summary: In this study, Co and Fe catalysts supported onto N-doped ketjenblack (Co/KB-N and Fe/KB-N) were synthesized using a template-free method and examined for dopamine electrooxidation reaction. Co/KB-N exhibited higher performance in terms of activity, sensitivity, stability and selectivity in a pH value close to human's serum. The improved performance could be attributed to the formation of the Co3+/Co4+ redox pair and the presence of N, which promoted electron transfer rate and high selectivity of Co/KB-N.
ELECTROCHIMICA ACTA
(2022)
Article
Environmental Sciences
Huanni Zhang, Chenchen Wang, Fangjie Guo, Lingmin Jin, Runqian Song, Fangxing Yang, Li Ji, Haiying Yu
Summary: In this study, density functional theory was used to investigate the hydroxylation metabolism of 28 aromatic amines. The results indicated that steric, inductive, and conjugative effects greatly contribute to the metabolism activity. Furthermore, the dissociation energy of -NH2 was found to successfully predict the activation energy, providing a means to quickly assess the potential toxicity of aromatic amines.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2022)
Article
Energy & Fuels
Zhaoqi Zhu, Jie Cui, Jingxin Han, Shujuan Wu, Hanxue Sun, Weidong Liang, An Li
Summary: A study on the synthesis of conjugated polymers based on poly(o-phenylenediamine) as a nitrogen-containing precursor for preparation of Co- and FeCl3-doped N-rich carbon for ORR was reported. Among the resulting electrocatalysts, FeCl3-OPD-800 displayed the highest catalytic activity with a largest half-wave potential and high diffusion limiting current density.
INTERNATIONAL JOURNAL OF ENERGY RESEARCH
(2021)
Article
Chemistry, Physical
Jing Wang, Wenwen Qiang, Sen Ye, Longfei Zhu, Xiang Liu, Teck-Peng Loh
Summary: A new efficient and versatile Ir/ZnO catalyst was developed for the additive-free N-methylation of amines with methanol. The high catalytic reactivity is attributed to the small sizes of Ir nanoparticles and the high ratio of oxidized iridium species on the catalyst. The selectivity of the catalytic N-methylation can be controlled between dimethylation and monomethylation by adjusting the catalyst loading and reaction solvent.
CATALYSIS SCIENCE & TECHNOLOGY
(2021)
Article
Nanoscience & Nanotechnology
Nithyarani Augustine, Sascha Putzke, Andreas Janke, Frank Simon, Astrid Drechsler, Cordelia A. Zimmerer
Summary: This study introduces a bio-inspired green approach using dopamine as an adhesion promoter for metallization on plastic surfaces, reducing energy consumption and the use of hazardous substances. The research shows that simple dip-coating with dopamine under optimal conditions is sufficient to support metal layers with good optical quality. Technologically relevant metal layer quality and adhesion can be achieved through optimized dopamine treatment and substrate pretreatment processes.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Nanoscience & Nanotechnology
Nithyarani Augustine, Sascha Putzke, Andreas Janke, Frank Simon, Astrid Drechsler, Cordelia A. Zimmerer
Summary: This study introduces a bio-inspired green approach to improve plastic metallization technology by using dopamine as an adhesion promoter. The research shows that simple dip-coating of the substrate with dopamine can support metal layers with good optical quality. Additionally, post-treatments such as thermal, UV, and plasma pretreatment can enhance the quality and adhesion of the metal film.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Chemistry, Physical
Sandra Abi Fayssal, Timothee Naret, Vincent Huc, Julien Buendia, Cyril Martini, Emmanuelle Schulz
Summary: The scalable synthesis of Pd-NHC cinnamyl complexes supported on benzyloxycalix[8]arene is reported. These catalysts are highly active for Buchwald-Hartwig cross-coupling reactions, enabling the coupling of aryl chlorides and bromides with alkyl and aryl amines at low catalytic loadings. The supported complexes also produce attractive unsymmetrical triarylamines and can even facilitate the synthesis of unprecedented Pd-catalyzed C-H activation products. Through an easy to implement procedure, these characterized catalysts combine the best features of homogeneous and heterogeneous catalysis, achieving high efficiency and low Pd leaching levels.
CATALYSIS SCIENCE & TECHNOLOGY
(2021)
Article
Chemistry, Physical
Peng Cheng, Mohamed Sarakha, Christine Mousty, Pierre Bonnet, Gilles Mailhot
Summary: The aim of this study was to prepare an Fe3O4/Tetra-n-butylammonium decatungstate (TBADT) catalyst for the selective oxidation of aromatic amine compounds using hydrogen peroxide (H2O2). The material M-DT, made from the interaction between TBADT and Fe3O4, was fully characterized. The M-DT catalyst showed efficient and selective conversion of sulfapyridine to nitroso-sulfapyridine in the presence of H2O2.
CATALYSIS SCIENCE & TECHNOLOGY
(2023)
Article
Materials Science, Multidisciplinary
Shaoju Fu, Yonghui Wang, Peixin Tang
Summary: Disinfecting pathogenic microorganisms in water streams efficiently and massively is still a big challenge. Available technologies suffer from irreversible consumption of disinfectants, production of carcinogenic byproducts, and high filtration resistance. In this study, a chlorine rechargeable fiber-supported biocidal porous organic polymer (FPOP) was designed, which showed promising potential for point-of-use water disinfection with superior killing capacity, high filtration flux, and low cost. The chlorinated FPOP demonstrated a high specific surface area, large and rechargeable active chlorine content, long-term stability, and efficient biocidal activity.
ACS APPLIED POLYMER MATERIALS
(2023)
Article
Chemistry, Multidisciplinary
Sona Krajcovicova, Jan Hlavac, Kristyna Vychodilova
Summary: This study presents a fast and simple method for accessing N-arylated 3-hydroxyquinolin-4(1H)-ones starting from easily available 1-methyl-2-iodoterephthalate and variously substituted anilines. N-Alkylated anthranilic acid derivatives are important intermediates and can be prepared advantageously by solid-phase synthesis, Buchwald-Hartwig amination, or reductive amination with wide substrate scope and excellent crude purities.
Article
Chemistry, Multidisciplinary
Vishakha Goyal, Naina Sarki, Mukesh Kumar Poddar, Anand Narani, Deependra Tripathi, Anjan Ray, Kishore Natte
Summary: The developed Ru/PNC-700 catalyst showed remarkable catalytic activity and selectivity in the N-alkylation and chemoselective hydrogenation of compounds, allowing for the synthesis of pharmaceutical agents and key drug intermediates in excellent yields under mild conditions using water as a green solvent. Furthermore, the catalyst could be easily recovered and reused up to five times without any noticeable loss in activity and selectivity.
NEW JOURNAL OF CHEMISTRY
(2021)
Article
Chemistry, Multidisciplinary
Xiaoran Zhang, Xiaomin Xu, Sixian Yao, Chao Hao, Can Pan, Xue Xiang, Zhi Qun Tian, Pei Kang Shen, Zongping Shao, San Ping Jiang
Summary: In this study, single cobalt atom catalysts embedded in nitrogen-doped carbon materials were successfully synthesized by precursor modulation. The researchers found that the catalyst with graphitic nitrogen coordination exhibited superior activity and stability in oxygen reduction and evolution reactions, due to the electron donation effect of graphitic nitrogen on the Co-N-4 active sites.
Article
Engineering, Chemical
Jing Yang, Ligang Lin, Fengling Tang, Junqiang Zhao
Summary: In this study, a novel N-oxide zwitterionic polymer (PTMAO) was developed with ultralow fouling property and superior hydrophilicity, inspired by the secretion of trimethylamine-N-oxide (TMAO) by saltwater fish. A zwitterionic polymer network was formed using a biomimetic co-deposition technique of dopamine (DA) and PTMAO. The fabricated membrane exhibited excellent superhydrophilicity and underwater superoleophobicity, achieving high efficiency of oil-water separation performance under ultra-low-pressure conditions.
SEPARATION AND PURIFICATION TECHNOLOGY
(2023)
Article
Biotechnology & Applied Microbiology
Nemah Abu Shama, Suleyman Asir, Mehmet Ozsoz, Ilgim Gokturk, Deniz Turkmen, Fatma Yilmaz, Adil Denizli
Summary: A molecularly imprinted polymer-based pencil graphite electrode sensor, modified with gold nanoparticles, was used to detect dopamine in the presence of other biochemical compounds. The pulse voltammetry methods showed the highest response. The study successfully differentiated dopamine from other biomolecules using overlapping voltammograms and obtained accurate calibration curves within a high sensitivity detection limit range.
BIOENGINEERING-BASEL
(2022)
Article
Chemistry, Applied
Fabio Mastrogiovanni, Annalisa Romani, Luca Santi, Nicola Lacetera, Roberta Bernini
Summary: The study demonstrated that pomegranate peel extracts have a protective effect on bovine peripheral blood mononuclear cells and are not cytotoxic at certain concentrations. Additionally, the extracts show significant anti-proliferative activity.
NATURAL PRODUCT RESEARCH
(2021)
Article
Chemistry, Applied
Elisa Pannucci, Rocco Caracciolo, Annalisa Romani, Francesco Cacciola, Paola Dugo, Roberta Bernini, Leonardo Varvaro, Luca Santi
Summary: An extract enriched with hydroxytyrosol (HTyr) obtained from olive mill wastewaters was tested on olive tree pathogens Pss and At, showing potent antioxidant and antimicrobial activity, highlighting the potential application in olive cultivation.
NATURAL PRODUCT RESEARCH
(2021)
Article
Chemistry, Applied
Elisa Pannucci, Donatella D'Eliseo, Francesca Ieri, Annalisa Romani, Luca Santi, Roberta Bernini, Maurizio Sabatti, Francesca Velotti
Summary: The hydroalcoholic extracts obtained from buds of P. nigra, P. deltoides and P. trichocarpa showed antioxidant and anti-inflammatory activities, with P. nigra demonstrating the highest antioxidant activity and all extracts suppressing the production of key pro-inflammatory cytokines. These results highlight the potential of these extracts as therapeutic agents.
NATURAL PRODUCT RESEARCH
(2022)
Article
Multidisciplinary Sciences
Annalisa Romani, Gabriele Simone, Margherita Campo, Lorenzo Moncini, Roberta Bernini
Summary: The antifungal activities of tannins-rich commercial sweet chestnut wood and green tea leaf extracts were evaluated against various filamentous fungi, showing higher inhibitory effects with increasing concentrations.
Article
Biochemistry & Molecular Biology
Francesca Luzi, Elisa Pannucci, Mariangela Clemente, Edoardo Grande, Silvia Urciuoli, Annalisa Romani, Luigi Torre, Debora Puglia, Roberta Bernini, Luca Santi
Summary: This study utilized a sustainable process to extract antioxidants from olive oil wastes and by-products, preparing novel PVA-based films with promising antioxidant properties. The films showed potential for use in active food packaging to protect oxidative-sensitive food products. This research demonstrates a valuable example of reusing and valorizing agro-industrial wastes and by-products in accordance with the circular economy model.
Article
Agronomy
Mounira Inas Drais, Elisa Pannucci, Rocco Caracciolo, Roberta Bernini, Annalisa Romani, Luca Santi, Leonardo Varvaro
Summary: The study revealed that hydroxytyrosol enriched extracts from olive mill waste products have antifungal activity against Verticillium dahliae, with HTE1 showing higher efficacy. This suggests the potential of these compounds as an eco-friendly control measure for Verticillium wilt in olive production.
PHYTOPATHOLOGIA MEDITERRANEA
(2021)
Editorial Material
Nutrition & Dietetics
Annalisa Noce, Annalisa Romani, Roberta Bernini
Article
Biochemistry & Molecular Biology
Manuela Leo, Livio Muccillo, Laura Dugo, Roberta Bernini, Luca Santi, Lina Sabatino
Summary: Olive oil production generates waste products rich in water-soluble polyphenols, which can pose environmental problems. However, these waste products can be exploited for their bioactive properties. This study chemically characterized the polyphenolic extracts from the waste products and investigated their biological activities in normal and colorectal cancer cells. The extracts showed anti-inflammatory effects and can potentially ameliorate inflammation associated with diseases and tumors.
Article
Chemistry, Applied
Loredana Basirico, Fabio Mastrogiovanni, Nicola Lacetera, Luca Santi, Roberta Bernini, Umberto Bernabucci
Summary: This in vitro study evaluated for the first time the antioxidant and anti-inflammatory effect of an Oleuropein-enriched extract on bovine mammary epithelial cells. The extract showed no cytotoxic effect on the cells and reduced ROS production induced by hydrogen peroxide. It also downregulated the expression of pro-inflammatory cytokines. These findings confirm the antioxidant and anti-inflammatory properties of the extract.
NATURAL PRODUCT RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Valentina Laghezza Masci, Roberta Bernini, Noemi Villanova, Mariangela Clemente, Vittoria Cicaloni, Laura Tinti, Laura Salvini, Anna Rita Taddei, Antonio Tiezzi, Elisa Ovidi
Summary: The antitumor activity of hydroxytyrosyl oleate (HTyr-OL) against neuroblastoma cells was evaluated in this study. Results showed that the biological activity of HTyr was maintained in HTyr-OL treatments at lower dosages. Additionally, HTyr-OL exhibited antioxidant, anti-proliferative, and anti-inflammatory activities.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Andrea Lombardi, Andrea Fochetti, Pamela Vignolini, Margherita Campo, Alessandra Durazzo, Massimo Lucarini, Debora Puglia, Francesca Luzi, Marco Papalini, Monia Renzi, Andrea Cavallo, Roberta Bernini
Summary: This review article summarizes the current research status of the activation technology of poly (lactic acid) (PLA)-based materials in food and biomedical applications using natural compounds and extracts from plant sources. It discusses the synthesis and properties of PLA, as well as the chemical properties and unconventional extraction technologies of active ingredients (AIs) used for PLA activation. The innovative techniques for incorporating AIs into PLA, characterization of the novel materials, and their antioxidant and antimicrobial properties are also discussed. The study highlights the need for further joint research between academia and industry, following green chemistry principles and circular economy strategies.
Article
Biochemistry & Molecular Biology
Andrea Lombardi, Margherita Campo, Pamela Vignolini, Marco Papalini, Mirco Pizzetti, Roberta Bernini
Summary: This study characterized phenolic-rich extracts from olive, chestnut, pomegranate, and grape residues through HPLC-MS-DAD analysis. The results showed that these extracts exhibited significant growth inhibition against fungi, especially pathogenic dermatophytes. These extracts have potential applications as antifungal agents in the agri-food and biomedical fields.
Review
Nutrition & Dietetics
Laura Micheli, Laura Bertini, Agnese Bonato, Noemi Villanova, Carla Caruso, Maurizia Caruso, Roberta Bernini, Felice Tirone
Summary: Aging is a complex process caused by cellular damage accumulation and reduction in physiological activities, leading to increased incidence of age-related diseases. The Mediterranean diet, particularly the bioactive compounds in extra virgin olive oil like hydroxytyrosol and oleuropein, has been associated with longevity and protection against age-related disorders. This review focuses on the effects of these compounds on the brain, skeletal muscle, and gut microbiota, discussing their role in neurodegenerative diseases, neurogenesis, senescence, muscle disorders, and gut microbiota composition.
Review
Nutrition & Dietetics
Francesca Velotti, Roberta Bernini
Summary: Inflammaging refers to chronic low-grade inflammation caused by immune and non-immune cells stimulated by endogenous/self, misplaced or altered molecules, belonging to physiological aging. This inflammatory status is characterized by increased inflammation and decreased autophagy, and predisposes to age-related diseases. Phenolic compounds, particularly hydroxytyrosol (HTyr) found in extra-virgin olive oil, have antioxidant and anti-inflammatory properties that may counteract inflammaging and contribute to healthy aging.
Article
Computer Science, Information Systems
Giorgia Perelli, Roberta Bernini, Massimo Lucarini, Alessandra Durazzo
Summary: This study provides an update to the Dietary Supplement Label Database in Italy focused on dietary supplements coding. The updated dataset serves as a valuable resource for applying classification coding systems to dietary supplements and for various applications such as epidemiological investigations, exposure studies, and dietary assessment.