The Role of the Medial Prefrontal Cortex in the Conditioning and Extinction of Fear

DREADDs (Designer Receptors Exclusively Activated by Designer Drugs): Chemogenetic Tools with Therapeutic Utility

(2015) Daniel J. Urban et al.   Annual Review of Pharmacology and Toxicology

Sign-tracking to an appetitive cue predicts incubation of conditioned fear in rats

(2015) Jonathan D. Morrow et al.   BEHAVIOURAL BRAIN RESEARCH

Neuronal Circuits for Fear Expression and Recovery: Recent Advances and Potential Therapeutic Strategies

(2015) Cyril Dejean et al.   BIOLOGICAL PSYCHIATRY

Ventromedial Prefrontal Cortex Is Critical for the Regulation of Amygdala Activity in Humans

(2015) Julian C. Motzkin et al.   BIOLOGICAL PSYCHIATRY

Differential roles of medial prefrontal subregions in the regulation of drug seeking

(2015) David E. Moorman et al.   BRAIN RESEARCH

Distinct ensembles of medial prefrontal cortex neurons are activated by threatening stimuli that elicit excitation vs. inhibition of movement

(2015) Lindsay R. Halladay et al.   JOURNAL OF NEUROPHYSIOLOGY

Pharmacogenetic Excitation of Dorsomedial Prefrontal Cortex Restores Fear Prediction Error

(2015) J. O.-Y. Yau et al.   JOURNAL OF NEUROSCIENCE

Revisiting the Role of Infralimbic Cortex in Fear Extinction with Optogenetics

(2015) F. H. Do-Monte et al.   JOURNAL OF NEUROSCIENCE

Inactivating the infralimbic but not prelimbic medial prefrontal cortex facilitates the extinction of appetitive Pavlovian conditioning in Long-Evans rats

(2015) J. Mendoza et al.   NEUROBIOLOGY OF LEARNING AND MEMORY

The prelimbic cortex uses contextual cues to modulate responding towards predictive stimuli during fear renewal

(2015) Melissa Sharpe et al.   NEUROBIOLOGY OF LEARNING AND MEMORY

Stress and Fear Extinction

(2015) Stephen Maren et al.   NEUROPSYCHOPHARMACOLOGY

Noradrenergic blockade stabilizes prefrontal activity and enables fear extinction under stress

(2015) Paul J. Fitzgerald et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Prefrontal neurons encode context-based response execution and inhibition in reward seeking and extinction

(2015) David E. Moorman et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Smaller hippocampal volume as a vulnerability factor for the persistence of post-traumatic stress disorder

(2015) S. J. H. van Rooij et al.   PSYCHOLOGICAL MEDICINE

Fear renewal preferentially activates ventral hippocampal neurons projecting to both amygdala and prefrontal cortex in rats

(2015) Jingji Jin et al.   Scientific Reports

Prefrontal and Auditory Input to Intercalated Neurons of the Amygdala

(2015) Cornelia Strobel et al.   Cell Reports

Prefrontal inputs to the amygdala instruct fear extinction memory formation

(2015) O. Bukalo et al.   Science Advances

Animal Models of Fear Relapse

(2014) T. D. Goode et al.   ILAR JOURNAL

Pathway-Selective Adjustment of Prefrontal-Amygdala Transmission during Fear Encoding

(2014) M. Arruda-Carvalho et al.   JOURNAL OF NEUROSCIENCE

Neural Structures Mediating Expression and Extinction of Platform-Mediated Avoidance

(2014) C. Bravo-Rivera et al.   JOURNAL OF NEUROSCIENCE

Impaired Contextual Modulation of Memories in PTSD: An fMRI and Psychophysiological Study of Extinction Retention and Fear Renewal

(2014) S. N. Garfinkel et al.   JOURNAL OF NEUROSCIENCE

Persistent prelimbic cortex activity contributes to enhanced learned fear expression in females

(2014) G. E. Fenton et al.   LEARNING & MEMORY

Durable fear memories require PSD-95

(2014) P J Fitzgerald et al.   MOLECULAR PSYCHIATRY

Sex differences in extinction recall in posttraumatic stress disorder: A pilot fMRI study

(2014) Erel Shvil et al.   NEUROBIOLOGY OF LEARNING AND MEMORY

Long-Range Connectivity Defines Behavioral Specificity of Amygdala Neurons

(2014) Verena Senn et al.   NEURON

Amygdala Microcircuits Controlling Learned Fear

(2014) Sevil Duvarci et al.   NEURON

Alterations in Reward, Fear and Safety Cue Discrimination after Inactivation of the Rat Prelimbic and Infralimbic Cortices

(2014) Susan Sangha et al.   NEUROPSYCHOPHARMACOLOGY

Frequency of Cocaine Self-Administration Influences Drug Seeking in the Rat: Optogenetic Evidence for a Role of the Prelimbic Cortex

(2014) Elena Martín-García et al.   NEUROPSYCHOPHARMACOLOGY

Spontaneous Recovery of Fear Reverses Extinction-Induced Excitability of Infralimbic Neurons

(2014) Emmanuel Cruz et al.   PLoS One

Ex vivo dissection of optogenetically activated mPFC and hippocampal inputs to neurons in the basolateral amygdala: implications for fear and emotional memory

(2014) Cora Hübner et al.   Frontiers in Behavioral Neuroscience

Fear Extinction and Relapse: State of the Art

(2013) Bram Vervliet et al.   Annual Review of Clinical Psychology

Altered resting-state brain activity at functional MRI during automatic memory consolidation of fear conditioning

(2013) Tingyong Feng et al.   BRAIN RESEARCH

Morphological and Physiological Characterization of Pyramidal Neuron Subtypes in Rat Medial Prefrontal Cortex

(2013) Karlijn I. van Aerde et al.   CEREBRAL CORTEX

Differential roles of the prefrontal cortical subregions and basolateral amygdala in compulsive cocaine seeking and relapse after voluntary abstinence in rats

(2013) Yann Pelloux et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Synaptic Mechanisms Underlying Strong Reciprocal Connectivity between the Medial Prefrontal Cortex and Basolateral Amygdala

(2013) J. P. Little et al.   JOURNAL OF NEUROSCIENCE

Ventromedial Prefrontal Cortex Pyramidal Cells Have a Temporal Dynamic Role in Recall and Extinction of Cocaine-Associated Memory

(2013) M. C. Van den Oever et al.   JOURNAL OF NEUROSCIENCE

Deep Brain Stimulation of the Nucleus Accumbens Shell Attenuates Cocaine Reinstatement through Local and Antidromic Activation

(2013) F. M. Vassoler et al.   JOURNAL OF NEUROSCIENCE

Exposure to a fearful context during periods of memory plasticity impairs extinction via hyperactivation of frontal-amygdalar circuits

(2013) J. M. Stafford et al.   LEARNING & MEMORY

Activity in prelimbic cortex subserves fear memory reconsolidation over time

(2013) C. A. J. Stern et al.   LEARNING & MEMORY

Prefrontal parvalbumin interneurons shape neuronal activity to drive fear expression

(2013) Julien Courtin et al.   NATURE

Rescuing cocaine-induced prefrontal cortex hypoactivity prevents compulsive cocaine seeking

(2013) Billy T. Chen et al.   NATURE

Prefrontal entrainment of amygdala activity signals safety in learned fear and innate anxiety

(2013) Ekaterina Likhtik et al.   NATURE NEUROSCIENCE

The contextual brain: implications for fear conditioning, extinction and psychopathology

(2013) Stephen Maren et al.   NATURE REVIEWS NEUROSCIENCE

From Pavlov to PTSD: The extinction of conditioned fear in rodents, humans, and anxiety disorders

(2013) Michael B. VanElzakker et al.   NEUROBIOLOGY OF LEARNING AND MEMORY

Nature and causes of the immediate extinction deficit: A brief review

(2013) Stephen Maren   NEUROBIOLOGY OF LEARNING AND MEMORY

Prefrontal single-unit firing associated with deficient extinction in mice

(2013) Paul J. Fitzgerald et al.   NEUROBIOLOGY OF LEARNING AND MEMORY

Synaptic Encoding of Fear Extinction in mPFC-amygdala Circuits

(2013) Jun-Hyeong Cho et al.   NEURON

Memory consolidation of fear conditioning: Bi-stable amygdala connectivity with dorsal anterior cingulate and medial prefrontal cortex

(2013) Pan Feng et al.   Social Cognitive and Affective Neuroscience

Inhibitory networks of the amygdala for emotional memory

(2013) Seungho Lee et al.   Frontiers in Neural Circuits

Ensemble coding of context-dependent fear memory in the amygdala

(2013) Caitlin A. Orsini et al.   Frontiers in Behavioral Neuroscience

Resting Amygdala and Medial Prefrontal Metabolism Predicts Functional Activation of the Fear Extinction Circuit

(2012) Clas Linnman et al.   AMERICAN JOURNAL OF PSYCHIATRY

Discriminative Inhibitory Control of Cocaine Seeking Involves the Prelimbic Prefrontal Cortex

(2012) Claudia Mihindou et al.   BIOLOGICAL PSYCHIATRY

Different effects of low frequency stimulation to infralimbic prefrontal cortex on extinction of aversive memories

(2012) Kamilia Shehadi et al.   BRAIN RESEARCH

The effects of muscimol and AMN082 injections into the medial prefrontal cortex on the expression and extinction of conditioned fear in mice

(2012) M. M. Morawska et al.   JOURNAL OF EXPERIMENTAL BIOLOGY

Subcellular Synaptic Connectivity of Layer 2 Pyramidal Neurons in the Medial Prefrontal Cortex

(2012) J. P. Little et al.   JOURNAL OF NEUROSCIENCE

Chronic alcohol remodels prefrontal neurons and disrupts NMDAR-mediated fear extinction encoding

(2012) Andrew Holmes et al.   NATURE NEUROSCIENCE

Biological studies of post-traumatic stress disorder

(2012) Roger K. Pitman et al.   NATURE REVIEWS NEUROSCIENCE

A DTI tractography analysis of infralimbic and prelimbic connectivity in the mouse using high-throughput MRI

(2012) David A. Gutman et al.   NEUROIMAGE

Gating of Fear in Prelimbic Cortex by Hippocampal and Amygdala Inputs

(2012) Francisco Sotres-Bayon et al.   NEURON

Medial prefrontal cortical innervation of the intercalated nuclear region of the amygdala

(2012) C.R. Pinard et al.   NEUROSCIENCE

Enhanced Extinction of Aversive Memories by High-Frequency Stimulation of the Rat Infralimbic Cortex

(2012) Mouna Maroun et al.   PLoS One

Functional anatomy of neural circuits regulating fear and extinction

(2012) E. Knapska et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Modulation of medial prefrontal cortical activity using in vivo recordings and optogenetics

(2012) Guangchen Ji et al.   Molecular Brain

The Development and Application of Optogenetics

(2011) Lief Fenno et al.   Annual Review of Neuroscience

Fear Extinction as a Model for Translational Neuroscience: Ten Years of Progress

(2011) Mohammed R. Milad et al.   Annual Review of Psychology

Resting cerebral metabolism correlates with skin conductance and functional brain activation during fear conditioning

(2011) Clas Linnman et al.   BIOLOGICAL PSYCHOLOGY

Brain Structure Correlates of Individual Differences in the Acquisition and Inhibition of Conditioned Fear

(2011) C. A. Hartley et al.   CEREBRAL CORTEX

Temporal factors control hippocampal contributions to fear renewal after extinction

(2011) Moriel Zelikowsky et al.   HIPPOCAMPUS

Physiological identification and infralimbic responsiveness of rat intercalated amygdala neurons

(2011) Alon Amir et al.   JOURNAL OF NEUROPHYSIOLOGY

The Fear Circuit Revisited: Contributions of the Basal Amygdala Nuclei to Conditioned Fear

(2011) T. Amano et al.   JOURNAL OF NEUROSCIENCE

Hippocampal and Prefrontal Projections to the Basal Amygdala Mediate Contextual Regulation of Fear after Extinction

(2011) C. A. Orsini et al.   JOURNAL OF NEUROSCIENCE

Impact of infralimbic inputs on intercalated amygdala neurons: A biophysical modeling study

(2011) G. Li et al.   LEARNING & MEMORY

Medial prefrontal cortex activation facilitates re-extinction of fear in rats

(2011) C.-h. Chang et al.   LEARNING & MEMORY

An analysis of rat prefrontal cortex in mediating executive function

(2011) Raymond P. Kesner et al.   NEUROBIOLOGY OF LEARNING AND MEMORY

Inactivation of the infralimbic prefrontal cortex in rats reduces the influence of inappropriate habitual responding in a response-conflict task

(2011) J.E. Haddon et al.   NEUROSCIENCE

Patterns of Coupled Theta Activity in Amygdala-Hippocampal-Prefrontal Cortical Circuits during Fear Extinction

(2011) Jörg Lesting et al.   PLoS One

Shift in the Intrinsic Excitability of Medial Prefrontal Cortex Neurons following Training in Impulse Control and Cued-Responding Tasks

(2011) Scott J. Hayton et al.   PLoS One

Strain difference in the effect of infralimbic cortex lesions on fear extinction in rats.

(2010) Chun-hui Chang et al.   BEHAVIORAL NEUROSCIENCE

Cytoarchitectonic and chemoarchitectonic characterization of the prefrontal cortical areas in the mouse

(2010) H. J. J. M. Van De Werd et al.   Brain Structure & Function

Prefrontal control of fear: more than just extinction

(2010) Francisco Sotres-Bayon et al.   CURRENT OPINION IN NEUROBIOLOGY

Neuronal circuits of fear extinction

(2010) Cyril Herry et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Lack of Medial Prefrontal Cortex Activation Underlies the Immediate Extinction Deficit

(2010) S. C. Kim et al.   JOURNAL OF NEUROSCIENCE

Target-Specific Encoding of Response Inhibition: Increased Contribution of AMPA to NMDA Receptors at Excitatory Synapses in the Prefrontal Cortex

(2010) S. J. Hayton et al.   JOURNAL OF NEUROSCIENCE

Projection-Specific Neuromodulation of Medial Prefrontal Cortex Neurons

(2010) N. C. Dembrow et al.   JOURNAL OF NEUROSCIENCE

Activation of the infralimbic cortex in a fear context enhances extinction learning

(2010) B. M. Thompson et al.   LEARNING & MEMORY

A chemical-genetic approach for precise spatio-temporal control of cellular signaling

(2010) Shuyun Dong et al.   Molecular BioSystems

Genetic dissection of an amygdala microcircuit that gates conditioned fear

(2010) Wulf Haubensak et al.   NATURE

Encoding of conditioned fear in central amygdala inhibitory circuits

(2010) Stephane Ciocchi et al.   NATURE

Interneurons in the basolateral amygdala

(2010) Jay Spampanato et al.   NEUROPHARMACOLOGY

Dissociable Roles of Prelimbic and Infralimbic Cortices, Ventral Hippocampus and Basolateral Amygdala in the Expression and Extinction of Conditioned Fear

(2010) Demetrio Sierra-Mercado et al.   NEUROPSYCHOPHARMACOLOGY

Plastic Synaptic Networks of the Amygdala for the Acquisition, Expression, and Extinction of Conditioned Fear

(2010) Hans-Christian Pape et al.   PHYSIOLOGICAL REVIEWS

Single-Unit Activity in the Medial Prefrontal Cortex during Immediate and Delayed Extinction of Fear in Rats

(2010) Chun-hui Chang et al.   PLoS One

Coherent amygdalocortical theta promotes fear memory consolidation during paradoxical sleep

(2010) D. Popa et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The rat prelimbic cortex mediates inhibitory response control but not the consolidation of instrumental learning.

(2009) Sietse Jonkman et al.   BEHAVIORAL NEUROSCIENCE

Neurobiological Basis of Failure to Recall Extinction Memory in Posttraumatic Stress Disorder

(2009) Mohammed R. Milad et al.   BIOLOGICAL PSYCHIATRY

Sustained Conditioned Responses in Prelimbic Prefrontal Neurons Are Correlated with Fear Expression and Extinction Failure

(2009) A. Burgos-Robles et al.   JOURNAL OF NEUROSCIENCE

Long-term synaptic changes in two input pathways into the lateral nucleus of the amygdala underlie fear extinction

(2009) J. Park et al.   LEARNING & MEMORY

Extinction circuits for fear and addiction overlap in prefrontal cortex

(2009) J. Peters et al.   LEARNING & MEMORY

Inactivation of the infralimbic but not the prelimbic cortex impairs consolidation and retrieval of fear extinction

(2009) V. Laurent et al.   LEARNING & MEMORY

Reciprocal patterns of c-Fos expression in the medial prefrontal cortex and amygdala after extinction and renewal of conditioned fear

(2009) E. Knapska et al.   LEARNING & MEMORY

Intracortical circuits of pyramidal neurons reflect their long-range axonal targets

(2009) Solange P. Brown et al.   NATURE

Human Fear Conditioning and Extinction in Neuroimaging: A Systematic Review

(2009) Christina Sehlmeyer et al.   PLoS One

The Rostral Anterior Cingulate Cortex Modulates the Efficiency of Amygdala-Dependent Fear Learning

(2008) Stephanie Bissière et al.   BIOLOGICAL PSYCHIATRY

Ultrastructural analysis of prefrontal cortical inputs to the rat amygdala: spatial relationships to presumed dopamine axons and D1 and D2 receptors

(2008) Aline Pinto et al.   Brain Structure & Function

Parvalbumin-Positive Basket Interneurons in Monkey and Rat Prefrontal Cortex

(2008) N. V. Povysheva et al.   JOURNAL OF NEUROPHYSIOLOGY

Firing-Pattern-Dependent Specificity of Cortical Excitatory Feed-Forward Subnetworks

(2008) T. Otsuka et al.   JOURNAL OF NEUROSCIENCE

Impaired Fear Extinction Learning and Cortico-Amygdala Circuit Abnormalities in a Common Genetic Mouse Strain

(2008) K. Hefner et al.   JOURNAL OF NEUROSCIENCE

Infralimbic Prefrontal Cortex Is Responsible for Inhibiting Cocaine Seeking in Extinguished Rats

(2008) J. Peters et al.   JOURNAL OF NEUROSCIENCE

Fear Conditioning and Extinction Differentially Modify the Intrinsic Excitability of Infralimbic Neurons

(2008) E. Santini et al.   JOURNAL OF NEUROSCIENCE

From Fear to Safety and Back: Reversal of Fear in the Human Brain

(2008) D. Schiller et al.   JOURNAL OF NEUROSCIENCE

Switching on and off fear by distinct neuronal circuits

(2008) Cyril Herry et al.   NATURE

Petilla terminology: nomenclature of features of GABAergic interneurons of the cerebral cortex

(2008)   NATURE REVIEWS NEUROSCIENCE

Neural Circuitry Underlying the Regulation of Conditioned Fear and Its Relation to Extinction

(2008) Mauricio R. Delgado et al.   NEURON

Role of ventral medial prefrontal cortex in incubation of cocaine craving

(2008) Eisuke Koya et al.   NEUROPHARMACOLOGY

Contributions of the amygdala and medial prefrontal cortex to incentive cue responding

(2008) A. Ishikawa et al.   NEUROSCIENCE

Prelimbic and Infralimbic Prefrontal Cortex Interact during Fast Network Oscillations

(2008) Karlijn I. van Aerde et al.   PLoS One