Review
Medicine, General & Internal
Anne M. M. van Dijk, Alexandra S. Bruins S. Slot, Piero Portincasa, Sebastiaan N. Siegerink, Najiba Chargi, Carina J. R. Verstraete, Joep de Bruijne, Frank P. P. Vleggaar, Karel J. J. van Erpecum
Summary: Prophylactic supplementation of BCAA appears to be safe and may improve survival in cirrhotic patients.
EUROPEAN JOURNAL OF CLINICAL INVESTIGATION
(2023)
Article
Oncology
Lu Long, Wanshui Yang, Li Liu, Deirdre K. Tobias, Ryoko Katagiri, Kana Wu, Lina Jin, Fang-Fang Zhang, Xiao Luo, Xing Liu, Shuji Ogino, Andrew T. Chan, Jeffrey A. Meyerhardt, Edward Giovannucci, Xuehong Zhang
Summary: This study evaluated the association between postdiagnostic BCAA intake and CRC-specific mortality and overall mortality among nonmetastatic CRC patients. The findings suggest positive associations between higher intake of dietary BCAAs and risk of all-cause mortality in CRC patients, with no statistically significant associations observed for CRC-specific mortality. Further research is needed to confirm these findings and elucidate potential mechanisms underlying this association.
INTERNATIONAL JOURNAL OF CANCER
(2021)
Review
Endocrinology & Metabolism
Phillip J. White, Robert W. McGarrah, Mark A. Herman, James R. Bain, Svati H. Shah, Christopher B. Newgard
Summary: The association of obesity and insulin resistance with increased levels of branched-chain and aromatic amino acids and decreased glycine levels is well-established. Human metabolomics and genetic studies have further confirmed these observations, with preclinical studies identifying mechanisms involved in amino acid homeostasis disruption and its connection to dysregulated glucose and lipid metabolism, particularly in the development of insulin resistance, type 2 diabetes, and cardiovascular diseases.
MOLECULAR METABOLISM
(2021)
Review
Biochemistry & Molecular Biology
Paola Cuomo, Rosanna Capparelli, Antonio Iannelli, Domenico Iannelli
Summary: Branched-chain amino acids (BCAAs) play an important role in human health. High levels of BCAAs are associated with various metabolic diseases, while low levels are beneficial for metabolic health. However, the exact mechanisms underlying the dysregulation caused by high levels of BCAAs are still under debate.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Endocrinology & Metabolism
Ralph G. Cosentino, James R. Churilla, Samantha Josephson, Zarela Molle-Rios, Md Jobayer Hossain, Wagner L. Prado, P. Babu Balagopal
Summary: This study investigated the role of BCAA and AAA in obesity among youth, finding correlations with body composition and novel biomarkers of CVD. However, a physical activity-based lifestyle intervention had minimal effects on BCAA and AAA concentrations.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Review
Cell Biology
Michaela E. Trautman, Nicole E. Richardson, Dudley W. Lamming
Summary: The proportion of people suffering from age-related diseases is increasing worldwide. Recent research has shown that low protein diets, particularly those low in branched-chain amino acids (BCAAs), can reduce mortality and promote metabolic health and extended lifespan in both humans and rodents. This article discusses the emerging evidence that BCAAs play a crucial role in healthy metabolism and longevity, and explores the physiological and molecular mechanisms behind the benefits of restricting dietary BCAAs. The findings suggest that the quality of protein, specifically the composition of dietary protein, may be a previously overlooked factor in metabolic dysfunction and reducing dietary BCAAs could be a promising new approach to delaying and preventing age-related diseases.
Article
Medicine, Research & Experimental
Yasuyuki Tamai, Zhen Chen, Yue Wu, Jun Okabe, Yoshinao Kobayashi, Hitoshi Chiba, Shu-Ping Hui, Akiko Eguchi, Motoh Iwasa, Masaaki Ito, Yoshiyuki Takei
Summary: The combined treatment of BCAA and L-carnitine significantly improved hepatocellular function, reduced lipid deposition and adipophilin expression, and protected the liver by maintaining mitochondrial integrity in cirrhotic rats, supporting their therapeutic potential in human chronic liver diseases.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Food Science & Technology
Vanessa Yanti, Vanessa Violina, Caecilia Eka Putri, Bibiana Widiyati Lay
Summary: In this study, mung bean tempeh powder was produced and a high branched amino acid ONS was formulated. The results showed that mung bean tempeh had high protein and BCAA content. The sensory analysis showed that ONS F1 and F4 were well-liked by panelists. Additionally, both F1 and F4 demonstrated significant antioxidant capacity. This suggests that mung bean tempeh can be recommended as a functional ingredient for ONS development.
Review
Biochemistry & Molecular Biology
Emily Kwun Kwan Lo, Felicianna, Jing-Hang Xu, Qiao Zhan, Zheng Zeng, Hani El-Nezami
Summary: Branched-chain amino acids (BCAAs) are related to chronic liver diseases, but BCAA supplementation has positive effects on cirrhosis and hepatocellular carcinoma (HCC) patients. This review aims to clarify the contradictory claims and study the role of BCAAs in liver health.
Review
Oncology
Er Xu, Bangju Ji, Ketao Jin, Yefeng Chen
Summary: Branched-chain amino acids (BCAAs) play a crucial role in tumorigenesis and can influence tumor growth and progression. Increased levels of BCAAs have been associated with tumor growth inhibition, while a deficiency in BCAAs can promote tumor metastasis. BCAAs serve as nitrogen donors, contributing to the synthesis of macromolecules crucial for cancer cell growth. This review discusses the dual role of BCAAs in cancer and provides insights into their potential as therapeutic interventions.
FRONTIERS IN ONCOLOGY
(2023)
Article
Clinical Neurology
Masakazu Minetama, Mamoru Kawakami, Masatoshi Teraguchi, Yoshio Enyo, Masafumi Nakagawa, Yoshio Yamamoto, Nana Sakon, Sachika Matsuo, Tomohiro Nakatani, Ryota Nakagawa, Wakana Nagata, Yukihiro Nakagawa
Summary: A randomized controlled trial found that supplementation with branched-chain amino acids (BCAA) and vitamin D did not improve postoperative recovery in patients with lumbar spinal stenosis (LSS).
Article
Pharmacology & Pharmacy
Tiangang Wu, Mengling Wang, Fengling Ning, Shilin Zhou, Xuetao Hu, Hong Xin, Svetlana Reilly, Xuemei Zhang
Summary: Fibrosis, characterized by excessive production of extracellular matrix, is a common pathological feature of organ diseases. Metabolic alterations, especially in the regulation of branched-chain amino acids (BCAAs), have been found to play significant roles in fibrogenesis. Dysregulation of BCAAs metabolism has been implicated in various diseases. This review summarizes the metabolic regulation of fibrosis, changes in BCAAs metabolism associated with fibrosis, and the effects and mechanisms of BCAAs intervention in hepatic, renal, and cardiac fibrosis, with a focus on liver fibrosis and associated hepatocellular carcinoma.
PHARMACOLOGICAL RESEARCH
(2023)
Review
Gastroenterology & Hepatology
Giuseppe Marrone, Amato Serra, Luca Miele, Marco Biolato, Antonio Liguori, Antonio Grieco, Antonio Gasbarrini
Summary: Liver cirrhosis is often accompanied by nutritional alterations, affecting about 20% of patients with compensated disease and over 60% of patients with decompensated cirrhosis. Imbalance of amino acids, especially branched-chain amino acids (BCAAs), has been shown to be associated with complications and prognosis in these patients. Various studies have explored the use of BCAAs supplementation as a therapeutic option, but uncertainties persist regarding its real efficacy, optimal administration route, and dosage.
WORLD JOURNAL OF GASTROENTEROLOGY
(2023)
Review
Medicine, Research & Experimental
Jingtong Wang, Wei Wang, Feng Zhu, Qiuhong Duan
Summary: Branched-chain amino acids (BCAAs) play a crucial role in human bodies and their metabolic disorders are closely associated with tumorigenesis and progression. This review discusses the significant role of BCAAs metabolic disorders in different tumor types and explores related proteins and therapeutic approaches.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Medicine, General & Internal
Jia-Yu Du, Liu Shu, Yu-Tian Zhou, Li Zhang
Summary: BCAAs reduce the incidence of complications in patients with LC and improve nutritional status.
WORLD JOURNAL OF CLINICAL CASES
(2022)