Article
Clinical Neurology
Askiel Bruno, Nina Paletta, Uttam Verma, Monika E. Grabowska, Heather M. Haughey, Prem P. Batchala, Solomon Abay, Joseph Donahue, John Vender, Sankara Sethuraman, Fenwick T. Nichols
Summary: The study analyzed clinical factors and CT measurements in patients with DC for MHI and found that patient age and post-DC midline shift may be predictors of functional outcome after DC for MHI.
WORLD NEUROSURGERY
(2022)
Article
Clinical Neurology
Daniel W. Griepp, Aaron Miller, Sahar Sorek, Stephanie Moawad, Ralph Rahme
Summary: Background: Bilaterally fixed and dilated pupils have traditionally been considered a sign of poor prognosis. This study aimed to determine the survival and functional outcome in patients who underwent aggressive medical and surgical management.
WORLD NEUROSURGERY
(2022)
Article
Clinical Neurology
Wolfgang Haupt, Lukas Meyer, Maximilian Wagner, Rosalie McDonough, Sarah Elsayed, Matthias Bechstein, Gerhard Schoen, Helge Kniep, Andre Kemmling, Jens Fiehler, Uta Hanning, Gabriel Broocks
Summary: This study suggests that the reduction of relative cerebral blood volume (rCBV) is predictive of irreversible tissue injury and functional outcome in patients with ischemic stroke, particularly in those with core volumes > 50 ml. Thus, analyzing rCBV reduction within ischemic lesions may provide additional information for acute stroke management.
TRANSLATIONAL STROKE RESEARCH
(2023)
Article
Clinical Neurology
Yong -Hong Duan, Jian He, Xiao-Fei Liu, Yuan -Ding Jiang, Tao Wang, Jie Luo, Peng Xu, Yong-Dong Li, Zhen-Kun Xiao, Aihua Liu, Fei Peng, Yong -Mei Yang
Summary: The study shows that SEBES can provide good imaging support for intracranial pressure management in poor-grade aSAH patients, potentially improving DC-related decision-making and 180-day survival.
WORLD NEUROSURGERY
(2022)
Article
Multidisciplinary Sciences
Yong Li, Li Tan, Caixia Yang, Liying He, Lin Liu, Bowen Deng, Sijing Liu, Jinlin Guo
Summary: This study compared two rodent models of ischemic stroke and analyzed the differences in model establishment, cerebral blood flow, and cerebral ischemia-reperfusion injury. The findings suggest that the MCAO-KM method is simple to operate with a high modeling success rate, suitable for studying brain edema under long-term hypoperfusion, while the MCAO-LG method is highly challenging for novices, suitable for studying CIRI caused by complete ischemia-reperfusion.
SCIENTIFIC REPORTS
(2023)
Article
Clinical Neurology
Maryam Said, Meltem Gumus, Annika Herten, Thiemo Florin Dinger, Mehdi Chihi, Marvin Darkwah Oppong, Cornelius Deuschl, Karsten H. Wrede, Christoph Kleinschnitz, Ulrich Sure, Ramazan Jabbarli
Summary: The study identified factors such as younger age, female sex, poor initial clinical condition, intracerebral hemorrhage, hypothyroidism, and renal comorbidity as being associated with the severity of early brain edema after aneurysm rupture. Furthermore, severe early brain edema was independently associated with the need for conservative ICP treatment, decompressive craniectomy, development of cerebral infarcts, and unfavorable outcome.
EUROPEAN JOURNAL OF NEUROLOGY
(2021)
Review
Clinical Neurology
Audrey Carlhan-Ledermann, Andrea Bartoli, Fabienne Gebistorf, Maurice Beghetti, Tornike Sologashvili, Monica Rebollo Polo, Joel Fluss
Summary: Malignant stroke is a life-threatening emergency with a high mortality rate. Decompressive hemicraniectomy (DCH) has been rarely reported in pediatric stroke patients and its indication remains controversial, but it could be a potential lifesaving option.
CHILDS NERVOUS SYSTEM
(2023)
Review
Clinical Neurology
Nathan A. Shlobin, Jeffrey R. Clark, Justin M. Campbell, Mark Bernstein, Babak S. Jahromi, Matthew B. Potts
Summary: This article outlines the application of bioethics in stroke care, discusses key ethical issues and special situations, and proposes methods to improve ethical decision-making for patients.
Article
Endocrinology & Metabolism
Felix C. Ng, Leonid Churilov, Nawaf Yassi, Timothy J. Kleinig, Vincent Thijs, Teddy Y. Wu, Darshan Shah, Helen M. Dewey, Gagan Sharma, Patricia M. Desmond, Bernard Yan, Mark W. Parsons, Geoffrey A. Donnan, Stephen M. Davis, Peter J. Mitchell, Bruce Cv Campbell
Summary: The relationship between reperfusion and edema in ischemic stroke patients with large vessel occlusion is complex. Core volume on pre-treatment CT-Perfusion is positively associated with edema, while mismatch volume has a significant interaction with reperfusion in influencing edema outcomes. Reperfusion appears to have a beneficial effect in reducing edema in patients with large mismatch volume but not in those with smaller mismatch volume.
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2021)
Review
Clinical Neurology
Jessica Lin, Jennifer A. Frontera
Summary: Large hemispheric infarcts are a serious consequence of ischemic strokes, potentially leading to disability. Current research and clinical efforts focus on identifying predictors of malignant edema, optimizing medical and surgical techniques, and selecting the most suitable patient population for decompressive surgery.
Article
Biochemistry & Molecular Biology
Nicole J. Sylvain, Mootaz M. Salman, M. Jake Pushie, Huishu Hou, Vedashree Meher, Rasmus Herlo, Lissa Peeling, Michael E. Kelly
Summary: Stroke is the second leading cause of death and the third leading cause of disability worldwide, with edema playing a major role in stroke-associated morbidity and mortality. Regulating water balance in the brain through targeting AQP4 channels may be a promising therapeutic approach for treating brain edema. The FDA-approved drug trifluoperazine (TFP) has shown efficacy in reducing cerebral edema in post-stroke mice by inhibiting AQP4 expression, without inducing deleterious changes in brain electrolytes or metabolic markers.
BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES
(2021)
Article
Endocrinology & Metabolism
Lukas Meyer, Michael Schoenfeld, Matthias Bechstein, Uta Hanning, Bastian Cheng, Goetz Thomalla, Gerhard Schoen, Andre Kemmling, Jens Fiehler, Gabriel Broocks
Summary: This study found that age is a significant factor in influencing brain edema formation after thrombectomy for LVO stroke. Younger patients showed higher edema formation on follow-up, while older patients had relatively lower levels. Successful recanalization reduced edema progression, but younger age remained independently associated with higher edema formation.
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2021)
Article
Endocrinology & Metabolism
Rajat Dhar, Ali Hamzehloo, Atul Kumar, Yasheng Chen, June He, Laura Heitsch, Agnieszka Slowik, Daniel Strbian, Jin-Moo Lee
Summary: The study indicates that the hemispheric CSF ratio can be used as an accessible early biomarker of edema severity in stroke patients, aiding in predicting the risk of developing malignant edema.
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2021)
Article
Clinical Neurology
Daniela Ferro, Margarida Matias, Joana Neto, Rafael Dias, Goreti Moreira, Nils Petersen, Elsa Azevedo, Pedro Castro
Summary: The study revealed that increased systemic inflammation following reperfusion therapy is associated with a higher severity of cerebral edema in stroke patients, leading to hindered clinical recovery. The neutrophil-to-lymphocyte ratio was identified as the best predictive marker, providing early warning alerts for patients at risk of severe neurological complications.
Article
Clinical Neurology
Wenting Guo, Jiali Xu, Wenbo Zhao, Mengke Zhang, Jin Ma, Jian Chen, Jiangang Duan, Qingfeng Ma, Haiqing Song, Sijie Li, Xunming Ji
Summary: This study developed and validated a nomogram to predict the risk of malignant cerebral artery infarction (MMI) after endovascular treatment (EVT) in patients with acute ischemic stroke (AIS) in the modern thrombectomy era. The nomogram, based on various factors, showed good discrimination and calibration.
FRONTIERS IN NEUROLOGY
(2022)
Article
Clinical Neurology
Martin Bendszus, Susanne Bonekamp, Eivind Berge, Florent Boutitie, Patrick Brouwer, Elke Gizewski, Antonin Krajina, Laurent Pierot, Gary Randall, Claus Z. Simonsen, Kamil Zelenak, Jens Fiehler, Goetz Thomalla
INTERNATIONAL JOURNAL OF STROKE
(2019)
Article
Clinical Neurology
Rani G. Sah, Christopher D. d'Esterre, Michael D. Hill, Moiz Hafeez, Sana Tariq, Nils D. Forkert, Richard Frayne, Andrew M. Demchuk, Mayank Goyal, Philip A. Barber
INTERNATIONAL JOURNAL OF STROKE
(2019)
Editorial Material
Endocrinology & Metabolism
Mohammed A. Almekhlafi, Fred Colbourne, Abdulaziz S. Al Sultan, Mayank Goyal, Andrew M. Demchuk
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2019)
Editorial Material
Endocrinology & Metabolism
Marcelo Rocha, Ashutosh P. Jadhav, Tudor G. Jovin
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2019)
Article
Neuroimaging
Simon Nagel, Christian Herweh, Johannes Alex Rolf Pfaff, Simon Schieber, Silvia Schoenenberger, Markus A. Moehlenbruch, Martin Bendszus, Peter Arthur Ringleb
JOURNAL OF NEUROINTERVENTIONAL SURGERY
(2019)
Article
Neuroimaging
Kevin Phan, Adam A. Dmytriw, Declan Lloyd, Julian M. Maingard, Hong Kuan Kok, Ronil V. Chandra, Mark Brooks, Vincent Thijs, Justin M. Moore, Albert Ho Yuen Chiu, Magdy Selim, Mayank Goyal, Vitor Mendes Pereira, Ajith J. Thomas, Joshua A. Hirsch, Hamed Asadi, Nelson Wang
JOURNAL OF NEUROINTERVENTIONAL SURGERY
(2019)
Article
Clinical Neurology
Bruce C. V. Campbell, Charles B. L. M. Majoie, Gregory W. Albers, Bijoy K. Menon, Nawaf Yassi, Gagan Sharma, Wim H. van Zwam, Robert J. van Oostenbrugge, Andrew M. Demchuk, Francis Guillemin, Philip White, Antoni Davalos, Aad van der Lugt, Kenneth S. Butcher, Aboubaker Cherifi, Henk A. Marquering, Geoffrey Cloud, Juan M. Macho Fernandez, Jeremy Madigan, Catherine Oppenheim, Geoffrey A. Donnan, Yvo B. W. E. M. Roos, Jai Shankar, Hester Lingsma, Alain Bonafe, Helene Raoult, Maria Hernandez-Perez, Aditya Bharatha, Reza Jahan, Olav Jansen, Sebastien Richard, Elad I. Levy, Olvert A. Berkhemer, Marc Soudant, Lucia Aja, Stephen M. Davis, Timo Krings, Marie Tisserand, Luis San Roman, Alejandro Tomasello, Debbie Beumer, Scott Brown, David S. Liebeskind, Serge Bracard, Keith W. Muir, Diederik W. J. Dippel, Mayank Goyal, Jeffrey L. Saver, Tudor G. Jovin, Michael D. Hill, Peter J. Mitchell
Article
Cardiac & Cardiovascular Systems
Moa Simonsson, Henric Winell, Henrik Olsson, Karolina Szummer, Joakim Alfredsson, Marlous Hall, Tatendashe B. Dondo, Chris P. Gale, Tomas Jernberg
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2019)
Article
Clinical Neurology
Romain Bourcier, Mayank Goyal, David S. Liebeskind, Keith W. Muir, Hubert Desal, Adnan H. Siddiqui, Diederik W. J. Dippel, Charles B. Majoie, Wim H. van Zwam, Tudor G. Jovin, Elad I. Levy, Peter J. Mitchell, Olvert A. Berkhemer, Stephen M. Davis, Linad Derraz, Geoffrey A. Donnan, Andrew M. Demchuk, Robert J. van Oostenbrugge, Michael Kelly, Yvo B. Roos, Reza Jahan, Aad van der Lugt, Marieke Sprengers, Stephane Velasco, Geert J. Lycklama A. Nijeholt, Wagih Ben Hassen, Paul Burns, Scott Brown, Emmanuel Chabert, Timo Krings, Hana Chloe, Christian Weimar, Bruce C. V. Campbell, Gary A. Ford, Marc Ribo, Phil White, Geoffrey C. Cloud, Luis San Roman, Antoni Davalos, Olivier Naggara, Michael D. Hill, Serge Bracard
Review
Biotechnology & Applied Microbiology
Aubrey M. Demchuk, Trushar R. Patel
BIOTECHNOLOGY ADVANCES
(2020)
Article
Neurosciences
Aubrey M. Demchuk, Sutherland T. Dube, Lilia Mesina, Bruce L. McNaughton
NEUROSCIENCE LETTERS
(2020)
Article
Public, Environmental & Occupational Health
Louise C. Hawkley, Andrew Steptoe, L. Philip Schumm, Kristen Wroblewski
SOCIAL SCIENCE & MEDICINE
(2020)
Article
Obstetrics & Gynecology
Amy Caldwell, Phil Schumm, Manoradhan Murugesan, Debra Stulberg
Summary: Delivery at a Catholic hospital is associated with an increased risk of short-interval pregnancy among Illinois Medicaid enrollees.
Article
Public, Environmental & Occupational Health
L. Philip Schumm, Mihai C. Giurcanu, Kenneth J. Locey, Jean Czerlinski Ortega, Zhenyu Zhang, Robert L. Grossman
Summary: During the initial 12 months of the pandemic, disparities in COVID-19 case fatality rates among U.S. Black and Latinx individuals under age 65 were evident, with Black and Latinx individuals having higher CFRs than White individuals in this age group. Disparities in CFRs varied substantially across states and time, making it challenging to understand racial and ethnic differences in COVID-19 CFRs due to limitations in available data.
ANNALS OF EPIDEMIOLOGY
(2022)
Article
Clinical Neurology
Anna C. Alegiani, Franziska Dorn, Moriz Herzberg, Frank A. Wollenweber, Lars Kellert, Eberhard Siebert, Christian H. Nolte, Regina von Rennenberg, Elke Hattingen, Gabor C. Petzold, Felix J. Bode, Waltraud Pfeilschifter, Jan H. Schaefer, Marlies Wagner, Joachim Roether, Bernd Eckert, Peter Kraft, Mirko Pham, Tobias Boeckh-Behrens, Silke Wunderlich, Kathleen Bernkopf, Arno Reich, Martin Wiesmann, Anastasios Mpotsaris, Marios Psychogios, Jan Liman, Ilko Maier, Joerg Berrouschot, Albrecht Bormann, Volker Limmroth, Joachim Spreer, Martina Petersen, Lars Krause, Stephan Lowens, Christoffer Kraemer, Sarah Zweynert, Kristin S. Lange, Sven Thonke, Andreas Kastrup, Panagiotis Papanagiotou, Burkhard Alber, Michael Braun, Jens Fiehler, Christian Gerloff, Martin Dichgans, Goetz Thomalla
INTERNATIONAL JOURNAL OF STROKE
(2019)